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| 1 | Self-adjusted elastic action and its CBM pool-forming effect of the high rank coal reservoir显示文摘The coal reservoir is a kind of geologic body with considerable elasticity, and its response to stress is more sensitive than the routine ones. In the pool-forming process of the coalbed methane, (CBM) the action of many external geodynamic factors in the coal reservoir is represented by the ability of CBM’s diffusion and migration in the coal reservoir. Therefore, the occurrence of the natural fissures in the coal reservoir becomes a key that determines whether the CBM pool can be formed or not. Based on the principle, the authors have designed a comprehensive method of physical modeling to study the elasticity of the coal matrix block with different coal ranks in the light of the solid to fluid coupling, have established the model of the volume deformation (self-adjusted elastic effect) of the coal reservoir under the condition of the effective stress-adsorption/desorption, and have obtained a correct understanding of the law of the elastic deformation. Afterwards, a new viewpoint, named as the self-closing elastic effect for forming the CBM pool in the high rank reservoir, is put forward, providing an initial point and a scientific basis for a further investigation into its dynamic factors, possible mechanism and role in the CBM energy-balancing system. | QIN Yong FU Xuehai WU Caifang FU Guoyou BU Yingying | 2005 | Chinese Science Bulletin2005，50，S1： | 9 |
| 2 | Mechanical microenvironments of living cells: a critical frontier in mechanobiology显示文摘The fields of biomechanics and mechanobiology have long been predicated on the premise that mechanics governs cell behavior. However, over the past few years, a growing body of evidence has suggested that the mechanical environment very close to cells–the cell microenvironment–plays the most important role in determining what a cell feels and how it responds to tissue-level stimuli. To complicate matters further, cells can actively manipulate their microenvironments through pathways of recursive mechanobiological feedback. Harnessing this recursive behavior to understand and control cell physiology and pathophysiology is a critical frontier in the field of mechanobiology. Recent results suggest that the key to opening this scientific frontier to investigation and engineering application is understanding a different frontier: the physical frontier that cells face when probing their mechanical microenvironments. | Guoyou Huang Feng Xu Guy M. Genin Tian Jian Lu | 2019 | Acta Mechanica Sinica2019，35，2： | 5 |
| 3 | Development of 8-inch Key Processes for Insulated-Gate Bipolar Transistor显示文摘Based on the construction of the 8-inch fabricat ion line, advanced process technology of 8-inch wafer, as well as the fourth-generation high-voltage double-diffused metal-oxide semiconductor(DMOS+) insulated-gate bipolar transistor(IGBT) technology and the fifth-generation trench gate IGBT technology, have been developed, realizing a great-leap forward technological development for the manufacturing of high-voltage IGBT from 6-inch to 8-inch. The 1600 A/1.7 kV and 1500 A/3.3 kV IGBT modules have been successfully fabricated, qualified, and applied in rail transportation traction system. | Guoyou Liu Rongjun Ding Haihui Luo | 2015 | Engineering2015，1，3： | 5 |
| 4 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 5 | Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells显示文摘Apoptotic 房间转移被发现了能便于 allograft 的嫁接。然而,内在的机制尚待充分被理解。这里,我们证明施主 apoptotic splenocytes 的静脉内的管理能由导致 tolerogenic 的产生支持胰腺的小岛嫁接树枝状的房间(Tol-DCs ) 和 CD4 + Foxp3 + 规章的 T 房间(Tregs ) 。在 vivo,树枝状的房间(DC ) 或 Tregs 的清理由 apoptotic 房间管理阻止了有免疫力的忍耐的正式就职。用 anti-CD25 的 Tregs 的短暂消除, monoclonal 抗体(mAb ) 在 apoptotic splenocytes 的管理以后废除了 Tol-DCs 的产生。相互地,在用白喉毒素(DT ) 的 CD11c 数据终端就绪老鼠以内的 DC 的弄空与 apoptotic splenocytes 的管理在接受者阻止了 Tregs 的产生。在二个房间之间的房间接触打的由直接要求,并且规划了死亡 1 ligand (PD-L1 ) 的 Tol-DCs 的 Tregs 的正式就职在 Tregs 扩大起了重要作用。Apoptotic 房间管理没能在 IL-10-deficient 和 Smad3 缺乏的老鼠导致 Tol-DCs,建议那 IL-10 和转变生长 factor-β(TGF-β) 被需要处于 tolerogenic 状态维持 DC。因此,我们证明 Tol-DCs 在他们的表面上并且相互地经由 PD-L1 支持 Tregs 的扩大 Tregs 便于 Tol-DCs 维持 apoptotic 房间经由 secreting IL-10 和 TGF-β 导致的移植忍耐;。 | Cong Wu Yi Zhang Yingnling Jiang Quanxing Wang Yao Long Chunmei Wang Xuetao Cao Guoyou Chen | 2013 | Cellular & Molecular Immunology2013，10，5： | 4 |
| 6 | The mechanism of the flowing ground water impacting on coalbed gas content显示文摘The hydrogeological condition affects the coal-bed gas storage dramatically. In an area of stronger hydrodynamics, the coal has a lower gas content, while a higher gas content exists in an area of weaker hydrodynamics. Obviously, the flowing groundwater is harmful to coalbed gas preservation. But few researches focus on the mechanism of how the flowing water diminishes the coalbed gas content Based on the phenomenon that the flowing groundwater not only makes coalbed gas content lower, but also fractionates the carbon isotope, this research puts forward an idea that it is the water solution that diminishes the coalbed gas content, rather than the water-driven action or the gas dissipation through cap rocks. Only water-soluble action can both fractionate the carbon isotope and lessen the coalbed gas content, and it is an efficient way to take gas away and affect the gas content. | QIN Shengfei SONG Yan TANG Xiuyi FU Guoyou | 2005 | Chinese Science Bulletin2005，50，S1： | 3 |
| 7 | Dissection of heterosis for yield and related traits using populations derived from introgression lines in rice显示文摘Despite the great success achieved by the exploitation of heterosis in rice,the genetic basis of heterosis is still not well understood.We adopted an advanced-backcross breeding strategy to dissect the genetic basis of heterosis for yield and eight related traits.Four testcross(TC) populations with 228 testcross F1 combinations were developed by crossing57 introgression lines with four types of widely used male sterile lines using a North Carolina II mating design.Analysis of variance indicated that the effects of testcross F1 combinations and their parents were significant or highly significant for most of the traits in both years,and all interaction effects with year were significant for most of the traits.Positive midparent heterosis(HMP) was observed for most traits in the four TC populations in the two years.The relative HMPlevels for most traits varied from highly negative to highly positive.Sixty-two dominant-effect QTL were identified for HMPof the nine traits in the four TC populations in the two years.Of these,22 QTL were also identified for the performance of testcross F1.Most dominant-effect QTL could individually explain more than 10% of the phenotypic variation.Four QTL clusters were observed including the region surrounding the RM9–RM297 region on chromosome 1,the RM110–RM279–RM8–RM5699–RM452 region on chromosome 2,the RM5463 locus on chromosome 6 and the RM1146–RM147 region on chromosome 10.The identified QTL for heterosis provide valuable information for dissecting the genetic basis of heterosis. | Chao Xiang Hongjun Zhang Hui Wang Shaobo Wei Binying Fu Jiafa Xia Zefu Li Yongming Gao Guoyou Ye | 2016 | The Crop Journal2016，4，6： | 3 |
| 8 | Measurement of Neutron Capture Cross Section for ^(180)Hf | Chen Jinxiang Shi Zhaomin Tang Guoyou Zhang Guohui Institute of Heavy Ion Physics,Peking University,Beijing 100871Lu Hanlin Han Xiaogang Huang Xiaolong China Institute of Atomic Energy,P.O.Box 275(3),Beijing 102413 | 1997 | Chinese journal of nuclear physics1997，，2： | 3 |
| 9 | Abnormal overpressure distribution and natural gas accumulation in foreland basins, Western China显示文摘Abnormal overpressure occurs in the forelandbasins of Kuqa, South Junggar and West Sichuan in China.The pressure coefficients are high. Overpressure exists inwide areas and various strata. The layers of overpressurehave a very close relationship with lithology, and the area ofoverpressure is controlled by the piedmont depression. Themechanisms of overpressure formation in the Kuqa andSouth Junggar Depression include disequilibrium compac-tion and tectonic compression; the importance of these twofactors varies in different basins and in different stages of thesame basin. Different models of gas accumulation are estab-lished to explain the relationship between overpressure dis-tribution and gas pool formation, and the influence of over-pressure on the gas pools. These models include: (i) theviolent tectonic movement leads to the pool formation inoverpressure belt (Kela-2 gas field in Kuqa); (ii) the pres-sure releases at shallow part and the gas pool forms in latetime (Hutubi gas field in southern Junggar Basin); (iii)through the pressure transfer the gas migrates and accumu-lates (Xinchang gas field in Western Sichuan Basin). | SONG Yan XIA Xinyu HONG Feng QIN Shengfei FU Guoyou | 2002 | Chinese Science Bulletin2002，47，S1： | 3 |
| 10 | Progress on Molecular Mechanism of Aluminum Resistance in Rice显示文摘Aluminum(Al)toxicity in acid soils is a significant limitation to crop production worldwide,as 13%of the world's rice is produced in acid soil with high Al content.Rice is likely the most Al-resistant cereal and also the cereal,where Al resistance is the most genetically complex with external detoxification and internal tolerance.Many Al-resistance genes in rice have been cloned,including Al resistance transcription factor 1(ART1)and other transcription factors,organic acid transporter genes,and metal ion transporter gene.This review summarized the recent characterized genes affecting Al tolerance in rice and the interrelationships between Al and other plant nutrients. | Chen Jingguang Lai Qi Zeng Baiquan Guo Longbiao Ye Guoyou | 2020 | Rice science2020，27，6： | 3 |
| 11 | A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 12 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 13 | The Matrix Stiffness and Physical Confinement of Hydrogel Microchannel Jointly Induce the Mesenchymal-Amoeboid Transition for Cancer Cell Migration显示文摘The migration mode transition of cancer cell enhances its invasive capability and the drug resistance,where physical confinement of cell microenvironment has been revealed to induce the mesenchymal-amoeboid transition(MAT).However,most existing studies are performed in PDMS microchannels,of which the stiffness is much higher than that of most mammalian tissues.Therefore,the amoeboid migration transition observed in these studies is actually induced by the synergistic effect of matrix stiffness and confinement.Since the stiffness of cell microenvironment has been reported to influence the cell migration in 2D substrate,the decoupling of stiffness and confinement effects is thus in need for elucidating the underlying mechanism of MAT.However,it is technically challenging to construct microchannels with physiologically relevant stiffness and channel size,where existing microchannel platforms with physiological relevance stiffness are all with>10μm channel width.Such size is too wide to mimic the physical confinement that migrating cancer cells confront in vivo,and also larger than the width of PDMS channel,in which the MAT of cancer cell was observed.Therefore,an in vitro cell migration platform,which could mimic both stiffness and confinement of the native physical microenvironment during cancer metastasis,could profoundly contribute to researches on cancer cell migration and cellular mechanotransduction.In this paper,we overcome the limitations of engineering soft materials in microscale by combining the collagen-alginate hydrogel with photolithography.This enables us to improve the accuracy of molded microchannel,and thus successfully construct a 3D microchannel platform,which matches the stiffness and width ranges of native environmental confinement that migrating cancer cells confront in vivo.The stiffness(0.3~20 kPa),confinement(channel width:3.5~14μm)and the adhesion ligand density of the microchannel can be tuned independently.Interestingly,using this platform,we observed that the migration speed of cancer cell is influenced by the synergistic effect of channel stiffness and width,and the increasing stiffness reverses the effect of channel width on the migration speed of cancer cells.In addition,MAT has a strong correlation with the channel stiffness.These findings make us reconsider the widely accepted hypothesis:physical confinement can induce MAT.Actually,this transition can only occur in stiff confined microenvironment not in soft one.For soft microchannels,the compliance of the channel walls could cause little cell/nucleus deformation,and the MAT could not be induced.To further investigate the mechanism of MAT,we developed a computational model to simulate the effect of nucleus deformation on MAT.With the model,we found that deforming the cell nuclear by decreasing the nucleus stiffness will reduce the cellmigration speed.This implies that nuclear stiffness plays an important role in the regulation of cancer migration speed and thus MAT in microchannels.The effect of channel stiffness on MAT and migration speed as observed in our experiment could partially explain previous findings reported in the literature,where the increasing matrix stiffness of tumor microenvironment promotes cancer metastasis.Our observations thus highlight the critical role of cell nuclear deformation not only in MAT,but also in regulating cellular mechanotransduction and cell-ECM interactions.This developed platform is capable of mimicking the native physical microenvironment during metastasis,providing a powerful tool for high-throughput screening applications and investigating the interaction between cancer migration and biophysical microenvironment. | Meng Wang Bo Cheng Yaowei Yang Han Liu Guoyou Huang Fei Li Feng Xu | 2019 | 医用生物力学2019，34，A01： | 2 |
| 14 | Local asymptotic behavior of regression splines for marginal semiparametric models with longitudinal data显示文摘In this paper, we study the local asymptotic behavior of the regression spline estimator in the framework of marginal semiparametric model. Similarly to Zhu, Fung and He (2008), we give explicit expression for the asymptotic bias of regression spline estimator for nonparametric function f. Our results also show that the asymptotic bias of the regression spline estimator does not depend on the working covariance matrix, which distinguishes the regression splines from the smoothing splines and the seemingly unrelated kernel. To understand the local bias result of the regression spline estimator, we show that the regression spline estimator can be obtained iteratively by applying the standard weighted least squares regression spline estimator to pseudo-observations. At each iteration, the bias of the estimator is unchanged and only the variance is updated. | QIN GuoYou ZHU ZhongYi | 2009 | Science China Mathematics2009，52，9： | 2 |
| 15 | Rice Heavy Metal P-type ATPase OsHMA6 Is Likely a Copper Efflux Protein显示文摘P1B-type heavy metal ATPases(HMAs)are transmembrane metal-transporting proteins that play a key role in metal homeostasis.We here reported the characterization of rice OsHMA6,a member of the P1B-type ATPase family.Phylogenetic tree analysis showed that OsHMA6 belonged to the Cu/Ag subgroup of the HMA family and had a close evolutionary relationship with OsHMA9.Amino acid sequence alignment showed 82.78%consistency between OsHMA6 and OsHMA9.OsHMA6 expressed in all organs at different growth stages,including spikelet,and abundant in leaf blades,however,OsHMA9 most strongly expressed in roots,but very low in spikelet.Excessive Cu^2+can up-regulate the expression of OsHMA6 and OsHMA9 in rice seedlings.The heterologous expression in yeast showed that OsHMA6 can significantly rescue the growth of yeast strain CM52 when supplied with 3 or 6 mmol/L Cu^2+.Compared with the empty vector pYES2,the Cu concentration in OsHMA6-pYES2 decreased by 23.4%and 30.3%under 3 or 6 mmol/L Cu2+,respectively.Subcellular localization revealed that OsHMA6 was located in the plasma membrane.These results suggested that OsHMA6,similar to OsHMA9,is likely a copper efflux protein located in the plasma membrane. | ZOU Wenli LI Chang ZHU Yajun CHEN Jingguang HE Haohua YE Guoyou | 2020 | Rice science2020，27，2： | 2 |
| 16 | Synthesis of La-Modified Ultra Stable Zeolite L and Its Application to Catalytic Cracking Catalyst显示文摘A new type of zeolite La-USL (ultra stable zeolite L (zeolite USL) modified by La), which has superior activity, stability and selectivity in catalytic cracking of hydrocarbons and thus can be used as an active catalyst component, is reported in this paper. The zeolite L with relative crystallinity of above 90% was synthesized by the hydrothermal crystallization method under optimum conditions and characterized by means of XRD, NH3-TPD and isotherm adsorption techniques. The in-situ synthesized zeolite L with a SiO2/Al2O3 mole ratio of 5-6 was modified by cation ion exchange, hydrothermal dealumination and chemical modifications with La in order to prepare La-containing USL with a higher framework SiO2/Al2O3 mole ratio of 15-30. The modified zeolite La-USL was used as an active additive component of fluid catalytic cracking (FCC) catalyst and the resulting catalysts were evaluated by microactivity test (MAT) and fixed-fluidized bed (FFB) experiments using heavy oil as feedstock. The influence of La content in La-USL on cracking product distribution, gasoline group composition and research octane number (RON) was investigated. The results showed that when La content in La-USL was 0.8 wt%, the addition of the corresponding La-USL could result in a FCC catalyst that produced significant improvement in product distribution and gasoline quality. | Pan Huifang Liu Xingyu Wei Guoyou Yuan Hailiang Pan Xinghong Huo Quan Yan Pingxiang | 2007 | Petroleum Science2007，4，2： | 2 |
| 17 | 结合QTL-seq和连锁分析发掘水稻中胚轴伸长相关QTL显示文摘中胚轴长度(mesocotyl length, ML)是影响旱直播水稻出苗和早期幼苗活力的重要性状。发掘中胚轴伸长相关位点,解析其遗传机制,选育长中胚轴品种是促进旱直播技术推广最为经济和有效的方式。本研究以长中胚轴品种‘Changai’和短中胚轴品种‘IR 145’为亲本构建的F_2遗传分离群体为材料,构建长池和短池并开展深度重测序(50×)。利用Δ(SNP-index)和G-value两种方法在3号染色体29.56~33.28 Mb处鉴定到1个中胚轴伸长相关位点qML3。在候选区域开发KASP标记,对184个F_2株系开展连锁分析,将候选区间缩小到28.89~31.03Mb。结合基因注释、连锁分析和基因表达分析结果,推测LOC_Os03g52450、LOC_Os03g56060、LOC_Os03g58290、LOC_Os03g58300、LOC_Os03g58320、LOC_Os03g56050和LOC_Os03g57640为候选基因。这些基因分别与植物激素的调控和细胞分裂相关机制有关。本研究发掘了一个水稻中胚轴伸长相关位点,对选育长中胚轴品种有一定帮助。 | 刘畅 孟云 刘金栋 王雅美 Guoyou Ye | 2021 | 作物学报2021，47，10： | 2 |
| 18 | Evaluation of Gibbs free energy of intermetallic compounds for Ti-Si-C ternary system显示文摘 | Gan Guoyou Chen Jingchao Sun Jialin | 2002 | Kunming University of Science and Technology2002，27，2： | 1 |
| 19 | Optimal allocation of water resources in Guanazhon City, South China显示文摘 | Chen Xiaohong Chen Yongqin Lai Guoyou | 2006 | Journal of Environmental Science and Health2006，41，7： | 1 |
| 20 | Effect of viscoelasticity on skin pain sensation显示文摘Pain sensation may appear under long-lasting mechanical stimulation. Although people have the experience that pain sensation generally decreases with time while the stimulation remains, the underlying mechanism remains elusive. We experimentally studied the thermal and strain ratedependent viscoelastic behavior of skin in uniaxial stretch and numerically investigated the effects of temperature and strain rate on pain sensation. The results indicate that the viscosity of skin tissue decreases with increasing temperature and reducing strain rate, which subsequently decreases the discharge frequency of skin nociceptor and thus relieves the pain sensation. The results would contribute to the understanding of pain relief mechanism and optimizing for mechanical treatment. | Fusheng Liu Chenghai Li Shaobao Liu Guy M.Genin Guoyou Huang TianJian Lu Feng Xu | 2015 | Theoretical & Applied Mechanics Letters2015，5，6： | 1 |
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