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| 1 | Performance of RegCM4 over Major River Basins in China显示文摘A long-term simulation for the period 1990–2010 is conducted with the latest version of the International Centre for Theoretical Physics' Regional Climate Model(RegCM4), driven by ERA-Interim boundary conditions at a grid spacing of 25 km. The Community Land Model(CLM) is used to describe land surface processes, with updates in the surface parameters,including the land cover and surface emissivity. The simulation is compared against observations to evaluate the model performance in reproducing the present day climatology and interannual variability over the 10 main river basins in China,with focus on surface air temperature and precipitation. Temperature and precipitation from the ERA-Interim reanalysis are also considered in the model assessment. Results show that the model reproduces the present day climatology over China and its main river basins, with better performances in June–July–August compared to December–January–February(DJF).In DJF, we find a warm bias at high latitudes, underestimated precipitation in the south, and overestimated precipitation in the north. The model in general captures the observed interannual variability, with greater skill for temperature. We also find an underestimation of heavy precipitation events in eastern China, and an underestimation of consecutive dry days in northern China and the Tibetan Plateau. Similar biases for both mean climatology and extremes are found in the ERA-Interim reanalysis, indicating the difficulties for climate models in simulating extreme monsoon climate events over East Asia. | Xuejie GAO Ying SHI Zhenyu HAN Meili WANG Jia WU Dongfeng ZHANG Ying XU Filippo GIORGI | 2017 | Advances in Atmospheric Sciences2017，34，4： | 33 |
| 2 | Oil–water pre-separation with a novel axial hydrocyclone显示文摘A novel hydrocyclone with guide vanes, named as axial hydrocyclone(AHC), is designed to tackle the problem of oil–water separation faced by most mature oilfields. Optimal design of the AHC is carried out by using numerical methods. The effects of guide vanes, cone angle, tapered angle and overflow pipe on the oil–water separation are discussed in this paper. The results show that a double swirling flow is generated in the tapered section where oil–water separation occurs. Both the cylindrical and the tapered section have important influences on AHC performance. On the basis of single factor results, response surface methodology is employed to optimize the AHC design. The experimental results indicate that the novel AHC has an excellent performance for the oil–water separation. | Meili Liu Jiaqing Chen Xiaolei Cai Yanhe Han Si Xiong | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 12 |
| 3 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 4 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 5 | Structural parameter optimization for novel internal-loop iron–carbon micro-electrolysis reactors using computational fluid dynamics显示文摘It is generally recognized that internal-loop reactors are well-developed mass and heat-transfer multiphase flow reactors. However, the internal flow field in the internal-loop reactor is influenced by the structure parameter of the reactor, which has a great effect on the reaction efficiency. In this study, the computational fluid dynamics simulation method was used to determine the influence of reactor structure on flow field, and a volume-offluid model was employed to simulate the gas–liquid, two-phase flow of the internal-loop micro-electrolysis reactor. Hydrodynamic factors were optimized when the height-to-diameter ratio was 4:1, diameter ratio was9:1, draft-tube axial height was 90 mm. Three-dimensional simulations for the water distributor were carried out, and the results suggested that the optimal conditions are as follows: the number of water distribution pipes was four, and an inhomogeneous water distribution was used. According to the results of the simulation,the suitable structure can be used to achieve good fluid mechanical properties, such as the good liquid circulation velocity and gas holdup, which provides a good theoretical foundation for the application of the reactor. | Lei Zhang Mengyu Wu Yanhe Han Meili Liu Junfeng Niu | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 3 |
| 6 | Efficient transformation of Actinidia arguta by reducing the strength of basal salts in the medium to illeviate callus browning显示文摘 | Han Meili Gleave Andrew P Wang Tianchi | 2010 | Plant Biotechnol Rep2010，4，2： | 1 |
| 7 | Prognostic factors in patients with stage IV non-small cell lung cancer显示文摘Objective: To investigate the prognostic factors for stage IV non-small cell lung cancer (NSCLC) with distant metas- tasis and establish a reliable model of clinical prognostic index. Methods: From January 1990 to April 2005, 313 primary NSCLC patients with metastasis, who had been treated in Shanghai Chest Hospital, were reviewed. Survival time was estimated accord- ing to the Kaplan-Meier method. Cox proportional hazard regression model was used for multivariate analysis. Results: Among the 313 cases of non-small cell lung cancer (NSCLC) at stage IV, there were 218 and 95 patients with metastasis to single and different organs, respectively. The overall median survival time for all 313 cases of NSCLC patients was 10.8 (9.00, 12.30) months and the overall 1-, 2-, 3-, 4- and 5-year survival rate was 45%, 18%, 12%, 4% and 0%. There were 63, 174, 127, 36, 18, 11 and 5 patients with metastasis to brain (20.13%), bone (55.59%), lung (40.58%), liver (11.50%), adrenal gland (5.75%), subcutaneous (3.51%) and others, respectively. The survival time was shortest in subcutaneous metastasis (4.6 months), and liver 7.0 months, brain 8.0 months, adrenal gland 8.6 months, bone 10.6 months, lung 11.8 months. Kaplan-Meier estimation showed that patients anatomic typing, KPS, numbers of organ with metastasis, appetite, liver, adrenal gland and subcutane- ous metastasis, body weight loss, smoking, index of smoking, chemotherapy, cycles of chemotherapy were the predictors of survival. Multivariate analysis showed survival statistically significant correlation with anatomic typing, KPS, appetite, liver and subcutaneous metastasis, body weight loss, cycles of chemotherapy. The relative risk (RR) was 1.51, 1.97, 1.55, 1.67, 2.56, and 2.56 respectively. Conclusion: Survival time decreases distinctly in patients who had distant metastasis to more than two different organs (P<0.01). Bone is the commonest organ for distant metastasis in lung cancer. The prognosis is poor when lung cancer appears subcutaneous metastasis and liver metastasis. Independent prognostic factors in patient with stage IV non-small cell lung cancer were liver and subcutaneous metastasis, anatomic typing, KPS, appetite, body weight loss, cycles of chemotherapy. | Meili Ma Jie Shen Liyan Jiang Baohui Han Hao Bai Hao Ji Yizuo Zhao Bo Jin Yongfeng Yu Jun Pei Wei Zhang | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，5： | 1 |
| 8 | Localization of putative stem cells and four cell populations with different differentiation degree in mouse mammary anlagen显示文摘 | Jianyong Han Suying Cao Hong Jin Ying Liu Meili Wang Jiazhe Song Ning Li | 2006 | Histochemistry and Cell Biology2006，，1： | 1 |
| 9 | Electrolytic coloration of oxygen-doped lithium fluoride crystals 显示文摘 | GUO Meili GU Hongen HAN Li | 2007 | J Appl Phys2007，100，01： | 1 |
| 10 | Impaired immunomodulatory ability of bone marrow mesenchymal stem cells on CD4 + T cells in aplastic anemia显示文摘 | Jianping Li Shihong Lu Shaoguang Yang Wen Xing Jianming Feng Wenqian Li Qinjun Zhao Hao Wu Meili Ge Fengxia Ma Hui Zhao Bin Liu Lei Zhang Yizhou Zheng Zhong Chao Han | 2012 | Results in Immunology2012，，： | 1 |
| 11 | Acid-catalyzed ring-expansion of 4-(1-hydroxycyclobutyl)-1,2,3-triazoles显示文摘We here report a direct ring-opening/semipinacol rearrangement reaction of 4-(1-hydroxycyclobutyl)-1,2,3-triazole,in which N-acyl substituted 1,2,3-triazole was generated in situ and would trigger thermo-dynamically controlled electrocyclization ring-opening to afford a rearrangement precursor(α-diazo-ol).This strategy avoided the usage of metal catalysts and the reservation of sulfonyl groups on the N^(1)-posi-tion of 1,2,3-triazole.The final cycloenaminone product is highly reactive and could be commonly used as a dinucleophilic acceptor to synthesize structurally diverse fused bicyclic products. | Mingchuan Xu Lei Liu Tao Wang Han Luo Meili Hou Luan Du Xiaolan Xin Qixing Lu Baosheng Li | 2022 | Organic Chemistry Frontiers2022，9，4： | 0 |
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