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| 1 | ALK,the Key Gene for Gelatinization Temperature,is a Modifier Gene for Gel Consistency in Rice显示文摘Gelatinization temperature(GT) is an important parameter in evaluating the cooking and eating quality of rice.Indeed,the phenotype,biochemistry and inheritance of GT have been widely studied in recent times.Previous map-based cloning revealed that GT was controlled by ALK gene,which encodes a putative soluble starch synthase II-3.Complementation vector and RNAi vector were constructed and transformed into Nipponbare mediated by Agrobacterium.Phenotypic and molecular analyses of transgenic lines provided direct evidence for ALK as a key gene for GT.Meanwhile,amylose content,gel consistency and pasting properties were also affected in transgenic lines.Two of four nonsynonymous single nucleotide polymorphisms in coding sequence of ALK were identified as essential for GT.Based on the single nucleotide polymorphisms(SNPs),two new sets of SNP markers combined with one cleaved amplified polymorphic sequence marker were developed for application in rice quality breeding. | Zhenyu Gao Dali Zeng Fangmin Cheng Zhixi Tian Longbiao Guo Yan Su Meixian Yan Hua Jiang Guojun Dong Yuchen Huang Bin Han Jiayang Li Qian Qian | 2011 | Journal of Integrative Plant Biology2011，53，9： | 13 |
| 2 | Analytical validation of GMEX rapid point- of care CYP2C19 genotyping system for the CHANCE-2 trial显示文摘Background and purpose Rapid genotyping is useful for guiding early antiplatelet therapy in patients with high-risk nondisabling ischaemic cerebrovascular events(HR-NICE).Conventional genetic testing methods used in CYP2C19 genotype-guided antiplatelet therapy for patients with HR-NICE did not satisfy the needs of the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events(CHANCE)-2 trial.Therefore,we developed the rapid-genotyping GMEX(point-of care)system to meet the needs of the CHANCE-2 trial.Methods Healthy individuals and patients with history of cardiovascular diseases(n=408)were enrolled from six centres of the CHANCE-2 trial.We compared the laboratory-based genomic test results with Sanger sequencing test results for accuracy verification.Next,we demonstrated the accuracy,timeliness and clinical operability of the GMEX system compared with laboratory-based technology(YZY Kit)to verify whether the GMEX system satisfies the needs of the CHANCE-2 trial.Results Genotypes reported by the GMEX system showed 100%agreement with those determined by using the YZY Kit and Sanger sequencing for all three CYP2C19 alleles(*2,*3 and*17)tested.The average result’s turnaround times for the GMEX and YZY Kit methods were 85.0(IQR:85.0-86.0)and 1630.0(IQR:354.0-7594.0)min(p<0.001),respectively.Conclusions Our data suggest that the GMEX system is a reliable and feasible point-of care system for rapid CYP2C19 genotyping for the CHANCE-2 trial or related clinical and research applications. | Xia Meng Anxin Wang Guojun Zhang Siying Niu Wei Li Sifei Han Fang Fang Xingquan Zhao Kehui Dong Zening Jin Huaguang Zheng Kelin Chen Hao Li Chengyuan Yang Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 7 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Identification of a novel tillering dwarf mutant and fine mapping of the TDDL(T) gene in rice (Oryza sativa L.)显示文摘Rice plant architecture is an important agronomic trait that affects the grain yield. To understand the molecular mechanism that controls plant architecture, a tillering dwarf mutant with darker-green leaves derived from an indica cultivar IR64 treated with EMS is characterized. The mutant, designated as tddl(t), is nonallelic to the known tillering dwarf mutants. It is controlled by one recessive nuclear gene, TDDL(T), and grouped into the dn-type dwarfism according to Takeda's definition. The dwarfism of the mutant is independent of gibberellic acid based on the analyses of two GA-mediated processes. The independence of brassinosteroid (BR) and naphthal-3-acetic acid (NAA) of the tddl(t) mutant, together with the decreased size of parenchyma cells in the vascular bundle, indicates that the TDDL(T) gene might participate in another hormone pathway. TDDL(T) is fine mapped within an 85.51 kb region on the long arm of rice chromosome 4, where 20 ORFs are predicted by RiceGAAS (http://ricegaas.dna.affrc. go.jp/rgadb/). Further cloning of TDDL(T) will benefit both marker assisted selection (MAS) of plant architecture and dissection of the molecular mechanism underlying tillering dwarf in rice. | GAO ZhenYu LIU XiaoHui GUO LongBiao LIU Jian DONG GuoJun HU Jiang HAN Bin QIAN Qian | 2009 | Chinese Science Bulletin2009，54，12： | 4 |
| 5 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 6 | FALSE FAILURE RETURNS: OPTIMAL PRICING AND RETURN POLICIES IN A DUAL-CHANNEL SUPPLY CHAIN显示文摘 | Guojun Ji Shangqing Han Kim HuaTan | 2018 | Journal of Systems Science and Systems Engineering2018，27，3： | 4 |
| 7 | A dynamic evaluation technique for assessing gas output from coal seams during commingling production within a coalbed methane well: a case study from the Qinshui Basin显示文摘Gas drainage is carried out based on output from each coal bed throughout commingling production of coalbed methane(CBM).A reasonable drainage process should therefore initially guarantee main coal bed production and then enhance gas output from other beds.Permanent damage can result if this is not the case,especially with regard to fracture development in the main gas-producing coal bed and can greatly reduce single well output.Current theoretical models and measuring devices are inapplicable to commingled CBM drainage,however,and so large errors in predictive models cannot always be avoided.The most effective currently available method involves directly measuring gas output from each coal bed as well as determining the dominant gas-producing unit.A dynamic evaluation technique for gas output from each coal bed during commingling CBM production is therefore proposed in this study.This technique comprises a downhole measurement system combined with a theoretical calculation model.Gas output parameters(i.e.,gas-phase flow rate,temperature,pressure)are measured in this approach via a downhole measurement system;substituting these parameters into a deduced theoretical calculation model then means that gas output from each seam can be calculated to determine the main gas-producing unit.Trends in gas output from a single well or each seam can therefore be predicted.The laboratory and field test results presented here demonstrate that calculation errors in CBM outputs can be controlled within a margin of 15%and therefore conform with field use requirements. | Chuan Wu Chengxiang Yuan Guojun Wen Lei Han Haojie Liu | 2020 | International Journal of Coal Science & Technology2020，7，1： | 3 |
| 8 | Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2显示文摘Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sinl, an essential component of mTORC2, in T lineage cells results in severely impaired thymocyte development at the CD4^- CD8^- double negative (DN) stages but not at the CD4^+ CD8^+ double positive (DP) or later stages. Notably, Sinl-deficient DN thymocytes show markedly reduced proliferation and glycolysis.Importantly, we discover that the M2 isoform of pyruvate kinase (PKM2) is a novel and crucial Sinl effector in promoting DN thymocyte development and metabolism. At the molecular level, we show that Sinl-mTORC2 controls PKM2 expression through an AKT-dependent PPAR-y nuclear translocation. Together, our study unravels a novel mTORC2-PPAR-γ-PKM2 pathway in immune-metabolic regulation of early thymocyte development. | Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 9 | Role of surface defects of carbon nanotubes on catalytic performance of barium promoted ruthenium catalyst for ammonia synthesis显示文摘Carbon nanotubes(CNTs) with abundant surface defects are prepared by a liquid oxidation and thermal annealing method. The defective CNTs-D supported Ba–Ru/CNTs-D catalysts exhibit superior catalytic performance in ammonia synthesis with a TOF be increased up to 0.30 s-1, which is 2.5 times of oxidized CNTs-O supported Ba–Ru/CNTs-O catalysts and 5 times of the Ba–Ru/CNTs. The characterizations by CO chemisorption, transmission electron microscope, Raman, and X-ray photoelectron spectroscopy revealed that the uniformly well dispersed Ru NPs can be stabilized on the defective sites of CNTs-D. The great improvement of the catalytic performance and stability of the Ba–Ru/CNTs-D is contributed to the strong interaction between Ru NPs and surface defect of the CNTs. | Yongcheng Ma Guojun Lan Wenzhao Fu Ying Lai Wenfeng Han Haodong Tang Huazhang Liu Ying Li | 2020 | Journal of Energy Chemistry2020，29，2： | 2 |
| 10 | Layered Dynamic Schedulings for BP Decoding of LDPC Codes over GF(q)显示文摘 | HAN Guojun LIU Xingcheng GONG Yi | 2013 | Chinese Journal of Electronics2013，22，3： | 2 |
| 11 | Quantificational Etching of AAO Template显示文摘Ni nanowires 被电极淀积在从 命令solution.Well 的 Ni nanowire 数组 withcontrollable 长度当时是的合成电解质的模板用磷的 acidand 的混合物由 AAO 的部分移动做了的多孔的阳极化的 aluminumoxide ( AAO )准备铬的酸( 6 wt % H3PO4:1.8 wt % H3CrO4 ) Ni nanowire 数组的 .The 图象是学习 byscanning 电子显微镜学( SEM )决定在蚀刻时间和 lengthof Ni nanowire arrays.The | Guojun SONG Dong CHEN Zhi PENG Xilin SHE Jianjiang LI Ping HAN | 2007 | Journal of Materials Science & Technology2007，23，3： | 2 |
| 12 | An Efficient Dynamic Schedule for Layered Belief-Propagation Decoding of LDPC Codes 显示文摘 | Han Guojun Liu Xingcheng | 2009 | IEEE Communication Letters2009，13，12： | 1 |
| 13 | Back-to-back Th- ree-level Double-fed Induction Motor Control System for Mine Hoist显示文摘 | Han Yaofei Tan Guojun Li Hao | 2009 | Procedia Earth and Planetary Science2009，1，1： | 1 |
| 14 | Research on robust control strategy of single DOF supporting system of MLDSB based on H∞ mixed-sensitivity Method显示文摘Because of hydraulic-electromagnetic double supporting forms,the supporting capacity and stiffness of magnetic-liquid double suspension bearing(MLDSB)can be improved sharply and then it is more suitable for medium speed,heavy load and frequent-starting occasions.Due to the multiple uncertainty,such as the coupling,the unmodeled dynamics,the parameter perturbation and the external disturbance perturbation,the robust stability and stiffness of control system of MLDSB are hard to meet the design requirements.Firstly,the structural features and the regulation mechanisms of MLDSB are presented and the radial 4-DOF kinetic equations are established.Secondly,the influence factors of the control system's coupling on unbalanced vibration caused by the deviation of the rotor center of mass are revealed,and then the weighting function of suppressing the unbalanced vibration can be obtained.Finally,H∞ controller of MLDSB is designed with H∞ mixed-sensitivity method,and the control performances of H∞ controller is compared with the state feedback controller.The simulation results show that single degree of freedom(DOF)supporting system of MLDSB with H∞ controller has good robust stability,stiffness and the ability to suppress unbalanced external disturbances.This study can provide the theoretical reference for stabilized suspension and control of MLDSB. | 赵建华 Chen Tao Han Fang Gao Dianrong Du Guojun | 2020 | High Technology Letters2020，26，3： | 1 |
| 15 | Overexpression of a NAC transcription factor enhances rice drought and salt tolerance显示文摘 | Xingnan Zheng Bo Chen Guojun Lu Bin Han | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 16 | Therapeutic Effect of Transcatheter Arterial Chemoembolization Combined with Percutaneous Ethanol Injection in Hepatocellular Carcinoma显示文摘Objective:To evaluate the clinical efficacy of the combined treatment with transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) on hepatocellular carcinoma (HCC). Methods:312 patients with moderate or advanced HCCs were divided into two groups: 170 cases underwent TACE treatment alone, 142 cases were treated with TACE and PEI under B-ultrasotmd guidance. Results:The rates of reduction in tumor diameter and the decline in serum AFP level were 41.2% and 40.4% in the TACE group and 75.4% and 74.1% in the TACE + PEI group respectively. The 6, 12 and 24 months survival rates in the TACE group were 77.1%,34.1% and 18.8%,respectively and in the TACE + PEI group 87.3%, 62.0% and 38.0%, respectively. Overall, there was a significant difference between the two treatment groups (P<0.05). Conclusion:Treatment on HCCs with TACE + PEI is convenient, safe and results in better survival rates than TACE alone. | QU Zengqiang, QIAN Guojun, CHEN Han Department of Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China | 2002 | The Chinese-German Journal of Clinical Oncology2002，1，1： | 1 |
| 17 | Low-Complexity Detection and Decoding Scheme for LDPC-Coded MLC NAND Flash Memory显示文摘With the development of manufacture technology, the multi-level cell(MLC)technique dramatically increases the storage density of NAND flash memory. As the result,cell-to-cell interference(CCI) becomes more serious and hence causes an increase in the raw bit error rate of data stored in the cells.Recently, low-density parity-check(LDPC)codes have appeared to be a promising solution to combat the interference of MLC NAND flash memory. However, the decoding complexity of the sum-product algorithm(SPA) is extremely high. In this paper, to improve the accuracy of the log likelihood ratio(LLR) information of each bit in each NAND flash memory cell, we adopt a non-uniform detection(N-UD) which uses the average maximum mutual information to determine the value of the soft-decision reference voltages.Furthermore, with an aim to reduce the decoding complexity and improve the decoding performance, we propose a modified soft reliabilitybased iterative majority-logic decoding(MSRBI-MLGD) algorithm, which uses a non-uniform quantizer based on power function to decode LDPC codes. Simulation results show that our design can offer a desirable trade-off between the performance and complexity for high-column-weight LDPC-coded MLC NAND flash memory. | Xusheng Lin Guojun Han Shijie Ouyang Yanfu Li Yi Fang | 2018 | China Communications2018，15，6： | 1 |
| 18 | In- formed Shuffled Belief-Propagation Decoding for Low -Density Parity-Check Codes 显示文摘 | GONG Yi LIU Xingcheng HAN Guojun | 2015 | IET Communica- tions2015，9，18： | 1 |
| 19 | Identification of OsbZIP72 as a positive regulator of ABA response and drought tolerance in rice显示文摘 | Guojun Lu Chenxi Gao Xingnan Zheng Bin Han | 2009 | Planta2009，，3： | 1 |
| 20 | An efficient dynamic schedule for layered belief-propagation decoding of LD- PC codes显示文摘 | Han Guojun Liu Xingeheng | 2009 | IEEE Communications Letters2009，13，12： | 1 |
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