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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Crohn's disease and growth deficiency in children and adolescents显示文摘Nutritional concerns, linear growth deficiency, and delayed puberty are currently detected in up to 85% of patients with Crohn's disease(CD) diagnosed at childhood. To provide advice on how to assess and manage nutritional concerns in these patients, a Medline search was conducted using 'pediatric inflammatory bowel disease', 'pediatric Crohn's disease', 'linear growth','pubertal growth', 'bone health', and 'vitamin D' as key words. Clinical trials, systematic reviews, and metaanalyses published between 2008 and 2013 were selected to produce this narrative review. Studies referring to earlier periods were also considered if the data was relevant to our review. Although current treatment strategies for CD that include anti-tumor necrosis factor-αtherapy have been shown to improve patients' growth rate, linear growth deficiencies are still common. In pediatric CD patients, prolonged diagnostic delay, high initial activity index, and stricturing/penetrating typeof behavior may cause growth deficiencies(in weight and height) and delayed puberty, with several studies reporting that these patients may not reach an optimal bone mass. Glucocorticoids and inflammation inhibit bone formation, though their impact on skeletal modeling remains unclear. Long-term control of active inflammation and an adequate intake of nutrients are both fundamental in promoting normal puberty. Recent evidence suggests that recombinant growth factor therapy is effective in improving short-term linear growth in selected patients, but is of limited benefit for ameliorating mucosal disease and reducing clinical disease activity. The authors conclude that an intense initial treatment(taking a 'top-down' approach, with the early introduction of immunomodulatory treatment) may be justified to induce and maintain remission so that the growth of children with CD can catch up, ideally before puberty. Exclusive enteral nutrition has a key role in inducing remission and improving patients' nutritional status. | Marco Gasparetto Graziella Guariso | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 3 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 4 | Treating children with inflammatory bowel disease: Current and new perspectives显示文摘Inflammatory bowel disease(IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and newer generation treatments can only target selected pathways of this complex inflammatory process. This narrative review aims to provide an update on the most recent advances in treatment of paediatric IBD. A MEDLINE search was conducted using 'paediatric inflammatory bowel disease', 'paediatric Crohn's disease', 'paediatric ulcerative colitis', 'treatment', 'therapy', 'immunosuppressant', 'biologic', 'monitoring' and 'biomarkers' as key words. Clinical trials, systematic reviews, and meta-analyses published between 2014 and 2016 were selected. Studies referring to earlier periods were also considered in case the data was relevant to our scope. Major advances have been achieved in monitoring the individual metabolism, toxicity and response to relevant medications in IBD including thiopurines and biologics. New biologics acting on novel mechanisms such as selective interference with lymphocyte trafficking are emerging treatment options. Current research is investing in the development of reliable prognostic biomarkers, aiming to move towards personalised treatments targeted to individual patients. | Graziella Guariso Marco Gasparetto | 2017 | World Journal of Gastroenterology2017，23，30： | 5 |
| 5 | Inflammatory Bowel Disease Developing in Paediatric and Adult Age显示文摘 | Graziella Guariso Marco Gasparetto Laura Visonà Dalla Pozza Renata D?Incà Lucia Zancan Giancarlo Sturniolo Francesca Brotto Paola Facchin | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，6： | 1 |
| 6 | Indications to Upper Gastrointestinal Endoscopy in Children With Dyspepsia显示文摘 | G Guariso A Meneghel L Visonà Dalla Pozza C Romano L Dall?Oglio G Lombardi S Conte M Calacoci A Campanozzi C Nichetti S Piovan L Zancan P Facchin | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，5： | 1 |
| 7 | Deletion of PTEN and BMPRIA on chromosome 10q23 is not al- ways associated with juvenile polyposis of infancy显示文摘 | Salviati L Patricelli M Guariso G | 2006 | Am J Hum Genet2006，79，3： | 1 |
| 8 | Migraine and food intolerance: A controlled study in pediatric patients显示文摘 | Guariso G Berbli S Cernetti R et a l | 1993 | Pediatr Med Chir1993，15，1： | 1 |
| 9 | A GIS-based approach to evaluate biomass potential from energy crops at regional scale显示文摘 | Fiorese G Guariso G | 2010 | Environmental Modelling & Software2010，，25： | 1 |
| 10 | Migraine and food ifitolerante a controlled study in pediatric patients显示文摘 | Guariso G Bertoli S Cernetti R | 1993 | Pediatr Med Chir1993，15，1： | 1 |
| 11 | Helicobacter pylori Eradication Therapy: Current Availabilities 显示文摘 | Gasparetto M Pescarin M Guariso G | 2012 | ISRN Gastroenterol2012，，18： | 1 |
| 12 | Migraine and food intolerance:a controlled study in pediatric patients显示文摘 | Guariso G Bertoli S Cernetti R | 1993 | Pediatr Med Chir1993，15，1： | 1 |
| 13 | Duodenal Bulb Biopsies in Celiac Disease: A Multicenter Study显示文摘 | Margherita Bonamico Enina Thanasi Paolo Mariani Raffaella Nenna Rita Pia Lara Luparia Cristiana Barbera Isabella Morra Pietro Lerro Graziella Guariso Costantino De Giacomo Serenella Scotta Stefano Pontone Francesco Carpino Fabio Massimo Magliocca | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，5： | 1 |
| 14 | Clinical Relevance of Helicobacter pylori cagA and vacA Gene Polymorphisms显示文摘 | Daniela Basso Carlo–Federico Zambon Darren P. Letley Alessia Stranges Alberto Marchet Joanne L. Rhead Stefania Schiavon Graziella Guariso Marco Ceroti Donato Nitti Massimo Rugge Mario Plebani John C. Atherton | 2008 | Gastroenterology2008，，1： | 1 |
| 15 | An application of pruning in the design of neural networks for real time flood forecasting显示文摘 | Corani G Guariso G | 2005 | Neural Computing and Applicaitons2005，14，1： | 1 |
| 16 | An Application of Pruning in the Design of Neural Networks for Real Time Flood Foreeasting显示文摘 | Giorgio Corani Giorgio Guariso | 2005 | Neural Computing and Applieaitons2005，14，1： | 1 |
| 17 | A GIS-based approach to evaluate biomass potential from energy crops at regional scale显示文摘 | Fiorese G Guariso G | 2010 | Environmental Modelling and Software2010，25，6： | 1 |
| 18 | GastroPanel: evaluation of the usefulness in the diagnosis of gastro-duodenal mucosal alterations in children 显示文摘 | Guariso G Basso D Bortoluzzi CF | 2009 | Clin C him Acta2009，402，12： | 1 |
| 19 | A GIS-based approach to evaluate biomass potential from energy crops at regional scale显示文摘 | FIORESE GIULIA GUARISO GIORGIO | 2011 | Enviromnental Modelling & Software2011，25，6： | 1 |
| 20 | Helicobacter pylori Erad- ication Therapy : Current Availabilities 显示文摘 | Gasparetto M Pescarin M Guariso G | 2012 | ISRN Gastroenterol2012，2012，18： | 1 |
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