|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis显示文摘EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation,metastasis and poor prognosis.Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer.3-Deazaneplanocin A(DZNep),as an EZH2 inhibitor,can suppress cancer cell growth.However,the anti-cancer role of DZNep in colon cancer cells has been rarely studied.In this study,we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis.The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells. | Mingquan Sha Genxiang Mao Guofu Wang Yufeng Chen Xiaojian Wu Zhen Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 10 |
| 2 | Lubricating performances of graphene oxide and onion-like carbon as water-based lubricant additives for smooth and sand-blasted steel discs显示文摘Graphene oxide(GO)nanosheets and onion‐like carbon(OLC)nanoparticles were synthesized from natural graphite powder and candle soot,respectively,and characterized by transmission electron microscopy and Raman spectroscopy.The lubricating performances of GO and OLC as lubricant additives in water were comparatively evaluated using a ball‐on‐disc tribometer.The effects of sand blasting of a steel disc on its morphology and tribological property were evaluated.The results show that the two nanomaterials,GO and OLC,when used as lubricant additives in water effectively reduce the friction and wear of the sliding discs,which is independent of the disc surface treatment.On applying heavy loads,it is observed that GO exhibits superior friction‐reducing and anti‐wear abilities compared to those of OLC—a trace amount of GO can achieve a lubricating ability equivalent to that of an abundant amount of OLC.Furthermore,it is observed that sand blasting cannot improve the wear resistance of the treated steel disc,even though the hardness of the disc increased after the treatment.The possible anti‐wear and friction‐reducing mechanisms of the GO and OLC as lubricant additives in water are discussed based on results for the wear surfaces obtained by scanning electron microscopy,Raman spectroscopy,and X‐ray photoelectron spectroscopy。 | Fenghua SU Guofu CHEN Ping HUANG | 2020 | Friction2020，8，1： | 9 |
| 3 | Organic matter enrichment in the first member of the Xiagou formation of the lower Cretaceous in the Jiuquan Basin, China显示文摘The sources and enrichment of organic matter in a sediment core in the first member of the Xiagou Formation(K_1g^1) from the Chang 2-2 borehole of the Jiuquan Basin,NW China,have been examined using Rock-Eval,maceral,carbon isotopes and biomarker data.This data indicates that highly variable organic matter sources and preservation conditions in response to climate change.TOC content,HI,and δ^(13)C value were strongly correlated with the abundance of gammacerane,woody organic matter content,steranes/hopanes ratio,and C_(29) sterane content.This correlation demonstrates the importance that the control of the salinity of the depositional environment and organic matter sources can have upon the enrichment,type,and carbon isotopic composition of organic matter.In the Jiuquan Basin's relatively high temperature and arid climate,high salinity lakes with high primary productivity of algae,planktons,and bacteria,and good organic matter preservation conditions(anoxic bottom water) resulted in the enrichment of isotopically-light algae-bacterial organic matter.In the Jiuquan Basin's regions with a relatively low temperature and wet climate,fresh lakes with low primary productivity of algae,planktons,and bacteria received significant terrigenous high plants input,resulting in the deposition of a low abundance of isotopically heavier terrestrial organic matter. | Lixin Pei Gang Gao Wenzhe Gang Zhilong Huang Guofu Ma Zhiming Yang Jianjun Chen | 2016 | Acta Geochimica2016，35，1： | 2 |
| 4 | Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma显示文摘Background:Exercise is widely known to lower intraocular pressure and increase ocular blood flow,which may be beneficial for glaucoma management.However,there are few studies that have reported on the relationship between exercise and glaucoma progression.The aim of our study was to investigate the exercise habits of those with primary open angle glaucoma(POAG)and its association with the progression of visual field(VF)loss.Methods:Daily physical activity(PA)was monitored by an accelerometer(ActiGraph wGT3x-BT)which patients wore for more than 10 h of being awake on their right wrists for 1 week.Results:Seventy-one non-progressive and 27 progressive patients were enrolled in the study.24-h moderate to vigorous physical activity(MVPA)exercise showed that POAG patients had similar variation trends consisting of 3 wave peaks and 2 wave hollows.Minutes spent in MVPA was 19.89±15.81 and 21.62±15.10 during 07:00–09:00 h(p=0.204),15.40±14.49 and 15.67±12.43 during 15:00–17:00 h(p=0.822)and 17.26±21.11 and 11.42±11.58 during 18:00–20:00 h(p=0.001)in the non-progressive and progressive group,respectively.Univariate analysis indicated that 10 min of MVPA(18:00–20:00 h)[odds ratio,OR(95%CI)=0.82(0.73,0.92)],average mean arterial pressure[OR(95%CI)=0.96(0.94,0.98)],age[OR(95%CI)=1.06(1.03,1.08)],male[OR(95%CI)=0.67(0.48,0.96)],spherical equivalent[OR(95%CI)=1.14(1.07,1.22)]and IOP-lowering medications[OR(95%CI)=1.54(1.16,2.05)]were significantly correlated with having progressive VF damage.Multivariable analysis showed that 10 min of MVPA(18:00–20:00 h)[OR(95%CI)=0.85(0.75,0.97)]was associated with progressive VF loss even after adjusting for other risk factors.Conclusions:Evening exercise may lower the odds of VF progression,suggesting that exercise habits possibly play an important role in glaucoma progression. | Xiafei Pan Kai Xu Xin Wang Guofu Chen Huanhuan Cheng Alice Jia Liu Laurence Tang Hou Lin Zhong Jie Chen Yuanbo Liang | 2020 | Eye and Vision2020，7，1： | 2 |
| 5 | Photochromic kinetic spectra and intermediates of BR-D96N显示文摘 | Yuan Zheng Baoli Yao Yingli Wang Ming Lei Guofu Chen Norbert Hampp | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，1： | 1 |
| 6 | Continuous wave diode laser end pumped Nd: YVO4/KTP high power solid-state green laser 显示文摘 | Jintao Bai Guofu Chen | 2002 | Optics & Laser Technology2002，34，4： | 1 |
| 7 | Association of biometric factors with anterior chamber angle widening and intraocular pressure reduction after uneventful phacoemulsification for cataract显示文摘 | Guofu Huang Eduardo Gonzalez Roland Lee Yi-Chun Chen Mingguang He Shan C. Lin | 2011 | Journal of Cataract & Refractive Surgery2011，，1： | 1 |
| 8 | Modeling and simulation of hermetically sealed electromagnetic relay under mechanical environment显示文摘 | Ren Wanbin Chen Yinghua Zhai Guofu | 2007 | IEICE Transactions on Electronics2007，90，7： | 1 |
| 9 | Ferroelectricity in dopant-free HfO_(2) thin films prepared by pulsed laser deposition显示文摘As a high-k material,hafnium oxide(HfO_(2))has been used in gate dielectrics for decades.Since the discovery of polar phase in Si-doped HfO_(2) films,chemical doping has been widely demonstrated as an effective approach to stabilize the ferroelectric phase in HfO_(2) based thin films.However,the extra capping layer deposition,post-growth annealing and wake-up effect are usually required to arouse the ferroelectricity in HfO_(2) based thin films,resulting in the increase of complexity for sample synthesis and the impediment of device application.In this study,the ferroelectricity is observed in non-capped dopant-free HfO_(2) thin films prepared by pulsed laser deposition(PLD)without post-growth annealing.By adjusting the deposited temperature,oxygen pressure and thickness,the maximum polarization up to 14.7 m C/cm^(2) was obtained in 7.4 nm-thick film.The fraction of orthorhombic phase,concentrations of defects and size effects are considered as possible mechanisms for the influences of ferroelectric prop-erties.This study indicates that PLD is an effective technique to fabricate high-quality ferroelectric HfO_(2) thin films in the absence of chemical doping,capping layer deposition and post-growth annealing,which may boost the process of nonvolatile memory device application. | Yongjian Luo Zhenxun Tang Xiaozhe Yin Chao Chen Zhen Fan Minghui Qin Min Zeng Guofu Zhou Xingsen Gao Xubing Lu Jiyan Dai Deyang Chen Jun-Ming Liu | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 10 | Modeling and simulation of hermetically sealed electromagnetic relay under mechanical environment显示文摘 | Ren Wanbin Chen Yinghua Zhai Guofu | | 0，，07： | 1 |
| 11 | Random characteristics of the heterogeneous structure in gas-solid fluidization显示文摘 | Heping Cui Jinghai Li Hongzhi An Min Chen Zhiming Ma Guofu Wu | 1998 | Science in China Series B: Chemistry1998，，4： | 1 |
| 12 | ((Diseussion On A Calculation Method Of The Magnetic Torque Of Radial Multi-Polar Electromagnetic Gears ) )显示文摘 | Chen Haihong Yin Guofu Chen Lunjun HuangJianna | 2006 | TCMT2006，，： | 1 |
| 13 | Kinetic spectra of light-adaptation dark-adaptation and M-intermediate of BR-D96N显示文摘 | Baoli Yao Yuan Zheng Yingli Wang Ming Lei Guofu Chen Norbert Hampp | 2003 | Optics Communications2003，，1： | 1 |
| 14 | Development of taxonomic rRNA-targeted probes of two harmful algae: Prorocentrum minimum and Karenia mikimotoi by fluorescence in situ hybridization显示文摘Harmful algal blooms recently have been under the spotlight throughout the world, because of their negative impact on the marine environment, aquaculture, fisheries as well as public health. The development of methods for rapid and precise identification and quantification of causative species is essential for the warning and monitoring of blooms, among which the techniques based on taxonomic probes are the most favored. In this study, two harmful algae, i.e., Prorocentrum minimum and Karenia mikimotoi were taken into consideration. The partial large subunit rDNA (D1-D2) of both species were firstly PCR-amplified, cloned and sequenced. The obtained sequences were then introduced to carry out alignment analysis for gene specific regions. Three respective candidate probes for each species were designed and used to screen the optimal probe by performing fluorescence in situ hybridization (FISH) tests. The results showed that the probes Pmin0443 and Kmik0602 displayed the best hybridization for P. minimum and K. mikimotoi, respectively. Both the specific (taxonomic) (Pmin0443 and Kmik0602) and the control probes (UniC0512 and UniR0499) were used for cross-reactivity tests with other microalgae in our laboratory. The probes Pmin0443 and Kmik0602 are specific and could be served as taxonomic probes introduced into the techniques targeting rRNA, such as FISH, sandwich hybridization, and DNA-microarray assay of P. minimum and K. mikimotoi in the future. Finally, FISH analyses with both probes were performed on the simulated field samples. The probes could hybridize exclusively with the target cells well, and no significant difference (p >0.05) was observed in the cell densities of the samples determined by FISH and light microscopy (LM). All suggest that the probes are specific and could be introduced into FISH for the monitoring of both harmful algae. | CHEN Guofu WANG Quanfu ZHANG Chunyun ZHANG Baoyu WANG Guangce LU Douding XU Zhong YAN Peishen | 2013 | Acta Oceanologica Sinica2013，32，2： | 1 |
| 15 | Dual Measurement of Strain and Temperature Using the Combination of Er^3+ -Doped Fibre Fluorescence Lifetime and a Fibre Bragg Grating 显示文摘 | Wade S A Forsyth D I Guofu Q Chen X | 2001 | Measurement +control2001，34，6： | 1 |
| 16 | Continuous-wave diode-laser end-pumped Nd: YVO4/KTP high-power solidstate green lasser 显示文摘 | BAI Jintao CHEN Guofu | 2002 | Optics & Laser Technology2002，34，4： | 1 |
| 17 | Pattern recognition approach to identify loose particle material based on modified MFCC and HMMs显示文摘 | Zhai Guofu Chen Jinbao Li Chao | 2014 | Neurocomputing2014，155，1： | 1 |
| 18 | The optimization of replica distribution in the unstructured overlays显示文摘Replication is a widely used technique in unstructured overlays to improve content availability or system performance. A fundamental question often addressed by previous work focused on: how many replicas ought to be allocated for each data item given the fixed query rates and limited storage capability? In this paper, we have put forth two optimal replica distributions to achieve the highest success rate and the lowest message consumption. Especially, we have investigated the influence of item size on replica distribution. Our results show that Square-Root Replication, which is traditionally considered to be optimal, is not always the best choice. Our study offers a new deep understanding of resource managment in self-organized unstructured overlays. | FENG GuoFu LI WenZhong LU SangLu CHEN DaoXu BUYYA Rajkumar | 2012 | Science China(Information Sciences)2012，55，3： | 1 |
| 19 | Experimental studies of self-starting passive mode locking Er3+ -doped fiber ring soliton laser显示文摘 | Dongfeng Liu Guofu Chen Xianhua Wang | 1999 | Science in China Series A: Mathematics1999，，9： | 1 |
| 20 | Continuous wave diode laser end pumped Nd: YVO4/KTP high power solid-state green laser 显示文摘 | Bai Jintao Chen Guofu | 2002 | Optic & Laser Technology2002，34，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员