|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Guidance law with impact time and impact angle constraints显示文摘A novel closed-form guidance law with impact time and impact angle constraints is pro- posed for salvo attack of anti-ship missiles, which employs missile's normal acceleration (not jerk) as the control command directly. Firstly, the impact time control problem is formulated as tracking the designated time-to-go (the difference between the designated impact time and the current flight time) for the actual time-to-go of missile, and the impact angle control problem is formulated as tracking the designated heading angle for the actual heading angle of missile. Secondly, a biased proportional navigation guidance (BPNG) law with designated heading angle constraint is constructed, and the actual time-to-go estimation for this BPNG is derived analytically by solving the system differential equations. Thirdly, by adding a feedback control to this constructed BPNG to eliminate the time-to-go errorthe difference between the standard time-to-go and the actual time-to-go, a guidance law with adjustable coefficients to control the impact time and impact angle simultaneously is developed. Finally, simulation results demonstrate the performance and feasibility of the proposed approach. | Zhang Youan Ma Guoxin Liu Aili | 2013 | Chinese Journal of Aeronautics2013，26，4： | 50 |
| 2 | Study on real working performance and overload safety factor of high arch dam显示文摘Considering the fact that high arch dams have problems such as complicated stress,high cost,and hazards after being damaged,this paper intends to study the effects of load,material strength,and safety analysis method on dam safety and working performance of arch dams.In this article,the effects of temperature,self weight exaction way and water loading on structure response are first discussed,and a more reasonable way of considering is then put forward.By taking into consideration the mechanical property of materials and comparing the effects of different yield criteria on overloading safety of high arch dams,this paper concludes that brittle characteristics of concrete should be fully considered when conducting safety assessment for high arch dams to avoid overestimating the bearing capacity of the dams.By comparing several typical projects,this paper works out a safety assessment system of multiple safety and relevant engineering analogical analysis methods,which is closer to the actual situation,and thus is able to assess the response of high arch dam structure in a more comprehensive way,elicit the safety coefficients in different situations,and provide a new way of considering the safety assessment of high arch dams. | ZHANG GuoXin,LIU Yi & ZHOU QiuJing Department of Structures and Materials,China Institute of Water Resources and Hydropower Research,Beijing 100038,China | 2008 | Science China(Technological Sciences)2008，51，S2： | 25 |
| 3 | One-step scalable preparation of N-doped nanoporous carbon as a high-performance electrocatalyst for the oxygen reduction reaction显示文摘做 N 的多孔的碳材料被 ethylenediaminetetraacetic 酸(EDTA ) 和三聚氰胺的简单一步舞热分解面对 KOH 和公司(NO3 ) 准备了 2 敨匠戭獡摥瀠潨潴慣慴祬瑳 ? 景敦楲杮洠牯 ? 晥敦瑣癩? 湥楶潲浮湥慴? 灡汰捩瑡潩獮慭吗?? | Zhenyu Liu Guoxin Zhang Zhiyi Lu Xiuyan Jin Zheng Chang Xiaoming Sun | 2013 | Nano Research2013，6，4： | 21 |
| 4 | Simulation of influence of multi-defects on long-term working performance of high arch dam显示文摘As an integrated structure,an arch dam is assumed to bear loads in its design consideration.However,multi-defects,such as cracks and the opening of transverse joints,are unavoidable during construction and operation.Multi-defects will reduce the structural integrity and stiffness of the dam and affect its working performance and degree of safety.In the current paper,a numerical model of defects and a simulation method of a high arch dam are introduced.The Chencun arch dam is analyzed as a case study.An entire course simulation analysis of the Chencun arch dam from construction to operation is carried out,through which the opening of the transverse and longitudinal joints,formation of cracks,and their influence on deformation and stress of the dam are studied.According to the results of the analysis,appropriate measures should be adopted to prevent the development of cracks,and observation should be strengthened for a more timely discovery of risks. | ZHANG GuoXin ,LIU Yi,ZHENG CuiYing & FENG Fan State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin,Beijing 100038,China China Institute of Water Resources and Hydropower Research,Beijing 100038,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 17 |
| 5 | Simulation of hydraulic fracture utilizing numerical manifold method显示文摘A 2nd order numerical manifold method(NMM) based method is developed to simulate the hydraulic fractures propagating process in rock or concrete. The proposed method uses a weak coupling technique to analyze the fluid phase and solid phase. To study the seepage behavior of the fluid phase, all the fractures in solid are identified by a block cutting algorithm and form a flow network. Then the hydraulic heads at crack ends are solved. To study the deformation and destruction of solid phase, the 2-order NMM and sub-region boundary element method are combined to solve the stress-strain field. Crack growth is controlled by the well-accepted criterion, including the tension criterion or Mohr-Coulomb criterion for the initialization of cracks and the maximum circumferential stress theory for crack propagation. Once the crack growth occurs, the seepage and deformation analysis will be resolved in the next simulation step. Such weak coupling analysis will continue until the structure becomes stable or is destructed. Five examples are used to verify the new method. The results demonstrate that the method can solve the SIFs at crack tip and fluid flow in crack network precisely, and the method is effective in simulating the hydraulic facture problem. Besides, the NMM shows great convenience and is of high accuracy in simulating the crack growth problem. | ZHANG GuoXin LI Xu LI HaiFeng | 2015 | Science China(Technological Sciences)2015，58，9： | 15 |
| 6 | Prognostic factors of primary gastrointestinal stromal tumors: a cohort study based on high-volume centers显示文摘Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors(GISTs).Methods: Data from 2,570 consecutive GIST patients from four medical centers in China(January2001–December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors.Results: Of the included patients, 1,375(53.5%) were male, and the patient age range was 18 to 95(median, 58)years. The tumors were mostly found in the stomach(64.5%), small intestine(25.1%) and colorectal region(5.1%).At the time of diagnosis, the median tumor size was 4.0(range: 0.1–55.0) cm, and the median mitotic index per 50 high power fields(HPFs) was 3(range: 0–254). Of the 2,168 resected patients, 2,009(92.7%) received curative resection. According to the modified National Institutes of Health(NIH) classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1(DOG-1), 8.0% for S-100, 31.0% for smooth muscle actin(SMA) and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib(P<0.001), whereas intermediate-risk patients did not(P=0.954).Conclusions: Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies. | Xuechao Liu Haibo Qiu Peng Zhang Xingyu Feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou | 2018 | Chinese Journal of Cancer Research2018，30，1： | 14 |
| 7 | Zircon U-Pb age of granitic gneiss on Duku highway in western Tianshan of China and its geological implications显示文摘Granitle gneiss on Duku highway in western Tianshan has been dated by the U-Pb zircon method. When plotted on the concordia diagram, the results give linear data array and the upper intercept age of (882±3)Ma, and the age was considered as the crystallization age of the protolith. Granitic gneiss has high ASI value (1.09), high LILE and LREE contents, significantly negative Eu depletion, distinctly negative Ba, Sr, P, Ti and Nb anomalies and indicate continental crust parentage, which is consistent with high initial 87Sr/86Sr ratios value (0.7170) and very negative εNd(t)=-14.1. The protolith magma is interpreted as a product of partial melting of the basement rocks of older basement crust. | Yibing Chen Aiqin Hu Guoxin Zhang Qianfeng Zhang | 2000 | Chinese Science Bulletin2000，45，7： | 13 |
| 8 | A review on tribology of polymer composite coatings显示文摘Self-lubricating polymer composite coatings,with tailorable tribological and mechanical properties,have been widely employed on mechanical parts to reduce friction and wear,which saves energy and improves the overall performance for applications such as aerospace satellite parts,shafts,gears,and bushings.The addition of functional fillers can overcome the limitations of single-polymer coatings and extend the service life of the coatings by providing a combination of low friction,high wear resistance,high load bearing,high temperature resistance,and high adhesion.This paper compares the heat resistance,and the tribological and mechanical properties of common polymer matrices,as well as the categories of functional fillers that improve the coating performance.Applicable scopes,process parameters,advantages,and limitations of the preparation methods of polymer coatings are discussed in detail.The tribological properties of the composite coatings with different matrices and fillers are compared,and the lubrication mechanisms are analyzed.Fillers reduce friction by promoting the formation of transfer films or liquid shear films.Improvement of the mechanical properties of the composite coatings with fillers of different morphologies is described in terms of strengthening and toughening mechanisms,including a stress transfer mechanism,shear yielding,crack bridging,and interfacial debonding.The test and enhancement methods for the adhesion properties between the coating and substrate are discussed.The coating adhesion can be enhanced through mechanical treatment,chemical treatment,and energy treatment of the substrate.Finally,we propose the design strategies for high-performance polymer composite coating systems adapted to specific operating conditions,and the limitations of current polymer composite coating research are identified. | Yilong REN Lin ZHANG Guoxin XIE Zhanbo LI Hao CHEN Hanjun GONG Wenhu XU Dan GUO Jianbin LUO | 2021 | Friction2021，9，3： | 13 |
| 9 | Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis显示文摘Phytoene synthase (PSY ) 是在类胡萝卜素 biosynthetic 小径的关键 plastidial 酶。然而,它的 translational 以后规定留下逃犯。同样, Clp 朊酶组成质体朊酶网络的中央部分,但是它为降级的底层不是众所周知的。在这研究,我们报导 PSY 是 Clp 朊酶的底层。PSY 被揭开身体上与各种各样的 Clp 朊酶子单元交往(即, ClpS1, ClpC1,和 ClpD ) 。在 clpc1, clpp4,和 clpr1-2 异种的 PSY 和几另外的 carotenogenic 酶蛋白质 overaccumulate 高级。overaccumulated PSY 被发现部分酶地活跃。在 clpc1 的 Clp 活动的缺陷导致 PSY 蛋白质周转的减少的率,进一步在降级的 PSY 支持 Clp 朊酶的角色蛋白质。在另一方面, ORANGE (或) 蛋白质,有 holdase 女伴活动的 PSY 的一个主要 translational 以后管理者,提高 PSY 蛋白质稳定性并且在 clpc1 增加 PSY 的酶地活跃的比例, counterbalancing 在维持 PSY 蛋白质动态平衡的调停 Clp 的解朊作用。一起,这些调查结果提供新奇卓见进质体局部性的蛋白质的质量控制并且建立迄今未辩别出的 translational 以后在在植物的 modulating 类胡萝卜素生合成的 carotenogenic 酶的规章的机制。 | Ralf Welsch Xiangjun Zhou Hui Yuan Daniel Alvarez Tianhu Sun Dennis Schlossarek Yong Yang Guoxin Shen Hong Zhang Manuel Rodriguez-Concepcion Theodore W. Thannhauser Li Li | 2018 | Molecular Plant2018，11，1： | 10 |
| 10 | Arsenic removal from contaminated soil via biovolatilization by genetically engineered bacteria under laboratory conditions显示文摘In Rhodopseudomonas palustris,an arsM gene,encoding bacterial and archaeal homologues of the mammalian Cyt19 As(III) S-adenosylmethionine methytransferase,was regulated by arsenicals.An expression of arsM was introduced into strains for the methylation of arsenic.When arsM was expressed in Sphingomonas desiccabilis and Bacillus idriensis,it had 10 folds increase of methyled arsenic gas compared to wild type in aqueous system.In soil system,about 2.2%–4.5% of arsenic was removed by biovolatilization during 30 days.This study demonstrated that arsenic could be removed through volatilization from the contaminated soil by bacteria which have arsM gene expressed.These results showed that it is possible to use microorganisms expressing arsM as an inexpensive,efficient strategy for arsenic bioremediation from contaminated water and soil. | Shuang Liu Fan Zhang Jian Chen Guoxin Sun | 2011 | Journal of Environmental Sciences2011，23，9： | 9 |
| 11 | Invited review:Remediation strategies for mycotoxin control in feed显示文摘Mycotoxins are secondary metabolites of different species of fungi.Aflatoxin B1(AFB1),deoxynivalenol(DON),zearalenone(ZEN)and fumonisin B1(FB1)are the main mycotoxins contaminating animal feedstuffs.These mycotoxins can primarily induce hepatotoxicity,immunotoxicity,neurotoxicity and nephrotoxicity,consequently cause adverse effects on the health and performance of animals.Therefore,physical,chemical,biological and nutritional regulation approaches have been developed as primary strategies for the decontamination and detoxification of these mycotoxins in the feed industry.Meanwhile,each of these techniques has its drawbacks,including inefficient,costly,or impractically applied on large scale.This review summarized the advantages and disadvantages of the different remediation strategies,as well as updates of the research progress of these strategies for AFB1,DON,ZEN and FB1 control in the feed industry. | Meng Liu Ling Zhao Guoxin Gong Lei Zhang Lei Shi Jiefan Dai Yanming Han Yuanyuan Wu Mahmoud Mohamed Khalil Lvhui Sun | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 8 |
| 12 | Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer显示文摘地岬相当或相同的事物基因家庭成员 A (RhoA ) 作为肿瘤的一个批评管理者被识别了好攻击的行为。在 thisstudy,我们在位于有鳞的细胞 carcinomaof 舌头(TSCC ) 的生长,移植,和侵略下面的机制估计了 RhoA 的角色。TSCC 房间线 SCC-4 和 CAL27 击倒的稳定的 RhoA 用 Lentiviral transfection 被完成。房间移植,侵略,和房间增长上的 RhoA 弄空的 Theeffects 是坚定的。TSCC 房间线上的可能的位于决定 Galectin-3 (Gal-3 ) 的表示下面 mechanismof RhoA 弄空被也评估,在 vivo 的 -catenin, andmatrix metalloproteinase-9 (MMP-9 ) 。同时, TSCC 生长的内在的机制被 cyclin D1/2 的分析学习, p21 CIP1/WAF1 , 和 p27 Kip1 蛋白质层次。Immunohistochemical 评价被执行进一步证明 Gal-3 和 -catenin expression.We 的改变发现了那,在与在舌头的人的 TSCC 房间注射的老鼠, RhoA 层次与在正常纸巾的那些相比在主要肿瘤和 metastasizedlymph 节点是更高的。RhoA 的 Silencing 显著地减少了肿瘤生长, Gal-3 的 decreasedthe 层次, -catenin, MMP-9,和 cyclin D1/2,并且增加了 p21 CIP1/WAF1 和 p27 Kip1 。在 vitro, RhoA 击倒也导致了房间移植,侵略,和增长的抑制。我们的数据建议 RhoA 由通过分别地通过房间周期规定表明小径 andcell 增长的 Wnt/-catenin 调整房间移植和侵略在 TSCC 前进起 asignificant 作用。RhoA 可能是 TSCC 的一个新奇治疗学的目标。 | Guoxin Yan Ronghai Zou Zhenggang Chen Bing Fan Zhaoyan Wang Ying Wang Xiaonan Yin Dong Zhang Lei Tong Fang Yang Weina Jiang Wensheng Fu Jiwei Zheng Martin O. Bergo Martin Dalin Jiawei Zheng Shulan Chen Jianhua Zhou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 7 |
| 13 | Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization显示文摘Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications. | Guobo Lan Mei Li Ying Tan Lihua Li Xiaoming Yang Limin Ma Qingshui Yin Hong Xia Yu Zhang Guoxin Tan Chengyun Ning | 2015 | Journal of Materials Science & Technology2015，31，2： | 7 |
| 14 | Hierarchical peony-like FeCo-NC with conductive network and highly active sites as efficient electrocatalyst for rechargeable Zn-air battery显示文摘Carbon materials featuring hierarchical pores and atomically dispersed metal sites are promising catalysts for energy storage and conversion applications.Herein,we developed a facile strategy to construct functional carbon materials with a fluffy peony-like structure and dense binary FeCo-Nx active sites(termed as f-FeCo-CNT).By regulating the metal content in precursors,a three-dimensional(3D)interconnected conductive carbon nanotubes network was in-situ formed throughout the atomically dispersed FeCo-NC matrix during pyrolysis.Taking advantage of rich pore hierarchy and co-existence of highly active FeCo-Nx sites and beneficial FeCo alloy nanoparticles,the f-FeCo-CNT material exhibited excellent bifunctional performance towards oxygen reduction reaction/oxygen evolution reactions(ORR/OER)with respect to the atomically dispersed FeCo-NC(SA-f-FeCo-NC)and commercial Pt/C+Ru02 mixture,surpassing the SA-f-FeCo-NC with a 20 mV higher ORR half-wave potential and a 100 mV lower OER overpotential(at 10.0 mA/cm^2).Remarkably,the f-FeCo-CNT-assembled Zn-air battery(ZAB)possessed a maximum specific power of 195.8 mW/cm^2,excellent rate capability,and very good cycling stability at large current density of 20.0 mA/cm^2.This work provides a facile and feasible synthetic strategy of constructing low-cost cathode materials with excellent comprehensive ZAB performance. | Yiyan Wang Anuj Kumar Mang Ma Yin Jia Yu Wang Ying Zhang Guoxin Zhang Xiaoming Sun Zifeng Yan | 2020 | Nano Research2020，13，4： | 5 |
| 15 | Photocatalytic Activity of Porous Magnesium Oxychloride Cement Combined with AC/TiO2 Composites显示文摘As a decorative material, magnesium oxychloride cement was used as a photocatalyst supporter to purify the pollutants indoors. Due to excellent adsorption properties of activated carbon(AC), the photocatalytic composties, TiO_2/AC, were prepared and introduced into the porous magnesium oxychloride cement(PMOC) substrate to composite a sort of photocatalytic cementitious material(PCM). The optimal composite processes were assessed by gas chromatograph, using toluene as the target. By comparing the perspective of toluene purification and thorough decomposition, it can be found that the optimal mass ratio for TiO_2/AC composites is 4/25, and the heat treatment to TiO_2/AC sample at 350 ℃ can play the optimal synergetic role of adsorbents in photocatalytic process. The synergistic effect of TiO_2, AC and magnesium oxychloride cement(MOC) was also evaluated by gas chromatograph. One-take molding process was adopted to introduce the TiO_2/AC into PMOC substrate, and its optimal mass fraction was 4 wt%, while the appropriate density of substrate was 0.35 g/cm3. Toluene degradation showed that the prepared PCM can degrade pollutants efficiently. The appropriate treatment process of TiO_2/AC, mass of TiO_2/AC, substrate density, and stable pore structure should be coordinated to maximize the adsorption-photodegradation performance. The combination of photocatalytic materials, adsorbents, and building materials provided a new idea for the application of photocatalysis. | 冯传法 王发洲 LIU Peng SUN Guoxin YANG Lu ZHANG Wenqin SHU Chang | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 5 |
| 16 | SNHG1 functions as an oncogenic lncRNA and promotes osteosarcoma progression by up-regulating S100A6 viamiR-493-5p显示文摘The mechanism behind the aberrant expression of S100A6 in osteosarcoma is seldom reported so far.This study sought to explore the regulatory axis targeting S100A6 involved in osteosarcoma progression.Clinical samples collected from osteosarcoma patients were used to detect the expressions of SNHG1,miR-493-5p,and S100A6 by western bolt analysis and reverse transcription-quantitative polymerase chain reaction(RT-qPCR).The effects of S100A6 on proliferation and osteogenic differentiation were investigated by the CCK-8 assay,colony formation assay,Ethynyl deoxyuridine staining,matrix mineralization assay,and alkaline phosphatase assay.The potential of lncRNAs/miRNAs targeting S100A6 was identified by the bioinformatics approach,and the results were verified by the dual luciferase assay and RNA immunoprecipitation assay.Both in vitro and in vivo rescue experiments were performed to investigate the regulatory relationship between the identified lncRNAs and S100A6.The results showed that S100A6 is highly expressed in osteosarcoma.S100A6 overexpression not only increases the proliferation but also reduces the osteogenic differentiation of osteosarcoma cells,while S1006A silence exerts the opposite effects.Then,SNHG1 is identified to directly interact with miR-493-5p to attenuate miR-493-5p binding to the 3′-untranslated region of S100A6.Notably,S100A6 silence partially rescues the effect of SNHG1 overexpression on proliferation and osteogenic differentiation of osteosarcoma cells.Furthermore,the suppressive role of SNHG1 silence in the growth of osteosarcoma xenograft tumors is countered by S100A6 overexpression.Collectively,this study reveals that S100A6 plays an important role in osteosarcoma progression,and SNHG1 promotes S100A6 expression by competitively sponging miR-493-5p. | Qi Liu Jiaying Luo Huan Wang Lei Zhang Guoxin Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 5 |
| 17 | A novel intronic circular RNA,circGNG7,inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82显示文摘Background:There is increasing evidence that circular RNAs(circRNAs)play a significant role in pathological processes including tumorigenesis.In contrast to exonic circRNAs,which are the most frequently reported circRNAs in cancer so far,the studies of intronic circRNAs have been greatly lagged behind.Here,we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma(HNSCC).Methods:We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients.Then,we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients.We also identified interactions between circGNG7 and functional proteins,which alter downstream signaling that regulate HNSCC progression.Results:In this study,we identified a new intronic circRNA,circGNG7,and validated its functional roles in HNSCC progression.CircGNG7 was predominately localized to the cytoplasm,and its expression was downregulated in both HNSCC tissues andCAL27,CAL33,SCC4,SCC9,HN6,and HN30 cells.Low expression of circGNG7 was significantly correlated with poor prognosis in HNSCC patients.Consistent with this finding,overexpression of circGNG7 strongly inhibited tumor cell proliferation,colony formation,in vitro migration,and in vivo tumor growth.Mechanistically,the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4(SMAD4).Importantly,we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27(HSP27),occupying its phosphorylation sites and hindering its phosphorylation,which reduced HSP27-JNK/P38 mitogen-activated protein kinase(MAPK)oncogenic signaling.Downregulation of circGNG7 expression in HNSCC increased HSP27-JNK/P38 MAPK signaling and promoted tumor progression.Conclusions:Our results revealed that a new intronic circRNA,circGNG7,functions as a strong tumor suppressor and that circGNG7/HSP27-JNK/P38 MAPK signaling is a novel mechanism by which HNSCC progression can be controlled. | Houyu Ju Zhenrong Hu Dongliang Wei Jinyun Huang Xinyi Zhang Mengyu Rui Zhi Li Xiaomeng Zhang Jingzhou Hu Wei Guo Guoxin Ren | 2021 | Cancer Communications2021，41，11： | 4 |
| 18 | A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication显示文摘Despite the recent advances in artificial tissue and organ engineering,how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine.Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues,yet it still faces difficulties to generate vasculatures and preserve cell functions in complex organ production.Here,we overcome the limitations of conventional bioprinting systems by converting a six degree-of-freedom robotic arm into a bioprinter,therefore enables cell printing on 3D complex-shaped vascular scaffolds from all directions.We also developed an oil bath-based cell printing method to better preserve cell natural functions after printing.Together with a self-designed bioreactor and a repeated print-and-culture strategy,our bioprinting system is capable to generate vascularized,contractible,and long-term survived cardiac tissues.Such bioprinting strategy mimics the in vivo organ development process and presents a promising solution for in vitro fabrication of complex organs. | Zeyu Zhang Chenming Wu Chengkai Dai Qingqing Shi Guoxin Fang Dongfang Xie Xiangjie Zhao Yong-Jin Liu Charlie CLWang Xiu-Jie Wang | 2022 | Bioactive Materials2022，7，12： | 4 |
| 19 | Fine mapping of the awn gene on chromosome 4 in rice by association and linkage analyses显示文摘Awnness is a key trait in rice domestication, yet no studies have been conducted on fine mapping or association mapping of the rice awn gene. In this study, we investigated the awnness and genotype of a core collection of 303 cultivated rice varieties and a BC5F2 segregating population of 200 individuals. Combining association and linkage analyses, we mapped the awnness related genes to chromosome 4. Primary association analysis using 24 SSR markers revealed five loci significantly associated with awnness on chromosome 4. The associated markers cover previously identified regions. Fine association mapping was conducted using another 29 markers within a 4-Mb region, covering the associated marker in34, which is close to the awn gene Awn4.1. Seven associated markers were revealed, distributed over an 870-kb region. Combining the fine association mapping and linkage analysis of awnness in the 200 BC5F2 segregating population, we finally identified a 330-kb region as the candidate region for Awn4.1. The results indicate that combining association mapping and linkage mapping provides an efficient and precise approach to both genome-wide mapping and fine mapping of rice genes. | HU GuangLong ZHANG DongLing PAN HuiQiao LI Ben WU JianTao ZHOU XueYa ZHANG QunYuan ZHOU Lei YAO GuoXin LI JunZhou LI JinJie ZHANG HongLiang LI ZiChao | 2011 | Chinese Science Bulletin2011，56，9： | 4 |
| 20 | Steganalytic method based on short and repeated sequence distance statistics显示文摘According to the distribution characteristics of short and repeated sequence (SRS),a steganalytic method based on the correlation of image bit planes is proposed. Firstly,we provide the conception of SRS distance statistics and deduce its statis-tical distribution. Because the SRS distance statistics can effectively reflect the correlation of the sequence,SRS has statistical features when the image bit plane sequence equals the image width. Using this characteristic,the steganalytic method is fulfilled by the distinct test of Poisson distribution. Experimental results show a good performance for detecting LSB matching steganographic method in still images. By the way,the proposed method is not designed for specific steg-anographic algorithms and has good generality. | WANG GuoXin PING XiJian XU ManKun ZHANG Tao BAO XiRui | 2008 | Science in China(Series F)2008，51，10： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员