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| 1 | LLDPE prepared by in situ polymerization using a dual-functional catalytic system of Ti(On-Bu)_4 /AlEt_3-Et(Ind)_2-ZrCl_2/MAO显示文摘Linear low-density polyethylene (LLDPE) was prepared by in situ polymerization using a dual-functional catalytic system containing Et(Ind)2ZrCl2/MAO and Ti(On-Bu)4 /AlEt3 used as co-polymerization catalyst and dimeriza-tion catalyst, respectively. The catalytic system showed high activity and the polymer with low melting point, narrow molecular weight distribution (MWD) and low crystallinity was produced. | LIU Zhongyang, XU Demin, GUO Cunyue, WANG Jun, HE Dawei & HU YouliangStale Key Lab of Engineering Plastics, Center for Molecular Science, Institute of Chemistry. Chinese Academy of Sciences, Beijing 100080, China Beijing Lab of Catalysis. China National Petroleum Corporation Key Lab of Catalysis, Beijing 100080, China | 2001 | Chinese Science Bulletin2001，46，24： | 7 |
| 2 | Genetic Types and Metallogenic Model for the Polymetallic Copper–Gold Deposits in the Tongling Ore District, Anhui Province, Eastern China显示文摘The Tongling ore district is one of the most economically important ore areas in the Middle–Lower Yangtze River Metallogenic Belt, eastern China. It contains hundreds of polymetallic copper–gold deposits and occurrences. Those deposits are mainly clustered(from west to east) within the Tongguanshan, Shizishan, Xinqiao, Fenghuangshan, and Shatanjiao orefields. Until recently, the majority of these deposits were thought to be skarn-or porphyry–skarn-type deposits; however there have been recent discoveries of numerous vein-type Au, Ag, and Pb-Zn deposits that do not fall into either of these categories. This indicates that there is some uncertainty over this classification. Here, we present the results of several systematic geological studies of representative deposits in the Tongling ore district. From investigation of the ore-controlling structures, lithology of the host rock, mineral assemblages, and the characteristics of the mineralization and alteration within these deposits, three genetic types of deposits(skarn-, porphyry-, and vein-type deposits) have been identified. The spatial and temporal relationships between the orebodies and Yanshanian intrusions combined with the sources of the ore-forming fluids and metals, as well as the geodynamic setting of this ore district, indicate that all three deposit types are genetically related each other and constitute a magmatic–hydrothermal system. This study outlines a model that relates the polymetallic copper–gold porphyry-, skarn-, and vein-type deposits within the Tongling ore district. This model provides a theoretical basis to guide exploration for deep-seated and concealed porphyry-type Cu(–Mo, –Au) deposits as well as shallow vein-type Au, Ag, and Pb–Zn deposits in this area and elsewhere. | FU Zhongyang XU Xiaochun HE Jun FAN Ziliang XIE Qiaoqin DU Jianguo CHEN Fang | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 6 |
| 3 | Preparation of long-branched polyethylene by in situ poly-merization using late transition metal and metallocene catalysts显示文摘An in situ polymerization method was investigated to prepare long-branched polyethylene (LBPE) with ethylene alone and a single cocatalyst, methylalumoxane (MAO), by using a dual functional catalytic system containing late transition metal oligomerization catalyst and metal-locene copolymerization catalyst. The obtained long-branched polyethylene has the characteristics of low melting point, high activity and well-dispersed sequence distribution. | LIU Zhongyang GUO Cunyue MAZhi WANG Jun XU Demin HE Dawei HU Youliang | 2001 | Chinese Science Bulletin2001，46，24： | 5 |
| 4 | Removal of NOx with radical injection caused by corona discharge显示文摘 | LIN He GAO Xiang LUO Zhongyang | 2004 | Fuel2004，83，10： | 1 |
| 5 | Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA显示文摘Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. Micro RNAs(mi RNAs), which function as post-transcriptional regulators, are utilized by human cytomegalovirus(HCMV) in its infection and pathogenesis. In the present study, the DNA replication inhibitor Geminin(GMNN) was identified to be a direct target of hcmv-mi R-US5-1. Overexpression of hcmv-mi R-US5-1 could block the accumulation of GMNN during HCMV infection, and the decrease of GMNN expression caused by hcmv-mi R-US5-1 or GMNN specific si RNA reduced HCMV DNA copies in U373 cells. Meanwhile, ectopic expression of hcmv-mi R-US5-1 and consequent lower expression of GMNN influenced host cell cycle and proliferation. These results imply that hcmv-mi R-US5-1 may affect viral replication and host cellular environment by regulating expression kinetics of GMNN during HCMV infection. | Shujuan Jiang Yujing Huang Ying Qi Rong He Zhongyang Liu Yanping Ma Xin Guo Yaozhong Shao Zhengrong Sun Qiang Ruan | 2017 | Virologica Sinica2017，32，5： | 1 |
| 6 | Removal of NO x with radical injection caused by corona discharge显示文摘 | He Lin Xiang Gao Zhongyang Luo Kefa Cen Zhen Huang | 2004 | Fuel2004，，10： | 1 |
| 7 | Effect of Carbon Source on Crystal Morphology of SiC in-situ Formed in AI_2O_3-Si-C Matrix显示文摘Three kinds of Al2O3- Si- C matrix specimens were prepared using tabular corundum powder and Si powder as starting materials,ultrafine flake graphite,nano carbon black,and carbon nanotubes as carbon sources,respectively,to research the effect of micro or nano carbon materials on structure and morphology of formed Si C crystals. The specimens were fired at 1 000,1 200 and 1 400℃ for 3 h in carbon-embedded condition,respectively.The phase composition was studied by XRD and the crystal morphology of Si C was investigated by FESEM. The results show that:( 1) the amount of Si C increases with the firing temperature rising;( 2) the in-situ reaction mechanism and the formed Si C crystal morphology vary with carbon source: carbon nanotubes are generally converted into Si C whiskers by carbon nanotubes-confined reaction; Si and nano carbon black react to nucleate quickly,and the nucleated Si C crystals grow evenly in all directions forming Si C particles; Si C whiskers are produced from edge to internal of ultrafine flake graphite. | LIANG Feng LI Nan LIU Baikuan HE Zhongyang | 2015 | China's Refractories2015，24，2： | 1 |
| 8 | Effect of chemical activation of an activated carbon using zinc chloride on elemental mercury adsorption显示文摘 | Changxing Hu Jinsong Zhou Sheng He Zhongyang Luo Kefa Cen | 2009 | Fuel Processing Technology2009，，6： | 1 |
| 9 | ASBase:The universal database for aggregate science显示文摘This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://119.91.135.188:8080/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in solvents.The web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data entries.In addition,a background calculation service optimizes the chemical structure of new entries on different levels of accuracies.The database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms. | Junyi Gong Wanjun Gong BoWu Haoran Wang Wei He Zhongyang Dai Yangzhong Li Yong Liu Zhiming Wang Xiaojun Tuo Jacky W.Y.Lam Zijie Qiu Zheng Zhao Ben Zhong Tang | 2023 | Aggregate2023，4，1： | 0 |
| 10 | Biotechnological and food synthetic biology potential of platform strain:Bacillus licheniformis显示文摘Bacillus licheniformis is one of the most characteristic Gram-positive bacteria.Its unique genetic background and safety characteristics make it have important biologic applications in the food industry,including,the biosyn-thesis of high value-added bioproducts,probiotic functions,biological treatment of wastes derived from food production,etc.In this review,these recent advances are summarized and presented systematically for the first time.In addition,we highlight synthetic biology strategies as a potential driver of developing this strain for wider and more efficient application in the food industry.Finally,we present the current challenges faced and provide our unique perspective on relevant future research directions.In summary,this review will provide an illumi-nating and comprehensive perspective that will allow an in-depth understanding of B.licheniformis and promote its more effective development in the food industry. | Hehe He Qianqian Yu Zhongyang Ding Liang Zhang Guiyang Shi Youran Li | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 11 | Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs显示文摘After decades of development,protein and peptide drugs have now grown into a major drug class in the marketplace.Target identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target selection.However,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are lacking.Here,we systematically explore the target spaces in the human genome specifically for protein and peptide drugs.Compared with other proteins,both successful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many aspects.Based on these features,we develop separate effective genome-wide target prediction models for protein and peptide drugs.Finally,a user-friendly web server,Predictor Of Protein and Pept Ide drugs’therapeutic Targets(POPPIT)(http://poppit.ncpsb.org.cn/),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets. | Zhongyang Liu Honglei Li Zhaoyu Jin Yang Li Feifei Guo Yangzhige He Xinyue Liu Yaning Qi Liying Yuan Fuchu He Dong Li | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 12 | Antioxidant Coating of SEN for Thin Slab Con-casting显示文摘The SEN for thin slab con-casting is easy to break and damage because of the oxidation during preheating and application.The enamel coating material is generally applied on the surface of SEN to avoid the oxidation.The coating material with born glass and silicon as main starting materials and silica sol as binder was studied.ZrO2-C and Al2O3-C materials containing 15% carbon were isostatic pressed,and heated at 600 ℃,900 ℃,1 200 ℃,1 500 ℃ for 2 h,respectively.The results show that the coating material with 70% of boron glass and 30% of silicon bonded by silica sol can form denser protection layer in the above mentioned materials at the range of 600-1 500 ℃.The oxidation area ratio and weight loss ratio with the coating are much lower than those without the coating. | PENG Dejiang HE Zhongyang LIU Baikuan | 2008 | China's Refractories2008，17，2： | 0 |
| 13 | Mechanisms and biotechnological applications of transcription factors显示文摘Transcription factors play an indispensable role in maintaining cellular viability and finely regulating complex internal metabolic networks.These crucial bioactive functions rely on their ability to respond to effectors and concurrently interact with binding sites.Recent advancements have brought innovative insights into the understanding of transcription factors.In this review,we comprehensively summarize the mechanisms by which transcription factors carry out their functions,along with calculation and experimental-based methods employed in their identification.Additionally,we highlight recent achievements in the application of transcription factors in various biotechnological fields,including cell engineering,human health,and biomanufacturing.Finally,the current limitations of research and provide prospects for future investigations are discussed.This review will provide enlightening theoretical guidance for transcription factors engineering. | Hehe He Mingfei Yang Siyu Li Gaoyang Zhang Zhongyang Ding Liang Zhang Guiyang Shi Youran Li | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 14 | Rickettsia-like organism infection associated with mass mortalities of blood clam, Tegillarca granosa, in the Yueqing Bay in China显示文摘A series of mass mortalities of the cultured blood clam, Tegillarca granosa, occurred in the Yueqing Bay of China from 2005 to 2009. An obligate intracellular prokaryote, designated as rickettsia-like organism (RLO), was frequently found in the moribund or dead blood clam sample during ultrastructural examination. These organisms were usually round, ellipsoid or occasionally dumbbell-shaped, ranged from approximately 0.28 to 0.71 μm in size and had a trilaminar cell wall. Two reproductive modes of organisms, transverse binary fission and budding, were observed. The organisms were able to form eosinophilic inclusions. Most inclusions were found within epithelial and connective tissues of the mantle, gills and digestive tube. The biological and morphological characteristics indicate that these organisms may belong to the family Rickettsiaceae. RLOs exhibited significant pathogenicity. Cytopathological examinations revealed extensive necrosis and destruction in the infected cell. The degree of tissue destruction was positively related to the number of RLO inclusions in the tissues, and the cytopathological effects were positively related to the number of intracellular RLO. RLOs and their inclusions were discovered throughout different disease areas and in different time periods. The infection intensity of the RLOs was positively correlated with the mortality rate of clams. Therefore, RLO infection might be associated with mass mortalities of cultured blood clams in the Yueqing Bay. | ZHU Zewen XU Ting HE Zhongyang WU Xinzhong WU Liuji MENG Qingguo | 2012 | Acta Oceanologica Sinica2012，31，1： | 0 |
| 15 | Ongoing Technology and Developing Trend of Ar-blowing Purging Plug显示文摘An introduction of the ongoing technology of argon-blowing purging plugs in China was presented in this work.Gel powders were used as starting materials to enhance the high temperature mechanical properties of the purging plugs.Composite purging plug adopting extrusion formed gas-purging bar and slit had its surface structural design improved,which enhanced the resistances to thermal shock and molten steel penetration,prolonging the service life.In addition,the safety was greatly improved by upgrading the framework and production process,enhancing the resistance to breakout.It is indicated that the developing trend is to produce purging plugs of longer service life and better gas purging rate with different starting materials and structure designs to meet the requirements of various metallurgical processes. | HE Zhongyang WANG Fenggang LIU Baikuan SHI Xubo | 2008 | China's Refractories2008，17，4： | 0 |
| 16 | Crystallographic Characterization and Themal Decomposition Behavior of High-Purity Microcrystalline Magnesite显示文摘The intergranular cracking face is smooth and transgranular cracking fracture shows trace of cleavage. It is hard to find characteristic rhombus in the dense small crystals.As measured by SEM, the particle size of microcrystalline magnesite originating in Sichuan-Tibet is uniform, most grains range in 2-4 μm. Three-dimensional (3D) crystal morphology assumes cubic or column. The result of chemical analysis shows that the microcrystalline magnesite has high purity and XRD indicates that the lattice constant is the same as macrocrystalline magnesite with standard d values and X-ray diffraction intensity. The decomposition temperature is 650 ℃ determined by DTA, which is also the same as macrocrystalline magnesite. Crystal morphology of nanometer periclase treated at 650 ℃ for 4 h and calcined at 1 000 ℃ respectively was observed by FE-SEM, the grain of periclase fired at 650 ℃ is <20 nm and that of the periclase calcined at 1 000 ℃ is <200 nm, both are round. The quality of high purity magnesite manufactured by high temperature shaft kiln is at the same level as sea water magnesite made in Japan and brine magnesite produced in the Netherlands, while the crystal size is slightly larger. | HE Zhongyang MA Letian LIU Baikuan | 2012 | China's Refractories2012，21，3： | 0 |
| 17 | Effect of Nano-CaCo_3 on Properties and Microstructure of Corundum Based Castables显示文摘The chrome-containing corundum castables specimens with different nano-CaCO3 additions (0-1.6 wt%) were prepared using tabular corundum,alumina powder,chrome oxide micropowder (average particle size < 5 μm),calcium aluminate cement (Secar71),commercial nano-CaCO3 (average particle size <100 nm) as main starting materials and FS10 as water reducer. The specimens heat treated at 1 000 ℃ and 1 600 ℃ were characterized in terms of apparent porosity,bulk density,cold and hot strengths,and microstructure. The results show that,when the nano-CaCO3 addition is no more than 1.0 wt%,the apparent porosity of the castables increases with nano-CaCO3 addition increasing,both the cold and hot strengths are enhanced; however,when the nano-CaCO3 addition excesses 1.0 wt%,both the cold and hot strengths go down remarkably with nano-CaCO3 addition increasing; the thermal shock resistance is gradually improved with nano-CaCO3 addition increasing in chosen range. | ZHANG Houxing HE Zhongyang GAN Mingliang LIU Baikuan | 2010 | China's Refractories2010，19，4： | 0 |
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