|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mutant Resources for the Functional Analysis of the Rice Genome显示文摘瑞斯是世界范围的最重要的庄稼之一,作为主食食物并且作为为 genomic 研究的一个模型系统。为了系统地把功能分到所有,在米饭染色体预言了基因,很多米饭异种线包括 T-DNA 插入创造的那些,标注的 Ds/dSpm,标注的 Tos17,和化学药品 / 照耀的 mutagenesis,被组在全世界产生了。在这研究,我们为米饭染色体的功能的分析考察了变异的资源的当前的地位。246 566 flanking 顺序的一个总数与 T-DNA, Ds/dSpm,或 Tos17 插入从米饭异种图书馆标注被收集了并且分析。在 211 470 唯一的点击之中,插入的结果表演在遗传因子的区域报道定位了因为 68.16% ,和 60.49% 原子基因包含至少一插入。当前,在米饭的 57% non-transposable-element-related 基因有 insertional 标签。另外, chemical/irradiation-induced 米饭异种图书馆为变异的地点的鉴定贡献了很多到基因鉴定和新技术。在这评论,我们总结这些工具怎么被用来产生异种的一个大集合。另外,我们讨论经典变化策略的优点。为了为基因在米饭,指向的 DNA,和象 RiceFox 一样的新资源完成 mutagenesis 的浸透,功能的鉴定从米饭异种资源的未来产生的一个观点被考察。 | Nili Wang Tuan Long Wen Yao Lizhong Xiong Qifa Zhang Changyin Wu | 2013 | Molecular Plant2013，6，3： | 21 |
| 2 | Efficacy of intramuscular matrine in the treatment of chronic hepatitis B显示文摘BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional Chinese herb Radix Sophorae Flavescentis by Guangzhou Ming Xing Pharmaceu cal Factory, Guangzhou, China) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B. | Yao Long, Xiao-Tian Lin, Kun-Lun Zeng and Lian Zhang Zhanjiang, China Department of Infectious Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China Haibin Centre Hospital, Zhanjiang 524005, China Centre of Hepatology of Nanfang Hospital, First Military Medical University, Guang- zhou 510515, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 21 |
| 3 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 4 | Effect of multiple-phase regional intra-arterial infusion chemotherapy on patients with resectable pancreatic head adenocarcinoma显示文摘背景地区性的intra动脉的注入化疗( RIAC )是更珍贵的与不能实行的胰腺的腺癌改进病人的生活的预后和质量,并且辅助 RIAC 在延长幸存并且在胰腺的癌症的激进的切除术以后减少肝转移的风险起一个重要作用,但是外科手术前或多重阶段的 RIAC 的效果(外科手术前与手术后的 RIAC 结合了)为 resectable ,胰腺的癌症没被调查。在这未来的研究,为有 resectable 的病人的多重阶段的 RIAC 的效果胰腺的头腺癌被评估,并且它与手术后的 RIAC 作比较的安全和有效性也是有胰腺的头癌症随机被分到二个组的 resectable 的 assessed.Methods 病人。在组 A (n=50 ) 的病人与与多重阶段的 RIAC 相结合的扩大 pancreaticoduodenectomy 的新治疗学的模式被对待,并且那些在组 B (n=50 ) 被对待,扩大 pancreaticoduodenectomy 在一样的时期与手术后的 RIAC 结合了。新治疗学的模式的可行性,依从和效率被 RIAC 的肿瘤尺寸,浆液肿瘤标记,临床的利益反应(CBR ) ,外科的复杂并发症,死亡和毒性评估。没有疾病的幸存时间,中部的幸存时间,肝转移的发生,在 1, 2, 3 和 5 年的幸存率也被观察。生活曲线被在组 A 的疼痛消除率和 CBR 是的 Kaplan-Meier method.Results 产生 80% 和 84% 分别地。浆液肿瘤标记显然减少了,肿瘤尺寸在组 A 在外科手术前的 RIAC 以后在 26% 病人减少了。不再外科的复杂并发症,死亡或严重全身的副作用与组 B 相比在组 A 被观察。在组 A 的肝转移的发生是 34% 它在组 B 是比 50% 低的。在组 A 的没有疾病的幸存时间和中部的幸存时间分别地是 15.5 个月和 18 个月。1- , 2- , 3 年、 5 年的幸存率分别地是 54.87% , 34.94% , 24.51% 和 12.25% 。没有在多重阶段的 RIAC 是的二 groups.Conclusions 之间的幸存时间或幸存率的重要差别在 resectable 的联合治疗有效由提高肿瘤生长和肝转移的减小的抑制的胰腺的头癌,没有病人的安全或外科的过程上的否定效果。 | JIN Chen YAO Lie LONG Jiang FU De-liang YU Xian-jun XU Jin YANG Feng NI Quan-xing | 2009 | Chinese Medical Journal2009，，3： | 17 |
| 5 | Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells显示文摘组织蛋白酶 L (CTSL ) , lysosomal 酸半胱氨酸朊酶,被知道在肿瘤起重要作用转移和化疗抵抗。在这研究,我们调查了在人的肺癌症 cells.Methods 由 CTSL 位于 chemoresistance 的规定下面的分子的机制:人的肺癌症 A549 房间, A549/PTX (paclitaxel 抵抗) 房间和 A549/DDP (cisplatin 抵抗) 房间被测试。到 cisplatin 或 paclitaxel 的抵抗用 MTT 和殖民地形成试金被检测。肌动朊改变与 FITC-Phalloidin 被观察荧光灯的染色或 immunofluorescence。愈合创伤的试金或 Transwell 试金被用来估计迁居或侵略能力。CTSL 和上皮、间充质的标记的表示与西方的弄污和 immunofluorescence 被分析。联系 EMT 的抄写因素的表示与西方的弄污或 q-PCR 被测量。BALB/c 裸体老鼠与 A549 房间 overexpressing CTSL 皮下地被植入,并且老鼠是管理 paclitaxel (10, 15 mg/kg, ip ) 为 5 times.Results 的每 3 d:Cisplatin 或 paclitaxel 治疗(10-80 ng/mL ) 在 A549 房间导致了 CTSL 表示。CTSL 层次比在 A549 房间在 A549/PTX 和 A549/DDP 房间是高得多的。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 chemoresistance,而 CTSL 的 overexpression 稀释了 A549 房间的敏感到 cisplatin 或 paclitaxel。而且, A549/DDP 和 A549/TAX 房间经历了词法并且有增加的房间侵略和迁居能力的细胞骨架变化,由上皮的标记( E-cadherin 和 cytokeratin-18 )的减少的表示伴随了并且增加间充质的标记( N-cadherin 和 vimentin )的表示,以及 联系EMT 的抄写因素的 upregulation 蜗牛,蛞蝓, ZEB1 和 ZEB2 。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 EMT;相反, CTSL 的 overexpression 在 A549 房间导致了 EMT。在异种皮移植裸体人鼠标模型,与 A549 房间 overexpressing CTSL 植入的鼠标展出了显著地减少的敏感到 paclitaxel 处理,并且在肿瘤 tissues.Conclusion 增加了联系 EMT 的蛋白质和抄写因素的表示:Cisplatin 和 paclitaxel 抵抗在 A549 房间与 CTSL 导致 upregulation 的 EMT 被联系。因此,调停 CTSL 的 EMT 可以作为一个目标被利用对肺癌症和恶意的另外的类型提高 cisplatin 或 paclitaxel 的功效。 | Mei-ling HAN Yi-fa n ZHAO Cai-hong TAN Ya-jie XIONG Wen-juan WANG Feng WU Yao FEI Long WANG Zhong-qin LIANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 15 |
| 6 | Spatial-temporal characteristics of lake area variations in Hoh Xil region from 1970 to 2011显示文摘As one of the areas with numerous lakes on the Tibetan Plateau, the Hoh Xil region plays an extremely important role in the fragile plateau eco-environment. Based on topographic maps in the 1970 s and Landsat TM/ETM+ remote sensing images in the 1990 s and the period from 2000 to 2011, the data of 83 lakes with an area above 10 km2 each were obtained by digitization method and artificial visual interpretation technology, and the causes for lake variations were also analyzed. Some conclusions can be drawn as follows.(1) From the 1970 s to 2011, the lakes in the Hoh Xil region firstly shrank and then expanded. In particular, the area of lakes generally decreased during the 1970s–1990s. Then the lakes expanded from the 1990 s to 2000 and the area was slightly higher than that in the 1970 s. The area of lakes dramatically increased after 2000.(2) From 2000 to 2011, the lakes with different area ranks in the Hoh Xil region showed an overall expansion trend. Meanwhile, some regional differences were also discovered. Most of the lakes expanded and were widely distributed in the northern, central and western parts of the region. Some lakes were merged together or overflowed due to their rapid expansion. A small number of lakes with the trend of area decrease or strong fluctuation were scattered in the central and southern parts of the study area. And their variations were related to their own supply conditions or hydraulic connection with the downstream lakes or rivers.(3) The increase in precipitation was the dominant factor resulting in the expansion of lakes in the Hoh Xil region. The secondary factor was the increase in meltwater from glaciers and frozen soil due to climate warming. | YAO Xiaojun LIU Shiyin LI Long SUN Meiping LUO Jing | 2014 | Journal of Geographical Sciences2014，24，4： | 14 |
| 7 | Spatial dynamics of aboveground carbon stock in urban green space:a case study of Xi'an,China显示文摘Greenhouse gas emission of carbon dioxide(CO2) is one of the major factors causing global climate change.Urban green space plays a key role in regulating the global carbon cycle and reducing atmospheric CO2.Quantifying the carbon stock,distribution and change of urban green space is vital to understanding the role of urban green space in the urban environment.Remote sensing is a valuable and effective tool for monitoring and estimating aboveground carbon(AGC) stock in large areas.In the present study,different remotely-sensed vegetation indices(VIs) were used to develop a regression equation between VI and AGC stock of urban green space,and the best fit model was then used to estimate the AGC stock of urban green space within the beltways of Xi'an city for the years 2004 and 2010.A map of changes in the spatial distribution patterns of AGC stock was plotted and the possible causes of these changes were analyzed.Results showed that Normalized Difference Vegetation Index(NDVI) correlated moderately well with AGC stock in urban green space.The Difference Vegetation Index(DVI),Ratio Vegetation Index(RVI),Soil Adjusted Vegetation Index(SAVI),Modified Soil Adjusted Vegetation Index(MSAVI) and Renormalized Difference Vegetative Index(RDVI) were lower correlation coefficients than NDVI.The AGC stock in the urban green space of Xi'an in 2004 and 2010 was 73,843 and 126,621 t,respectively,with an average annual growth of 8,796 t and an average annual growth rate of 11.9%.The carbon densities in 2004 and 2010 were 1.62 and 2.77 t/hm2,respectively.Precipitation was not an important factor to influence the changes of AGC stock in the urban green space of Xi'an.Policy orientation,major ecological greening projects such as 'transplanting big trees into the city' and the World Horticultural Exposition were found to have an important impact on changes in the spatiotemporal patterns of AGC stock. | ZhengYang YAO JianJun LIU XiaoWen ZHAO DongFeng LONG Li WANG | 2015 | Journal of Arid Land2015，7，3： | 13 |
| 8 | Rapid Detection and Identification of Infectious Pathogens Based on High-throughput Sequencing显示文摘 | Pei-Xiang Ni Xin Ding Yin-Xin Zhang Xue Yao Rui-Xue Sun Peng Wang Yan-Ping Gong Jia-Li Zhou Dong-Fang Li Hong-Long WO Xin Yi Ling Yang Yun Long | 2015 | Chinese Medical Journal2015，，7： | 13 |
| 9 | New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer显示文摘With the development of proteomics and epigenetics,a large number of RNA-binding proteins(RBPs)have been discovered in recent years,and the inter-action between long non-coding RNAs(lncRNAs)and RBPs has also received increasing attention.It is extremely important to conduct in-depth research on the lncRNA-RBP interaction network,especially in the context of its role in the occurrence and development of cancer.Increasing evidence has demonstrated that lncRNA-RBP interactions play a vital role in cancer progression;there-fore,targeting these interactions could provide new insights for cancer drug discovery.In this review,we discussed how lncRNAs can interact with RBPs to regulate their localization,modification,stability,and activity and discussed the effects of RBPs on the stability,transport,transcription,and localization of lncRNAs.Moreover,we explored the regulation and influence of these inter-actions on lncRNAs,RBPs,and downstream pathways that are related to can-cer development,such as N6-methyladenosine(m6A)modification of lncRNAs.In addition,we discussed how the lncRNA-RBP interaction network regulates cancer cell phenotypes,such as proliferation,apoptosis,metastasis,drug resis-tance,immunity,tumor environment,and metabolism.Furthermore,we sum-marized the therapeutic strategies that target the lncRNA-RBP interaction net-work.Although these treatments are still in the experimental stage and various theories and processes are still being studied,we believe that these strategiesmay provide new ideas for cancer treatment. | Zi-Ting Yao Yan-Ming Yang Miao-Miao Sun Yan He Long Liao Kui-Sheng Chen Bin Li | 2022 | Cancer Communications2022，42，2： | 13 |
| 10 | Optimization of N18 Zirconium Alloy for Fuel Cladding of Water Reactors显示文摘In order to optimize the microstructure and composition of N18 zirconium alloy(Zr-1Sn-0.35Nb-0.35Fe-0.1Cr,in mass fraction,%),which was developed in China in 1990s,the effect of microstructure and composition variation on the corrosion resistance of the N18 alloy has been investigated.The autoclave corrosion tests were carried out in super heated steam at 400 ℃/10.3 MPa,in deionized water or lithiated water with 0.01 mol/L LiOH at 360 ℃/18.6 MPa.The exposure time lasted for 300-550 days according to the test temperature.The results show that the microstructure with a fine and uniform distribution of second phase particles(SPPs),and the decrease of Sn content from 1%(in mass fraction,the same as follows) to 0.8% are of benefit to improving the corrosion resistance;It is detrimental to the corrosion resistance if no Cr addition.The addition of Nb content with upper limit(0.35%) is beneficial to improving the corrosion resistance.The addition of Cu less than 0.1% shows no remarkable influence upon the corrosion resistance for N18 alloy.Comparing the corrosion resistance of the optimized N18 with other commercial zirconium alloys,such as Zircaloy-4,ZIRLO,E635 and E110,the former shows superior corrosion resistance in all autoclave testing conditions mentioned above.Although the data of the corrosion resistance as fuel cladding for high burn-up has not been obtained yet,it is believed that the optimized N18 alloy is promising for the candidate of fuel cladding materials as high burn-up fuel assemblies.Based on the theory that the microstructural evolution of oxide layer during corrosion process will affect the corrosion resistance of zirconium alloys,the improvement of corrosion resistance of the N18 alloy by obtaining the microstructure with nano-size and uniform distribution of SPPs,and by decreasing the content of Sn and maintaining the content of Cr is discussed. | B.X. Zhou M. Y. Yao Z.K. Li X.M. Wang J. Zhoua C.S. Long Q. Liu B.F. Luan | 2012 | Journal of Materials Science & Technology2012，28，7： | 13 |
| 11 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 12 | Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines显示文摘Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the | TAN Long SANG Zhong Na SHEN Jun WU Yun Tang YAO Zhai Xiao ZHANG Jin Xiang ZHAO Na ZHANG Wan Qi | 2013 | Biomedical and Environmental Sciences2013，26，11： | 10 |
| 13 | New Diterpenoids from Coleus forskohlii显示文摘Two new diterpenoids, forskolin G and H were isolated from the chloroform extract of the roots of Coleus forskohlii, and based on spectroscopic data, their structures were identified as 1a-hydroxy-6b,7b-diacetoxy-8,13-epoxylabd-14-ene-11-one (1), and 1a,6b-diacetoxy-8,13-epoxy labd-14-ene-11-one (2), respectively. | Yun Heng SHEN, Chun Suo YAO, Yun Long XU* State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming 650204 | 2002 | Chinese Chemical Letters2002，13，8： | 10 |
| 14 | Characteristics of secondary inorganic aerosol and sulfate species in size-fractionated aerosol particles in Shanghai显示文摘Sulfate, nitrate and ammonium(SNA) are the dominant species in secondary inorganic aerosol, and are considered an important factor in regional haze formation. Size-fractionated aerosol particles for a whole year were collected to study the size distribution of SNA as well as their chemical species in Shanghai. SNA mainly accumulated in fine particles and the highest average ratio of SNA to particulate matter(PM) was observed to be 47% in the fine size fraction(0.49–0.95 μm). Higher sulfur oxidation ratio and nitrogen oxidation ratio values were observed in PM of fine size less than 0.95 μm. Ion balance calculations indicated that more secondary sulfate and nitrate would be generated in PM of fine size(0.49–0.95 μm). Sulfur K-edge X-ray absorption near-edge structure(XANES) spectra of typical samples were analyzed. Results revealed that sulfur mainly existed as sulfate with a proportion(atomic basis) more than 73% in all size of PM and even higher at 90% in fine particles. Sulfate mainly existed as(NH4)2SO4 and gypsum in PM of Shanghai. Compared to non-haze days, a dramatic increase of(NH4)2SO4 content was found in fine particles on haze days only, which suggested the promoting impact of(NH4)2SO4 on haze formation. According to the result of air mass backward trajectory analysis, more(NH4)2SO4 would be generated during the periods of air mass stagnation. Based on XANES, analysis of sulfate species in size-fractionated aerosol particles can be an effective way to evaluate the impact of sulfate aerosols on regional haze formation. | Shilei Long Jianrong Zeng Yan Li Liangman Bao Lingling Cao Ke Liu Liang Xu Jun Lin Wei Liu Guanghua Wang Jian Yao Chenyan Ma Yidong Zhao | 2014 | Journal of Environmental Sciences2014，26，5： | 10 |
| 15 | Output Characteristics of a Series Three-port Axial Piston Pump显示文摘Driving a hydraulic cylinder directly by a closed-loop hydraulic pump is currently a key research area in the field of electro-hydraulic control technology,and it is the most direct means to improve the energy efficiency of an electro-hydraulic control system.So far,this technology has been well applied to the pump-controlled symmetric hydraulic cylinder.However,for the differential cylinder that is widely used in hydraulic technology,satisfactory results have not yet been achieved,due to the asymmetric flow constraint.Therefore,based on the principle of the asymmetric valve controlled asymmetric cylinder in valve controlled cylinder technology,an innovative idea for an asymmetric pump controlled asymmetric cylinder is put forward to address this problem.The scheme proposes to transform the oil suction window of the existing axial piston pump into two series windows.When in use,one window is connected to the rod chamber of the hydraulic cylinder and the other is linked with a low-pressure oil tank.This allows the differential cylinders to be directly controlled by changing the displacement or rotation speed of the pumps.Compared with the loop principle of offsetting the area difference of the differential cylinder through hydraulic valve using existing technology,this method may simplify the circuits and increase the energy efficiency of the system.With the software SimulationX,a hydraulic pump simulation model is set up,which examines the movement characteristics of an individual piston and the compressibility of oil,as well as the flow distribution area as it changes with the rotation angle.The pump structure parameters,especially the size of the unloading groove of the valve plate,are determined through digital simulation.All of the components of the series arranged three distribution-window axial piston pump are designed,based on the simulation analysis of the flow pulse characteristics of the pump,and then the prototype pump is made.The basic characteristics,such as the pressure,flow and noise of the pumps under different rotation speeds,are measured on the test bench.The test results verify the correctness of the principle.The proposed research lays a theoretical foundation for the further development of a new pump-controlled cylinder system. | ZHANG Xiaogang QUAN Long YANG Yang WANG Chengbin YAO Liwei | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 10 |
| 16 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 17 | A feasible,economical,and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways显示文摘Aconiti Lateralis Radix Praeparata(Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines(MDAs) and diester-diterpenoidaconitines(DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components(SSDMC) method was developed and fully validated. Benzoylmesaconine was used as the unique reference standard. This method was proven as accurate(recovery varying between 97.5%-101.8%, RSD < 3%), precise(RSD 0.63%-2.05%), and linear(R > 0.999 9) over the concentration ranges, and subsequently applied to quantitative evaluation of 62 batches of samples, among which 45 batches were from good manufacturing practice(GMP) facilities and 17 batches from the drug market. The contents were then analyzed by principal component analysis(PCA) and homogeneity test. The present study provided valuable information for improving the quality standard of Aconiti Lateralis Radix Praeparata. The developed method also has the potential in analysis of other Aconitum species, such as Aconitum carmichaelii(prepared parent root) and Aconitum kusnezoffii(prepared root). | ZHANG Yi-Bei DA Juan ZHANG Jing-Xian LI Shang-Rong CHEN Xin LONG Hua-Li WANG Qiu-Rong CAI Lu-Ying YAO Shuai HOU Jin-Jun WU Wan-Ying GUO De-An | 2017 | Chinese Journal of Natural Medicines2017，15，4： | 10 |
| 18 | A new method to predict fatigue crack growth rate of materials based on average cyclic plasticity strain damage accumulation显示文摘By introducing a fatigue blunting factor, the cyclic elasto-plastic Hutchinson-Rice-Rosengren (HRR) field near the crack tip under the cyclic loading is modified. And, an average damage per loading-cycle in the cyclic plastic deformation region is defined due to Manson-Coffin law. Then, according to the linear damage accumulation theory-Miner law, a new model for predicting the fatigue crack growth (FCG) of the opening mode crack based on the low cycle fatigue (LCF) damage is set up. The step length of crack propagation is assumed to be the size of cyclic plastic zone. It is clear that every parameter of the new model has clearly physical meaning which does not need any human debugging. Based on the LCF test data, the FCG predictions given by the new model are consistent with the FCG test results of Cr2Ni2MoV and X12CrMoWVNbN 10-1-1. What's more, referring to the relative researches, the good predictability of the new model is also proved on six kinds of materials. | Chen Long Cai Lixun Yao Di | 2013 | Chinese Journal of Aeronautics2013，26，1： | 9 |
| 19 | Plant food sources and stone tools' function at the site of Shunshanji based on starch grain analysis显示文摘The upper-middle Huai River valley(HRV) is located in the transition zone in the middle of eastern China. Previous studies have shown that the past populations in the upper HRV obtained plant food through gathering and cultivation of both rice and millet during the middle Neolithic. However, for the middle HRV it is not very clear what methods were used by humans to obtain plant food in that time. In this paper, starch grain analysis was carried out on 17 stone tools and 29 cauldron pottery sherds unearthed at Shunshanji(8.5–7.0 kyr BP), which is known as the earliest Neolithic site in the middle HRV excavated so far. Here, ancient starches from Coix lacryma-jobi, Triticeae, Oryza sativa, Trichosanthes kirilowii and one unidentified specie were recovered. This study contributes to the limited knowledge of food strategies as observed in the middle HRV. It demonstrates that both gathering and cultivation of rice took place during the middle-Neolithic. Among the identified species, Coix lacryma-jobi appears to have been the main plant food at Shunshanji. Moreover, it is clear that Oryza sativa was not consumed as much as other plant species according to the occurrence frequency of different starch grains. Starch grains were also found on the used surfaces of grinding stone implements as well as pestles, which means that these stone tools were used for food processing. In addition, axes from Shunshanji may also have been used for food processing as well as wood working because starches were also found on the edge of axes. Information about subsistence strategies and tool use at Shunshanji will also be helpful to understanding the utilization of plants and agricultural development in the middle HRV during the early-middle Neolithic period. | YANG YuZhang LI WeiYa YAO Ling CHENG ZhiJie LUO WuHong ZHANG JuZhong LIN LiuGen GAN HuiYuan YAN Long | 2016 | Science China Earth Sciences2016，59，8： | 9 |
| 20 | Effect of co-transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of hepatocellular carcinoma Huh7显示文摘Objective:To investigate the effects of co-transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of hepatocellular carcinoma Huh7.Methods:Hepatocellular carcinoma Huh7 was cultured in vitro and lipidosome was used to transfect miR-520c-3p and miR-132 respectively or together.The effects of transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of Huh7 were detected by CCK8 and Annexin V staining and flow cytometry,and the expression level of the targeted gene of over-expressed miR-520c-3p and miR-132 was determined by Western blot and realtime PCR.Results:Compared with the control group,the proliferation ability of Huh7 of the single transfected and co-transfected miR-520c-3p and miR-132 decreased significantly,and the apoptosis ratio increased distinctly(P<0.05).Besides,the affect of the co-transfection group was better than that of the single transfection group.The protein levels of GPC3(Glypican-3) and YAP(Yes-associated protein),the target genes transfected only by miR-520c-3p and miR-132,respectively,reduced obviously(P<0.05),which was similar with the co-infected cells,but cells transfected by miR-132 only showed a decrease of YAP.Conclusions:The co-transfection of miR-520c-3p and miR-132 can target-regulate the expression of GPC3 and YAP,enhance the exhibition effect on proliferation of hepatocellular carcinoma Huh7 and induce cell apoptosis synergistically. | Chang-Jiang Lei Chun Yao De-Ke Li Zhi-Xiong Long Yuan Li Dan Tao Yan-Ping Liou Jiang-Zhou Zhang Ning Liu | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员