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| 1 | The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cells显示文摘Astrocytes are intimately involved in the formation and development of retinal vessels.Astrocyte dysfunction is a major cause of blood-retinal barrier injury and other retinal vascular diseases.In this study,the development of the retinal vascular system and the formation of the blood-retinal barrier in mice were investigated using immunofluorescence staining,gelatin-ink perfusion,and transmission electron microscopy.The results showed that the retinal vascular system of mice develops from the optic disc after birth,and radiates out gradually to cover the entire retina,taking the papilla optica as the center.First,the superficial vasculature is formed on the inner retinal layer; then,the vasculature extends into the inner and outer edges of the retinal inner nuclear layer,forming the deep vasculature that is parallel to the superficial vasculature.The blood-retinal barrier is mainly composed of endothelium,basal lamina and the end-feet of astrocytes,which become mature during mouse development.Initially,the naive endothelial cells were immature with few organelles and many microvilli.The basal lamina was uniform in thickness,and the glial end-feet surrounded the outer basal lamina incompletely.In the end,the blood-retinal barrier matures with smooth endothelia connected through tight junctions,relatively thin and even basal lamina,and relatively thin glial cell end-feet.These findings indicate that the development of the vasculature in the retina follows the rules of 'center to periphery' and 'superficial layer to deep layers'.Its development and maturation are spatially and temporally consistent with the functional performance of retinal neurons and photosensitivity.The blood-retinal barrier gradually becomes mature via the process of interactions between astrocytes and blood vessel cells. | Huanling Yao Tianshi Wang Jiexin Deng Ding Liu Xiaofei Li Jinbo Deng | 2014 | Neural Regeneration Research2014，9，10： | 6 |
| 2 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 3 | Trace Amounts of Triple-Functional Additives Enable Reversible Aqueous Zinc-Ion Batteries from a Comprehensive Perspective显示文摘Although their cost-effectiveness and intrinsic safety,aqueous zinc-ion batteries suffer from notorious side reactions including hydrogen evolution reaction,Zn corrosion and passivation,and Zn dendrite formation on the anode.Despite numerous strategies to alleviate these side reactions have been demonstrated,they can only provide limited performance improvement from a single aspect.Herein,a triple-functional additive with trace amounts,ammonium hydroxide,was demonstrated to comprehensively protect zinc anodes.The results show that the shift of electrolyte pH from 4.1 to 5.2 lowers the HER potential and encourages the in situ formation of a uniform ZHS-based solid electrolyte interphase on Zn anodes.Moreover,cationic NH^(4+)can preferentially adsorb on the Zn anode surface to shield the“tip effect”and homogenize the electric field.Benefitting from this comprehensive protection,dendrite-free Zn deposition and highly reversible Zn plating/stripping behaviors were realized.Besides,improved electrochemical performances can also be achieved in Zn//MnO_(2)full cells by taking the advantages of this triple-functional additive.This work provides a new strategy for stabilizing Zn anodes from a comprehensive perspective. | Ruwei Chen Wei Zhang Quanbo Huang Chaohong Guan Wei Zong Yuhang Dai Zijuan Du Zhenyu Zhang Jianwei Li Fei Guo Xuan Gao Haobo Dong Jiexin Zhu Xiaohui Wang Guanjie He | 2023 | Nano-Micro Letters2023，15，6： | 2 |
| 4 | Traffic dynamics on multilayer networks显示文摘Many real-world networks are demonstrated to either have layered network structures in themselves or interconnect with other networks,forming multilayer network structures.In this survey,we give a brief review of recent progress in traffic dynamics on multilayer networks.First,we introduce several typical multilayer network models.Then,we present some mainstream performance indicators,such as network capacity,average transmission time,etc.Moreover,we discuss some optimization strategies for improving the transmission performance.Finally,we provide some open issues that could be further explored in the future. | Jiexin Wu Cunlai Pu Lunbo Li Guo Cao | 2020 | Digital Communications and Networks2020，6，1： | 2 |
| 5 | Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization显示文摘Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell viability.Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical practice.Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia.In this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics technology.The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the exosomes.In addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1αpathway.In brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization. | Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen | 2022 | Bioactive Materials2022，7，8： | 2 |
| 6 | Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease(Tg2576)显示文摘Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hippocampus.The aim of this study was to investigate Cajal-Retzius cells in Alzheimer's disease pathology.Results revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695(transgenic(Tg) 2576 mice).Numerous reelin-positive neurons were positive for activated caspase 3 in Tg2576 mice,suggesting that Cajal-Retzius neuronal loss occurred via apoptosis in this Alzheimer's disease model.Compared with wild type,the number of Cajal-Retzius cells was significantly lower in Tg2576 mice.Western blot analysis confirmed that reelin levels were markedly lower in Tg2576 mice than in wild-type mice.The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral deficits.Overall,these data indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease. | Dongming Yu Wenjuan Fan Ping Wu Jiexin Deng Jing Liu Yanli Niu Mingshan Li Jinbo Deng | 2014 | Neural Regeneration Research2014，9，4： | 1 |
| 7 | pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery显示文摘 | LI Yunxia DU Wenjuan FU Zhiguang WANG Huanhuan WANG Jiexin LE Yuan ZHANG Jianjun WEN Ning | 2018 | Chemical Research in Chinese Universities2018，34，6： | 0 |
| 8 | Effect of microwave-assisted acidification on the microstructure of coal:XRD,^(1)H-NMR, and SEM studies显示文摘Microwave heating contributes to coal fracturing and gas desorption. However, problems of low penetration depth, local overheating and fracture closure exist. Coal demineralisation by acids has advantages in coal unblocking and permeability improvement, while it is difficult for acid to enter microcracks.Microwave-asisted acidification may offer an alternative. In this work, XRD,^(1)H-NMR, and SEM were used to evaluate the effect of microwave-assisted acidification on the microstructure of coal. Results show that kaolinite, calcite, and dolomite can be dissolved by acid. After microwave irradiation, the graphitization of microcrystalline structure of carbon improves. Microwave-assisted acidification erodes minerals in coal and enhances the graphitization degree of microcrystalline structure. Compared to individual microwave irradiation or acidification, the pore volume and pore connectivity can be greatly enhanced by microwave-assisted acidification. The NMR permeability of coal increased by 28.05%. This study demonstrates the potential of microwave-assisted acidification for coalbed methane recovery. | He Li Wuche Liu Jiexin Lu Yi Lu Shiliang Shi Zheng Wang Qing Ye Zhenzhen Jia | 2023 | International Journal of Mining Science and Technology2023，33，7： | 0 |
| 9 | N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA显示文摘Mitochondria undergo fission and fusion that are critical for cell survival and cancer development,while the regulatory factors for mitochondrial dynamics remain elusive.Herein we found that RNA m^(6)A accelerated mitochondria fusion of colorectal cancer(CRC)cells.Metabolomics analysis and function studies indicated that m^(6)A triggered the generation of glutathione(GSH)via the upregulation of RRM2B-a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential.This in turn resulted in the mitochondria fusion of CRC cells.Mechanistically,m^(6)A methylation of A1240 at 3'UTR of RRM2B increased its mRNA stability via binding with IGF2BP2.Similarly,m^(6)A methylation of A2212 at the coding sequence(CDS)of OPA1-an essential GTPase protein for mitochondrial inner membrane fusion-also increased mRNA stability and triggered mitochondria fusion.Targeting m^(6)A through the methyltransferase inhibitor STM2457 or the dm^(6)ACRISPR system significantly suppressed mitochondria fusion.In vivo and clinical data confirmed the positive roles of the m^(6)A/mitochondrial dynamics in tumor growth and CRC progression.Collectively,m^(6)A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression,which facilitated cancer cell growth and CRC development. | Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng Qin Peng Zigang Li Hongsheng Wang | 2024 | National Science Review2024，11，3： | 0 |
| 10 | Interface-induced polymerization strategy for constructing titanium dioxide embedded carbon porous framework with enhanced chemical immobilization towards lithium polysulfides显示文摘The shuttle effect induced by soluble lithium polysulfides(LiPSs)is known as one of the crucial issues that limit the practical applications of lithium-sulfur(Li-S)batteries.Herein,a titanium dioxide nanoparticle embedded in nitrogen-doped porous carbon nanofiber(TiO_(2)@NCNF)composite is constructed via an interface-induced polymerization strategy to serve as an ideal sulfur host.Under the protection of the nanofiber walls,the uniformly dispersed TiO_(2) nanocrystalline can act as capturing centers to constantly immobilize LiPSs towards durable sulfur chemistry.Besides,the mesoporous microstructure in the fibrous framework endows the TiO_(2)@NCNF host with strong physical reservation for sulfur and LiPSs,sufficient pathways for electron/ion transfer,and excellent endurance for volume change.As expected,the sulfur-loaded TiO_(2)@NCNF composite electrode presents a fabulous rate performance and long cycle lifespan(capacity fading rate of 0.062%per cycle over 500 cycles)at 2.0 C.Furthermore,the assembled Li-S batteries harvest superb areal capacity and cycling stability even under high sulfur loading and lean electrolyte conditions. | Yue Ouyang Xiaoxiao Li Jiexin Zhu Wei Zong Yuhang Dai Xuan Gao Wei Zhang Shengyuan Yang Roohollah Bagherzadeh Feili Lai Yue-E Miao Tianxi Liu | 2024 | Nano Research2024，17，3： | 0 |
| 11 | Ultrathin Metal Silicate Hydroxide Nanosheets with Moderate Metal-Oxygen Covalency Enables Efficient Oxygen Evolution显示文摘Exploring efficient,cost-effective,and durable electrocatalysts for electrochemical oxygen evolution reaction(OER)is pivotal for the large-scale application of water electrolysis.Recent advance has demonstrated that the activity of electrocatalysts exhibits a strong dependence on the surface electronic structure.Herein,a series of ultrathin metal silicate hydroxide nanosheets(UMSHNs)M_(3)Si_(2)O_(5)(OH)_(4)(M=Fe,Co,and Ni)synthesized without surfactant are introduced as highly active OER electrocatalysts.Cobalt silicate hydroxide nanosheets show an optimal OER activity with overpotentials of 287 and 358 m V at 1 and 10 m A cm^(-2),respectively.Combining experimental and theoretical studies,it is found that the OER activity of UMSHNs is dominated by the metal-oxygen covalency(MOC).High OER activity can be achieved by having a moderate MOC as reflected by aσ^(*)-orbital(e_(g))filling near unity and moderate[3d]/[2p]ratio.Moreover,the UMSHNs exhibit favorable chemical stability under oxidation potential.This contribution provides a scientific guidance for further development of active metal silicate hydroxide catalysts. | Jiexin Zhu Shikun Li Zechao Zhuang Shan Gao Xufeng Hong Xuelei Pan Ruohan Yu Liang Zhou Lyudmila V.Moskaleva Liqiang Mai | 2022 | Energy & Environmental Materials2022，5，1： | 0 |
| 12 | Boosting rate and cycling performance of K-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) cathode for high-energy-density sodium-ion batteries显示文摘As a promising cathode material,Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF)has attracted wide attention for sodium-ion batteries(SIBs)because of its high operating voltage and high structural stability.However,the low intrinsic electronic conductivity and insufficient Na ion mobility of NVPF limit its development.Herein,K-doping NVPF is prepared through a facile ball-milling combined calcination method.The effects of K-doping on the crystal structure,kinetic properties and electrochemical performance are investigated.The results demonstrate that the Na_(2.90)K_(0.10)V_(2)(PO_(4))_(3)F_(3)(K0.10-NVPF)exhibits a high capacity(120.8 mAh g^(-1) at 0.1 C),high rate capability(66 mAh g^(-1) at 30 C)and excellent cycling performance(a capacity retention of 97.5%at 1 C over 500 cycles).Also,the occupation site of K ions in the lattice,electronic band structure and Na-ion transport kinetic property in K-doped NVPF are investigated by density functional theory(DFT)calculations,which reveals that the K-doped NVPF exhibits improved electronic and ionic conductivities,and located K^(+) ions in the lattice to contribute to high reversible capacity,rate capability and cycling stability.Therefore,the K-doped NVPF serves as a promising cathode material for high-energy and high-power SIBs. | Jiexin Zhang YangYang Lai Peng Li Yanxia Wang Faping Zhong Xiangming Feng Weihua Chen Jianjun Liu Xinping Ai Hanxi Yang Yuliang Cao | 2022 | Green Energy & Environment2022，7，6： | 0 |
| 13 | Expansion and adaptive evolution of the WRKY transcription factor family in Avicennia mangrove trees显示文摘Mangroves are adapted to intertidal zones,which present extreme environmental conditions.WRKYs are among the most prominent transcription factors(TFs)in higher plants and act through various interconnected networks to regulate responses to multiple abiotic stressors.Here,based on omic data,we investigated the landscape and evolutionary patterns of WRKYs in the main mangrove genus Avicennia.We found that both the number and the proportion of TFs and WRKYs in Avicennia species exceeded their inland relatives,indicating a signifcant expansion of WRKYs in Avicennia.We identifed 109 WRKY genes in the representative species Avicennia marina.Comparative genomic analysis showed that two recent wholegenome duplication(WGD)events played a critical role in the expansion of WRKYs,and 88%of Avicennia marina WRKYs(AmWRKYs)have been retained following these WGDs.Applying comparative transcriptomics on roots under experimental salt gradients,we inferred that there is high divergence in the expression of WGD-retained AmWRKYs.Moreover,we found that the expression of 16 AmWRKYs was stable between freshwater and moderately saline water but increased when the trees were exposed to high salinity.In particular,14 duplicates were retained following the two recent WGD events,indicating potential neo-and sub-functionalization.We also found that WRKYs could interact with other upregulated genes involved in signalling pathways and natural antioxidant biosynthesis to enhance salt tolerance,contributing to the adaptation to intertidal zones.Our omic data of the WRKY family in A.marina broadens the understanding of how a TF family relates to the adaptive evolution of mangroves. | Xiao Feng Guohong Li Weihong Wu Haomin Lyu Jiexin Wang Cong Liu Cairong Zhong Suhua Shi Ziwen He | 2023 | Marine Life Science & Technology2023，5，2： | 0 |
| 14 | STUDY ON THE ON-LINE OPTIMAL CONTROL OF PARAMETERS OF THREE-CONE BLAST HOLE DRILLS显示文摘STUDYONTHEON-LINEOPTIMALCONTROLOFPARAMETERSOFTHREE-CONEBLASTHOLEDRILLSSTUDYONTHEON-LINEOPTIMALCONTROLOFPARAMETERSOFTHREE-CONE... | Zhang Hui Li Kuixian Tong Jiexin Wen Bangchun(Northeastern University) | 1995 | Chinese Journal of Mechanical Engineering1995，8，1： | 0 |
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