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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Crustal structure of the northeastern Tibetan plateau,the Ordos block and the Sichuan basin from ambient noise tomography显示文摘We apply ambient noise tomography to significant seismic data resources in a region including the northeastern Tibetan plateau,the Ordos block and the Sichuan basin.The seismic data come from about 160 stations of the provincial broadband digital seismograph networks of China.Ambient noise cross-correlations are performed on the data recorded between 2007 and 2009 and high quality inter-station Rayleigh phase velocity dispersion curves are obtained between periods of 6 s to 35 s.Resulting Rayleigh wave phase velocity maps possess a lateral resolution between 100 km and 200 km.The phase velocities at short periods (<20 s) are lower in the Sichuan basin,the northwest segment of the Ordos block and the Weihe graben,and outline sedimentary deposits.At intermediate and long periods (>25 s),strong high velocity anomalies are observed within the Ordos block and the Sichuan basin and low phase velocities are imaged in the northeastern Tibetan plateau,reflecting the variation of crustal thickness from the Tibetan plateau to the neighboring regions in the east.Crustal and uppermost mantle shear wave velocities vary strongly between the Tibetan plateau,the Sichuan basin and the Ordos block.The Ordos block and the Sichuan basin are dominated by high shear wave velocities in the crust and uppermost mantle.There is a triangle-shaped low velocity zone located in the northeastern Tibetan plateau,whose width narrows towards the eastern margin of the plateau.No low velocity zone is apparent beneath the Qinling orogen,suggesting that mass may not be able to flow eastward through the boundary between the Ordos block and the Sichuan basin in the crust and uppermost mantle. | Yong Zheng Yingjie Yang Michael H. Ritzwoller Xiufen Zheng Xiong Xiong Zuning Li | 2010 | Earthquake Science2010，23，5： | 43 |
| 3 | Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing显示文摘The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite(As~Ⅲ), monomethylarsonous acid(MMA~Ⅲ) originating from the oxide and iodide forms, dimethylarsinous acid(DMA~Ⅲ), dimethylarsinic glutathione(DMAG~Ⅲ), phenylarsine oxide(PAO~Ⅲ), arsenate(AsV), monomethylarsonic acid(MMA~Ⅴ), dimethylarsinic acid(DMA~Ⅴ),monomethyltrithioarsonate(MMTTA~Ⅴ), dimethylmonothioarsinate(DMMTA~Ⅴ),dimethyldithioarsinate(DMDTA~Ⅴ), 3-nitro-4-hydroxyphenylarsonic acid(Roxarsone, Rox),and 4-aminobenzenearsenic acid(p-arsanilic acid, p-ASA). Cellular responses were measured in real time for 72 hr in human lung(A549) and bladder(T24) cells. IC50 values for the arsenicals were determined continuously over the exposure time, giving rise to IC50 histograms and unique cell response profiles. Arsenic accumulation and speciation were analyzed using inductively coupled plasma-mass spectrometry(ICP-MS). On the basis of the 24-hr IC50 values, the relative cytotoxicity of the tested arsenicals was in the following decreasing order: PAO~Ⅲ? MMA~Ⅲ≥ DMA~Ⅲ≥ DMAG~Ⅲ≈ DMMTA~Ⅴ≥ As~Ⅲ? MMTTA~Ⅴ> AsV> DMDTA~Ⅴ>DMA~Ⅴ> MMA~Ⅴ≥ Rox ≥ p-ASA. Stepwise shapes of cell response profiles for DMA~Ⅲ, DMAG~Ⅲ,and DMMTA~Ⅴcoincided with the conversion of these arsenicals to the less toxic pentavalent DMA~Ⅴ. Dynamic monitoring of real-time cellular responses to fourteen arsenicals provided useful information for comparison of their relative cytotoxicity. | Birget Moe Hanyong Peng Xiufen Lu Baowei Chen Lydia W.L.Chen Stephan Gabos Xing-Fang Li X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 19 |
| 4 | Research on the Optimum Configuration Strategy for the Adjustable Parameters in Ant Colony Algorithm显示文摘 | Haibin Duan Daobo Wang Xiufen Yu | 2005 | 通讯和计算机(中英文版)2005，2，9： | 16 |
| 5 | Measurement of interstation phase velocity by wavelet transformation显示文摘In this paper,we present wavelet transformation method to measure interstation phase velocity. We use Morlet wavelet function as mother wavelet to filter two seismograms at various period of interest,and correlate the wavelet filtered seismograms to form cross-correlogram. If both wavelet filtered signals are in phase at that period,the phase of the cross-correlogram is a minimum. Using 3-spline interpolation to transform cross-correlation matrix to a phase velocity verse period image,it is convenient for us to measure interstation phase velocity. | Qingju Wu Xiufen Zheng Jiatie Pan Fengxue Zhang Guangcheng Zhang | 2009 | Earthquake Science2009，22，4： | 14 |
| 6 | Characteristics and Origin of Tight Oil Accumulations in the Upper Triassic Yanchang Formation of the Ordos Basin,North-Central China显示文摘The Upper Triassic oil accumulations in the Ordos Basin is the most successful tight oil play in China,with average porosity values of less than 10% and permeability values below 1.0 mD.This study investigated the geological characteristics and origin of the tight oil accumulations in the Chang 6 member of the Upper Triassic Yanchang Formation in the Shanbei area based on over 50,000 petrological,source-rock analysis,well logging and production data.The tight oil accumulation of the Chang 6 member is distributed continuously in the basin slope and the centre of the basin.The oilwater relationships are complex.Laumontite dissolution pores are the most important storage spaces,constituting 30%-60% of total porosity and showing a strong positive relationship with oil production.The pore-throat diameter is less than 1 μm,and the calculated critical height of the oil column is much larger than the tight sand thickness,suggesting that the buoyancy was probably of limited importance for oil migration.The pressure difference between the source rocks and sandstone reservoirs is inferred to have provided driving force for hydrocarbon migration.Two factors of source-reservoir configuration and laumontite dissolution contributed to the formation of the Chang 6 tight oil accumulations.Intense hydrocarbon generation and continuous sand bodies close to the hydrocarbon kitchen are the foundation for the large-scale oil distribution.Dissolution of feldspar-laumontite during the process of organic matter evolution generated abundant secondary pores and improved the reservoir quality. | WU Songtao ZOU Caineng ZHU Rukai YAO Jingli TAO Shizhen YANG Zhi ZHAI Xiufen CUI Jingwei LIN Senhu | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 13 |
| 7 | AN EXISTENCE THEOREM OF POSITIVE SOLUTIONS FOR ELASTIC BEAM EQUATION WITH BOTH FIXED END-POINTS显示文摘By using the degree theory on cone an existence theorem of positive solution for a class of fourth-order two-point BVP’s is obtained. This class of BVP’s usually describes the deformation of the elastic beam with both fixed end-points. | Jiang Xiufen Yao Qingliuof Math., Northwest Normal Univ., Lanzhou 730070. | 2001 | Applied Mathematics(A Journal of Chinese Universities)2001，16，3： | 12 |
| 8 | Methylated and thiolated arsenic species for environmental and health research——A review on synthesis and characterization显示文摘Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following14 trivalent(Ⅲ) and pentavalent() arsenic compounds: monomethylarsonous acid(MMA~Ⅲ), dicysteinylmethyldithioarsenite(MMA~Ⅲ(Cys)_2), monomethylarsonic acid(MMA~Ⅴ),monomethylmonothioarsonic acid(MMMTAⅤ) or monothio-MMA~Ⅴ, monomethyldithioarsonic acid(MMDTA~Ⅴ) or dithio-MMA~Ⅴ, monomethyltrithioarsonate(MMTTA~Ⅴ) or trithio-MMA~Ⅴ,dimethylarsinous acid(DMA~Ⅲ), dimethylarsino-glutathione(DMA~Ⅲ(SG)), dimethylarsinic acid(DMA~Ⅴ), dimethylmonothioarsinic acid(DMMTA~Ⅴ) or monothio-DMAⅤ, dimethyldithioarsinic acid(DMDTA~Ⅴ) or dithio-DMA~Ⅴ, trimethylarsine oxide(TMAO~Ⅴ), arsenobetaine(AsB), and an arsenicin-A model compound. We have reviewed and compared the available methods,synthesized the arsenic compounds in our laboratories, and provided characterization information. On the basis of reaction yield, ease of synthesis and purification of product, safety considerations, and our experience, we recommend a method for the synthesis of each of these arsenic compounds. | William R.Cullen Qingqing Liu Xiufen Lu Anthony McKnight-Whitford Hanyong Peng Aleksandra Popowich Xiaowen Yan Qi Zhang Michael Fricke Hongsui Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 12 |
| 9 | An intracellular toxic protein (Xin) isolated from Xenorhabdus nematophilus strain BJ显示文摘An intracellular toxic protein, designated Xin and with remarkable inhibitory effect on growth of Helicoverpa armigera, was isolated from X. Nematophilus strain BJ by ion exchange chromatography and hydrophobic interaction chromatography. After placing neonates on the artificial diet containing Xin at concentration of 0 or 3.48μg/g for 7 days, the average weight of insects was 23.50mg and 0.55mg, respectively. The activity of Xin was lost by heating, freeze-drying, digestion with proteases or urea. The Xin molecular weight, over kD, was determined by gel filtration on Superose 12, and there were six component proteins analyzed by SDS-PAGE. The results show that Xin is a high molecular protein complex inhibiting growth of insect pest. | PAN Yinghong , JIAN Heng , ZHANG Jie , LIU Zheng, CHEN Zhongyi , YANG Xiufen, YANG Huaiwen and HUANG Dafang( State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China Institute of Biocontrol Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China Institute of Biotechnology Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 9 |
| 10 | Stable isotope labelled mass spectrometry for quantification of the relative abundances for expressed proteins induced by PeaT1显示文摘The protein elicitor from the mycelium of Alternaria tenuissima has been isolated.The elicitor triggered resistance to the tobacco mosaic virus in tobacco by inducing relative oxygen species,but without causing hypersensitive necrosis.The elicitor is reported to impart resistance against Verticillium dahliae and to increase yield in cotton,but its mechanism is not yet clear.In this study,the stable isotope labelled mass spectrometry method was used to quantify the relative abundances of protein expression induced by PeaT1 in Arabidopsis.A significant difference in the relative abundances for the expression of different proteins related to metabolism,modification,regulatory,defense,stress and antioxidation was found in Arabidopsis. | LI GuangYue,YANG XiuFen,ZENG HongMei,MAO JianJun,LIU Hua,ZHANG YunHua & QIU DeWen* Key Laboratory for Biological Control of the Ministry of Agriculture,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100081,China | 2010 | Science China(Life Sciences)2010，53，12： | 7 |
| 11 | Digitally determining forest inventory units with an ecological classification system显示文摘Management-level forest resource data in China were obtained with a combination of two forest inventories. However, inconsistencies in the spatial attributes of forest data vary between the two inventory types and between two inventories of the same type. The inconsistencies make it inconvenient for long-term forest management planning with digital technologies. Ecological Land Types (ELTs) and Ecological Land Type Phases (ELTPs) have been mapped in selected forestry regions in northeast China, where important forest industries are located. The boundaries of ELTs are determined by geomorphic conditions, which are quantified by Digital Elevation Models (DEM); ELTPs are classified by overlaying ELTs with forest vegetation data layers that are obtained with both remotely sensed and ground data. The ELTPs represent the divisions of land in terms of both natural and human-induced forest conditions, and therefore they are reliable units for forest inventories and management. This paper introduces a case study for digitally determining forest inventory units in Benxi City, Liaoning Province, northeast China. The general objective of the study was to explain how a compatible forest inventory system should be designed and why the compatible forest inventory system was significant to digital forestry in China. | TANG Una, WANG Qingli, Guofan Shao, DAI Limin, WANG Shunzhong, LI Xiufen & XU Dong Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate University of Chinese Academy of Sciences, Beijing 100101, China Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA | 2006 | Science China(Technological Sciences)2006，49，z1： | 6 |
| 12 | Insight into the distribution of metallic elements in membrane bioreactor: Influence of operational temperature and role of extracellular polymeric substances显示文摘The distribution of metallic elements in a submerged membrane bioreactor(MBR) was revealed at different temperatures using inductively coupled plasma-optical emission spectrometry(ICP-OES), and the role of extracellular polymeric substances(EPS) was probed by integrating scanning electron microscopy(SEM) with confocal laser scanning microscopy(CLSM) over long-term operation. More metallic elements in the influent were captured by suspended sludge and built up in the fouling layer at lower temperature. The concentration of metallic elements in the effluent was 5.60 mg/L at 10°C operational temperature, far lower than that in the influent(51.35 mg/L). The total contents of metallic elements in suspended sludge and the membrane fouling layer increased to 40.20 and 52.19 mg/g at 10°C compared to 35.14 and 32.45 mg/g at 30°C, and were dominated by the organically bound fraction. The EPS contents in suspended sludge and membrane fouling layer sharply increased to 37.88 and 101.51 mg/g at 10°C, compared to 16.87 and 30.03 mg/g at 30°C. The increase in EPS content at lower temperature was responsible for the deposition of more metallic ions. The strong bridging between EPS and metallic elements at lower temperature enhanced the compactness of the fouling layer and further decreased membrane flux. This was helpful for understanding the mechanism of membrane fouling at different operational temperatures and the role of EPS, and also of significance for the design of cleaning strategies for fouled membranes after long-term operation. | He Wang Xiufen Li Xinhua Wang Yueping Ren | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 13 | Influences of tissue composition and structural features of biological media on the ultrasonic nonlinearity parameter显示文摘The Acoustic nonlinearity parameter is an important parameter innonlinear acoustics.In this article,the nonlinearity parameter B/A of normaland eight kinds of pathological porcine liver tissues were measured by finiteamplitude insert-substitution method.The mixture law for nonlinearityparameter is used to analyze and predict the volume fractions of the compo-nents in a given tissue.It was found that the nonlinearity parameter is sensitiveto the pathological forms of biological tissues and the values of B/A dependon the tissue composition and structural features. | GONG Xiufen LIU Xiaozhou ZHANG Dong Rui Bing and CAO Lianzhi(Institute of Acoustics, Nanjing University, Nanjing 210008)Nanjing Meat Processing Plant. | 1993 | Chinese Journal of Acoustics1993，12，3： | 4 |
| 14 | Molecular characterization of bacterial community in aerobic granular sludge stressed by pentachlorophenol显示文摘To characterize the effects of pentachlorophenol (PCP) on the performance and microbial community of aerobic granular sludge in sequencing batch reactor (SBR), the web-based terminal restriction fragment length polymorphism (T-RFLP) and real-time PCR (RT- PCR) techniques were used to explore the bacterial community structure. When PCP increased from 0 to 50 mg/L, the COD removal rate changed little, while the ammonia removal rate dropped from 100% to 64.9%. The results of molecular characterization showed that the quantity of ammonia oxidizing bacteria (AOB) kept constantly, although the number of bacteria species decreased with the increase of PCP concentration. Significant shift in bacterial community structure at different PCP stresses was observed within aerobic granular sludge. When the PCP was absent, there are 69 strains in aerobic granular sludge detected by T-RFLP method. With the increase of PCP, most of bacteria disappeared and only 19 bacteria existed at all five PCP concentrations. These results contributed to comprehensive understanding of the microbial community structure under the PCP stress and its relationship with the performance for wastewater treatment by aerobic granular sludge. | LIU, He LI, Guangwei LI, Xiufen CHEN, Jian | 2008 | Journal of Environmental Sciences2008，20，10： | 4 |
| 15 | Discovery and its geological significance of the mantle- derived helium in the inclusions of the Ordovician oil-bearing reservoir rocks in the Huanghua depression,China显示文摘The values of the helium isotopes in the inclusions of the Ordovician reservoir rocks in the Kongxi buried hill belt in the Huanghua depression were first measured and the source of helium and its geological significance were investigated in comparison with those of the helium isotopes in the conclusions in the Ordovician rocks in the Ordos basin and the Tarim basin. The input of the mantle-derived helium into the inclusions in the carbonate reservoir rocks was found from the Konggu 3 well, the Konggu 4 well, and the Konggu 7 well in the Kongxi buried hill belt. The 3He/4He and R/Ra in the conclusions in the Ordovician oil-bearing reservoir rocks in the Konggu 7 well average 2.54×10-6(3) (sample quantity, the same below) and 1.82(3), respectively. The percent of the mantle-derived helium in the inclusions of the reservoir rocks in the Konggu 7 well reaches up to an average of 23.0%(3). The age of the contribution of the mantle-derived helium to the inclusions in the Kongxi buried hill belt is in the Late Triassic or the Early Tertiary. The finding of the mantle-derived helium shows that the interaction of the deep crust with mantle and the activity of deep faults occurred, the terrestrial heat flow value was high, and mantle-derived inorganic gas pools might be formed in the Kongxi buried hill belt. The finding of the mantle-derived helium in the inclusions of oil-bearing reservoir rocks also provides a new way for researching the activity of mantle-derived matter and its associated geological problems. | ZHANG Xiaobao XU Yongchang SUN Mingliang CHENG Keming LIU Wenhui LI Xiufen MA Liyuan | 2004 | Science China Earth Sciences2004，47，1： | 4 |
| 16 | Inactivation of the positive LuxR-type oligomycin biosynthesis regulators OlmRI and OlmRII increases avermectin production in Streptomyces avermitilis显示文摘Oligomycins are a group of 26 macrocyclic lactones that exhibit broad biological activities,including antifungal,anticancer and nematocidal activities.Analysis of the oligomycin biosynthetic gene cluster (olm) in S.avermitilis revealed 2 tandem LuxR-type regulators,OlmRI (931 aa) and OlmRII (941 aa),with shared identity of 38%.Gene replacement of olmRI or olmRII abolished oligomycin production,and this production could be partially restored in the disruptants by introducing cloned olmRI and olmRII with their native promoters,demonstrating the essential role of OlmRI and OlmRII for oligomycin biosynthesis.Quantitative real-time RT-PCR analysis revealed that transcription of 14 olm genes was differentially affected by the deletion of olmRI and olmRII.Unexpectedly,avermectin production in both mutants was enhanced at least 4-fold.The identification of the positive cluster-situated regulators,OlmRI and OlmRII,paves the way for the transcriptional analysis of oligomycin biosynthesis and for the enhancement of oligomycin and avermectin production through regulator engineering. | YU Qing BAI LinQuan ZHOU XiuFen DENG ZiXin | 2012 | Chinese Science Bulletin2012，57，8： | 4 |
| 17 | Altered small-world,functional brain networks in patients with lower back pain显示文摘In this study, we aimed to investigate the functional network changes that occur in patients with lower back pain(LBP). We also investigated the link between LBP and the small-world properties of functional networks within the brain. Functional MRI(fMRI) was performed on 20 individuals with LBP and 17 age and gender-matched normal controls during the resting state. The severity of the pain in the individuals with LBP ranged from 5 to 8 on a 0–10 scale, with 0 indicating no pain. Network-based statistics were performed to investigate the differences between the brain networks of individuals with LBP and those of normal controls. Several small-world parameters of brain networks were calculated, including the clustering coefficient, characteristic path length, local efficiency, and global efficiency. These criteria reflect the overall network efficiency. The brain networks in the individuals with LBP due to herniation of a lumbar disc demonstrated a significantly longer characteristic path length as well as a lower clustering coefficient, global efficiency, and local efficiency compared to those in control subjects. We found that LBP patients tended to have unstable and inefficient brain networks when compared with healthy controls. In addition, LBP individuals showed significantly decreased functional connectivity in the anterior cingulate cortex, middle cingulate cortex, post cingulate cortex, inferior frontal gyrus, middle temporal gyrus, occipital gyrus, postcentral gyrus, precentral gyrus, supplementary motor area, thalamus, fusiform, caudate, and cerebellum. We believe that these regions may be involved in the pathophysiology of lower back pain. | Jing Liu Feng zhang Xiufen Liu Zhizheng Zhuo Juan Wei Minyi Du Queenie Chan Xiaoying Wang Dongxin Wang | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 18 | microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro显示文摘Objective To investigate the effects of microRNA-18a(miR-18a) on migration and invasion of hepatocellular carcinoma(HCC) cells,and its possible mechanism associated with Dicer l. Methods HepG 2 and HepG 2.2.15 cells were transfected with miR-18 a inhibitor using Lipofectamine. Cell invasion was evaluated by transwell invasion assay,and cell migration was detected by transwell migration and wound-healing assays. Moreover,luciferase reporter assay was used to identify whether Dicer expression was regulated by miR-18 a. Real-time RT-PCR and western blot were performed to analyze Dicer 1 expression. In addition,a functional restoration assay was performed to investigate whether miR-18 a promotes HCC cell migration and invasion by directly targeting Dicer 1. Results miR-18 a inhibitor can suppress the migration and invasion of HCC cells. Furthermore,suppression of Dicer l expression by small interfering RNA essentially abolished the inhibition of cell migration and invasion induced by miR-18 a inhibitor,restorating these activities to levels similar to the parental HCC cells. Interestingly,suppression of miR-18 a in HCC cells resulted in enhanced expression of Dicer l. In addition,the results of a luciferase assay demonstrated targeted regulation of Dicer l by miR-18 a. Conclusion Our findings suggest that miR-18 a promotes migration and invasion of HCC cells by inhibiting Dicer l expression. | Xiufen Zhang Bo Yu Fuzheng Zhang Zijian Guo Lihua Li | 2017 | Chinese Medical Sciences Journal2017，32，1： | 3 |
| 19 | Public cloud computing for seismological research:Calculating large-scale noise cross-correlations using ALIYUN显示文摘The amount of seismological data is rapidly increasing with accumulating observational time and increasing number of stations, requiring modern technique to provide adequate computing power. In present study, we proposed a framework to calculate large-scale noise crosscorrelation functions(NCFs) using public cloud service from ALIYUN. The entire computation is factorized into small pieces which are performed parallelly on specified number of virtual servers provided by the cloud. Using data from most seismic stations in China, five NCF databases are built. The results show that, comparing to the time cost using a single server, the entire time can be reduced over two orders of magnitude depending number of evoked virtual servers. This could reduce computation time from months to less than 12 hours. Based on obtained massive NCFs, the global body waves are retrieved through array interferometry and agree well with those from earthquakes. This leads to a solution to process massive seismic dataset within an affordable time and is applicable to other large-scale computing in seismological researches. | Weitao Wang Baoshan Wang Xiufen Zheng | 2018 | Earthquake Science2018，31，5： | 3 |
| 20 | Analysis of the simultaneous adsorption mechanism of ammonium and phosphate on magnesium-modified biochar and the slow release effect of fertiliser显示文摘To decrease the eutrophication caused by nitrogen(N)and phosphorus(P)in water,magnesium-modified corn stalk biochar(MgB)was prepared under the synergistic impact of the multi-pyrolysis temperatures and Mg^(2+)contents for the co-adsorption of ammonium(NH_(4)^(+)-N)and phosphate(PO_(4)^(3−)).The co-adsorption mechanism,slow-release performance and plant application of MgB were systematically studied.The results showed that pyrolysis temperatures(350-650℃)and Mg^(2+)(0-3.6 g/L)contents not only altered the physicochemical properties of biochar,but also significantly affected the adsorption efficacy of MgB.The adsorption of NH_(4)^(+)-N and PO_(4)^(3−)was in accordance with Langmuir-Freundlich and pseudo-second-order kinetic models(Q_(max)=37.72 and 73.29 mg/g,respectively).Based on the characteristics,adsorption kinetics and isotherms results,the adsorption mechanism was determined and found to mainly involve struvite precipitation,ion exchange,and surface precipitation or electrostatic attraction.Compared with the leaching performance of chemical fertilizers(CF),after adsorption of NH_(4)^(+)-N and PO_(4)^(3−)(MgB-A),MgB had a more stable pH and lower conductivity.Leaching of NH_(4)^(+)-N and PO_(4)^(3−)by MgB-A was controlled by both the diffusion mechanism and the dissolution rate of struvite and Mg-P.The excel-lent long-term slow-release performance and abundant Mg^(2+)of MgB-A promoted the growth of Zea mays L.and Lolium perenne L.Overall,this study suggested that MgB could realize a win-win outcome of struvite biochar-based fertiliser production and wastewater treatment. | Qingshan He Xiufen Li Yueping Ren | 2022 | Biochar2022，4，1： | 3 |
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