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| 1 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties显示文摘 | Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. G?ktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neu | 2013 | Cell2013，，： | 3 |
| 2 | 射流泵系统在非开挖HDD中的应用研究显示文摘非开挖HDD技术被广泛应用于给排水、电力、通信、油气等领域的新管道敷设和既有管线修复中。当在浅部地层以及上覆地层应力较小的区域进行HDD施工时,易出现'溢浆'现象。本文结合国内外'溢浆'防控技术研究现状,对德国某公司的孔内新型射流泵系统在非开挖工程中的应用进行了论述。该系统利用在近钻头位置安装的高压射流泵系统收集前端钻头扩孔后形成的钻屑,从而减少钻孔环状空间的钻屑含量。系统主要由钻屑收集装置、射流泵体和连接装置3部分组成,可实现98%左右孔内钻屑的清理。根据工程需要,可采用清孔、软土扩(清)孔、组合以及管道回拉等4种模式进行工程作业。工程实践表明,采用该系统后单日最长掘进长度达到122m。同时提出了存在的问题:由于小直径复杂地层钻进中易出现钻屑团积,从而对筛格产生堵塞。在管道回拉模式中,如何改变钻屑返排的回路等问题仍是该系统在应用中亟待解决的关键问题。 | 朱俊毅 孙平贺 曹函 Gerhard Lang 张绍和 王靖源 | 2018 | 探矿工程(岩土钻掘工程)2018，45，10： | 2 |
| 3 | Su1261 Expression of Interleukins 22 and 33, Matrix Metalloproteinases 9 and 13, Mast Cell Markers and Hypoxia-Inducible Factor 1α in Crohn’s Disease Associated Fistulae显示文摘 | Sandra M. Frei Silvia Lang Ekkehard C. Jehle Michael Fried Gerhard Rogler Michael Scharl | 2013 | Gastroenterology2013，，5： | 1 |
| 4 | Hidden Markov Model-Baed Emotion Recognition 显示文摘 | Bjom Sehuller Gerhard RigoU Manfred Lang | 2003 | IEEE Signal Processing Magazine2003，10，6： | 1 |
| 5 | Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn’s disease (CD) mucosa显示文摘 | Julia Brenmoehl Markus Lang Martin Hausmann Sandra N. Leeb Werner Falk Jürgen Sch?lmerich Michael G?ke Gerhard Rogler | 2007 | International Journal of Colorectal Disease2007，，6： | 1 |
| 6 | Aquifer characterisation using Surface NMR jointly with other geophysical techniques at the Nauen/Berlin test site显示文摘 | Yaramanci U Gerhard Lange Marian Hertrich | 2002 | Journal of Applied Geophysics2002，2002，50： | 1 |
| 7 | Aquifer Characterisation Using Surface NMR Jointly with Other 显示文摘 | UGUR YARAMANCI GERHARD LANGE MARIAN HERTRICH | 2002 | Journal of Applied Geophysics2002，50，12： | 1 |
| 8 | Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel显示文摘 | Jolanta M. Siller-Matula Alexander O. Spiel Irene M. Lang Gerhard Kreiner Guenter Christ Bernd Jilma | 2009 | American Heart Journal2009，，1： | 1 |
| 9 | Aquifer Characterisation Using Surface NMR Jointly withother Geophysical Techniques at the Nauen/ Berlin Test Site 显示文摘 | UGUR YARAMANCI GERHARD LANGE MARIAN HERTRICH | 2002 | Journal of Applied Geophysics2002，50，12： | 1 |
| 10 | ScopularidesA and B,Cyclodepsipeptides from a Marine Sponge-DerivedFungus,Scopulariopsis brefiicaulis显示文摘 | Zhiguo Yu Gerhard Lang Inga Kajahn | 2008 | J Nat Prod2008，71，： | 1 |
| 11 | The Helicobacter pylofi blood group antigen binding adhesin facilitates bacterial colonization and augments a nonspecific immune response显示文摘 | RAD R GERHARD M LANG R | 2002 | J Tmmunol2002，168，6： | 1 |
| 12 | Improved detection of renal pathologic features on multiphasic helical CT compared with IVU in patients presenting with microscopic hematuria显示文摘 | Erich K Lang Richard J Macchia Raju Thomas Richard A Watson Michael Marberger Gerhard Lechner Brian Gayle Frank Richter | 2003 | Urology2003，，： | 1 |
| 13 | Clinical utility of anti‐glycan antibodies in pediatric crohn’s disease in comparison with an adult cohort显示文摘 | Florian Rieder Philipp Hahn Lydia Finsterhoelzl Stephan Schleder Alexandra Wolf Andrea Dirmeier Rocio Lopez Bo Shen Gerhard Rogler Frank Klebl Thomas Lang | 2011 | Inflamm Bowel Dis2011，，7： | 1 |
| 14 | Changes of protein expression during tumorosphere formation of small cell lung cancer circulating tumor cells显示文摘Small cell lung cancer(SCLC)is frequently disseminated and has a dismal prognosis with survival times of approximately two years.This cancer responds well to initial chemotherapy but recurs within a short time as a globally chemoresistant tumor.Circulating tumor cells(CTCs)are held responsible for metastasis,the extremely high numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell lines.These CTCs are distinguished by the spontaneous formation of large spheroids,termed tumorospheres,in regular tissue culture.These contain quiescent and hypoxic cells in their interior and are associated with high chemoresistance compared to single cell cultures.Nine CTC lines were compared for their expression of 84 proteins associated with cancer either as single cells or in the form of tumorospheres in Western blot arrays.With the exception of the UHGc5 line,all other CTC lines express EpCAM and lack a complete EpCAM-negative,vimentin-positive epithelial-mesenchymal transition(EMT)phenotype.Upon formation of tumorospheres the expression of EpCAM,that mediates cell-cell adhesion is markedly upregulated.Proteins such as E-Cadherin,p27 KIP1,Progranulin,BXclx,Galectin-3,and Survivin showed variable changes for the distinct CTC cell lines.In conclusion,EpCAM presents the most critical marker for individual SCLC CTCs and the assembly of highly chemoresistant tumorospheres. | SANDRA STICKLER BARBARA RATH MAXIMILIAN HOCHMAIR CLEMENS LANG LUKAS WEIGL GERHARD HAMILTON | 2023 | Oncology Research2023，31，1： | 0 |
| 15 | AF4通道技术表征病毒样颗粒显示文摘病毒样颗粒(VLP)是一种越来越受到广泛关注的抗体疫苗。为了对其进行质量控制,采用灵敏的分析方法非常重要。这项研究阐述了将非对称流分离(AF4)方法开发用于VLP研究。结果表明,AF4在研究VLP表达方面具有很大的潜力,超过了通常使用的动态光散射和尺寸排阻高效液相色谱法。 | Rainer LANG Lorenz VOGT Alexander ZüRCHER Gerhard WINTER | 2010 | 生命科学仪器2010，8，4： | 0 |
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