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| 1 | Distribution of isotopes and chemicals in precipitation in Shule River Basin,northwestern China:an implication for water cycle and groundwater recharge显示文摘The distribution of stable isotopes and ions in precipitation in the Shule River Basin,northwestern China,were investigated to understand the regional water cycle and precipitation input to groundwater recharge.The study found that the mean annual concentrations of Ca2+,Na+,SO42–,Cl–,Mg2+,NO3–,and K+ in the basin were lower than those in other arid areas of northwestern China.The average concentrations of ions in the lower reaches of the Shule River were higher than those in the upper reaches.The results showed that the main ionic concentrations decreased with the increase of precipitation amount,indicating that heavy precipitation cannot only wash crustal aerosols out of the atmosphere,but also create a dilution effect.Cl– and Na+ in precipitation had a strong and positive correlation,suggesting a common origin for the two ions.However,the excess of Na+,combined with non-marine SO42– and NO3–,indicated that some ions were contributed by terrestrial origins.In the extremely arid regions of northwestern China,the evaporation process obviously changes the original relationship between δ2H and δ18O in precipitation,and leads to dexcess values <8‰.δ18O and temperature were significantly correlated,suggested that temperature strongly affected the characteristics of isotopes in the study area.The δ18O value indicates a dominant effect of westerly air masses and southwest monsoon in warm months,and the integrated influence of westerly and Siberian-Mongolian polar air masses in cold months.The d-excess values were generally lower in warm months than those in cold months,indicating that post-condensation processes played a significant role in the water cycle.The results provide reliable precipitation input information that can be used in future groundwater recharge calculations in the study area. | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2016 | Journal of Arid Land2016，8，6： | 6 |
| 2 | A case study of regional eco-hydrological characteristics in the Tao River Basin, northwestern China, based on evapotranspiration estimated by a coupled Budyko Equation-crop coefficient approach显示文摘In a case study in Tao River Basin, China, we derived a high spatial-resolution regional distribution of evapotranspiration(ET) using the single crop coefficient method and Budyko equation. We then further analyzed the spatio-temporal characteristics of this diverse eco-hydrological basin from 2001–2010. The results suggest that the single crop coefficient method based on leaf area index captures better spatial and temporal dynamics of the regional ET than did the Budyko Equation method. The rising temperature was the main reason for the increasing ET in the Tao River Basin during 2001–2010. Areas with high ET efficiency were distributed mainly in the areas where the vegetation coverage was high, and a lower runoff coefficient responded. The estimated spatial patterns of ET allowed an improved understanding of the eco-hydrological processes within the Tao River Basin and the method used might be generalized as a reference for future regional-scale eco-hydrological research. | LI ChangBin ZHANG XueLei QI JiaGuo WANG ShuaiBing YANG LinShan YANG WenJin ZHU GaoFeng HAO Qiang | 2015 | Science China Earth Sciences2015，58，11： | 5 |
| 3 | Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer显示文摘diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer.Herein,we aimed to develop a novel mesoporous polydopamine(MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging(MRI)-guided cancer chemo-photothermal therapy.Superparamagnetic iron oxide(SPIO)-loaded MPDA NPs(MPDA@SPIO)was firstly prepared,followed by modifying with a targeted molecule of sialic acid(SA)and chelating with Fe^(3+)(SA-MPDA@SPIO/Fe^(3+) NPs).After that,doxorubicin(DOX)-loaded SA-MPDA@SPIO/Fe^(3+) NPs(SA-MPDA@SPIO/DOX/Fe^(3+))was prepared for tumor theranostics.The prepared SAPEG-MPDA@SPIO/Fe^(3+) NPs were water-dispersible and biocompatible as evidenced by MTT assay.In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability,with relaxivity of being r1=4.29 mM��1s��1 and r2=105.53 mM��1s��1,respectively.SAPEG-MPDA@SPIO/Fe^(3+) NPs could effectively encapsulate the DOX,showing dual pH-and thermal-triggered drug release behavior.In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe^(3+) NPs could effectively target to the hepatic tumor tissue,which was possibly due to the specific interaction between SA and the overexpressed E-selectin.This behavior also endowed SA-MPDA@SPIO/DOX/Fe^(3+)NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification.In addition,SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs displayed a superior therapeutic effect,which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy.These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs is an effective targeted nanoplatform for tumor theranostics,having potential value in the effective treatment of hepatic cancer. | Gaofeng Shu Minjiang Chen Jingjing Song Xiaoling Xu Chenying Lu Yuyin Du Min Xu Zhongwei Zhao Minxia Zhu Kai Fan Xiaoxi Fan Shiji Fang Bufu Tang Yiyang Dai Yongzhong Du Jiansong Ji | 2021 | Bioactive Materials2021，6，5： | 4 |
| 4 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 5 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 6 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 7 | Tripod measured residual currents and sediment flux: Impacts on the silting of the deepwater navigation channel in the Changjiang Estuary 显示文摘 | Liu Gaofeng Zhu Jianrong Wang Yuanye | 2011 | Estuarine Coastal and Shelf Science2011，93，3： | 1 |
| 8 | Environmental iso-topic and hydrochemical study of groundwater in the Ejina Basin, northwest China 显示文摘 | Su Yonghong Zhu Gaofeng Feng Qi | 2009 | Environmental Geology2009，58，3： | 1 |
| 9 | Estimating actual evapotranspiration from an alpine grassland on Qinghai-Tibetan plateau using a two-source model and parameter uncertainty analysis by Bayesian approach显示文摘 | Gaofeng Zhu Yonghong Su Xin Li Kun Zhang Changbin Li | 2013 | Journal of Hydrology2013，，： | 1 |
| 10 | Erratum to: Distribution of isotopes and chemicals in precipitation in Shule River Basin, northwestern China: an implication for water cycle and groundwater recharge显示文摘 | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2017 | Journal of Arid Land2017，9，2： | 1 |
| 11 | Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells显示文摘 | Gaofeng Jiang Lei Xu Shizhen Song Changcai Zhu Qing Wu Ling Zhang Lei Wu | 2007 | Toxicology2007，，1： | 1 |
| 12 | Modelling evapo- transpiration in an alpine grassland ecosystem on Qinghai-Tibetan Plateau 显示文摘 | Zhu Gaofeng Su Yonghong Li Xin | 2014 | Hydrological Processes2014，28，3： | 1 |
| 13 | Estimating actual e- vapotranspiration from an alpine grassland on Qinghai-Tibetan Plateau using a two-source model and parameter uncertainty anal- ysis by Bayesian approach 显示文摘 | Zhu Gaofeng Su Yonghong Li Xin | 2013 | Journal of Hydrology2013，476，： | 1 |
| 14 | The hydrochemical characteristics and evolution of groundwater and surface water in the Heihe River Basin, northwest China 显示文摘 | ZHU Gaofeng SU Yonghong FENG Qi | 2008 | Hydrogeology Journal2008，16，： | 1 |
| 15 | Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics显示文摘Sweat contains a broad range of critical biomarkers including ions,small molecules,and macromolecules that may indirectly or directly reflect the health status of the human body and thereby help track disease progression.Wearable sweat biosensors enable the collection and analysis of sweat in situ,achieving real-time,continuous,and noninvasive monitoring of human biochemical parameters at the molecular level.This review summarizes the physiological/pathological information of sweat and wearable sweat biosensors.First,the production of sweat pertaining to various electrolytes,metabolites,and proteins is described.Then,the compositions of the wearable sweat biosensors are summarized,and the design of each subsystem is introduced in detail.The latest applications of wearable sweat biosensors for outdoor,hospital,and family monitoring are highlighted.Finally,the review provides a summary and an outlook on the future developments and challenges of wearable sweat biosensors with the aim of advancing the field of wearable sweat monitoring technology. | Wenhui Ji Jingyu Zhu Wanxia Wu Nanxiang Wang Jiqing Wang Jiansheng Wu Qiong Wu Xuewen Wang Changmin Yu Gaofeng Wei Lin Li Fengwei Huo | 2021 | Research2021，，1： | 1 |
| 16 | Tripod measured residual currents and sediment flux: Impacts on the silting of the Deepwater Navigation Channel in the Changjiang Estuary显示文摘 | Gaofeng Liu Jianrong Zhu Yuanye Wang Hui Wu Jiaxue Wu | 2010 | Estuarine Coastal and Shelf Science2010，，3： | 1 |
| 17 | Parameter Optimization of a Short Open Optical Path's Oxygen Concentration Detection System Based on WMS显示文摘In Wavelength modulation spectroscopy(WMS) system with a short open optical path to detect the oxygen concentration, the system parameter optimization is the preconditions for the accurate inversion of oxygen concentration. Absorption spectroscopy parameters of oxygen were obtained from the HIRTAN database, and the optimal center wavelength and its wavelength offset were confirmed. The laser's working temperature and direct current were determined according to the absorption peak position of photoelectric detection. Modulation parameters and time constant of lock-in amplifier were determined by analyzing intensity and standard deviation of the second harmonic signal. This method has been applied to detect the oxygen concentration in a glass vial, and the results indicate that the linear correlation coefficient of concentration and the second harmonic intensity is 0.9950. The resolution and stability of the detection system have been improved and it can meet the requirements of industrial field. | ZHU Gaofeng ZHU Hongqiu YANG Chunhua GUI Weihua | 2017 | Chinese Journal of Electronics2017，26，4： | 1 |
| 18 | The hydrochemical char- acteristics and evolution of groundwater and surface water in the Heihe River Basin, northwest China显示文摘 | Zhu Gaofeng Su Yonghong Feng Qi | 2008 | Hydrogeology Jour- nal2008，16，1： | 1 |
| 19 | Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics显示文摘Sweat contains a broad range of critical biomarkers including ions,small molecules,and macromolecules that may indirectly or directly reflect the health status of the human body and thereby help track disease progression.Wearable sweat biosensors enable the collection and analysis of sweat in situ,achieving real-time,continuous,and noninvasive monitoring of human biochemical parameters at the molecular level.This review summarizes the physiological/pathological information of sweat and wearable sweat biosensors.First,the production of sweat pertaining to various electrolytes,metabolites,and proteins is described.Then,the compositions of the wearable sweat biosensors are summarized,and the design of each subsystem is introduced in detail.The latest applications of wearable sweat biosensors for outdoor,hospital,and family monitoring are highlighted.Finally,the review provides a summary and an outlook on the future developments and challenges of wearable sweat biosensors with the aim of advancing the field of wearable sweat monitoring technology. | Wenhui Ji Jingyu Zhu Wanxia Wu Nanxiang Wang Jiqing Wang Jiansheng Wu Qiong Wu Xuewen Wang Changmin Yu Gaofeng Wei Lin Li Fengwei Huo | 2022 | Research2022，，1： | 1 |
| 20 | Hydrogeochemi- cal and isotope evidence of groundwater evolution and recharge in Minqin Basin, Northwest China 显示文摘 | Zhu Gaofeng Li Zizhen Su Yonghong | 2007 | Journal of Hydrology2007，333，2： | 1 |
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