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| 1 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 2 | H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells显示文摘 | Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang | 2015 | Cell Research2015，25，1： | 4 |
| 3 | The chemistry of heavy haze over Urumqi, Central Asia显示文摘 | Juan Li Guoshun Zhuang Kan Huang Yanfen Lin Qiongzhen Wang Yuhong Guo Jinghua Guo Shulong Yu Caixia Cui Joshua S. Fu | 2008 | Journal of Atmospheric Chemistry2008，，1： | 2 |
| 4 | The effect of pH on the sorption of gold nanoparticles on illite显示文摘Sorption between nanoparticles(NPs)and minerals may critically affect the migration of associated elements as well as the environmental impact of NPs.Since illite is widely present in soil,sediment,and water,we have experimentally investigated the sorption behavior of citrate-coated gold nanoparticles(AuNPs)as model NPs on illite under different pH and mineral mass conditions.We demonstrated that sorption of these negatively charged AuNPs strongly depended on the suspension pH.At pH above 8,which coincided with the apparent point of zero charge(pH 7.9)of our illite sample,only marginal sorption of AuNPs was observed.At pH 3-8,significant sorption of AuNPs on illite was found,with almost complete sorption occurring at more acidic conditions(pH 3-4).TEM observations revealed that sorption took place through the attachment AuNPs on illite edges.At pH 2,AuNPs mostly formed chain-like fused structures and precipitated out of the suspension.Based upon the above pH dependence,residual organic ligand content after sorption,and complementary sorption results with positively charged AuNPs,we conclude that the sorption process is mainly driven by the electrostatic attraction between negatively charged AuNPs and positively charged illite edges,with possible competitive involvement of citrate molecules.We expect that our findings will improve our understanding of NP-mineral interaction and the environmental fate of NPs. | Yuhong Fu Quan Wan Zonghua Qin Xin Nie Wenbin Yu Shanshan Li | 2020 | Acta Geochimica2020，39，2： | 2 |
| 5 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 6 | NSD3S stabilizes MYC through hindering its interaction with FBXW7显示文摘The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological processes. Our previous work identified the histone lysine methyltransferase nuclear receptor binding SET domain protein 3 (NSD3) as a MYC modulator. NSD3S, a noncatalytic isoform of NSD3 with oncogenic activity, appears to bind, stabilize, and activate the transcriptional activity of MYC. However, the mechanism by which NSD3S stabilizes MYC remains to be elucidated. To uncover the nature of the interaction and the underlying mechanism of MYC regulation by NSD3S, we characterized the binding interface between both proteins by narrowing the interface to a 15-amino acid region in NSD3S that is partially required for MYC regulation. Mechanistically, NSD3S binds to MYC and reduces the association of F-box and WD repeat domain containing 7 (FBXW7) with MYC, which results in suppression of FBXW7-mediated proteasomal degradation of MYC and an increase in MYC protein half-life. These results support a critical role for NSD3S in the regulation of MYC function and provide a novel mechanism for NSD3S oncogenic function through inhibition of FBXW7-mediated degradation of MYC. | Valentina Gonzalez-Pecchi Albert KKwan Sean Doyle Andrey AIvanov Yuhong Du Haian Fu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 2 |
| 7 | TET2 Expression in Bone Marrow Mononuclear Cells of Patients with Myelodysplastic Syndromes and Its Clinical Significances显示文摘Objective To investigate the expression of TET2 mRNA and protein in the bone marrow mononuclear cells(BMMNC) of patients with myelodysplastic syndrome(MDS) and its clinical significance. Methods The expression of TET2 mRNA and protein in bone marrow mononuclear cells(BMMNC) of 32 patients with MDS and 20 healthy donors was examined by qPCR and Western blot. Results The expression of TET2 mRNA in BMMNC was down-regulated in MDS patients compared with the donor group [(0.41±0.28)%vs.(1.07±0.56)%](P<0.001).Compared with lower expression group(TET2<0.4)[(6.53±6.17)%],patients with higher expression of TET2(≥0.4) presented significantly lower proportion of bone marrow blasts[(1.21±1.56)%](P<0.05).The expression of TET2 mRNA in BMMNC of MDS patients was inversely correlated with malignant clone burden(r=-0.398,P<0.05) and IPSS(r=-0.412, P<0.05).The expression of TET2 protein was down-regulated in MDS patients compared with that in the donor group. Conclusions The mRNA and protein expression of TET2 in BMMNC of MDS patients is decreased,which might be useful as an important parameter for the evaluation of MDS clone burden. | Wei Zhang Zong-hong Shao Rong Fu Hua-quan Wang Li-juan Li Jun Wang Wen Qu Yong Liang Guo-jin Wang Xiao-ming Wang Yuhong Wu Hong Liu Jia Song Jing Guan Li-min Xing | 2012 | Clinical oncology and cancer resexreh2012，9，1： | 2 |
| 8 | Geochemical and palynological investigation of the Shengli River marine oil shale (China):Implications for paleoenvironment and paleoclimate显示文摘 | Fu Xiugen Wang Jian Zeng Yuhong | 2009 | International Journal of Coal Geology2009，78，3： | 1 |
| 9 | Concentrations and modes of occurrence of platinum group elements in the Shengli River oil shale,northern Tibet,China显示文摘 | Fu Xiugen Wang Jian Zeng Yuhong | 2010 | Fuel2010，89，12： | 1 |
| 10 | Geochemistry and origin of rare earth elements (REEs) in the Shengli River oil shale,northern Tibet,China显示文摘 | Fu Xiugen Wang Jian Zeng Yuhong | 2011 | Chemie der Erde-Geochemistry2011，71，1： | 1 |
| 11 | Serum Helicobacter pylori CagA antibody may not be used as a tumor marker for diagnosing gastric cancer in east Asian countries显示文摘 | Zhicheng Zhao Yuhong Li Shengxin Liu Weihua Fu | 2014 | Tumor Biology2014，，12： | 1 |
| 12 | State of Charge estimation of lithium-ion batteries in electric drive vehicles using extended Kalman filter显示文摘 | Zheng Chen Yuhong Fu Chunting Chris Mi | 2013 | IEEE Transactions on Vehicular Tech- nology2013，62，3： | 1 |
| 13 | Hepcidin and GDF15 in anemia of multiple myeloma显示文摘 | Shuchong Mei Huaquan Wang Rong Fu Wen Qu Limin Xing Guojin Wang Jia Song Hong Liu Lijuan Li Xiaoming Wang Yuhong Wu Jin Guan Erbao Ruan Zonghong Shao | 2014 | International Journal of Hematology2014，，3： | 1 |
| 14 | Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells显示文摘Ovarian cancer is one of the most common gynecologic malignancies in women and has a poor prognosis.Taxanes are a class of standard first-line chemotherapeutic agents for the treatment of ovarian cancer.However,tumor-intrinsic and acquired resistance to taxanes poses major challenges to improving clinical outcomes.Hence,there is an urgent clinical need to understand the mechanisms of resistance in order to discover potential biomarkers and therapeutic strategies to increase taxane sensitivity in ovarian cancer.Here,we report the identification of an association between the TP53 status and taxane sensitivity in ovarian cancer cells through complementary experimental and informatics approaches.We found that TP53 inactivation is associated with taxane resistance in ovarian cancer cells,supported by the evidence from(i)drug sensitivity profiling with bioinformatic analysis of large-scale cancer therapeutic response and genomic datasets and(ii)gene signature identification based on experimental isogenic cell line models.Further,our studies revealed TP53-dependent gene expression patterns,such as overexpression of ACSM3,as potential predictive biomarkers of taxane resistance in ovarian cancer.The TP53-dependent hyperactivation of the WNT/β-catenin pathway discovered herein revealed a potential vulnerability to exploit in developing combination therapeutic strategies.Identification of this genotype-phenotype relationship between the TP53 status and taxane sensitivity sheds light on TP53-directed patient stratification and therapeutic discoveries for ovarian cancer treatment. | Changfa Shu Xi Zheng Alafate Wuhafu Danielle Cicka Sean Doyle Qiankun Niu Dacheng Fan Kun Qian Andrey AIvanov Yuhong Du Xiulei Mo Haian Fu | 2022 | Acta Pharmacologica Sinica2022，43，9： | 1 |
| 15 | Multi point Forming: a Flexible Manufacturing Method for a 3-D Surface Sheet 显示文摘 | Li Mingzhe Liu Yuhong Fu Wenzhi | 1999 | Journal of Materials Processing Technology1999，87，： | 1 |
| 16 | Geochemical and paly- nological investigation of the Shengli River marine oil shale(China):Implications for paleoenvironment and paleoclimate 显示文摘 | Fu Xiugen Wang Jian Zeng Yuhong | 2009 | Intemational Journal of Coal Geology2009，78，： | 1 |
| 17 | Image a- nalysis by modified Legendre moments显示文摘 | FU Bo ZHOU Jianzhong LI Yuhong | 2007 | Pattern Rec- ognition Society2007，40，2： | 1 |
| 18 | Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening显示文摘The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug discovery.However,organoid culturing with extracellular matrix to support 3D architecture has been challenging for high-throughput screening(HTS)-based drug discovery due to technical difficulties.Using genetically engineered human colon organoids as a model system,here we report our effort to miniaturize such 3D organoid culture with extracellular matrix support in high-density plates to enable HTS.We first established organoid culturing in a 384-well plate format and validated its application in a cell viability HTS assay by screening a 2036-compound library.We further miniaturized the 3D organoid culturing in a 1536-well ultra-HTS format and demonstrated its robust performance for large-scale primary compound screening.Our miniaturized organoid culturing method may be adapted to other types of organoids.By leveraging the power of 3D organoid culture in a high-density plate format,we provide a physiologically relevant screening platform to model tumors to accelerate organoid-based research and drug discovery. | Yuhong Du Xingnan Li Qiankun Niu Xiulei Mo Min Qui Tingxuan Ma Calvin J.Kuo Haian Fu | 2020 | Journal of Molecular Cell Biology2020，12，8： | 1 |
| 19 | Equine Viperin Restricts Equine Infectious Anemia Virus Replication by Inhibiting the Production and/or Release of Viral Gag,Env,and Receptor via Distortion of the Endoplasmic Reticulum显示文摘 | Yandong Tang Lei Na Chunhui Zhu Nan Shen Fei Yang Xianqiu Fu Yuhong Wang Lihua Fu Jiayi Wang Yuezhi Lin Xuefeng Wang Xiaojun Wang Jianhua Zhou Chengyao Li | 2014 | J Virol2014，88，12： | 1 |
| 20 | Geochemical and palynological investigation of the Shengli River marine oil shale (China):Implications for paleoenvironment and p aleoclimate 显示文摘 | Fu Xiugen Wang Jian Zeng Yuhong Li Zhongiong | 2009 | International Journal of Coal Geology2009，78，： | 1 |
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