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| 1 | Main seagrass beds and threats to their habitats in the coastal sea of South China显示文摘The distribution, species, biomass,productivity of main seagrasses and their sufferedmain threats are introduced and discussed in thispaper based on the field surveys in the offshore areas of Guangdong, Guangxi and Hainan provinces.The seagrass beds distributed mainly in Liusha Bay,Donghai Island and Hailing Island of GuangdongProvince; Hepu and Pearl Bay of Guangxi ZhuangAutonomous Region; Li’an Bay, Xincun Bay, Longwan Bay and Sanya Bay of Hainan Province and soon. The total area of seagrass beds in the coastal seaof South China is about 2400 ha. There are about 8species, such as Halophila ovalis, Halodule uninervisHalophila beccarii, Zostera japonica, Enhalus acoroides, Thalassia hemperichii, Ruppia martime andCymodocea rotundata. These seagrasses have highbiomass and productivity. However, they are subjected to some threats resulting from artificial andnatural factors, especially anthropogenic causes,such as culture of shrimps and fishes, shellfish collection, fishing by means of poisons, electric powerand explosives as well as trawling, artificial pollution,dredging channels, and typhoons natural disaster. | HUANG Xiaoping HUANG Liangmin LI Yinghong XU Zhanzhou FONG C W HUANG Daojian HAN Qiuying HUANG Hui TAN Yehui LIU Sheng | 2006 | Chinese Science Bulletin2006，51，B12： | 36 |
| 2 | 基于剩余容量估算的快速蓄电池均衡显示文摘针对现有蓄电池均衡方法工作时间长、只对电压均衡而不对容量均衡等缺点,采用基于Kalman滤波器与系统参数辨识集成的方法计算蓄电池剩余容量,并提出了一种新型蓄电池容量均衡结构。该容量均衡方法采用将串联蓄电池组单体分层的结构,使得每层的蓄电池单体不但能够在层内进行容量均衡,同时还可以与其他层之间均衡,因此均衡速度得到很大提高,均衡时间比传统方法缩短50%左右,而快速均衡电路的成本并没有增加。仿真和实验结果表明,该结构比传统结构均衡速度显著增加。 | 董博 李永东 HAN Yehui | 2012 | 清华大学学报(自然科学版)2012，52，3： | 15 |
| 3 | Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway显示文摘A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer. | Yehui Shi Wenwen Zhang Yingnan Ye Yanan Cheng Lei Han Pengpeng Liu Weipeng Zhao Zhongsheng Tong Jinpu Yu | 2018 | Cancer Biology & Medicine2018，15，3： | 6 |
| 4 | Quantification of volatile compoundsin Chinese ciders by stir bar sorptive extraction (SBSE) and gaschromatography-mass spectrometry (GC-MS)显示文摘 | FAN Wenlai XU Yan HAN Yehui | 2011 | J Inst Brew2011，117，1： | 1 |
| 5 | The percentage of peripheral blood blasts on day 7 of induction chemotherapy predicts response to therapy and survival in patients with acute myeloid leukemia显示文摘 | Gao Sujun Tan Yehui Liu Xiaoliang Su Long Yu Ping Han Wei Cui Jiuwei Li Wei | 2014 | Chinese Medical Journal2014，，2： | 1 |
| 6 | Resistance compression networks for radio-frequency power conversion显示文摘 | Yehui Han Leitermann O Jackson D A | 2007 | IEEE Transactions on Power Electronics2007，22，1： | 1 |
| 7 | Quantification of volatile compounds in Chinese ciders by stir bar sorptive extraction (SBSE) and gas chromatography-mass spectrometry(GC-MS)显示文摘 | FAN Wenlai XU Yan HAN Yehui | 2011 | Journal of Ournal of the Institute of Brewing2011，117，1： | 1 |
| 8 | Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60显示文摘 | Jing Zhao Lihua Guo Hongmei Zeng Xiufen Yang Jingjing Yuan Huaixing Shi Yehui Xiong Mingjia Chen Lei Han Dewen Qiu | 2012 | Peptides2012，，2： | 1 |
| 9 | Effectiveness and safety evaluation of graded levels of N-carbamylglutamate in growing-finishing pigs显示文摘The aim of this study was as follows:1)to investigate the effects of graded levels of N-carbamylglutamate(NCG)on performance,blood biochemical indexes,carcass traits and related indicators in growingfinishing pigs,and 2)to determine the optimal supplemental level.The toxicity of high-dose(much higher than recommended levels)NCG was assessed by routine blood tests and blood biochemical and histopathologic examinations of the heart,liver,spleen,lung,kidney and stomach.One hundred and forty-four growing-finishing pigs(DurocLarge WhiteLandrace,32.24±1.03 kg)were used in a 74-d experiment and each treatment was replicated 6 times with 4 pigs(2 barrows and 2 gilts)per replicate.The dietary treatments were a corn-soybean meal basal diet supplemented with 0%(control),0.05%,0.1%,0.15%,0.2%or 1%NCG.The first 5 groups were used to explore the optimal supplemental level of NCG,while the control,0.1%and 1%NCG groups were used to explore the safety of high-dose NCG.Compared with the normal control group,the final body weight and average daily gain tended to be higher in the 0.1%group(P=0.08),the lean percentage tended to be higher in the 0.05%group(P=0.07),the levels of free amino acids in the blood significantly increased in the 0.1%group(P<0.05),both 0.1%and 0.15%NCG supplementation increased the levels of nitric oxide(NO)in serum(P=0.07)and muscle growth-and lipid metabolism-related gene expression(P<0.05)and NCG supplementation improved C18:1N9C monounsaturated fatty acids(MUFA)in a dose-dependent manner(P=0.08).In addition,routine blood tests,blood biochemical indexes and histopathological examination revealed no abnormalities.Overall,increasing the levels of NCG did not linearly improve the above indicators;the 0.1%dose showed the best effect,and a high dose(1%)did not pose a toxicity risk. | Chunping Wang Lijun Shang Qiuping Guo Yehui Duan Mengmeng Han Fengna Li Yulong Yin Shiyan Qiao | 2022 | Animal Nutrition2022，，3： | 1 |
| 10 | Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli(ETEC) K88-infected piglet显示文摘Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating properties.In this study,we built the recombinant Bacillus subtilis WB800 expressing antimicrobial peptide KR32(WB800-KR32)using genetic engineering methods and investigated its protective effects of nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway activation in intestinal oxidative disturbance induced by enterotoxigenic Escherichia coli(ETEC)K88 in weaned piglets.Twenty-eight weaned piglets were randomly distributed into four treatment groups with seven replicates fed with a basal diet.The feed of the control group(CON)was infused with normal sterilized saline;meanwhile,the ETEC,ETEC+WB800,and ETEC+WB800-KR32 groups were orally administered normal sterilized saline,5×10^(10)CFU(CFU:colony forming units)WB800,and 5×10^(10)CFU WB800-KR32,respectively,on Days 1-14 and all infused with ETEC K881×10^(10)CFU on Days 15-17.The results showed that pretreatment with WB800-KR32 attenuated ETEC-induced intestinal disturbance,improved the mucosal activity of antioxidant enzyme(catalase(CAT),superoxide dismutase(SOD),and glutathione peroxidase(GPx))and decreased the content of malondialdehyde(MDA).More importantly,WB800-KR32 downregulated genes involved in antioxidant defense(GPx and SOD1).Interestingly,WB800-KR32 upregulated the protein expression of Nrf2 and downregulated the protein expression of Keap1 in the ileum.WB800-KR32 markedly changed the richness estimators(Ace and Chao)of gut microbiota and increased the abundance of Eubacterium_rectale_ATCC_33656 in the feces.The results suggested that WB800-KR32 may alleviate ETEC-induced intestinal oxidative injury through the Nrf2-Keap1 pathway,providing a new perspective for WB800-KR32 as potential therapeutics to regulate intestinal oxidative disturbance in ETEC K88 infection. | Chaoyue WEN Hong ZHANG Qiuping GUO Yehui DUAN Sisi CHEN Mengmeng HAN Fengna LI Mingliang JIN Yizhen WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 11 | Screening of Dominant Species of Triehogramma sp. and Evaluation of Field Control Effect显示文摘[Objective]The paper was to screen out the dominant species of Trichogramma sp.parasitized on Osirinia nub ilalis eggs and to evaluate the field control effect of Trichogramma sp..[Method]Six kinds of fresh egg masses of Trichogramma sp.parasitized on O.nubilalis were used to screen out three dominant species of Trichogramma sp.,and the single factor experimental design was used to evaluate field control effect.The dominant species were determined by combining yield,recovery yield loss rate and yield increase rate.[Result]T.osiriniae had the highest parasitic rate on O.nub ilalis;the parasitic rate of egg masses was 74.0%,and the parasitic rate of egg granules was 65.4%.The second was T.dendrolimi;the parasitic rate of egg masses was 62.0%,and the parasitic rate of egg granules was 59.5%.The parasitic rates of egg masses and egg granules of T.chilonis were 58.0%and 47.1%,respectively.The three Trichogramma sp.were the dominant bee species parasitized on O.nubilalis eggs.The average control effect of T.osirinae parasitized on O.nubilalis in the field was 73.86%;the average control effect of T.dendrolimi was 68.47%;and the average control effect of T.chilonis was 47.97%.The recovery yield loss rates was 9.58%,7.02%and 4.02%,and the yield increase rates were 9.65%,7.47%and 4.52%,respectively.[Conclusion]Considering the control effect and cost control comprehensively,T.dendrolimi should be used to control O.nubilalis in actual production. | Li Qingchao Wang Lida Zhao Xiumei Liu Yang Han Yehui Yang Ying Gao Chong | 2020 | Plant Diseases and Pests2020，11，3： | 0 |
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