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| 1 | Principles and technology for stepwise utilization of resources for mitigating deep mine heat hazards显示文摘As is well known, deep mines are hot. As mining depth increases, the temperature of the surrounding rock also increases. This seriously affects mine safety and production and has restricted the exploitation of deep coal resources. Therefore, reducing the working face temperature to improve working conditions by controlling these heat hazards is an urgent problem. Considering problems in cooling deep mines both domestically and abroad along with the actual conditions of the Zhangshuanglou coal mine, we propose a HEMS technology that uses heat resources from deep mines in a stepwise manner. HEMS means a high temperature ex-change machinery system. Mine inrush-water is used as a source of cooling. Twice the energy is extracted from the mine inrush water. Heat is used for building heating in the winter and cold water is used for cooling buildings in the summer. This opens a new technology for stepwise utilization of heat energy in deep mines. Energy conservation and reduced pollution, an improved environment and sustainable economic development are realized by this technique. The economic and social effects are obvious and illustrate a good prospect for the application and extension of the method. | HE Manchao CAO Xiuling XIE Qiao YANG Jiahua QI Ping YANG Qing CHEN Xueqian | 2010 | Mining Science and Technology2010，20，1： | 15 |
| 2 | Distribution of isotopes and chemicals in precipitation in Shule River Basin,northwestern China:an implication for water cycle and groundwater recharge显示文摘The distribution of stable isotopes and ions in precipitation in the Shule River Basin,northwestern China,were investigated to understand the regional water cycle and precipitation input to groundwater recharge.The study found that the mean annual concentrations of Ca2+,Na+,SO42–,Cl–,Mg2+,NO3–,and K+ in the basin were lower than those in other arid areas of northwestern China.The average concentrations of ions in the lower reaches of the Shule River were higher than those in the upper reaches.The results showed that the main ionic concentrations decreased with the increase of precipitation amount,indicating that heavy precipitation cannot only wash crustal aerosols out of the atmosphere,but also create a dilution effect.Cl– and Na+ in precipitation had a strong and positive correlation,suggesting a common origin for the two ions.However,the excess of Na+,combined with non-marine SO42– and NO3–,indicated that some ions were contributed by terrestrial origins.In the extremely arid regions of northwestern China,the evaporation process obviously changes the original relationship between δ2H and δ18O in precipitation,and leads to dexcess values <8‰.δ18O and temperature were significantly correlated,suggested that temperature strongly affected the characteristics of isotopes in the study area.The δ18O value indicates a dominant effect of westerly air masses and southwest monsoon in warm months,and the integrated influence of westerly and Siberian-Mongolian polar air masses in cold months.The d-excess values were generally lower in warm months than those in cold months,indicating that post-condensation processes played a significant role in the water cycle.The results provide reliable precipitation input information that can be used in future groundwater recharge calculations in the study area. | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2016 | Journal of Arid Land2016，8，6： | 6 |
| 3 | Evaluation of channel-like porous-structured titanium in mechanical properties and osseointegration显示文摘The porous titanium with a channel-like pore structure fabricated by infiltration casting followed by selectively dissolving the precursor woven three dimensional(3D)structure technique was comprehensively investigated by means of mechanical tests,in vitro and in vivo evaluation.Such porous structure exhibited superiority in compressive,tensile strength and osseointegration.At 40%porosity,the average compressive and tensile strength reached about 145MPa and 85 MPa,which was superior to that of other porous titanium,e.g.,Selective Laser Melting or powder sintered ones,and was comparable to that of the human cortical bone.Without any bioactive surface treatment,this porous titanium exhibited good cell adhesion,rapid cell proliferation and excellent osseointegration.Based on the study,the 0.4mm pore size resulted in the most rapid cell proliferation and the maximal BV/TV ratio and trabecular bone number of the new bone that ingrew into the porous titanium.To balance the excellent osseointegration and adequate mechanical properties,the optimal structural parameters were 0.4mmpore size with 40%porosity.This porous titanium is very promising for orthopedic applications where compressive and tensile load-bearing is extremely important. | Dong Wang Guo He Ye Tian Ning Ren Jiahua Ni Wei Liu Xianlong Zhang | 2020 | Journal of Materials Science & Technology2020，44，9： | 2 |
| 4 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 5 | Erratum to: Distribution of isotopes and chemicals in precipitation in Shule River Basin, northwestern China: an implication for water cycle and groundwater recharge显示文摘 | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2017 | Journal of Arid Land2017，9，2： | 1 |
| 6 | Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development显示文摘The human brain undergoes rapid development during childhood,with significant improvement in a wide spectrum of cognitive and affective functions.Mapping domain-and age-specific brain activity patterns has important implications for characterizing the development of children’s cognitive and affective functions.The current mainstay of brain templates is primarily derived from structural magnetic resonance imaging(MRI),and thus is not ideal for mapping children’s cognitive and affective brain development.By integrating task-dependent functional MRI data from a large sample of 250 children(aged 7 to 12)across multiple domains and the latest easy-to-use and transparent preprocessing workflow,we here created a set of age-specific brain functional activity maps across four domains:attention,executive function,emotion,and risky decision-making.Moreover,we developed a toolbox named Developmental Brain Functional Activity maps across multiple domains that enables researchers to visualize and download domain-and age-specific brain activity maps for various needs.This toolbox and maps have been released on the Neuroimaging Informatics Tools and Resources Clearinghouse website(http://www.nitrc.org/projects/dbfa).Our study provides domain-and age-specific brain activity maps for future developmental neuroimaging studies in both healthy and clinical populations. | Lei Hao Lei Li Menglu Chen Jiahua Xu Min Jiang Yanpei Wang Linhua Jiang Xu Chen Jiang Qiu Shuping Tan Jia-Hong Gao Yong He Sha Tao Qi Dong Shaozheng Qin | 2021 | Neuroscience Bulletin2021，37，6： | 1 |
| 7 | Energy research of block walls with XKD insu-lation foam concrete显示文摘 | HE Junlin LI Jiahua | 2008 | Sichuan Building2008，28，6： | 1 |
| 8 | Dynamic spectrum access in heterogeneous unlicensed wireless networks 显示文摘 | He Jiahua Yan Zhang Kaleshi D | 2008 | International Journal of Autonomous and Adaptive Communications Systems2008，1，1： | 1 |
| 9 | An o- verview of the engineered graphene nanostructures and nanocomposites显示文摘 | Zhu Jiahua Chen Minjiao He Qingliang | 2013 | RSC Adv2013，3，22： | 1 |
| 10 | Constructing retroviral vector carrying green fluorescent protein(GFP)and investigating the expression of GFP in primary rat myoblast显示文摘Objective:To construct green fluorescent protein(GFP)retroviral vector(pLgXSN),and to investigate the expression of GFP in primary rat myoblast.Methods:GFP cDNA was subcloned into the plasmid pLgXSN,and the recombinant vector was transfected into packaging cell PT67.G418 was used to select positive colony.Myoblasts were infected by a high-titer viral supernatant.The recombinant retroviral plasmid vector was identified by restriction endonuclease analysis and DNA sequence analysis.Confocal microscopy and flow cytometry were used to detect the expression of GFP.Results:The GFP cDNA sequence was identical to that of GenBank.Recombinant retroviral plasmid vector pLgGFPSN was constructed successfully.The titer of the packaged recombinant retrovirus was 1 × 106 cfu/ml.Bright green fluorescence of the transfected cells was observed under confocal microscope 48 h after transfection.The transfection rate was 33%.The effective expression of GFP in myoblast infected by recombinant retrovirus lasted for 6 weeks.Conclusion:GFP gene could be effectively and stably expressed in myoblast,which suggests that GFP could act as a marker for studies on myoblast. | Shuling Rong Yongxin Lu Yuhua Liao Xiaolin Wang Xiaoqing Li Jiahua Zhang Yanli He | 2006 | Journal of Nanjing Medical University2006，20，4： | 1 |
| 11 | Additive Manufacturing of Hydroxyapatite Bioceramic Scaffolds with Projection Based 3D Printing显示文摘Hydroxyapatite(HA)bioceramics have garnered considerable attention owing to their applications in the field of bone repair and excellent biocompatibility.Compared to extrusion-based 3D printing,projection-based 3D print-ing(3DPP)can fabricate parts with complex geometry,high accuracy,and efficiency,which is very promising for bioceramic scaffolds.However,conventional 3DPP using a paste with low viscosity will cause severe shrinkage of the parts after sintering,which makes it unsuitable for bioceramic scaffolds,and a system investigation of the printing process remains insufficient.In this study,we proposed a 3DPP device suitable for bioceramic scaffolds and investigated the additive manufacturing of HA scaffolds.Ceramic paste properties and process parameters of curing,debinding,and sintering were initially examined.The mechanical properties,shrinkage,and biocompati-bility in vitro of the sintered samples were further investigated.The obtained results indicate that HA bioceramics with uniform morphology,complex structure,and high accuracy can be manufactured using the 3DPP equip-ment.HA scaffolds have the mechanical strength of human cancellous bone,while HA scaffolds cultured with osteoblast precursor cells possess strong biocompatibility and can promote osteoblast adhesion,proliferation,and differentiation.These results suggest a promising application of the 3DPP technique in the preparation of bioceramic scaffolds,and the HA scaffolds fabricated using the 3DPP technique exhibit promising potential in fulfilling a constructive role in the biomedical field of human bone regeneration repair. | Huifeng Shao Zhiheng Nian Zhuoluo Jing Tao Zhang Jiahua Zhu Xiang Li Youping Gong Yong He | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，2： | 0 |
| 12 | The Method and Experiment Research on Down-stroke Abrasive Belt Grinding under Micro Feeding for Noise Reduction Surface显示文摘This paper proposes a down-stroke abrasive belt grinding under micro feeding for noise reduction surface.Firstly,a physical model of processing under micro feeding for noise reduction structure was established.Based on the flexible contact characteristics of abrasive belt grinding and Hertz contact theory,a mathematical model suitable for this method was established,considering vibration and abrasive belt wear.Secondly,a simulation analysis was carried out.Then,an experimental platform was built to analyze the influence of process parameters on surface roughness and surface microstructure,with the model verified.Finally,the propeller with pit structure was simulated,and the noise reduction performance of the propeller under this method and general abrasive belt grinding was compared and analyzed.The results show that the maximum error of the model based on proposed method does not exceed 10%,and the coincidence degree of the minimum error point can reach 90%at lower feed speed and higher linear velocity of the abrasive belt.The noise reduction effect of the propeller with pit-shaped surfaces can reach 35%.Through the above analysis,the proposed method can be used for the processing of noise reduction surfaces. | Ying Liu Shayu Song Guijian Xiao Yi He Yun Huang Shuai Liu Suolang Jiahua | 2021 | Journal of Bionic Engineering2021，18，4： | 0 |
| 13 | Determination of telomerase activity in stem cells and non-stem cells of breast cancer显示文摘Although all normal tissue cells,including stem cells,are genetically homologous,variation in gene expression patterns has already determined the distinct roles for individual cells in the physiological process due to the occurrence of epigenetic modification.This is of special importance for the existence of tissue stem cells because they are exclusively immortal within the body,capable of selfreplicating and differentiating by which tissues renew and repair itself and the total tissue cell population maintains a steady-state.Impairment of tissue stem cells is usually accompanied by a reduction in cell number,slows down the repair process and causes hypofunction.For instance,chemotherapy usually leads to depression of bone marrow and hair loss.Cellular aging is closely associated with the continuous erosion of the telomere while activation of telomerase repairs and maintains telomeres,thus slowing the aging process and prolonging cell life.In normal adults,telomerase activation mainly presents in tissue stem cells and progenitor cells giving them unlimited growth potential.Despite the extensive demonstration of telomerase activation in malignancy(>80%),scientists found that heterogeneity also exists among the tumor cells and only minorities of cells,designated as cancer stem cells,undergo processes analogous to the self-renewal and differentiation of normal stem cells while the rest have limited lifespans.In this study,telomerase activity was measured and compared in breast cancer stem cells and non-stem cells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells.In addition,associated with the repair of cancer tissue(or relapse)after chemotherapy,telomerase activity in stem cells was markedly increased. | LI Zhi HE Yanli ZHANG Jiahua ZHANG Jinghui HUANG Tao | 2007 | Frontiers of Medicine2007，1，3： | 0 |
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