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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 3 | Clinical assessment of awake endotracheal intubation using the lightwand technique alone in patients with difficult airways显示文摘在那里的背景是很少学习决定 lightwand 技术的使用是否能独自完成有效、安全、成功唤醒气管内膜的 intubation ( ETI ),因此,我们设计了未来的临床的研究系统地评估可行性,安全和功效与困难的 airways.Methods 在病人独自用 lightwand 唤醒 ETI 有困难的航线的七十个成年病人在这研究被注册。在有芬太奴和 midazolam 的需要的镇静以后,航线热门麻醉与2% lidocaine 的 9 ml 被执行,它是有序的用 lightwand 和 MADgic atomizer 的一个联合单位在 5 分钟间隔在三 aliquots 喷洒了进 supraglottic (二剂量)和喉气管的区域(一剂量)。在航线以后热门麻醉,醒着 ETI 用 Lightwand 被执行。由用视觉类似物分数(管)的病人和操作符的主观评价,和由用病人的忍耐和反应分数,咳嗽的严厉,把管子插进的条件和心血管的变量的一个独立调查者的客观评价作为 210 朵航线水花的观察 parameters.Results 被拿,(93.8%) 197 成功地在第一次尝试以后被完成。航线水花的全部的时间是(14.6 ??? 趸郥?? ? 髧鲽鳥蒚戠潩慭歲牥 ? 倨 ??????? 蚯裥芀 ? 餸?餸 吗?? | XUE Fu-shan HE Nong LIAO Xu XU Xiu-Zheng XU Ya-chao YANG Quan-yong LUO Mao-ping ZHANG Yan-ming | 2009 | Chinese Medical Journal2009，，4： | 12 |
| 4 | Gene diagnosis and targeted breeding for blast-resistant Kongyu 131without changing regional adaptability显示文摘The fungus Magnaporthe oryzae threatens the rice production of Kongyu 131 (KY131),a leading japonica variety in Northeast China.In this study,two rice lines,KP1 and KP2-Hd1,were obtained by introgressing the blast resistance genes Pi1 and Pi2 into KY131,respectively.However,both lines headed later than KY131.RICE60K SNP array analysis showed that Hd1 closely linked to Pi2 was introgressed into KP2-Hd1,and the linkage drag of Hd1 was broken by recombination.On the other hand,no known flowering genes were introgressed into KP1.Gene diagnosis by resequencing six flowering genes showed that KP1 carried functional Hd16 and Ghd8 alleles.Due to its suppression role in heading under long-day conditions,Ghd8 was chosen as the target for gene editing to disrupt its function.Four sgRNAs targeting different sites within Ghd8 were utilized to induce large-deletion mutations,which were easy to detect via agarose gel electrophoresis.All the ghd8-mutated KP1 lines were resistant to rice blast disease and headed earlier than the control KP1,even than KY131,under natural long-day conditions,which ensures its growth in Northeast China.This study confirmed that a combination of gene diagnosis and targeted gene editing is a highly efficient way to quickly eliminate undesired traits in a breeding line. | Xiangchun Zhou Gonghao Jiang Longwei Yang Lei Qiu Ping He Chunxiao Nong Yunyue Wang Yuqing He Yongzhong Xing | 2018 | Journal of Genetics and Genomics2018，45，10： | 7 |
| 5 | P120ctn overexpression enhances β-catenin-E-cadherin binding and down regulates expression of survivin and cyclin D1 in BEL-7404 hepatoma cells显示文摘AIM:To understand the role of P120ctn in E-cadherin-mediated cell-cell adhesion and signaling as well as inhepatoma cell biological function.METHODS:We stably overexpressed p120ctn isoform3A in BEL-7404 human hepatoma cells and studied theeffect of p120ctn on β-catenin and E-cadherin bindingas well as p120ctn and β-catenin subcellular localizationusing immunoprecipitation,Western blotting and confocalmicroscopy.We also investigated the inhibitory effectof p120ctn transfection on the expression of apoptoticprotein survivin survivin and cell cycle regulator cyclin D1in the cells.RERULTS:Western blotting indicated that p120ctnexpression increased after cells were transfected withp120ctn isoform 3A.The protein was located mainlyat membrane under immunofluorescent microscope.β-catenin nuclear expression was reduced afteroverexpression of p120ctn isoform 3A.The p120ctn-E-cadherin binding increased after transfection of p120ctnisoform 3A.Furthermore,overexpression of p120ctndown regulated the expression of apoptotic protein sur-vivin and cell cycle regulator cyclin D1.These effects ledto reduction of cell proliferation.CONCLUSION:Our results indicate that p120ctnplays an important role in regulating the formation ofE-cadherin and-catenin complex,cell apoptosis,cellcycle and cancer cell biological function. | Chao-Zan Nong Li-Li Pan Wei-Sheng He Xi-Liang Zha Hai-HongYe Hua-Yi Huang | 2006 | World Journal of Gastroenterology2006，12，8： | 6 |
| 6 | Online Unsupervised Learning Classification of Pedestrian and Vehicle for Video Surveillance显示文摘This paper presents an online unsupervised learning classification of pedestrians and vehicles for video surveillance. Different from traditional methods depending on offline training, our method adopts the online label strategy based on temporal and morphological features,which saves time and labor to a large extent. It extract the moving objects with their features from the original video.An online filtering procedure is adopted to label the moving objects according to certain threshold of speed and area feature. The labeled objects are sent into a SVM classifier to generate the pedestrian & vehicle classifier. Experimental results illustrate that our unsupervised learning algorithm is adapted to polymorphism of the pedestrians and diversity of the vehicles with high classification accuracy. | HE Yi SANG Nong GAO Changxin HAN Jun | 2017 | Chinese Journal of Electronics2017，26，1： | 5 |
| 7 | Germline promoter hypermethylation of tumor suppressor genes in gastric cancer显示文摘AIM: To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16INK4a in suspected cases of hereditary gastric cancer (GC). METHODS: A group of 140 Chinese GC patients in whom the primary cancer had developed before the age of 60 or who had a familial history of cancer were screened for germline hypermethylation of the MLH1, CDH1 and P16INK4a tumor suppressor genes. GenomicDNA was extracted from peripheral blood leukocytes and modified by sodium bisulfite. The treated DNA was then subjected to bisulfi te DNA sequencing for a specif ic region of the MLH1 promoter. The methylation status of CDH1 or P16INK4a was assayed using methylation-specif ic PCR. Clonal bisulf ite allelic sequencing in positive samples was performed to obtain a comprehensive analysis of the CpG island methylation status of these promoter regions. RESULTS: Methylation of the MLH1 gene promoter was detected in the peripheral blood DNA of only 1/140 (0.7%) of the GC patient group. However, this methylation pattern was mosaic rather than the allelic pattern which has previously been reported for MLH1 in hereditary non-polyposis colorectal cancer (HNPCC) patients. We found that 10% of the MLH1 alleles in the peripheral blood DNA of this patient were methylated, consistent with 20% of cells having one methylated allele. No germline promoter methylation of the CDH1 or P16INK4a genes was detected. CONCLUSION: Mosaic germline epimutation of the MLH1 gene is present in suspected hereditary GC patients in China but at a very low level. Germline epimutation of the CDH1 or P16INK4a gene is not a frequent event. | Pu-Yuan Wu Zheng Zhang Jing-Mei Wang Wen-Wen Guo Nong Xiao Qiong He Ya-Ping Wang Yi-Mei Fan | 2012 | World Journal of Gastroenterology2012，18，1： | 4 |
| 8 | STUDIES ON THE CHEMICAL CONSTITUENTS OF CLAUSENA LANSIUM(LOUR.)SKEELS Ⅲ.The structural elucidation of homo-and zeta-clausenamide(1)显示文摘The structures of two novel lactams isolated from Clausenalansium were elucidated mainly on the bases of their spectral data.They are homoclausenamide(1),a -lactam,and zetaclausenamide(4),an eight-membered ring lactam. | Ming He YANG Yan Yong CHEN Liang HUANG Institute of Materia Medica,Chinese Academy of Medical Sciences 1 Xian Nong Tan St.,Beijing 100050 | 1991 | Chinese Chemical Letters1991，2，4： | 3 |
| 9 | Small RNA deep sequencing reveals the presence of multiple viral infections in cucurbit crops in Guangdong,China显示文摘Viral diseases are among the most critical damaging factors that impose a global threat to the cucurbit industry.China is the world’s leading country for the production and consumption of cucurbits.Guangdong,a province in southern China dominated by the tropical and subtropical climate,favors the survival of different plant viruses and their vectors.Five main cucurbit crops showing various disease symptoms were surveyed and collected to identify viruses infecting cucurbits in Guangdong during 2018–2020.In the field,the incidence ranged from 5-30%,or even 60-100% in the case of severely infected cucurbits.A total of 357 symptomatic samples were collected and subsequently screened for cucurbit viruses by small RNA deep sequencing and assembly(sRSA).Seventeen virus species belonging to 10 genera were identified in the five main cucurbit crops.The most common viruses were papaya ringspot virus(PRSV;Potyvirus),zucchini tigre mosaic virus(ZTMV;Potyvirus),zucchini yellow mosaic virus(ZYMV;Potyvirus),and watermelon silver mottle virus(WSMoV;Orthotospovirus),with infection rates of 24.4,19.0,17.1,and 14.3%,respectively.Notably,the most prevalent viruses were melon yellow spot orthotospovirus(MYSV)in cucumber,PRSV in squash,cucumber green mottle mosaic virus(CGMMV;Tobamovirus)in bottle gourd,WSMoV in white gourd,and ZYMV in luffa.Mixed infections were prevalent,and the types of mixed infections varied substantially in different cucurbit crops.Moreover,the full-length nucleotide sequences of watermelon green mottle mosaic virus(WGMMV),CGMMV,and watermelon virus A(WVA;Wamavirus)identified in bottle gourd were cloned and analyzed.This study is the first reporting WGMMV infecting bottle gourd in China mainland.In summary,the results demonstrate that in Guangdong,the most prevalent viruses belong to potyviruses,orthotospoviruses,and tobamoviruses groups.The findings will facilitate agricultural researchers and farmers to plan and implement effective disease control strategies aiming at timely detection and management of cucurbit-infecting viral pathogens. | LI Zheng-gang NONG Yuan Tahir FAROOQ TANG Ya-fei SHE Xiao-man YU Lin LAN Guo-bing ZHOU Xue-ping HE Zi-fu | 2022 | Journal of Integrative Agriculture2022，21，5： | 2 |
| 10 | Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients显示文摘Objective Recent studies have shown abnormal expression of NANOG and IL-18 to be related to cancer. However, the molecular mechanism by which IL-18 and NANOG gene polymorphisms are associated with prostate cancer is unclear. In this study, we examined whether IL-18 and NANOG gene polymorphisms and their interaction with prostate cancer-related risk factor are associated with the susceptibility to and clinicopathological development of prostate cancer among Chinese men.Methods Polymorphisms in the NANOG and IL-18 genes were evaluated for susceptibility in 120 patients with prostate cancer. The control group consisted of 125 samples from Chinese men. Genotyping was conducted using Taq Man allelic discrimination assays. Statistical analysis was performed using SPSS software. Results No association of NANOG and IL-18 gene polymorphisms and overall prostate cancer susceptibility was detected. The IL-18-607 CC genotype was significantly associated with a higher tumor grade(P = 0.025) and stage(P =0.001). The IL-18-137 GG genotype correlated with a higher tumor grade(P = 0.028) and stage(P = 0.008). The IL-18-137 G allele was significantly more frequent in patients with lymph node metastasis(P = 0.035). The IL-18-607 CC genotype was associated with distant metastasis(P = 0.025). However, no significant association was observed between NANOG polymorphisms and any clinicopathological feature. The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors in IL-18, while IL-18 polymorphism was not. Polymorphism variants in the IL-18(IL-18-607 and IL-18-137) and NANOG(genotypes AC) genes might be associated with a worse prognosis of patients with prostate cancer.Conclusion NANOG may be associated with the early stages of prostate cancer carcinogenesis. IL-18 and NANOG gene polymorphisms may play a major role in the growth, invasion, and metastasis of prostate cancer. | Shaojun Nong Yangbo Guan Zhiwei Wang Zhongqing Wei Yueping Zhang Jian Ni Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2018 | Oncology and Translational Medicine2018，4，6： | 2 |
| 11 | Novel CDH1 germline mutations identified in Chinese gastric cancer patients显示文摘AIM:To give a comprehensive report of E-cadheringene (CDH1) variations in a population at a high risk for gastric cancer (GC).METHODS:The samples consisted of 178 men and 58 women with a mean age of 62.3 ± 9.4 years and an age range of 30-84 years.A total of 240 cancerfree controls were recruited (mean age of 61.8 ± 10.1 years,age range of 26-82 years).Samples were screened for CDH1 germline mutations by high-resolution melting analysis or directly sequencing.Luciferase reporter assay,RNA splicing assay and bioinformatic analysis were used to evaluate the effect of mutations.RESULTS:Four novel CDH1 sequence alterations were identified in GC patients including a G>T transition 49 bp before the start codon;a three-nucleotide deletion,c.44_46del TGC;one missense mutation,c.604G>A (V202I);and one variation in the intron,c.1320+7A>G.In addition,polymorphism frequencies were observed for CDH1-164delT,-161C>A,-73A>C,c.48+6C>T,c.48+62_48+63delinsCGTGCCCCAGCCC,c.894C>T (A298A),c.1224G>A (A408A),c.1888C>G (L630V),c.2076T>C (A692A),and c.2253C>T (N751N) which is similar to the data reported in http://www.ncbi.nlm.nih.gov/projects/SNP/.RNA splicing analysis suggested that the c.1320+7A>G and c.1224G>A variations did not affect exon splicing ability.Luciferase reporter assay demonstrated that the c.-49T variation might be helpful for E-cadherin transcription,though the increase in transcription activity is limited (only 33%).SIFT score and PolyPhen analysis both demonstrated that the L630V missense mutation probably damages protein function,while the V202I variant does not.CONCLUSION:This study reveals novel mutations in sporadic GC patients which had been poorly investigated for susceptibility genes. | Qin-Hua Chen Wei Deng Xiao-Wei Li Xiu-Fang Liu Jing-Mei Wang Li-Feng Wang Nong Xiao Qiong He Ya-Ping Wang Yi-Mei Fan | 2013 | World Journal of Gastroenterology2013，19，6： | 2 |
| 12 | Triterpenoids from Fuscoporia obliqua显示文摘Two new lanosta triterpenoids, 3β,22α -dihydroxy-lanosta-8,24E-diene-25-peroxide, 3β,22α,25-trihydroxy lanosta-8,24E-diene were isolated from the petroleum ether extracts of Fuscoporia obliqua and their structures had been determined by spectral data, chemical method and X-ray crystallographic analysis. | Jian HE Xiao zhang FENG Bin ZHAO Yang LU (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,1 Xian Nong Tan Street, Beijing 100050) | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 13 | Chronological Video Synopsis via Events Rearrangement Optimization显示文摘Video synopsis aims at retrieving interested events and reducing human labor on browsing long surveillance video. Traditional video synopsis methods based on energy function minimization is high computational and time consuming. Besides, the unchronological tubes shifting strategy may cause chaotic temporality and uncomfortable collisions. We propose a spatiotemporal events rearrangement optimization algorithm,which formulates the events rearrangement problem as iteration judgment on trajectory correlation and events compactability to generate the output synopsis video. An events subsection modification strategy has been presented to solve the spatial incompleteness of certain single event caused by imperfect object tracking. The experimental results have shown that the output synopsis video reserves the chronological order and avoids collisions of events. | HE Yi HAN Jun SANG Nong QU Zhiguo GAO Changxin | 2018 | Chinese Journal of Electronics2018，27，2： | 2 |
| 14 | Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer显示文摘Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4(OCT4) and interleukin-18(IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene polymorphisms are associated with prostate cancer remain unclear. In this study, we aimed to determine whether the presence of IL-18 and OCT4 polymorphisms were associated with size, grade, tumor, nodes and metastasis(TNM) stage, or survival in patients with prostate cancer.Methods Polymorphisms in OCT4 and IL-18 genes were evaluated to determine susceptibility to prostate cancer in 120 patients. A control group consisted of 125 Chinese participants. Genotyping was performed using TaqMan allelic discrimination assays, and statistical analysis was performed using SPSS. Results No association was found between OCT4 and IL-18 gene polymorphisms and prostate cancer susceptibility. For OCT4 AA and IL-18-607 CC genotypes, there was a significant association with higher tumor grade(P = 0.03 and P = 0.025) and stage(P = 0.04 and P = 0.001). The OCT4 and IL-18-137 GG genotype was correlated with higher tumor grade(P = 0.028) and stage(P = 0.008). Furthermore, OCT4 AA was significantly more frequent in patients with lymph node metastasis(P = 0.02) and distant metastasis(P = 0.01). The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors but IL-18 and OCT4 polymorphisms were not. Conclusion The OCT4 gene may have a profound effect on prostate cancer risk. Polymorphism variants in the IL-18(IL-18-607 and IL-18-137) and OCT4 genes may be associated with poor prognoses for individuals with prostate cancer. | Shaojun Nong Yangbo Guan Zhiwei Wang Zhongqing Wei Yueping Zhang Jian Ni Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2019 | Oncology and Translational Medicine2019，5，3： | 2 |
| 15 | N/S co-doped 3D carbon framework prepared by a facile morphology-controlled solid-state pyrolysis method for oxygen reduction reaction in both acidic and alkaline media显示文摘Developing high-performance non-precious metal electrocatalysts for oxygen reduction reaction(ORR)is crucial for the commercialization of fuel cells and metal-air batteries.However,doped carbon-based materials only show good ORR activity in alkaline medium,and become less effective in acidic environment.We believe that an appropriate combination of both ionic and electronic transport path,and well dopant distribution of doped carbon-based materials would help to realize high ORR performance un-der both acidic and alkaline cond让ions.Accordingly,a nitrogen and sulfur co-doped carbon framework with hierarchical through-hole structure is fabricated by morphology-controlled solid-state pyrolysis of poly(aniline-co-2-ami no thiophenol)foam.The uniform high concentrations of nitrogen and sulfur,high intrinsic conductivity,and integrated three dimensional ionic and electronic transfer passageways of the 3D porous structure lead to synergistic effects in catalyzing ORR.As a result,the limiting current density of the carbonized poly(aniline-co-2-aminothiophenol)foam is equivalent to commercial Pt/C in acidic environment,and twice the latter in alkaline medium. | Juan Nong Min Zhu Kun He Aosheng Zhu Pu Xie Minzhi Rong Mingqiu Zhang | 2019 | Journal of Energy Chemistry2019，28，7： | 2 |
| 16 | Acquired cisplatin resistance in human lung adenocarcinoma cells is associated with enhanced autophagy显示文摘 | Ren JH He WS Nong L | 2010 | Cancer Biother Radiopharm2010，25，1： | 1 |
| 17 | Acquired cisplatin resistance in human lung adenocarcinoma ceLls is associated with enhanced autophagy 显示文摘 | Ren JH He WS Nong L | 2010 | Cancer Biother Radiopharm2010，25，1： | 1 |
| 18 | Approximate Factorization of Univariate Polynomials Using Functional Networks显示文摘 | He Dexu Nong Zheng Zhou Yongquan | 2005 | Journal of Information and Computational Science2005，2，3： | 1 |
| 19 | Modeling and safety strategy of passenger evacuation in a metro station in China 显示文摘 | SHI Cong-ling ZHONG Mao-hua NONG Xing-zhon HE Li SHI Jie-hong FENG Guo-guan | 2012 | Safety Science2012，50，5： | 1 |
| 20 | Genetic variations of mTORC1 genes and risk of gastric cancer in an eastern chinese population显示文摘 | Jing He Meng‐Yun Wang Li‐Xin Qiu Mei‐Ling Zhu Ting‐Yan Shi Xiao‐Yan Zhou Meng‐Hong Sun Ya‐Jun Yang Jiu‐Cun Wang Li Jin Ya‐Nong Wang Jin Li Hong‐Ping Yu Qing‐Yi Wei | 2013 | Carcinog2013，，1： | 1 |
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