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| 1 | SHRIMP zircon U-Pb dating for volcanic rocks of the Dasi Formation in southeast Hubei Province,middle-lower reaches of the Yangtze River and its implications显示文摘The Jinniu Basin in southeast Hubei,located at the westernmost part of middle-lower val-ley of the Yangtze River,is one of the important vol-canic basins in East China. Volcanic rocks in the Jin-niu Basin are distributed mainly in the Majiashan Formation,the Lingxiang Formation and the Dasi Formation,consisting of rhyolite,basalt and basaltic andesite,(trachy)-basalt and basaltic trachy-andesite and (trachy)-andesite and (trachy)-dacite and rhyolite respectively,in which the Dasi volcanism is volumet-rically dominant and widespread. The Dasi volcanic rocks were selected for SHRIMP zircon U-Pb dating to confirm the timing of volcanism. The results indi-cate that there exist a large amount of magmatic zir-cons characterized by high U and Th contents in the volcanic rocks. The concordia ages for 13 points are 128 ± 1Ma (MSWD = 3.0). On account of the shape of zircons and Th/U ratios,this age is considered to represent the crystallization time of the Dasi volcan-ism. The volcanic rocks in the Dasi,Majiashan and Lingxiang Formations share similar trace elementand REE partition patterns as well as Sr-Nd isotopic compositions. In combination with the regional geol-ogy,it is proposed that the southeast Hubei volcanic rocks were formed mainly during the Early Creta-ceous,just like other volcanic basins in middle-lower Yangtze valley. A lithospheric extension is also sug-gested for tectonic regime in this region in the Cre-taceous Period. | XIE Guiqing MAO Jingwen LI Ruiling ZHOU Shaodong YE Huishou YAN Quanren ZHANG Zusong | 2006 | Chinese Science Bulletin2006，51，24： | 38 |
| 2 | STUDY ON CONCENTRATING SULFURIC ACID SOLUTION BY VACUUM MEMBRANE DISTILLATION显示文摘Concentrating sulfuric acid solution by vacuum membrane distillation with flat PEFE membrane is explored. The effects of sulfuric acid concentration, temperature of the feed, the vacuum degree of the vacuum side on the flux of membrane distillation and the separation efficiency of acid are investigated. The results illustrate that the flux of the membrane distillation increases with the rise of feed temperature and the vacuum degree of the vacuum side, but it decreases with the rise of the sulfuric acid concentration of the feed. The separation efficiency of acid is correlated with the flux of membrane distillation; the separation efficiency of the acid can amount to 100% in the process, when operative conditions are properly controlled. It can also been obtained from the experiment that, compared with other methods of membrane distillation, the vacuum membrane distillation can obtain greater distillation flux. | Zhang Guiqing Zhang Qixiu Zhou Kanggen (Department of Metallurgical Science and Engineering, Central South University of Technology, Changsha 410083, China) | 1999 | Journal of Central South University1999，11，2： | 16 |
| 3 | Towards an Artificial Intelligence Framework for Data-Driven Prediction of Coronavirus Clinical Severity显示文摘The virus SARS-CoV2,which causes the Coronavirus disease COVID-19 has become a pandemic and has spread to every inhabited continent.Given the increasing caseload,there is an urgent need to augment clinical skills in order to identify from among the many mild cases the few that will progress to critical illness.We present a first step towards building an artificial intelligence(AI)framework,with predictive analytics(PA)capabilities applied to real patient data,to provide rapid clinical decision-making support.COVID-19 has presented a pressing need as a)clinicians are still developing clinical acumen given the disease’s novelty,and b)resource limitations in a rapidly expanding pandemic require difficult decisions relating to resource allocation.The objectives of this research are:(1)to algorithmically identify the combinations of clinical characteristics of COVID-19 that predict outcomes,and(2)to develop a tool with AI capabilities that will predict patients at risk for more severe illness on initial presentation.The predictive models learn from historical data to help predict specifically who will develop acute respiratory distress syndrome(ARDS),a severe outcome in COVID-19.Our experimental results based on two hospitals in Wenzhou,Zhejang,China identify features most predictive of ARDS in COVID-19 initial presentation which would not have stood out to clinicians.A mild increase in elevated alanine aminotransferase(ALT)(a liver enzyme)),a presence of myalgias(body aches),and an increase in hemoglobin,in this order,are the clinical features,on presentation,that are the most predictive.Those two centers’COVID-19 case series symptoms on initial presentation can help predict severe outcomes.Predictive models that learned from historical data of patients from two Chinese hospitals achieved 70%to 80%accuracy in predicting severe cases. | Xiangao Jiang Megan Coffee Anasse Bari Junzhang Wang Xinyue Jiang Jianping Huang Jichan Shi Jianyi Dai Jing Cai Tianxiao Zhang Zhengxing Wu Guiqing He Yitong Huang | 2020 | Computers, Materials & Continua2020，，4： | 15 |
| 4 | Gradual solution heat treatment of AlSiCuMg cast alloys显示文摘The microstmcture characteristics of AlSiCuMg cast alloys were studied with different Cu content and the gradual solution treatment by DSC, SEM, TEM and mechanical method. The melting point of α(Al) + Si decreases and polynary eutectic phases with low melting point form with increase of Cu content. Gradual solution treatment includes two steps:solution treating near the melting point of polynary eutectic phase to take it dissolve first, and then increasing solution temperature to take the remainder copper intermetallics dissolved into o(Al). Grain boundaries melting can be avoided by gradual solution treatment, even the maximum solution temperature is above final solidification point, and the age hardening response increases correspondingly. | WANG Guiqing , BIAN Xiufang ,and ZHANG Junyan1) The Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, Jinan 250061, China2) Department of Material Science and Technology, Shandong Architectural Engineering Institute, Jinan 250014, China | 2003 | Rare Metals2003，22，4： | 13 |
| 5 | Mesozoic Large-scale Mineralization and Multiple Lithospheric Extensions in South China显示文摘华南是最重要的 polymetallic (钨,锡,铋,铜,银,锑,水银,稀罕金属,重稀土元素元素,黄金和铅锌) 在中国的省。这篇论文在华南描述中生代 large-scalemineralization 的基本特征。大规模矿化作用主要发生在三个 intervals:170-150 妈, 140-126 妈和 110-80 妈。在这些之中,第一个阶段被铜,铅锌和钨矿化作用和第三个阶段主要标记被锡,黄金,银和铀矿化作用主要描绘。钨和听矿化作用主要描绘的 140-126 妈的阶段是从第一的过渡间隔到第三个阶段。考虑到地区性的构造进化的当前的研究结果,在三个阶段的 large-scalemineralization 与有关,这被建议在华南块和北方中国块之间碰撞以后,到 E-Wdirection 的从 N-S 的构造政体的主要压力地的转移,并且球的延期由 Paleo-Pacificplate 的 subductlon 引起了的多重背弧石版印刷。 | MAO Jingwen XIE Guiqing LI Xiaofeng ZHANG Changqing WANG Yitian | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 13 |
| 6 | Solvent extraction of vanadium from sulfuric acid solution显示文摘The behaviour of vanadium(V) extracted from sulfuric acid solution was investigated using Cyanex 923 as an extractant. The effects of the concentration of Cyanex 923 and the pH of the solution were studied. The extraction of vanadium(V) increases with the increase of Cyanex 923 concentration and shaking time. Cyanex 923 can extract vanadium(V) from sulfuric acid solution at low pH conditions, and the best pH conditions for extraction of vanadium(V) are at pH 1.0-2.0. The species extracted into the organic phase is VO2HSO4 with one molecule of Cyanex 923. Equilibrium studies were used to assess the extraction efficiency of vanadium(V) recovery from the sulfuric acid solution. | WANG Mingyu ZHANG Guiqing WANG Xuewen ZHANG Jialiang | 2009 | Rare Metals2009，28，3： | 11 |
| 7 | Cd uptake in rice cultivars treated with organic acids and EDTA显示文摘A pot experiment was conducted to examine the activity of antioxidant enzymes, the content of malondialdehyde (MDA), proline and protein, and Cd uptake in different rice cultivars exposed to Cd (0, 1 and 5 mg/kg) in the presence of organic acids and ethylenediamine tetraacetic acid (EDTA). The results showed the increase in activity of dismutase (SOD), contents of proline and protein but a decline in activities of peroxidase (POD) and catalase (CAT), and MDA content for cultivars Xiushui63 and IIyou527. The resistance to Cd was higher in Xiushui63 than that in IIyou527 under the same Cd treatment. Cadmium contents in grain, straw and roots of both cultivars were markedly reduced in the presence of organic acids and EDTA. Grain Cd contents was the highest for plants treated with organic acids, followed by organic acids + 1/2EDTA, and the lowest with EDTA; Cd contents in straw and root were the lowest for plants treated with organic acids, followed by organic acids + 1/2EDTA, and the highest with EDTA treatment when exposed to Cd. | Weihong Xu Yangrui Li Jianping He Qifu Ma Xiaojing Zhang Guiqing Chen Huixian Wang Haibo Zhang | 2010 | Journal of Environmental Sciences2010，22，3： | 9 |
| 8 | Removal of impurities from scandium chloride solution using 732-type resin显示文摘The deep removal of Al, Fe(Ⅱ/Ⅲ), Ca, Zr, Ti and Si from scandium chloride solution was carried out by using 732-type strong acid cation exchange resin. The effects of pH value, contact time and complexing agents(EDTA) on the purification process are investigated. The results indicate that the 732-type resin have a good scandium selectivity and the adsorption order is Sc > Fe(Ⅲ)>Al > Ca > Zr > Ti > Si in the pH range of 1-3. The separation of Sc and Zr, Si, Ti can be directly carried out because the resin have a good adsorption effect on Sc, AI and Fe(Ⅲ) but poor adsorption effect on Zr, Si and Ti under the condition of pH = 2.5 and contact time 180 min. The Fe(Ⅱ), Ca and Al are selectively adsorbed on the resin by adding reducing agent ascorbic acid and EDTA into the solution for reducing Fe(Ⅲ) to Fe(Ⅱ) and complexing Sc.By using two-step ion exchange adsorption separation method, the removal rates of Fe(Ⅲ), Ti, Al, Ca, Zr and Si are 95.5%,99.8%,100%,98.2%,98.6% and 100%,respectively. | Guotao Zhou Qinggang Li Pan Sun Wenjuan Guan Guiqing Zhang Zuoying Cao Li Zeng | 2018 | Journal of Rare Earths2018，36，3： | 7 |
| 9 | Acoustic vector sensor signal processing显示文摘声学的向量传感器同时, colocately 并且直接在声学的地里在单个点象压力一样测量粒子速度的直角的部件以便是可能的改进性能传统在水下声学的测量设备或察觉系统并且为解决扩大新想法实际在水下的声学的设计问题。尽管出现在的声学的向量传感器历史在水下声学的区域不长,但是与巨大、潜在的军人一起要求声学的向量传感器在最后一十年有强壮的发展趋势,它正在演变为中的一一个重要在水下声学的技术。在这个背景下面,我们试着在声学的向量传感器信号处理上在学习考察最近的进步,例如信号察觉, DOA 评价, beamforming 等等。 | SUN Guiqing LI Qihu ZHANG Bin | 2006 | Chinese Journal of Acoustics2006，25，1： | 7 |
| 10 | ACID RECOVERY FROM WASTE SULFURIC ACID BY DIFFUSION DIALYSIS显示文摘In the process of sulfuric acid production from pyrite, there is a lot of waste acid produced in fume washing with dilute acid. Acid recovery from this sort of waste sulfuric acid by diffusion dialysis is studied in the paper. The mass transfer dialysis coefficient of sulfuric acid of the membrane AFX is measured, the effect of the flowrate of the feed and ratio of feed to water is investigated, and the two kinds of membrane (AFX and S203) are compared. The results show that diffusion dialysis process can separate the metal cation from sulfuric acid effectively, but it is difficult to separate non cation impurities as As - and F -. The contrast tests of the two membranes show that the dialysis mass transfer coefficient of the membrane AFX is larger, while capacity of the removing impurities of membrane S203 is somewhat better. | Zhang Guiqing Zhang Qixiu Zhou Kanggen (Department of Metallurgical Science and Engineering, Central South University of Technology, Changsha 410083, China) | 1999 | Journal of Central South University1999，11，2： | 6 |
| 11 | Action mechanisms of a new erythrocyte-derived depressing factor显示文摘To investigate the action mechanisms of a new erythrocyte-derived depressing factor(EDDF), the focus is placed on the effect of EDDF on both cytosolic and nuclear free calcium (Ca2+) transportation in vascular smooth muscle cell (VSMC), as well as the apoptosis and cell cycle of VSMC of rats. EDDF has been extracted from human erythrocytes. The changes of Ca2+ levels in cytoplasm ([Ca2+],) and nucleus ([Ca2+]n) have been observed using a laser scanning confocal microscope together with fluo-3/AM as a calcium indicator. Flow cytometric technique was used to study the effect of EDDF on cell cycle and apoptosis of VSMC. [Ca2+]j and [Ca2+]n were significantly decreased through several different pathways: ( i) it reduced the Ca2+ influx by blocking L-type voltage-dependent calcium channel (L-VDC) and R-type voltage-dependent calcium channel (R-VDC); (ii) it inhibited the Ca2+ release from inositol 1, 4, 5-trisphosphate (IP3) sensitive calcium store; and (iii) activated Ca2+-ATPase of sarcoplasmic reticulum ( | Yunyi Wen Xiaochun Zhang Xiaorong Xu Guiqing Zhao Fang Wan | 2000 | Chinese Science Bulletin2000，45，23： | 4 |
| 12 | 乳腺癌患者的心理状况及相关因素分析(英文)显示文摘Sufferers of breast cancer are often plagued by various psychological problems. Mastectomy, which has a serious influence on the female sex characteristics, can bring about especially serious psychological problems. These problems affect not only the patients’ quality of life but also the beginning, development, and end of the disease. This paper reviewed the relationships between the patients’ personal factors, the disease itself, treatment factors, and other socio-psychological factors and psychological conditions so as to provide new ideas for the psychological intervention on breast cancer patients, comprehensive clinical diagnosis and treatment, and prevention and cure. | Guilin Huang Yiping Wu Guiqing Zhang Pinghua Zhang Jie Gao | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 3 |
| 13 | Hierarchical red phosphorus incorporated TiO_(2) hollow sphere heterojunctions toward superior photocatalytic hydrogen production显示文摘Solar-to-hydrogen conversion through photocatalysis is a sustainable and promising strategy for storing solar energy.Recently,elemental red phosphorus(RP)with broad light absorption has been recognized as a potential candidate for photocatalytic hydrogen evolution,while challenges remain due to the rapid recombination of photogenerated carriers.In this work,RP modified TiO_(2)hollow spheres were designed and fabricated through the chemical vapor deposition method.The optimal hydrogen production rate reaching 215.5μmol/(g h)over TiO_(2)@RP heterostructure was obtained under simulated solar light irradiation.Experimental results evidenced that the hollow sphere structure and RP light absorber extended light absorption ability,and the heterostructure induced interfacial charge migration facilitated photoinduced charge separation,which benefited the photocatalytic hydrogen production performance. | Guiqing Huang Wanneng Ye Chunxiao Lv Denys S.Butenko Chen Yang Gaolian Zhang Ping Lu Yan Xu Shuchao Zhang Hongwei Wang Yukun Zhu Dongjiang Yang | 2022 | Journal of Materials Science & Technology2022，，13： | 3 |
| 14 | Neck observation versus elective neck dissection in management of clinical T1/2N0 oral squamous cell carcinoma: a retrospective study of 232 patients显示文摘Objective: The management of early-stage(cT1/2N0) oral squamous cell carcinoma(OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation(OBS) and elective neck dissection(END) in treating patients with cT1/2N0 OSCC.Methods: A total of 232 patients with cT1/2N0 OSCC were included in this retrospective study. Of these patients, 181 were treated with END and 51 with OBS. The survival curves of 5-year overall survival(OS), diseasespecific survival(DSS), and recurrence-free survival(RFS) rates were plotted using the Kaplan-Meier method for each group, and compared using the Log-rank test.Results: There was no significant difference in 5-year OS and DSS rates between END and OBS groups(OS:89.0% vs. 88.2%, P=0.906; DSS: 92.3% vs. 92.2%, P=0.998). However, the END group had a higher 5-year RFS rate than the OBS group(90.1% vs. 76.5%, P=0.009). Patients with occult metastases in OBS group(7/51) had similar 5-year OS rate(57.1% vs. 64.1%, P=0.839) and DSS rate(71.4% vs. 74.4%, P=0.982) to those in END group(39/181). In the regional recurrence patients, the 5-year OS rate(57.1% vs. 11.1%, P=0.011) and DSS rate(71.4% vs. 22.2%, P=0.022) in OBS group(7/51) were higher than those in END group(9/181).Conclusions: The results indicated that OBS policy could obtain the same 5-year OS and DSS as END. Under close follow-up, OBS policy may be an available treatment option for patients with clinical T1/2N0 OSCC. | Xiangqi Liu Xiaomei Lao Lizhong Liang Sien Zhang Kan Li Guiqing Liao Yujie Liang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 2 |
| 15 | Impact of Asarum Essential Oils on Physiological and Biochemical Indicators of Two Agricultural Pests显示文摘[Objective]The paper was to study the effects of asarum essential oils on physiological and biochemical indices of two agricultural pests. [Method]Asarum essential oils were extracted by different methods,and their effects on physiological and biochemical indices related to the structure of body wall( chitin and phenoloxidase),the physiological and biochemical indices acting on the nervous system( Acetylcholinesterase),and the physiological and biochemical indices acting on the digestive system( protease,amylase and lipase) of Ostrinia furnacalis and Mythimna seperata were studied. [Result]Asarum essential oils had no effect no chitin content of body wall under the experimental concentration,and had no inhibitory effect but activated effect on polyphenol oxidase activity. Asarum essential oils could act on the nervous system of insect,and had strong inhibitory effect against acetylcholinesterase activity of O. furnacalis larvae,with inhibition rates of 24. 86%- 38. 79%. Asarum essential oils showed a significant activated effect on pepsin activity in midgut,but the activated amplitude became smaller with the prolongation of treatment time. Asarum essential oils showed a significant inhibitory effect on activities of amylase and lipase,indicating that it could play an insecticidal effect by inhibiting activity of amylase and lipase,and it could act on digestive system of insect. [Conclusion]The study laid the foundation for further development of asarum as botanical pesticide. | Liu Yan Ji Lanzhu Wang Guiqing Wang Yuanxia Zhang Yue Yi Xuemei | 2014 | Plant Diseases and Pests2014，5，3： | 2 |
| 16 | Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression显示文摘The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression (TRD) and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with the International Classification of Diseases, Tenth Revision. Before treatment, and at 4, 6, and 8 weeks after treatment, the plasma metabolite products of monoamine neurotransmitters in TRD group, including 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol and homovanillic acid, were significantly lower than those in the non-TRD group. After two types of anti-depressive therapy with 5-serotonin and norepinephrine reuptake inhibitor, combined with psychotherapy, the Hamilton Depression Rating Scale scores were significantly reduced in both groups of patients, and the serous levels of 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenyl ethylene glycol were significantly increased. In contrast, the homovanillic acid level exhibited no significant change. The levels of plasma metabolite products of peripheral monoamine neurotransmitters in depressive patients may predict the degree of depression and the therapeutic effects of treatment. | Guiqing Zhang Yanxia Zhang Jianxia Yang Min Hu Yueqi Zhang Xia Liang | 2012 | Neural Regeneration Research2012，7，14： | 2 |
| 17 | GPU-based composite subdivision显示文摘This paper proposes a novel strategy based on fragment meshes of Shiue et al.for GPU rendering of composite subdivision surfaces.Two enumeration systems are established to label the primitives of each fragment mesh.A sector-layer-index enumeration system is responsible for retrieving proximities for subdivision masks while a sector-index enumeration system designates a 2D texture buffer in GPU.Recurring to the free conversion between them,our approach may get rid of lookup tables that are designed to record subdivision masks.In addition,relatively small composite subdivision masks make it easy to develop automatically retrieving techniques.Finally,as center vertices are often irregular,their computation is related to an average with alterable number of items.Considering that variable loop is not efficient in GPU,we evaluate the center vertex of each fragment mesh using the linear combination of its level 0,level 1 and limit positions instead of averaging schemes.Experiments demonstrate that our approach generally outperforms that of Shiue et al.in FPS by a long way. | LI Guiqing ZHANG ,liahua LIANG Cheng YIN Mengxiao XIONG Yunhui | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，3： | 2 |
| 18 | Daily power demand prediction for buildings at a large scale using a hybrid of physics-based model and generative adversarial network显示文摘Power demand prediction for buildings at a large scale is required for power grid operation.The bottom-up prediction method using physics-based models is popular,but has some limitations such as a heavy workload on model creation and long computing time.Top-down methods based on data driven models are fast,but less accurate.Considering the similarity of power demand patterns of single buildings and the superiority of generative adversarial network(GAN),this paper proposes a new method(E-GAN),which combines a physics-based model(EnergyPlus)and a data-driven model(GAN),to predict the daily power demand for buildings at a large scale.The new E-GAN method selects a small number of typical buildings and utilizes EnergyPlus models to predict their power demands.Utilizing the prediction for those typical buildings,the GAN then is adopted to forecast the power demands of a large number of buildings.To verify the proposed method,the E-GAN is used to predict 24-hour power demands for a set of residential buildings.The results show that(1)4.3%of physics-based models in each building category are required to ensure the prediction accuracy;(2)compared with the physics-based model,the E-GAN can predict power demand accurately with only 5%error(measured by mean absolute percentage error,MAPE)while using only approximately 9%of the computing time;and(3)compared with data-driven models(e.g.,support vector regression,extreme learning machine,and polynomial regression model),E-GAN demonstrates at least 60%reduction in prediction error measured by MAPE. | Chenlu Tian Yunyang Ye Yingli Lou Wangda Zuo Guiqing Zhang Chengdong Li | 2022 | Building Simulation2022，15，9： | 2 |
| 19 | Reactive changes in astrocytes, and delayed neuronal death, in the rat hippocampal CA1 region following cerebral ischemia/reperfusion显示文摘BACKGROUND: Blood supply to the hippocampus is not provided by the middle cerebral artery. However, previous studies have shown that delayed neuronal death in the hippocampus may occur following focal cerebral ischemia induced by middle cerebral artery occlusion. OBJECTIVE: To observe the relationship between reactive changes in hippocampal astrocytes and delayed neuronal death in the hippocampal CA1 region following middle cerebral artery occlusion. DESIGN, TIME AND SETTING: The immunohistochemical, randomized, controlled animal study was performed at the Laboratory of Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, from July to November 2007. MATERIALS: Rabbit anti-glial fibrillary acidic protein (GFAP) (Neomarkers, USA), goat anti-rabbit IgG (Sigma, USA) and ApoAlert apoptosis detection kit (Biosciences Clontech, USA) were used in this study. METHODS: A total of 42 healthy adult male Wistar rats, aged 3–5 months, were randomly divided into a sham operation group (n = 6) and a cerebral ischemia/reperfusion group (n = 36). In the cerebral ischemia/reperfusion group, cerebral ischemia/reperfusion models were created by middle cerebral artery occlusion. In the sham operation group, the thread was only inserted into the initial region of the internal carotid artery, and middle cerebral artery occlusion was not induced. Rats in the cerebral ischemia/reperfusion group were assigned to a delayed neuronal death (+) subgroup and a delayed neuronal death (–) subgroup, according to the occurrence of delayed neuronal death in the ischemic side of the hippocampal CA1 region following cerebral ischemia. MAIN OUTCOME MEASURES: Delayed neuronal death in the hippocampal CA1 region was measured by Nissl staining. GFAP expression and delayed neuronal death changes were measured in the rat hippocampal CA1 region at the ischemic hemisphere by double staining for GFAP and TUNEL. RESULTS: After 3 days of ischemia/reperfusion, astrocytes with abnormal morphology were detected in the rat hippocampal CA1 region in the delayed neuronal death (+) subgroup. No significant difference in GFAP expression was found in the rat hippocampal CA1 region at the ischemic hemisphere in the sham operation group, delayed neuronal death (+) subgroup and delayed neuronal death (–) subgroup (P > 0.05). After 7 days of ischemia/reperfusion, many GFAP-positive cells, which possessed a large cell body and an increased number of processes, were activated in the rat hippocampal CA1 region at the ischemic hemisphere. GFAP expression in the hippocampal CA1 region was greater in the delayed neuronal death (+) subgroup and delayed neuronal death (–) subgroup compared with the sham operation group (P < 0.01). Moreover, GFAP expression was significantly greater in the delayed neuronal death (–) subgroup than in the delayed neuronal death (+) subgroup (P < 0.01). After 30 days of ischemia/reperfusion, GFAP-positive cells were present in scar-like structures in the rat hippocampal CA1 region at the ischemic hemisphere. GFAP expression was significantly greater in the delayed neuronal death (+) subgroup and delayed neuronal death (–) subgroup compared with the sham operation group (P < 0.05). GFAP expression was significantly lower in the delayed neuronal death (–) subgroup than in the delayed neuronal death (+) subgroup (P < 0.05). The delayed neuronal death rates were 42% (5/12), 33% (4/12) and 33% (4/12) at 3, 7 and 30 days, respectively, followingischemia/reperfusion. No significant differences were detected at various time points (χ2 = 0.341, P > 0.05). CONCLUSION: The activation of astrocytes was poor in the hippocampal CA1 region during the early stages of ischemia, which is an important reason for delayed neuronal death. Glial scar formation aggravated delayed neuronal death during the advanced ischemic stage. | Guiqing Zhang Xiang Luo Zhiyuan Yu Chao Ma Shabei Xu Wei Wang | 2009 | Neural Regeneration Research2009，4，1： | 2 |
| 20 | Multi-agent system design for energy saving 显示文摘 | Shen Bin Zhang Guiqing Zhang Lin | 2010 | Industrial Electronics and Applications2010，，5： | 1 |
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