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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Infiltrating lithium into carbon doth decorated with zinc oxide arrays for dendrite-free lithium metal anode显示文摘Lithium metal anode for batteries has attracted extensive attentions, but its application is restricted by the hazardous dendritic Li growth and dead Li formation. To address these issues, a novel Li anode is developed by infiltrating molten Li metal into conductive carbon cloth decorated with zinc oxide arrays. In carbonate-based electrolyte, the symmetric cell shows no short circuit over 1,500 h at 1 mA·cm^-2, and stable voltage profiles at 3 mA cm^-2 for ~ 300 h cycling. A low overpotential of ~ 243 mV over 350 cycles at a high current density of 10 mA·cm^-2 is achieved, compared to the seriously fluctuated voltage and fast short circuit in the cell using bare Li metal. Meanwhile, the asymmetric cell withstands 1,000 cycles at 10 C (1 C = 167 mAh·g^-1) compared to the 210 cycles for the cell using bare Li anode. The excellent performance is attributed to the well-regulated Li plating/stripping drive n from the formation of LiZn alloy on the wavy carb on fibers, resulting in the suppress!on of dendrite growth and pulverization of the Li electrode during cycling. | Xianshu Wang Zhenghui Pan Yang Wu Xiaoyu Ding Xujia Hong Guoguang Xu Meinan Liu Yuegang Zhang Weishan Li | 2019 | Nano Research2019，12，3： | 8 |
| 3 | In-situ growth of vertically aligned nickel cobalt sulfide nanowires on carbon nanotube fibers for high capacitance all-solid-state asymmetric fiber-supercapacitors显示文摘Fiber-supercapacitors(FSCs)are promising power sources for miniature portable and wearable electronic devices.However,the development and practical application of these FSCs have been severely hindered by their low volumetric capacitance and narrow operating voltage.In this work,vertically aligned nickel cobalt sulfide(Ni Co2S4)nanowires grown on carbon nanotube(CNT)fibers were achieved through an in-situ two-step hydrothermal reaction method.The as-prepared Ni Co2S4@CNT fiber electrode exhibits a high volumetric capacitance of 2332 F cm-3,benefiting from its superior electric conductivity,large surface area,and rich Faradic redox reaction sites.Furthermore,a Ni Co2S4@CNT//VN@CNT(vanadium nitride nanosheets grown on CNT fibers)asymmetric fiber-supercapacitor(AFSC)was successfully fabricated.The device exhibits an operating voltage up to 1.6 V and a high volumetric energy density of 30.64m Wh cm-3.The device also possesses outstanding flexibility as evidenced by no obvious performance degradation under various bending angles and maintaining high capacitance after 5000 bending cycles.This work promotes the practical application of flexible wearable energy-storage devices. | Na Liu Zhenghui Pan Xiaoyu Ding Jie Yang Guoguang Xu Linge Li Qi Wang Meinan Liu Yuegang Zhang | 2020 | Journal of Energy Chemistry2020，29，2： | 5 |
| 4 | Thermogravimetric study of the effect of a PVA oxygen-insulating barrier on the spontaneous combustion of coal显示文摘Coal samples in the air for three months were characterized by Thermogravimetric Analysis (TGA). The effect of a PVA oxygen-insulating barrier on the spontaneous combustion of coal was examined. The moisture loss activation energy, oxidation activation energy and combustion activation energy were calculated by an integral method using the Coats-Redfen formula. The results show that the tendency for spontaneous combustion of three coal samples (judged by the activation energy) falls in the order: CYW>YJL>SW. The oxidation activation energy and combustion activation energy of coal protected by the PVA oxygen-insulating barrier increased. A significant increase in the combustion activation energy was noted, especially for the CYW coal where the in-crease was 28.53 kJ/mol. Hence, oxidation of the protected coal samples was more difficult. The PVA oxygen-insulating barrier helps to prevent spontaneous combustion of the coal. | MENG Xianhang CHU Ruizhi WU Guoguang XU Hongfeng ZHU Jiamei WANG Zhihua | 2010 | Mining Science and Technology2010，20，6： | 5 |
| 5 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 6 | Differential protein expression in substantia nigra induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in a mouse model of chronic Parkinson’s disease显示文摘BACKGROUND: To date, a complete protein expression profile of the midbrain substantia nigra in a mouse model of chronic Parkinson’s disease, induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), does not exist. In addition, there are no reports of analysis of differential protein expression. OBJECTIVE: To separate and evaluate MPTP-induced differential protein expression through the use of proteomics in the substantia nigra of a mouse model of chronic Parkinson’s disease. DESIGN: Randomized controlled animal study. SETTING: Department of Neurology, the First Affiliated Hospital, Chongqing Medical University. MATERIALS: Sixteen 8–10-week old, healthy, male, C57BL mice, weighing 20–25 g, and of clean grade, were provided by the Experimental Animal Center of Chongqing Medical University. The experimental animals were disposed according to ethical criteria. MPTP was provided by Sigma Company, USA; Pdquest 2D image analysis software and gelatum/irradiance image analysis system (ChemiDoc XRS) by Bio-Rad, USA; and Voyager DE-PROMALDI-TOF-MS mass spectroscopy analyzer by ABI Company, USA. METHODS: This study was performed in Chongqing Neurological Laboratory between November 2006 and July 2007. Mice were randomly divided into model and control groups, with 8 mice in each group. Mice in the model group were received a subcutaneous injection of MPTP (25 mg/kg), twice a week, for five successive weeks, to establish a chronic Parkinson’s disease model. Mice in the control group received the same volume of a subcutaneous saline injection at the same time points. Mice were sacrificed by anesthesia to rapidly obtain the midbrain for protein separation of the substantia nigra. MAIN OUTCOME MEASURES: (1) 2-ED handbook (Bio-Rad Company) was referenced for two-dimensional electrophoresis. (2) PDQUEST8.0 analytical electrophoresis pattern was adopted to evaluate differential protein expression. (3) Peptide mass finger print map and data were retrieved on http://www.prospector.ucsf.edu to compare differential substantia nigral protein expression in the two groups. RESULTS: Two-dimensional gel electrophoresis of substantia nigra tissue indicated that there were 33 differential protein expressions between the two groups. Three new proteins were evaluated, including α-enolase, which exhibited regulated expression, tumor necrosis factor ligand superfamily member 4, and cyclin-dependent kinase inhibitor 1B. CONCLUSION: There are three proteins that exhibit differential expression in the substantia nigra- α-enolase, tumor necrosis factor ligand superfamily member 4, and cyclin-dependent kinase inhibitor 1B. | Wenbin Tu Furong Xu Guoguang Peng | 2008 | Neural Regeneration Research2008，3，5： | 2 |
| 7 | Long‐term lamivudine treatment achieves regression of advanced liver fibrosis/cirrhosis in patients with chronic hepatitis B显示文摘 | Bei Xu Lanyi Lin Guoguang Xu Yan Zhuang Qing Guo Yunye Liu Hui Wang Xiaqiu Zhou Shanming Wu Shisan Bao Wei Cai Qing Xie | 2015 | J Gastroenterol Hepatol2015，，2： | 1 |
| 8 | Alterations in amplitude of low frequency fluctuation in treatment‐na?ve major depressive disorder measured with resting‐state fMRI显示文摘 | Jie Liu Ling Ren Fay Y. Womer Jue Wang Guoguang Fan Wenyan Jiang Hilary P. Blumberg Yanqing Tang Ke Xu Fei Wang | 2014 | Hum. Brain Mapp2014，，10： | 1 |
| 9 | The preparation of Zn 2+ -doped TiO 2 nanoparticles by sol–gel and solid phase reaction methods respectively and their photocatalytic activities显示文摘 | Guoguang Liu Xuezhi Zhang Yajie Xu Xinshu Niu Liqing Zheng Xuejun Ding | 2004 | Chemosphere2004，，9： | 1 |
| 10 | The preparation of Zn2+-doped TiO2 nanoparticles by sol-gel and solid phase reaction methods respectively and their photocatalytic activities显示文摘 | LIU Guoguang ZHANG Xuezhi XU Yajie | 2005 | Chemosphere2005，59，9： | 1 |
| 11 | The preparation of Zn^2+-doped TiO2 nanoparticles by sol-gel and solid phase reaction methods respectively and their photocatalytic activities 显示文摘 | LIU Guoguang ZHANG Xuezhi XU Yajie | 2005 | Chemosphere2005，59，9： | 1 |
| 12 | Tectonic characteristics of large earthquakes in the Bohaiwan Basin Area 显示文摘 | Chen Guoguang Xu Jie Gao Zhanwu | 2003 | North China Earthquake Sciences2003，21，2： | 1 |
| 13 | Recent tectonic stress field and seismicity in Bohai Basin 显示文摘 | Chen Guoguang Xu Jie Ma Zongjin | 2004 | Acta Seismologica Sinica2004，25，4： | 1 |
| 14 | Long-term survival of exogenous embryonic stem cells in adult bone marrow显示文摘 | Yueying Li Yanfeng Liu Jing He Fengchao Wang Sheng Liu Yu Zhang Zhaohui Kou Zhenyu JU Guoguang Zheng Jing Xu Weiping Yuan Shaorong Gao Tao Cheng | 2011 | Cell Research2011，21，7： | 1 |
| 15 | A Preliminary Analysis of Seismotectonics for the Indonesia M8.7 Earthquake on December 26, 2004显示文摘The Indonesian region is one of the most seismically active zones on the earth. On December 26, 2004, an M_S 8.7 earthquake (as measured by the China Seismograph Network, or M_w = 9.3 as measured by USGS) struck the west coast of northern Sumatra, Indonesia. By its magnitude it is classified as the world’s fourth largest earthquake since 1900 and the largest one since the 1964 Alaska earthquake. The spatial distribution of the relocation of larger aftershocks (M>4.5) following the main shock suggests a length and width of the rupture of about 1200km and 200km, respectively. The shock triggered massive tsunamis that affected several countries throughout South and Southeast Asia. It is a shallow interplate event of thrust type in the trench. Its epicenter is located at the northwestern end of the Indonesia-Melanesia plate boundary tectonic zone. In 2004, eight shocks of M≥7.0 occurred in this area, showing a migration from east to west. It implies that these shocks represent a correlated and consistent dynamic process along this subduction zone. These interplate events are associated with convergence of several plates and their fast motion in this region, which result in strong and complex structures and deformation. The India-Australia plate is underthrusting toward the Sunda continental block or Burma plate at a low angle, producing a great locked area on the shallow portion of the subduction zone where enormous strain is accumulated. Interseismic uplift recorded by coral growth and horizontal velocities measured by GPS show the geometry of the locked portion of the Sumatra subduction zone. The vertical and horizontal data reasonably match with a model in which the plate interface is fully locked over a significant width. This locked fault zone extends to a horizontal distance of 132km from the trench, which corresponds to a depth of 50km. The sudden ruptures and large-scale slip of this locked area as a release of stress occurred, are the direct cause of the M8.7 earthquake near Indonesia in 2004. | Xu Jie Gao Xianglin Chen Guoguang Zhou Bengang Zhang Jin | 2006 | Earthquake Research in China2006，20，1： | 0 |
| 16 | Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms显示文摘ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesized that ZNF804 A may influence brain activity by interacting with COMT.Here,we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants.Amplitudes of low-frequency fluctuations(ALFFs)were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680.The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 x COMT rs4680 interaction,manifesting as a U-shaped modulation,presumably by dopamine signaling.Significant main effects were also found.These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT,and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia. | Lingling Cui Fei Wang Miao Chang Zhiyang Yin Guoguang Fan Yanzhuo Song Yange Wei Yixiao Xu Yifan Zhang Yanqing Tang Xiaohong Gong Ke Xu | 2019 | Neuroscience Bulletin2019，35，4： | 0 |
| 17 | Catalytic kinetics of dimethyl ether one-step synthesis over CeO_2–CaO–Pd/HZSM-5 catalyst in sulfur-containing syngas process显示文摘CeO_2–CaO–Pd/HZSM-5 catalyst was prepared for the dimethyl ether(DME) one-step synthesis in a continuous fixed-bed micro-reactor from the sulfur-containing syngas. The catalytic stability over hybrid catalyst of CeO_2–CaO–Pd/HZSM-5 was investigated to ensure that the kinetics experimental results were not significantly influenced by induction period and catalytic deactivation. A large number of kinetic data points(40 sets) were obtained over a range of temperature(240–300 °C), pressure(3–4 MPa), gas hourly space velocity(GHSV)(2000–3000 L·kg^(-1)·h^(-1)) and H_2/CO mole ratio(2–3). Kinetic model for the methanol synthesis reaction and the dehydration of methanol were obtained separately according to reaction mechanism and Langmuir–Hinshelwood mechanism. Regression parameters were investigated by the method combining the simplex method and Runge–Kutta method. The model calculations were in appropriate accordance with the experimental data. | Ruizhi Chu Wenxin Hou Xianliang Meng Tingting Xu Zhenyong Miao Guoguang Wu Lei Bai | 2016 | Chinese Journal of Chemical Engineering2016，24，12： | 0 |
| 18 | A rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy显示文摘Cancer vaccines represent a promising immunotherapeutic treatment modality.The promotion of cross-presentation of extracellular tumor-associated antigens on the major histocompatibility complex(MHC) class I molecules and dendritic cell maturation at the appropriate time and place is crucial for cancer vaccines to prime cytolytic T cell response with reduced side effects.Current vaccination strategies,however,are not able to achieve the spatiotemporal control of antigen cross-presentation.Here,we report a liposomal vaccine loading the second near-infrared window(NIR-II,1000—1700 nm) fluorophore BPBBT with an efficient photothermal conversion effect that offers an NIR-light-triggered endolysosomal escape under the imaging guidance.The NIR-II image-guided vaccination strategy specifically controls the cytosolic delivery of antigens for cross-presentation in the draining lymph nodes(DLNs).Moreover,the photothermally induced endolysosomal rupture initiates autophagy.We also find that the adjuvant simvastatin acts as an autophagy activator through inhibiting the PI3K/AKT/m TOR pathway.The light-induced autophagy in the DLNs together with simvastatin treatment cooperatively increase MHC class II expression by activating autophagy machinery for dendritic cell maturation.This study presents a paradigm of NIR-II image-guided light-triggered vaccination.The approach for remote control of antigen cross-presentation and autophagy represents a new strategy for vaccine development. | Aihua Wu Afeng Yang Qinli Tong Guoguang Wei Sihang Zhang Sheng Yu Chen Zhang Jiaojiao Xu Wei Lu | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 19 | Apolipoprotein C1 promotes tumor progression in gastric cancer显示文摘Background:Gastric cancer(GC)is a malignancy with the worst prognosis that seriously threatens human health,especially in East Asia.Apolipoprotein C1(apoc1)belongs to the apolipoprotein family.In addition,apoc1 has been associated with various tumors.However,its role in GC remains unclear.Methods:Firstly,we quantified its expression in GC and adjacent tumor tissues,using The Cancer Genome Atlas(TCGA).Next,we assessed cell invasion and migration abilities.Finally,we revealed the role of apoc1 in the tumor microenvironment(TME),immune cell infiltration and drug sensitivity.Results:Firstly,in TCGA database,it has been shown that elevated expression of apoc1 was identified in various cancers,including GC,then we found that high expression of apoc1 was significantly correlated with poor prognosis in GC.Histologically,apoc1 expression is proportional to grade,cancer stage,and T stage.The experimental results showed that apoc1 promoted cell invasion and migration.Then GO,KEGG,and GSEA pathway analyses indicated that apoc1 may be involved in the WNT pathway and immune regulation.Furthermore,we found out the tumor-infiltrating immune cells related to apoc1 in the tumor microenvironment(TME)using TIMER.Finally,we investigated the correlation between apoc1 expression and drug sensitivity,PD-1 and CTLA-4 therapy.Conclusions:These results suggest that apoc1 participates in the evolution of GC,and may represent a potential target for detection and immunotherapy in GC. | QIOU GU TIAN ZHAN XIAO GUAN CHUILIN LAI NA LU GUOGUANG WANG LEI XU XIANG GAO JIANPING ZHANG | 2023 | Oncology Research2023，31，3： | 0 |
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