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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Bronchiolitis:Recent Evidence on Diagno- sis and Management 显示文摘 | Zorc JJ Hall CB | 2010 | Pediatrics2010，125，2： | 1 |
| 3 | A review and meta-analysis of formaldehyde exposure and pancreatic cancer显示文摘 | Collins JJ Esmen NA Hall TA | 2001 | Am J Ind Med2001，39，3： | 1 |
| 4 | Noninvasive coronary angiography: agreement of multi-slice spiral computed tomography and selective catheter angiography 显示文摘 | Fine JJ Hopkins CB Hall PAX | 2004 | Internat J Cardiovascular Imaging2004，20，6： | 1 |
| 5 | Delayed cell death in neonatal mouse hippocampus from hypoxia-ischemia is neither apoptotic nor necrotic显示文摘 | Sheldon RA Hall JJ Noble LJ | 2001 | Nevi Lett2001，304，： | 1 |
| 6 | The role of Dickkopf-1 in bone development, homeostasis, and disease显示文摘 | Pinzone JJ Hall BM Thudi NK | 2009 | Blood2009，113，3： | 1 |
| 7 | Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function显示文摘 | Kuo JJ Silva AA Hall JE | 2003 | Hypertension2003，41，32： | 1 |
| 8 | Impact of the obesity epi- demic on hypertension and renal disease显示文摘 | Hall JE Jones DW Kuo JJ | 2003 | Curr Hypertens rep2003，5，5： | 1 |
| 9 | Fat embolism precipitated by rea ming of the femoral canal during revision of a total knee arthroplasty: A case r eport显示文摘 | Calahan JJ | 1994 | J Bone Joint Surg(Am)1994，76，： | 1 |
| 10 | Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer 显示文摘 | Hall JJ Eoggie BW Shen P | 2004 | J Gastrointest Surg2004，8，4： | 1 |
| 11 | A review and meta-analysis of formaldehyde exposure and pancreatic cancer显示文摘 | Collins JJ Esmen NA Hall TA | 2001 | Am J Ind Med2001，39，3： | 1 |
| 12 | The role of Dickkopf-1 in bone development,homeo-stasis,and disease显示文摘 | Pinzone JJ Hall BM Thudi NK | 2009 | Blood2009，113，： | 1 |
| 13 | Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat显示文摘 | Noble LJ Mautes AE Hall JJ | 1996 | J Comp Neurol1996，376，4： | 1 |
| 14 | Role of hypothalamic melanocor- tin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin 显示文摘 | da Silva AA Kuo JJ Hall JE | 2004 | Hypertension2004，43，6： | 1 |
| 15 | The role of Dickkopf-1 in bone development, homeostasis and disease 显示文摘 | Pinzone JJ Hall BM Thudi NK | 2009 | Blood2009，113，3： | 1 |
| 16 | Immunolocalization of endothelin in the traumatized spinal cord:Relationship to blood-spinal cord barrier breakdown显示文摘 | Hall JJ Aihara N | 1995 | J Neurotrauma1995，2，： | 1 |
| 17 | The role ofDickkopf-1 in bone development homeostasis,anddisease显示文摘 | Pinzone JJ Hall BM Thudi NK | 2009 | Blood2009，113，3： | 1 |
| 18 | Bronchiolitis:recent evidence on diagnosis and management显示文摘 | Zorc JJ Hall CB | 2010 | Pediatrics2010，125，2： | 1 |
| 19 | Inhibitor of NO synthesis enhances chronic cardiovasular and renal actions of leptin显示文摘 | Jones OB Hall JE | 2001 | Hypertens2001，37，： | 1 |
| 20 | The role of Dickkopf-1 in bone development,homeostasis,and disease显示文摘 | Pinzone JJ Hall BM Thudi NK | 2009 | BLOOD2009，113，3： | 1 |
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