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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 3 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 4 | IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways显示文摘人有 IFIT (有 tetratricopeptide 重复的导致 IFN 的蛋白质) 的不同联合家庭 orthologs,包括的 IFIT1 (ISG56 ) , IFIT2 (ISG54 ) , IFIT3 (ISG60 ) ,和 IFIT5 (ISG58 ) 。IFIT1/IFIT2/IFIT3 的功能强烈地被调查了。然而,很少在任何细胞的过程对 IFIT5 的角色被知道。在这研究,我们报导 mRNA 和 IFIT5 的蛋白质层次响应 RNA 病毒感染或 polyinosiniccytidylic 酸刺激是起来调整的。IFIT5 的宫外的表示能 synergize IRF3-B-mediated 和 NF-B-mediated 基因表示,而 IFIT5 击倒损害这些基因的抄写。一致地,宿主细胞的抗病毒的回答显著地当面被增加或减少或 IFIT5 的缺席。机械学地, IFIT5 与线粒体部分共同本地化并且与 RIG-I 和 MAVS 交往。我们的学习鉴别 IFIT5 是在天生的有免疫力的反应的重要 enhancer。 | Bianhong Zhang Xinyi Liu Wei Chen Liang Chen | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 12 |
| 5 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 6 | Comparative Analysis of Nutrient Composition of Caulerpa lentillifera from Different Regions显示文摘This study investigated the difference of nutrient composition in Caulerpa lentillifera collected from different regions.The nutrient compositions of C.lentillifera from China's Hainan and Shandong provinces were determined and compared with those from Semporna(Malaysia),Sabah(Malaysia),Petchburi(Thailand),and two other species of seaweeds(Malaysia).The results showed that the polysaccharide and protein contents of C.lentillifera from Hainan(44.82%±0.98%and 12.5%±0.70%),Shandong(43.22%±1.42%and 14.7%±0.72%),Petchburi(59.27%±2.31%and 12.49%±0.30%),and Sabah(44.02%±2.01%and 19.38%±1.48%)were higher than those of Eucheuma cottonii(26.49%±3.01%and 9.76%±1.33%)and Sargassum polycystum(33.49%±1.70%and 5.40%±0.07%),respectively.The polyunsaturated fatty acid contents in C.lentillifera from Hainan(29.98%)and Shandong(22.11%)were higher than that in Semporna(16.76%±0.27%),Sabah(9.49%),and S.polycystum(20.34%±0.43%),but lower than that in E.cottonii(51.55%±0.57%).In Caulerpa lentillifera of Hainan and Shandong provinces,the essential amino acid(EAA)/total amino acid(TAA)ratios were 35.22%and 38.78%,respectively;and the EAA/ETAA ratios were 54.36%and 63.35%,respectively.The EAA composition of C.lentillifera was close to the ideal model of Food and Agriculture Organization/World Health Organization.C.lentillifera was rich in mineral elements,including calcium((3315.85±127.55)mg(100 g)^-1 and(3728.35±92.38)mg(100 g)^-1),magnesium((6715.74±82.58)mg(100 g)^-1 and(8128.59±242.72)mg(100 g)^-1),and trace elements,including iron((510.65±5.47)mg(100 g)^-1 and(1972.97±183.35)mg(100 g)^-1),selenium((1.04±0.08)mg(100 g)^-1 and(0.83±0.15)mg(100 g)^-1),and zinc((33.90±0.13)mg(100 g)^-1 and(11.75±2.05)mg(100 g)^-1).These results showed that C.lentillifera was more nutritious than S.polycystum or E.cottonii in terms of polysaccharide,protein,and fatty acid contents.Furthermore,both C.lentillifera species collected from Hainan and Shandong provinces show more basic nutrients.Therefore,C.lentillifera has important development and application prospects. | ZHANG Meijian MA Yurong CHE Xinyi HUANG Zumei CHEN Peng XIA Guanghua ZHAO Meihui | 2020 | Journal of Ocean University of China2020，19，2： | 8 |
| 7 | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis显示文摘最近的研究在嗅觉的薄板 propria 作为居民干细胞的一种新类型识别了嗅觉的 ecto 间充质的干细胞(OE-MSCs ) 。然而,它仍然保持不清楚是否 OE-MSCs 拥有任何 immunoregulatory 功能。在这研究,我们发现老鼠 OE-MSCs 比骨头表示了更高转变的生长因素贝它和 interleukin-10 层次导出髓的 MSC。在文化, OE-MSCs 经由直接压制受动器 T 房间增长并且增加规章的 T (Treg ) 房间扩大施加了他们的抑制免疫力的能力。在有导致骨胶原的关节炎的老鼠, OE-MSCs 的采纳转移显著地压制了关节炎发作和疾病严厉,它被增加的 Treg 房间伴随并且在 vivo 减少了 Th1/Th17 房间回答。一起拿,我们的调查结果在调整 T 房间回答识别了 OE-MSCs 的新奇功能,显示那 OE-MSCs 可以为风湿性关节炎和另外的自体免疫的疾病的处理代表新房间治疗。 | Ke Rui Zhijiang Zhang Jie Tian Xiang Lin Xiaohui Wang Jie Ma Xinyi Tang Huaxi Xu Liwei Lu Shengjun Wang | 2016 | Cellular & Molecular Immunology2016，13，3： | 8 |
| 8 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 9 | Changes of Petroleum Acid Distribution Characterized by FT-ICR MS in Heavy Acidic Crude Oil after True Boiling Point Distillation显示文摘The molecular transformations of carboxylic acids in heavy acidic SL crude before and after true boiling point distillation were examined by ultra-high resolution negative-ion electrospray ionization(ESI) Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS). The acid class(heteroatom number), type(z numbers) and carbon number distributions were positively characterized. It was found out that the total acid number(TAN) of SL crude decreased after true boiling point distillation, and the abundance of O2 class in mass spectra was also found to be reduced from 67.6% to 34.5% in SL TBP mixed crude as measured by MS spectra, indicating to a potential carboxylic acid decomposition. However, it was interesting that the carboxylic acids type distribution in both oils was almost the same although their relative abundance in SL TBP mixed crude turned to be much lower, suggesting that various petroleum carboxylic acid types have the similar thermal decomposition reaction behavior. Furthermore, for each O2 type of acids in SL TBP mixed crude, the abundance of carboxylic acids with carbon number higher than 35 was reduced greatly, especially for those with carbon number higher than 60, the mass peaks of which were nearly totally removed, indicating that the large carboxylic acid molecules in heavy fractions decomposed more significantly because of longer heating time during the true boiling point distillation process. As a result, the reduction of TAN may be caused by the thermal decomposition of carboxylic acids especially those with high carbon number, suggesting that quick distillation or much lower pressure is required to avoid the thermal decomposition. | Liu Yingrong Zhang Qundan Wang Wei Liu Zelong Zhu Xinyi Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 8 |
| 10 | Understanding Urban Spatial Structure of Shanghai Central City Based on Mobile Phone Data显示文摘Taking Shanghai Central City as its case study, this paper presents an approach to exploring the urban spatial structure through mobile phone positioning data. Firstly, based on base station location data and mobile phone signaling data, the paper analyses the number of users connecting to each base station, and further generates the maps of mobile phone user density through kernel density analysis. We move on to calculate the multi-day average user density based on a time frame of 10:00 and 23:00 at workdays and 15:00 and 23:00 at weekends for Shanghai Central City. Then, through spatial aggregation and density classifi cation on the density maps of 10:00 at workdays and 15:00 at weekends, we identify the ranks and functions of public centers within Shanghai Central City. Lastly, we identify residential areas, business off ice areas, and leisure areas in Shanghai Central City and measure the degree of functional mix by comparing the ratio of day and night user density as well as the user density at nighttime of workdays and weekends. | Niu Xinyi Ding Liang Song Xiaodong Zhang Qingfei | 2015 | China City Planning Review2015，24，3： | 7 |
| 11 | Spatial-temporal Evolution and Determinants of the Belt and Road Initiative: A Maximum Entropy Gravity Model Approach显示文摘The spatial interaction model is an effective way to explore the geographical disparities inherent in the Belt and Road Initiative(BRI) by simulating spatial flows. The traditional gravity model implies the hypothesis of equilibrium points without any reference to when or how to achieve it. In this paper, a dynamic gravity model was established based on the Maximum Entropy(MaxEnt) theory to estimate and monitor the interconnection intensity and dynamic characters of bilateral relations. In order to detect the determinants of interconnection intensity, a Geodetector method was applied to identify and evaluate the determinants of spatial networks in five dimensions. The empirical study clearly demonstrates a heterogeneous and non-circular spatial structure. The main driving forces of spatial-temporal evolution are foreign direct investment, tourism and railway infrastructure construction, while determinants in different sub-regions show obvious spatial differentiation. Southeast Asian countries are typically multi-island area where aviation infrastructure plays a more important role. North and Central Asian countries regard oil as a pillar industry where power and port facilities have a greater impact on the interconnection. While Western Asian countries are mostly influenced by the railway infrastructure, Eastern European countries already have relatively robust infrastructure where tariff policies provide a greater impetus. | HUANG Qinshi ZHU Xigang LIU Chunhui WU Wei LIU Fengbao ZHANG Xinyi | 2020 | Chinese Geographical Science2020，30，5： | 7 |
| 12 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 13 | The R2R3-type MYB transcription factor MdMYB90-like is responsible for the enhanced skin color of an apple bud sport mutant显示文摘The anthocyanin content in apple skin determines its red coloration,as seen in a Fuji apple mutant.Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and the skin color mutant.A novel R2R3-MYB transcription factor,MdMYB90-like,was uncovered as the key regulatory gene for enhanced coloration in the mutant.The expression of MdMYB90-like was 21.3 times higher in the mutant.MdMYB90-like regulates anthocyanin biosynthesis directly through the activation of anthocyanin biosynthesis genes and indirectly through the activation of other transcription factors that activate anthocyanin biosynthesis.MdMYB90-like bound to the promoters of both structural genes(MdCHS and MdUFGT)and other transcription factor genes(MdMYB1 and MdbHLH3)in the yeast one-hybrid system,electrophoretic mobility shift assay,and dual-luciferase assay.Transgenic analysis showed that MdMYB90-like was localized in the nucleus,and its overexpression induced the expression of other anthocyanin-related genes,including MdCHS,MdCHI,MdANS,MdUFGT,MdbHLH3,and MdMYB1.The mutant had reduced levels of DNA methylation in two regions(−1183 to−988 and−2018 to−1778)of the MdMYB90-like gene promoter,which might explain the enhanced expression of the gene and the increased anthocyanin content in the mutant apple skin. | Chao Sun Chunming Wang Wang Zhang Shuai Liu Weiyao Wang Xinyi Yu Tao Song Maxwell Yu Weichang Yu Shenchun Qu | 2021 | Horticulture Research2021，8，1： | 6 |
| 14 | Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies显示文摘大多数病原体在人的 mucosal 表面开始他们的感染。因此, mucosal 种痘,通过特别口头或 intranasal 管理线路,高度为传染疾病被需要。同时,基于蛋白质的抗原提供一种更安全的选择给基于的整个病原体或 DNA 在疫苗的开发的。然而,在他们到达指向,相对低的 immunogenicity ,以及蛋白质抗原的低稳定性的地点以前, intranasally 或口头上地交付了蛋白质疫苗的唯一的 biopharmaceutical 障碍需要克服,要求有头脑、调整的 mucosal 疫苗明确的表达包括 immunostimulants 的选择,合适的疫苗的交货系统的鉴定,和准确作文和生产条件的决心。这评论试图提供蛋白质的新调查基于抗原的疫苗的明确的表达开发,包括 immunostimulants 和为 intranasal 和口头的政府的疫苗的交货系统的优化的用法。 | Shujing Wang Huiqin Liu Xinyi Zhang Feng Qian | 2015 | Protein & Cell2015，6，7： | 6 |
| 15 | Multi-level multi-area hybrid automatic voltage control system and its trial operation in Northeast China Grid显示文摘In order to coordinate automatic voltage control(AVC)systems of a large interconnected system,a multi-level multi-area hybrid automatic voltage control(MLMA-HAVC)system was constructed.This system began its trial operation in the Northeast China Grid in January 2010,and for the first time in China and abroad it realized automatic close-loop control of multi-area and multi-level interconnected power grid and multi-objective self-approaching optimization in aspects of security,high quality and economic operation.This system has three breakthroughs in theory and engineering application:1)Established the MLMA-HAVC theory to solve multi-objective optimization of large-scale system;2)proposed reactive power/voltage coordination control method to inhibit or further eliminate regional oscillations;3)presented advanced state estimation algorithm to guarantee acquisition of high reliability data.This paper summarizes the basic principle of MLMA-HAVC,and reports engineering realization of MLMA-HAVC system in the Northeast China Grid. | ZHANG XueMin MEI ShengWei SU XinYi WANG Gang JIA Wei SHAO GuangHui XU XingWei | 2011 | Science China(Technological Sciences)2011，54，9： | 6 |
| 16 | New dammarane-type saponins from the leaves of Panax notoginseng显示文摘Two new triterpenoid saponins named notoginsenoside-Ng3(1) and notoginsenoside-Ng4(2) along with three known saponins (3-5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were elucidated by HRESIMS, NMR, X-ray techniques and acid hydrolysis. Moreover,compound 2 was characterized with the conjugated double bonds side-chain, which was rarely found in this plant. The absolute configuration of notoginsenoside Fa (3) with five sugars was confirmed by the single-crystal X-ray diffraction for the first time. Acetylcholinesterase inhibitory activity experiments were also conducted, all the isolated saponins showed weak inhibitory activities in the final concentration of 0.16 mmol/L. | Jiwu Huang Chuangjun Li Junzi Cao Jie Ma Yiqian Du Xinyi Liu Jingzhi Yang Dongming Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 6 |
| 17 | Physical sensors for skin-inspired electronics显示文摘Skin,the largest organ in the human body,is sensitive to external stimuli.In recent years,an increasing number of skin-inspired electronics,including wearable electronics,implantable electronics,and electronic skin,have been developed because of their broad applications in healthcare and robotics.Physical sensors are one of the key building blocks of skin-inspired electronics.Typical physical sensors include mechanical sensors,temperature sensors,humidity sensors,electrophysiological sensors,and so on.In this review,we systematically review the latest advances of skin-inspired mechanical sensors,temperature sensors,and humidity sensors.The working mechanisms,key materials,device structures,and performance of various physical sensors are summarized and discussed in detail.Their applications in health monitoring,human disease diagnosis and treatment,and intelligent robots are reviewed.In addition,several novel properties of skin-inspired physical sensors such as versatility,self-healability,and implantability are introduced.Finally,the existing challenges and future perspectives of physical sensors for practical applications are discussed and proposed. | Shuo Li Yong Zhang Yiliang Wang Kailun Xia Zhe Yin Huimin Wang Mingchao Zhang Xiaoping Liang Haojie Lu Mengjia Zhu Haomin Wang Xinyi Shen Yingying Zhang | 2020 | InfoMat2020，2，1： | 5 |
| 18 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 19 | Genomic variants of genes associated with three horticultural traits in apple revealed by genome re-sequencing显示文摘The apple(Malus×domestica Borkh.)cultivar‘Su Shuai’exhibits greater disease resistance,shorter internodes and lighter fruit flavor compared with its parents‘Golden Delicious’and‘Indo’.To obtain a comprehensive overview of the sequence variation in these three horticultural traits,the genomes of‘Su Shuai’and‘Indo’were resequenced using next-generation sequencing and compared to the genome of‘Golden Delicious’.A wide range of genetic variations were detected,including 2454406 and 18749349 single nucleotide polymorphism(SNP)and 59547 and 50143 structural variants(SVs)in the‘Indo’and‘Su Shuai’genomes,respectively.Among the SVs in‘Su Shuai’,17 genes related to disease resistance,10 genes related to Gibberellin(GA)and 19 genes associated with fruit flavor were identified.The expression patterns of eight of the SV genes were examined using reverse transcription-quantitative polymerase chain reaction(RT-qPCR).The results of this study illustrate the genomic variation in these cultivars and provide evidence for a genetic basis for the horticultural traits of disease resistance,short internodes and lighter flavor exhibited in these cultivars.These results provide a genetic basis for the phenotypic characteristics of‘Su Shuai’and,as such,these SVs could serve as gene-specific molecular markers in maker-assisted breeding of apples. | Shijie Zhang Weiping Chen Lu Xin Zhihong Gao Yingjun Hou Xinyi Yu Zhen Zhang Shenchun Qu | 2014 | Horticulture Research2014，1，1： | 5 |
| 20 | SENP3 regulates the global protein turnover and the Spl level via antagonizing SUM02/ 3-targeted ubiquitination and degradation显示文摘 | Ming Wang Jing Sang Yanhua Ren Kejia Liu Xinyi Liu Jian Zhang Haolu Wang Jian Wang Amir Orian Jie Yang Jing Yi | 2016 | Protein & Cell2016，7，1： | 5 |
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