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| 1 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 2 | TMEM43-S358L mutation enhances NF-κBTGFp signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy显示文摘Arrhythmogenic right ventricular dysplasia/cardiomyopathy(ARVD/C)is a genetic cardiac muscle disease that accounts for approximately 30%sudden cardiac death in young adults.The Ser358Leu mutation of transmembrane protein 43(TMEM43)was commonly identified in the patients of highly lethal and fully penetrant ARVD subtype,ARVD5.Here,we generated TMEM43 S358L mouse to explore the underlying mechanism.This mouse strain showed the classic patholo.gies of ARVD patients,including structural abnormalities and cardiac fibrofatty.TMEM43 S358L mutation led to hyper-activated nuclear factor kB(NFkB)activation in heart tissues and primary cardiomy.ocyte cells.Importantly,this hyper activation of NF-κB directly drove the expression of pro-fibrotic gene,transforming growth factor beta(TGFβ),and enhanced downstream signal,indicating that TMEM43 S358L mutation up-regulates NF-κB-TGFβ signal cascade during ARVD cardiac fibrosis.Our study partially reveals the regulatory mechanism of ARVD development. | Guoxing Zheng Changying Jiang Yulin Li Dandan Yang Youcai Ma Bing Zhang Xuan Li Pei Zhang Xiaoyu Hu Xueqiang Zhao Jie Du Xin Lin | 2019 | Protein & Cell2019，10，2： | 5 |
| 3 | Targeted thrombolysis strategies for neuroprotective effect显示文摘Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with adverse effects such as fibrinogenolysis and bleeding. In an attempt to increase the efficacy, safety, and specificity of thrombolytic therapy, a number of targeted thrombolytic agents have been studied in recent years. This review focuses on the concepts underlying targeted thrombolytic therapy and describes recent drug developments in this field. | Junping Zhang Guoxing Ma Zhimin Lv Yu Zhou Chunguang Wen Yaqing Wu Ruian Xu | 2014 | Neural Regeneration Research2014，9，13： | 2 |
| 4 | Generalized Jordan derivation on triangular matrix algebra显示文摘 | Ma Fei Ji Guoxing | 2007 | Linear and Multilinear Al- gebra2007，55，4： | 1 |
| 5 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 6 | Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells显示文摘 | Alexis D Guoxing X Andrea MA | 1999 | J Hepatol1999，30，4： | 1 |
| 7 | A Repeated Halving Approach to Fabricate Ultrathin Single‐Walled Carbon Nanotube Films for Transparent Supercapacitors显示文摘 | Zhiqiang Niu Weiya Zhou Jun Chen Guoxing Feng Hong Li Yongsheng Hu Wenjun Ma Haibo Dong Jinzhu Li Sishen Xie | 2012 | Small2012，，4： | 1 |
| 8 | Generalized Jordan derivations on triangular matrix algebras显示文摘 | MA Fei JI Guoxing | 2007 | Linear and Multilinear Algebra2007，55，： | 1 |
| 9 | Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells显示文摘 | Guoxing X Andrea MA | 1999 | J Hepatol1999，30，： | 1 |
| 10 | Generalized Jordan derivations on triangular matrix algebras显示文摘 | Ma Fei Ji Guoxing | 2007 | Linear and Multilinear Alg2007，55，4： | 1 |
| 11 | Generalized Jordan derivation on triangular algebra 显示文摘 | MA FEI JI GUOXING | 2007 | Linear and Multilinear Algebra2007，55，： | 1 |
| 12 | Generalized Jordan derivation on triangular algebra 显示文摘 | Ma Fei Ji Guoxing | 2007 | Linear and Multilinear Algebra2007，55，： | 1 |
| 13 | Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review显示文摘Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering communities.This paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three decades.The focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy soils.In particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation characteristics.Insights gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjected to cyclic loadings associated with seismic events in marine environments. | Chen Guoxing Qin You Ma Weijia Liang Ke Wu Qi C.Hsein Juang | 2024 | Earthquake Engineering and Engineering Vibration2024，23，1： | 0 |
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