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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Power Grid Islands Service Restoration Based on Cloud Computing显示文摘提出了一种基于云计算思想的电网恢复重构方法,利用网络中大量的分布式计算资源加速求取孤岛间网络恢复重构的最优解。利用电力系统分层分布式体系结构将含有多个微网的复杂配电网络视为不同的子云计算区,每个子云计算区根据自身情况将重构的服务请求分解为多个可独立处理的计算块并提交分布的计算节点进行并行处理和结果取优。相关联子云计算区之间可通信以协调不同区域间的负荷转供,最终实现故障恢复重构的目标。算例分析结果验证了该方法的有效性。 | ZHANG Hao HE Jinghan YIN Hang BO Zhiqian B Kirby | 2011 | 中国电机工程学报2011，31，34： | 14 |
| 3 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 4 | Groundwater contributions in water-salt balances of the lakes in the Badain Jaran Desert,China显示文摘Groundwater-fed lakes are essential for the ecology in arid and semiarid regions.As a typical arid region,the Badain Jaran Desert (BJD) is famous in the world for the presence of a large number of groundwater-fed saline lakes among the mega dunes.Based on the up to date geological surveys and observations,this study analyzed the groundwater contributions in water-salt balances of the lakes in the desert.We found different types of springs,including the sublacustrine springs that indicate an upward flow of groundwater under the lakebed.A simplified water balance model was developed to analyze the seasonal variations of water level in the Sumu Barun Jaran Lake,which revealed an approximately steady groundwater discharge in the lake and explained why the amplitude of seasonal changes in lake level is less than 0.5 m.In addition,a salt balance model was developed to evaluate the salt accumulations in the groundwater-fed lakes.The relative salt accumulation time is 800–7,000 years in typical saline lakes,which were estimated from the concentration of Cl-,indicating a long history evolution for the lakes in the BJD.Further researches are recommended to provide comprehensive investigations on the interactions between the lakes and groundwater in the BJD. | GONG Yanping WANG Xusheng HU B Xiao ZHOU Yangxiao HAO Chunbo WAN Li | 2016 | Journal of Arid Land2016，8，5： | 7 |
| 5 | Rice monitoring and production estimation using multitemporal RADARSAT显示文摘 | Yun Shao Xiangtao Fan Hao Liu Jianhua Xiao S Ross B Brisco R Brown G Staples | 2001 | Remote Sensing of Environment2001，，3： | 3 |
| 6 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 7 | A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer显示文摘 | Hao B Miao X Li Y | 2006 | Oncogene2006，25，25： | 1 |
| 8 | High-thermoelectric pergormance of nanostructured bismuth antimony telluride bulk alloys显示文摘 | POUDEL B HAO QING MA YI | 2008 | Science2008，320，5812： | 1 |
| 9 | Symbolic dynamics and characterization of complexity显示文摘 | HAO B L | 1991 | Physica D1991，51，： | 1 |
| 10 | A Hybrid GA/SVM Approach for Gene Selection and Classification of Microarray Data显示文摘 | Huerta E B Duval B Hao J K | 2006 | Lecture Notes in Computer Science2006，3907，： | 1 |
| 11 | Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis显示文摘 | Hao X Sun B Hu L | 2004 | Cancer2004，100，6： | 1 |
| 12 | Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus显示文摘 | Hao DC Sun J Furnes B Schlenk D Hou ZF Zhang YP | 2006 | Biochem Genet2006，44，78： | 1 |
| 13 | Ozone air quality during the 2008 Beijing Olympics: effectiveness of emission restrictions显示文摘 | Wang Y X Hao J M McElroy M B | 2009 | Atmospheric Chemistry and Physics2009，9，14： | 1 |
| 14 | Heterotrophic nitrifica- tion and aerobic devitrification by the bacterium Pseud- omonas stutzeri YZN-O01 显示文摘 | Zhang J Wu P Hao B | 2011 | Bioresour Technol2011，102，21： | 1 |
| 15 | Laticifer differentiation in Hevea brasilienais: induction by exogenous jasmonic acid and linolenic acid显示文摘 | Hao B Z Wu J L | 2000 | Ann Bot2000，85，： | 1 |
| 16 | Ductile titanium alloy with low poission's ratio显示文摘 | HAO Y L LI S J SUN B B SUI M L YANG R | 2007 | Phys Rev Lctt2007，98，21： | 1 |
| 17 | A comprehensive analytical on-current model for polycrystalline silicon thin film transistors based on effective channel mobility 显示文摘 | Hao H Wang M Zhang B | 2008 | J Appl Phys2008，103，09： | 1 |
| 18 | The second total synthesis of diazonamide A显示文摘 | Nicolaou K C Rao P B Hao J | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 19 | Plotting of acid rain and sulfur dioxide pollution control zones and integrated control planning in China显示文摘 | Hao J M Wang S X Liu B J | 2001 | Water Air and Soil Pollution2001，130，14： | 1 |
| 20 | Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations显示文摘 | Hao D Sun J Furnes B Schlenk D Li M Yang S | 2007 | Cell Biochem Funct2007，25，4： | 1 |
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