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| 1 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 2 | Particle swarm optimization and its application to seismic inversion of igneous rocks显示文摘In order to improve the fine structure inversion ability of igneous rocks for the exploration of underlying strata, based on particle swarm optimization(PSO), we have developed a method for seismic wave impedance inversion. Through numerical simulation, we tested the effects of different algorithm parameters and different model parameterization methods on PSO wave impedance inversion, and analyzed the characteristics of PSO method. Under the conclusions drawn from numerical simulation, we propose the scheme of combining a cross-moving strategy based on a divided block model and high-frequency filtering technology for PSO inversion. By analyzing the inversion results of a wedge model of a pitchout coal seam and a coal coking model with igneous rock intrusion, we discuss the vertical and horizontal resolution, stability and reliability of PSO inversion. Based on the actual seismic and logging data from an igneous area, by taking a seismic profile through wells as an example, we discuss the characteristics of three inversion methods, including model-based wave impedance inversion, multi-attribute seismic inversion based on probabilistic neural network(PNN) and wave impedance inversion based on PSO.And we draw the conclusion that the inversion based on PSO method has a better result for this igneous area. | Yang Haijun Xu Yongzhong Peng Gengxin Yu Guiping Chen Meng Duan Wensheng Zhu Yongfeng Cui Yongfu Wang Xingjun | 2017 | International Journal of Mining Science and Technology2017，27，2： | 3 |
| 3 | Identification of QTLs for Branch Number in Oilseed Rape(Brassica napus L.)显示文摘Oilseed rape(Brassica napus L.)is one of the most important oil crops worldwide and provides about 50 percent of the vegetable oil supply in China(Yin et al.,2009).The development of rapeseed varieties with higher yield is an effective measure to optimize balance between the supply and | Jinsong Xu Xi Song Yong Cheng Xiling Zou Liu Zeng Xing Qiao Guangyuan Lu Guiping Fu Zhen Qu Xuekun Zhang | 2014 | Journal of Genetics and Genomics2014，41，10： | 2 |
| 4 | Hierarchical Dispatch Method for Integrated Heat and Power Systems Based on a Feasible Region of Boundary Variables显示文摘Fully utilizing the flexibility provided by a district heating system(DHS)can promote wind power accommodation for an electric power system(EPS).However,for privacy or communication reasons,existing power and heat dispatch methods are not suitable for practical application.In this paper,a general math formulation of the hierarchical dispatch method is proposed to coordinate EPS and DHS operators based on the feasible region of boundary variables(FRBV),and a method based on the simplicial approximation approach is proposed to obtain a conservative FRBV approximation of a DHS.A simulation based on a real 41-node DHS is constructed to determine the factors that may impact the boundaries of the FRBV,and then the performance of the simplicial approximation approach is displayed by visualizing the approximation process for the FRBV,and finally three dispatch methods are compared to show the advantages of the proposed hierarchical dispatch method. | Tuo Jiang Yong Min Weichun Ge Lei Chen Qun Chen Fei Xu Huanhuan Luo Guiping Zhou | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 2 |
| 5 | Formulation optimization and in vitro antibacterial ability investigation of azithromycin loaded FDKP microspheres dry powder inhalation显示文摘Azithromycin loaded fumaryl diketopiperazine(FDKP)dry powder inhalation was designed and prepared for the treatment of community-acquired pneumonia.The solubility of FDKP and stability of azithromycin solution was investigated.Formulation of azithromycin loaded FDKP microparticle was investigated and optimized by the single factor experiment.High-pressure homogenization and spray drying conditions were also optimized to prepare the particles by spray drying azithromycin dissolved FDKP microparticle suspension at pH 4.5.The in vitro antibacterial efficiency and in vitro dispersion performance was also investigated to confirm the antibacterial efficiency,dispersion and deposition behavers.FDKP/azithromycin mass ratio(3:2)was the optimized formulation of azithromycin loaded FDKP microparticle with the maximal drug loading efficiency.High-pressure homogenization and spray drying conditions were also optimized.The in vitro antibacterial results indicated that only with the antibiotic concentration higher than mutant prevention concentration could totally inhibit the reproduction of bacteria.In vitro dispersion performance of azithromycin loaded FDKP microparticles(AZM@FDKP-MPs)also shows remarkable improvement of dispersion and deposition behavers of AZM.AZM@FDKP-MPs dry powder inhalation as a targeting delivery route has better potential for lung infection treatment. | Qiyue Wang Liang Ge Lu Wang Ying Xu Si Miao Guiping Yu Yan Shen | 2021 | Chinese Chemical Letters2021，32，3： | 2 |
| 6 | On solutions of Matrix equation AXB + CYD = F 显示文摘 | Xu Guiping Wei Musheng Zheng Daosheng | 1998 | Linear Algebra Appl1998，279，： | 1 |
| 7 | Dispatch Model for Integrated Heat and Power Systems Considering Internal Composition of CHP Plants显示文摘An integrated heat and power system(IHPS)is a promising approach for alleviating wind curtailment problems.In an IHPS,the combined heat and power(CHP)plant is the key component,which supplies both heat and electric loads,and couples the thermal system and power system.However,existing research commonly ignores or simplifies the internal composition of CHP plants,which could lead to some unavoidable errors.This paper focuses on the internal composition of CHP plants,and models the physical processes in different components and flexible resources in the CHP plant.Furthermore,a joint dispatch problem of an IHPS with the above CHP plant models is formulated,and an iterative algorithm is developed to handle the nonlinearity in this problem.Case studies are performed based on a real CHP plant in Northern China,and the results indicate that the synergistic effect of different energy resources in the CHP plant is realized by the joint dispatch model,which promotes wind power accommodation and reduces fossil fuel consumption. | Tuo Jiang Yong Min Guiping Zhou Lei Chen Qun Chen Fei Xu | 2021 | CSEE Journal of Power and Energy Systems2021，7，2： | 1 |
| 8 | Load-Balancing and QoS Based Dynamic Resource Allocation Method for Smart Gird Fiber-Wireless Networks显示文摘Real-time network resource allocation based on virtualization technology is an important method to solve the solidification problem of Fiber-wireless(Fi-Wi)access networks.To increase the resource utilization and meet the specific QoS requirements of smart gird communication services,a Load-balancing and QoS based dynamic resource allocation method(LbQ-DR)is proposed with three sub-mechanisms.A time-window based substrate network resource update mechanism is designed to describe the realtime resource consumption of substrate networks,which can balance the accuracy of resource status and the complexity of the allocation algorithm.A QoS-based Virtual network request(VNR)sorting mechanism is presented to precisely calculate the priority of VNRs and reasonably sort the incoming services.A load-balancing based resource allocation mechanism is designed to avoid unbalanced resource consumption.Especially,the channel interference is considered in the cost of embedding and a collision domain mechanism is introduced to decrease interference.Simulation results demonstrate that the proposed method can provide heterogeneous smart grid businesses with differentiated service,improve the utilization and economic benefits of the network and make the network more balanced. | XU Siya LI Peng QI Feng GUO Shaoyong ZHOU Guiping DENG Wei LI Yueyue | 2019 | Chinese Journal of Electronics2019，28，6： | 1 |
| 9 | Preparation and characterization of PES/TiO 2 composite membranes显示文摘 | Guiping Wu Shuying Gan Longzhe Cui Youyi Xu | 2008 | Applied Surface Science2008，，21： | 1 |
| 10 | On Solutions of Matrix Equation AXB + CYD = F显示文摘 | Wei Musheng Zheng Daosheng | 1998 | Linear Algebra Appl1998，279，： | 1 |
| 11 | On solutions of matrix equation AXB + CYD = F显示文摘 | Guiping Xu Musheng Wei Daosheng Zheng | 1998 | Linear Algebra Appl1998，279，： | 1 |
| 12 | Cadmium-induced accumulation of hydrogen peroxide in the leaf apoplast of Phaseolus aureus and Vicia sativa and the roles of different antioxidant enzymes显示文摘 | Fenqin Zhang Hongxiao Zhang Guiping Wang Langlai Xu Zhenguo Shen | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 13 | Cenozoic magmatic activity and oblique uplifting of the Ailao Mountain: Evidence from a short-period dense seismic array显示文摘Geological studies show that the southern part of Ailaoshan-Red River shear zone(ALSRRSZ)has experienced complex metallogenic processes and multi-stage non-uniform uplifting,called oblique uplifting since the Cenozoic.To detect the deep structure and geodynamic background beneath Daping,Chang’an and other gold and polymetallic deposits in this area,we carried out a high-density short-period seismic array survey in southern Yunnan province.The array used is approximately240 km long with an interval of 500 m between two adjacent stations.Based on the data collected by the array,we used H-κstacking and common conversion point(CCP)methods of receiver functions to reveal the fine crustal structure beneath this array,which was located from Lvchun(western end)to the east and ended in Maguan.The three main conclusions are as follows.(1)The average crustal thickness is approximately 37 km and the Vp/Vsratio is 1.75.However,the thickness and Vp/Vsratio of the Ailao Mountain are rather greater or higher than those of the western Lanping-Simao Basin and eastern South-China block.These results may indicate that the crust is rich in ferromagnesian minerals or has a thermal fluid anomaly after orogenic movement.(2)There are two obvious inclined interfaces beneath the Ailao Mountain in the mid-upper crust,which suggests that strong deformation occurred there during the orogenic period.Some evidences,such as the weak converted-wave Pms phase from the Moho,low P-wave velocities of the upper mantle,high surface heat flow values,and generally developed hot springs,indicate that a strong crust-mantle interaction exists in the southern segments of the Ailaoshan-Red River shear zone.These interactions include a diapir of mantle-sourced magma(stronger in the east than that in the west),lateral collision from the Indian Plate,and the differential uplift caused by the strike-slip movement of the Red River Fault.All of above deep processes led to the Cenozoic oblique uplifting of Ailao Mountain.(3)By combining the location of the deposits on the surface,characteristics of the average crustal Vp/Vsratio,hypocenters of the small earthquakes along the research profile,Moho shape,and horizontal variations of the Pms phase amplitudes,we speculate that the Ailaoshan Fault was the upgoing conduit for metallogenic magma and played a significant role in the Cenozoic development of the multiform metal deposits around the Ailao Mountain area. | Lu ZHANG Zhiming BAI Tao XU Zhenbo WU Minfu HUANG Guiping YU Junlei CHEN Mengjie ZHENG | 2020 | Science China Earth Sciences2020，63，9： | 1 |
| 14 | Estrogen improved metabolic syndrome through down-regulation of VEGF and HIF-1α to inhibit hypoxia of periaortic and intra-abdominal fat in ovariectomized female rats显示文摘 | JinWen Xu QiuLing Xiang GuiPing Lin XiaoDong Fu KeWen Zhou Ping Jiang ShuHui Zheng TingHuai Wang | 2012 | Molecular Biology Reports2012，，8： | 1 |
| 15 | Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions显示文摘 | Juan Xu Lili Ma Yang Liu Fei Xu Jun Nie Guiping Ma | 2012 | International Journal of Biological Macromolecules2012，，2： | 1 |
| 16 | On solutions of matrix equation AXB+CYD=-F 显示文摘 | Xu Guiping Wei Musheng Zheng Daosheng | 1998 | Linear Algebra and its Applications1998，279，123： | 1 |
| 17 | On solutions of matrix equation AXB + CYD = F显示文摘 | Guiping Xu Musheng Wei Daosheng Zheng | 1998 | Linear Algebra and Its Applications1998，，1： | 1 |
| 18 | Establishment of a risk assessment system for complications of hepatectomy based on preoperative variables显示文摘Background and aims:To reduce the incidence of postoperative complications,it is important to predict them and intervene before surgery if necessary.However,there is no ideal system to evaluate the overall risk of post-operative complications of liver surgery on the basis of preoperative variables.Therefore,this study aimed to design and validate a risk assessment system to predict postoperative complications of hepatectomy on the basis of preoperative variables.Methods:Binomial logistic regression was used to derive the“hepatectomy overall risk formula”(HORF)for predicting postoperative complications on the basis of preoperative variables.Results:Multivariate analysis revealed that Child–Pugh grade B–C(odds ratio[OR]=1.984,p=0.002),medical diseases requiring drug treatment(OR=1.883,p=0.003),major hepatectomy(OR=1.947,p<0.001),adjacent organ invasion(OR¼3.616,p¼0.023),and preoperative hospital stay>7 days(OR=1.565,p=0.004)were independent risk factors for postoperative complications of hepatectomy.The area under the curve for the HORF was 0.736.The optimal cut-off value for predicting complications was 0.32(32%).The area under the curve for the HORF in the validation dataset was 0.727.Conclusion:The HORF can accurately predict postoperative complications of hepatectomy on the basis of pre-operative variables,and thus enables the determination of the necessity for intervention before surgery. | Lining Xu Guiping Li Bo Yang | 2022 | iLIVER2022，1，4： | 1 |
| 19 | A Novel Multi- obiective Optimization Method Based on an Ap- proximation Model Management Technique 显示文摘 | Liu Guiping Han Xu Jiang Chao | 2008 | Computer Methods in Applied Mechanics and Engi- neering2008，197，33： | 1 |
| 20 | Ray tracing of turning wave in elliptically anisotropic media with an irregular surface显示文摘Seismic ray tracing in anisotropic media with irregular surface is crucial for the exploration of the fine crustal structure. Elliptically anisotropic medium is the type of anisotropic media with only four independent elastic parameters. Usually, this medium can be described by only the vertical phase velocity and the horizontal phase velocity for seismic wave propagation. Model parameterization in this study is described by flexible triangular grids,which is beneficial for the description of irregular surface with high degree of approximation. Both the vertical and horizontal phase velocities are defined in the triangular grids, respectively, which are used for the description of phase velocity distribution everywhere in the model by linear interpolation. We develop a shooting ray tracing method of turning wave in the elliptically anisotropic media with irregular surface. Runge-Kutta method is applied to solve the partial differential equation of seismic ray in elliptically anisotropic media. Linearly modified method is used for adjusting emergent phase angles in the shooting scheme. Numerical tests demonstrate that ray paths coincide well with analytical trajectories in transversely homogeneous elliptically anisotropic media. Seismic ray tracing results in transversely inhomogeneous elliptically anisotropic media demonstrate that our method is effective for further first-arrival tomography in elliptically anisotropic media with an irregular surface. | Minghui Zhang Tao Xu Zhiming Bai Youshan Liu Jue Hou Guiping Yu | 2017 | Earthquake Science2017，30，5： | 1 |
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