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| 1 | Late Quaternary glacial cycle and precessional period of clay mineral assemblages in the Western Pacific Warm Pool显示文摘Variability of clay mineral assemblages in the Western Pacific Warm Pool(WPWP) over the past 370 ka shows the prominent glacial-interglacial cyclicity.Smectite(62%-91%) is the dominant clay mineral,with decreased contents during interglacials while increased in glacials.In contrast,variations in chlorite(4%-21%),illite(4%-12%),and kaolinite(2%-10%) share a similar pattern with higher contents during interglacials than glacials,mirroring to that of smectite.The results indicate that the smectite-dominated clay minerals derive mainly from the river detrital inputs of New Guinea.The glacial-interglacial cycle of clay mineral assemblages well correspond to the fluctuation of sea level.When the sea level was low,the river materials can travel more easily across the narrow shelf off the island of New Guinea,inject directly into the subsurface currents flowing westwards,then merge into the Equatorial Undercurrent(EUC),and eventually deposit on the central part of WPWP.Precessional periods of the smectite content indicate the intensity of mechanical erosion in its provenance of New Guinea,responding to the river runoff and precipitation,and this could also be linked to the meridional migration of the Intertropical Convergence Zone(ITCZ). | WU JiaWang LIU ZhiFei ZHOU Chao | 2012 | Chinese Science Bulletin2012，57，28： | 11 |
| 2 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 3 | Enhanced piezo-response in copper halide perovskites based PVDF composite films显示文摘In-situ fabricated perovskite nanocrystals in polymeric matrix provide new generation composite materials for plenty of cutting edge technology. In this work, we report the in-situ fabrication of copper halide perovskite(MA_2CuCl_4, MA:CH_3NH_3^+) embedded poly(vinylidene fluoride)(PVDF) composite films. The optimized MA_2CuCl_4/PVDF composite films exhibit greatly enhanced piezo-response in comparasion with pure PVDF films. The enhancements were invesitgated and explained by applying piezo-response force microscopy(PFM) measurements and density functional theory(DFT) caculations. We proposed that the high piezoelectric properties of MA_2CuCl_4/PVDF composite films could be related to the large Cu off-centering displacement, the strong interactions between MA_2CuCl_4 and PVDF as well as large stress concentration around the MA_2CuCl_4 particles in the films. These piezoelectric composite films are expected to be suitable functional materials for flexible and/or wearable piezoelectrics. | Sheng Huang Gang Tang Hailong Huang Xian-gang Wu Puming Zhou Lin Zou Lei Xie Jianming Deng Xueyun Wang Haizheng Zhong Jiawang Hong | 2018 | Science Bulletin2018，63，19： | 4 |
| 4 | Deformation Analysis and Fixture Design of Thin-walled Cylinder in Drilling Process Based on TRIZ Theory显示文摘Thin-walled cylindrical workpiece is easy to deform during machining and clamping processes due to the insufficient rigidi.Moreover,it’s also difficult to ensure the perpendicularity of flange holes during drilling process.In this paper,the element birth and death technique is used to obtain the axial deformation of the hole through finite element simulation.The measured value of the perpendicularity of the hole was compared with the simulated value to verify then the rationality of the simulation model.To reduce the perpendicularity error of the hole in the drilling process,the theory of inventive principle solution(TRIZ)was used to analyze the drilling process of thin-walled cylinder,and the corresponding fixture was developed to adjust the supporting surface height adaptively.Three different fixture supporting layout schemes were used for numerical simulation of drilling process,and the maximum,average and standard deviation of the axial deformation of the flange holes and their maximum hole perpendicularity errors were comparatively analyzed,and the optimal arrangement was optimized.The results show that the proposed deformation control strategy can effectively improve the drilling deformation of thin-walled cylindrical workpiece,thereby significantly improving the machining quality of the parts. | Fulin WANG Bo SHENG Yongwen WU Jiawang LI Zhou XU Zhaoxia ZHU | 2021 | Mechanical Engineering Science2021，3，1： | 1 |
| 5 | Flexo- electricity induced increase of critical thickness in epitaxial fer- roelectric thin films显示文摘 | ZHOU Hao HONG Jiawang ZHANG Yihui | 2012 | Physica B: Condensed Matter2012，407，： | 1 |
| 6 | Impeded degradation of perovskite solar cells via the dual interfacial modification of siloxane显示文摘It is challenging to improve the long-term stability of perovskite solar cells(PSCs) without sacrificing efficiency. The perovskite absorbers degrade from the film surface/interfaces, which follows entangled mechanisms that have not been fully revealed yet.Herein, we decouple and elaborate two distinctive pathways regarding film degradation based on FACsPbI3perovskites.Moreover, a dual interfacial modification strategy has been developed for improving the material’s intrinsic stability, thus leading to the film degrading in a more retardant pathway. The corresponding PSCs achieve a stable power output efficiency of 23.75%.More importantly, the unencapsulated PSCs devices retain over 93% of their initial PCE after the maximum power point(MPP)tracking under the continuous 1-sun illumination and show significantly improved stability after aged under the thermal treatment or stored in ambient atmosphere for over 1500 hours without obvious PCE decay. This work shows the importance of modulating the degradation pathway on stability improvement, and at the same time, proposes a strategy for designing perovskite-based optoelectronics with excellent performance and stability. | Xiao Zhang Changsu Cao Yang Bai Cheng Zhu Huachao Zai Sai Ma Yihua Chen Zhenhua Cui Congbo Shi Chenyue Wang Chenxiao Zhou Guizhou Yuan Ziyan Gao Jiawang Hong Jie Dou Hao Wang Huanping Zhou Hai Xiao Jun Li Qi Chen | 2022 | Science China Chemistry2022，65，11： | 0 |
| 7 | Effect of sand-fixing vegetation on the hydrological regulation function of sand dunes and its practical significance显示文摘Soil water content is a key controlling factor for vegetation restoration in sand dunes.The deep seepage and lateral migration of water in dunes affect the recharge process of deep soil water and groundwater in sand dune ecosystems.To determine the influence of vegetation on the hydrological regulation function of sand dunes,we examined the deep seepage and lateral migration of dune water with different vegetation coverages during the growing season in the Horqin Sandy Land,China.The results showed that the deep seepage and lateral migration of water decreased with the increase in vegetation coverage on the dunes.The accumulated deep seepage water of mobile dunes(vegetation coverage<5%)and dunes with vegetation coverage of 18.03%,27.12%,and 50.65%accounted for 56.53%,51.82%,18.98%,and 0.26%,respectively,of the rainfall in the same period.The accumulated lateral migration of water in these dunes accounted for 12.39%,6.33%,2.23%,and 7.61%of the rainfall in the same period.The direction and position of the dune slope affected the soil water deep seepage and lateral migration process.The amounts of deep seepage and lateral migration of water on the windward slope were lower than those on the leeward slope.The amounts of deep seepage and lateral migration of water showed a decreasing trend from the bottom to the middle and to the top of the dune slope.According to the above results,during the construction of sand-control projects in sandy regions,we suggest that a certain area of mobile dunes(>13.75%)should be retained as a water resource reservoir to maintain the water balance of artificial fixed dune ecosystems.These findings provide reliable evidence for the accurate assessment of water resources within the sand dune ecosystem and guide the construction of desertification control projects. | Alamusa SU Yuhang YIN Jiawang ZHOU Quanlai WANG Yongcui | 2023 | Journal of Arid Land2023，15，1： | 0 |
| 8 | Highly Prevalent SARS-CoV-2 Antigenemia in COVID-19 Patients显示文摘Background:Many issues,such as severity assessment and antibody responses,remain to be answered eagerly for evaluation and understanding of COVID-19.Immune lesion is one of key pathogenesis of the disease.It would be helpful to understand the disease if an investigation on antigenemia and association was conducted in the patients with SARS-CoV-2 infection.Methods:A total of 156 patients admitted to the First People’s Hospital of Hefei or Anhui Provincial Hospital on January to February 2020 were involved in this study.SARS-CoV-2 nucleocapsid(NP)antigen,specific IgM/IgG antibodies,and RNA were detected in sequential sera from three COVID-19 patients,and additional 153 COVID-19 patients by means of NP-antigen capture enzyme-linked immunosorbent assay,colloidal gold quick diagnosis,and real-time RT-PCR,respectively.The clinical types of COVID-19 patients were classified into asymptomatic,mild,moderate,severe,and critical,following on the Chinese guideline of COVID-19 diagnosis and treatment.The demographic and clinical data of patients were obtained for comparable analysis.Results:NP antigen was detected in 5 of 20 sequential sera collected from three COVID-19 patients with typically clinical symptoms,and 60.13%(92/153)expanded samples collected within 17days after illness onset.No SARS-CoV-2 RNA segment was detected in these sera.The NP positive proportion reached a peak(84.85%,28/33)on 6 to 8days after illness onset.Both NP concentration and positive proportion were increased with the increase of clinical severity of COVID-19.Compared to NP negativepatients,NP positive patients had older age[years,medians(interquartileranges(IQR)),49(6)vs.31(11)],lowerpositive proportion of NP specific IgM[27.17%(25/92)vs.59.02%(36/61)],and IgG[21.74%(20/92)vs.59.02%(36/61)]antibodies,and longer duration[days,medians(IQR),24(10)vs.21(13)]from illness to recovery.Conclusions:SARS-CoV-2 NP antigenemia occurred in COVID-19,and presented highly prevalent at early stage of the disease.The antigenemia was related to clinical severity of the disease,and may beresponsible for the delay of detectable SARS-Cov-2IgM. | Wenyan Zhang Wei Liu Jiawang Lin Jing Jin Kefu Zhao Liwei Zhu Xiuzhen Wang Lijie Wang Renshu Tang Yindi Zhu Wei Zhou Enqing You Lei Zhang Xuxiang Liu Jinju Wu Lili Chen Wenjing Wang Qiang Zhang Rongbao Gao | 2022 | Infectious Diseases & Immunity2022，2，3： | 0 |
| 9 | Stress compensation based on interfacial nanostructures for stable perovskite solar cells显示文摘The long-term stability issue of halide perovskite solar cells hinders their commercialization.The residual stress-strain affects device stability,which is derived from the mismatched thermophysical and mechanical properties between adjacent layers.In this work,we introduced the Rb_(2)CO_(3)layer at the interface of SnO_(2)/perovskite with the hierarchy morphology of snowflake-like microislands and dendritic nanostructures.With a suitable thermal expansion coefficient,the Rb_(2)CO_(3)layer benefits the interfacial stress relaxation and results in a compressive stress-strain in the perovskite layer.Moreover,reduced nonradiative recombination losses and optimized band alignment were achieved.An enhancement of open-circuit voltage from 1.087 to 1.153 V in the resultant device was witnessed,which led to power conversion efficiency(PCE)of 22.7%(active area of 0.08313 cm^(2))and 20.6%(1 cm2).Moreover,these devices retained 95%of its initial PCE under the maximum power point tracking(MPPT)after 2700 h.It suggests inorganic materials with high thermal expansion coefficients and specific nanostructures are promising candidates to optimize interfacial mechanics,which improves the operational stability of perovskite cells. | Cheng Zhu Xi Wang Hangxuan Li Chenyue Wang Ziyan Gao Pengxiang Zhang Xiuxiu Niu Nengxu Li Zipeng Xu Zhenhuang Su Yihua Chen Huachao Zai Haipeng Xie Yizhou Zhao Ning Yang Guilin Liu Xueyun Wang Huanping Zhou Jiawang Hong Xingyu Gao Yang Bai Qi Chen | 2023 | Interdisciplinary Materials2023，2，2： | 0 |
| 10 | N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA显示文摘Mitochondria undergo fission and fusion that are critical for cell survival and cancer development,while the regulatory factors for mitochondrial dynamics remain elusive.Herein we found that RNA m^(6)A accelerated mitochondria fusion of colorectal cancer(CRC)cells.Metabolomics analysis and function studies indicated that m^(6)A triggered the generation of glutathione(GSH)via the upregulation of RRM2B-a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential.This in turn resulted in the mitochondria fusion of CRC cells.Mechanistically,m^(6)A methylation of A1240 at 3'UTR of RRM2B increased its mRNA stability via binding with IGF2BP2.Similarly,m^(6)A methylation of A2212 at the coding sequence(CDS)of OPA1-an essential GTPase protein for mitochondrial inner membrane fusion-also increased mRNA stability and triggered mitochondria fusion.Targeting m^(6)A through the methyltransferase inhibitor STM2457 or the dm^(6)ACRISPR system significantly suppressed mitochondria fusion.In vivo and clinical data confirmed the positive roles of the m^(6)A/mitochondrial dynamics in tumor growth and CRC progression.Collectively,m^(6)A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression,which facilitated cancer cell growth and CRC development. | Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng Qin Peng Zigang Li Hongsheng Wang | 2024 | National Science Review2024，11，3： | 0 |
| 11 | Design and comparative analysis of self-propelling drill bit applied to deep-sea stratum drilling robot显示文摘Robotic subsea stratum drilling robot is a method for new subsea stratigraphic geological investigation and resource exploration.Resistance at the front end is the main source of resistance to the robot’s motion in the strata.Since there is no continuous and strong downward drilling force as in conventional drilling rigs,robot movement relies heavily on the drill bit to reduce the drilling resistance.In this study we propose a self-propelling drill bit that can discharge soil debris to provide propulsive force and reduce the resistance.The key parameter of the drill bit design,the spiral blade lead angle,was determined by theoretical analysis of the drill bit’s soil discharging effect.To verify the structural advantages of the self-propelling drill bit in reducing resistance,a comparative analysis with a conventional conical drill bit was conducted.The drilling process of both bits was simulated using finite element simulation at various rotation speeds,the penetration force and torque data of both drill bits were obtained,and tests prepared accordingly in subsea soil were conducted.The simulations and tests verified that the penetration force of the self-propelling drill bit was lower than that of the conventional conical drill bit.The self-propelling drill bit can reduce the resistance effectively,and may play an important role in the stratum movement of drilling robots. | Peihao ZHANG Xingshuang LIN Hao WANG Jiawang CHEN Zhenwei TIAN Zixin WENG Ziqiang REN Peng ZHOU | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，10： | 0 |
| 12 | Preparation of Spherical Tungsten Particles Assisted by Hydrothermal Method显示文摘We presented a strategy to prepare spherical tungsten powder by the combination of hydrothermal method and H2reduction process.In hydrothermal process,the micelle of tetraethylammonium bromide(TEAB)act as spherical templates for the deposition of tungsten oxide,whereas the excessive TEAB inhibit the formation of spherical tungsten oxide due to the dense molecular layer of TEAB on the tungsten oxide particles.Citric acid(CA)can control the formation rate and structure of the tungsten oxide when its concentration is more than 0.2 mol/L,because of its ability to coordinate with tungsten atoms.The synergistic effect of TEAB and CA facilitates the formation of spherical tungsten oxide with nanorod crown.After being treated by H_(2)at 600 and 650℃,the tungsten oxide particles are reduced to tungsten particles,which maintain the spherical structure of tungsten oxide and have porous structure. | GUO Jiawang WEN Xiaoqiang WU Ying XU Jianbing ZHOU Jieying | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，6： | 0 |
| 13 | Development of underwater electric manipulator based on interventional autonomous underwater vehicle (AUV)显示文摘In applications such as marine rescue,marine science,archaeology,and offshore industries,autonomous underwater vehicles(AUVs)are frequently used for survey missions and monitoring tasks,with most operations being performed by manned submersibles or remotely operated vehicles(ROVs)equipped with robotic arms,as they can be operated remotely for days without problems.However,they require expensive marine vessels and specialist pilots to operate them.Scientists exploring oceans are no longer satisfied with the use of manned submersibles and ROVs.There is a growing desire for seabed exploration to be performed using smarter,more flexible,and automated equipment.By improving the field operation and intervention capability of AUVs,large-scale and long-range seafloor exploration and sampling can be performed without the support of a mother ship,making it a more effective,economical,convenient,and rapid means of seafloor exploration and sampling operations,and playing a critical role in marine resource exploration.In this study,we explored the integration technology of underwater electric robotic arms and AUVs and designed a new set of electric manipulators suitable for water depths greater than 500 m.The reliability of the key components was analyzed by finite element analysis and,based on the theory of robot kinematics and dynamics,simulations were performed to verify the reliability of the key components.Experiments were conducted on land and underwater,trajectory tracking experiments were completed,and the experimental data in air and water were compared and analyzed.Finally,the objectives for further research on the autonomous control of the manipulator underwater were proposed. | Xiaohui HU Jiawang CHEN Hang ZHOU Ziqiang REN | 2024 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2024，25，3： | 0 |
| 14 | Constructing the bonding between conductive agents and active materials/binders stabilizes silicon anode in Lithium-ion batteries显示文摘Silicon(Si)anode has been considered a promising candidate due to its remarkable theoretical capacity but it was plagued by severe pulverization because of the inherent huge volume variation.Enhancing electrode stability is an effective approach to improve electrochemical performance.Herein,a stable Si anode was established by an innovative construction of the bonding between conductive agents and active materials/binders.As a result,the strong interaction of electrode components not only effectively alleviates the volume expansion of Si but also achieves a stable interface by generating the beneficial solid electrolyte interphase(SEI)composition.Attributed to the deliberate scheme of the electrode,the Si anode exhibits sterling electrochemical performance.Besides,the device of the electrode is not only effective for other binders but also for other anode materials with high volume variation,thus shedding light on the rational design of electrodes for high-energy-density lithium-ion batteries. | Jie Tang Jiawang Zhou Xingyu Duan Yujie Yang Xinyi Dai Fuzhong Wu | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
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