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| 1 | Cap-specific, terminal N^6-methylation by a mammalian m6Am methyltransferase显示文摘Dear Editor,Dynamic and reversible N6-methyladenosine (m6A) RNA methylation has been found to greatly impact gene expression, leading to the field of epitranscriptomics.1 Unlike m6A that is an internal modification, a terminal modification at mRNA cap in higher eukaryotes exists, termed as N6,2′-O-dimethyladenosine (m6Am) (Fig. 1a). | Hanxiao Sun Meiling Zhang Kai Li Dongsheng Bai Chengqi Yi | 2019 | Cell Research2019，29，1： | 7 |
| 2 | Viral MIPα homologous with human MIP-1α acts on HIV co-receptor CCR5显示文摘The function and usage of vMIPα encoded by K6 gene of herpesvirus 8 (HHV8) which has homology with human macrophage protein (MIP) have not been clearly known. In the present note the K6 gene of HHV8 was cloned and transfected into NIH3T3 cells and E. coli cells. Conditional media from the 3T3-transfected cells and K6 product vMIPa from E. coli. Cells were used to perform the experiments of ligand-receptor binding and cellular adhesion with peripheral blood macrophages. The conditional media and the purified vMIPa from E. coli could compete to bind to CCR5 located on macrophages from peripheral blood with I125-hMIP-1α chemokine of human. Cellular adhesion showed that the conditional media from transfected cells and the purified vMIPa did not induce the adhesion of macrophages from peripheral blood to ICAM-1. In conclusion, vMIPα encoded by K6 gene of HHV8 can bind to CCR5 of peripheral blood macrophage cells and does not induce their adhesion. This suggests that vMIPa enclosed CCR5, also known as HIV | Hanxiao Sun Lixia Feng Yicheng Li Wenfang He | 2001 | Chinese Science Bulletin2001，46，15： | 6 |
| 3 | The m^(6)A methylome of SARS-CoV-2 in host cells显示文摘The newly identified Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)has resulted in a global health emergency because of its rapid spread and high mortality.The molecular mechanism of interaction between host and viral genomic RNA is yet unclear.We demonstrate herein that SARS-CoV-2 genomic RNA,as well as the negative-sense RNA,is dynamically N6-methyladenosine(m^(6)A)-modified in human and monkey cells.Combined RIP-seq and miCLIP analyses identified a total of 8 m^(6)A sites at single-base resolution in the genome.Especially,epidemic strains with mutations at these identified m^(6)A sites have emerged worldwide,and formed a unique cluster in the US as indicated by phylogenetic analysis.Further functional experiments showed that m^(6)A methylation negatively regulates SARS-CoV-2 infection.SARS-CoV-2 infection also triggered a global increase in host m^(6)A methylome,exhibiting altered localization and motifs of m^(6)A methylation in mRNAs.Altogether,our results identify m^(6)A as a dynamic epitranscriptomic mark mediating the virus–host interaction. | Jun’e Liu Yan-Peng Xu Kai Li Qing Ye Hang-Yu Zhou Hanxiao Sun Xiaoyu Li Liu Yu Yong-Qiang Deng Rui-Ting Li Meng-Li Cheng Bo He Jia Zhou Xiao-Feng Li Aiping Wu Chengqi Yi Cheng-Feng Qin | 2021 | Cell Research2021，31，4： | 5 |
| 4 | Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-Ⅱ and its Mechanism of signal transmission in vitro显示文摘Dear Editor,COVID-19 cases showed a significant decrease in the number of peripheral CD4^(+) and CD8^(+)T cells accompanied by overactivation of cells.1 HHV8-derived viral macrophage inflammatory protein vMIP-Ⅱ is the only broad-spectrum chemokine receptor inhibitor that binds to three subtribes of chemokine receptors,which can significantly increase the specific cell immune response in infected organisms and have an effect of reducing plasma viral load on the viremia period.24 Here we report the effect of vMIP-Ⅱ in COVID-19. | Shiyu Li Shuting Liu Zhenyou Jiang Lixia Feng Yong Gao Youyu Chen Anding Xu Wenhua Huang Nuofu Zhang Hanxiao Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 5 |
| 5 | Isolation and gut microbiota modulation of antibiotic-resistant probiotics from human feces显示文摘 | Peng Tian Bo Xu Hanxiao Sun | 2014 | Diagnostic Microbiology and Infectious Disease2014，79，： | 1 |
| 6 | Turnpike Properties for Stochastic Linear-Quadratic Optimal Control Problems显示文摘This paper analyzes the limiting behavior of stochastic linear-quadratic optimal control problems in finite time-horizon[0,T]as T→∞.The so-called turnpike properties are established for such problems,under stabilizability condition which is weaker than the controllability,normally imposed in the similar problem for ordinary differential systems.In dealing with the turnpike problem,a crucial issue is to determine the corresponding static optimization problem.Intuitively mimicking the deterministic situations,it seems to be natural to include both the drift and the diffusion expressions of the state equation to be zero as constraints in the static optimization problem.However,this would lead us to a wrong direction.It is found that the correct static problem should contain the diffusion as a part of the objective function,which reveals a deep feature of the stochastic turnpike problem. | Jingrui SUN Hanxiao WANG Jiongmin YONG | 2022 | Chinese Annals of Mathematics,Series B2022，43，6： | 1 |
| 7 | Emerging roles of ILC2s in antitumor immunity显示文摘Group 2 innate lymphoid cells(ILC2s)are a subset of ILCs that lack T and B-cell antigen receptors[1].ILC2s share similarities with CD4+T helper 2 cells(Th2)in transcription factor GATA3 expression and signature cytokines production,such as IL-5 and IL-13[1]. | Zhao Li Hanxiao Sun Zhitao Gua Ju Qiu | 2022 | Cellular & Molecular Immunology2022，19，11： | 0 |
| 8 | Differential immune responses in pregnant patients recovered from COYID-19显示文摘Pregnant women are generally more susceptible to viral infection.Although the impact of SARS-CoV-2 in pregnancy remains to be determined,evidence indicates that the risk factors for severe COVID-19 are similar in pregnancy to the general population.Here we systemically analyzed the clinical characteristics of pregnant and non-pregnant female COVID-19 patients who were hospitalized during the same period and found that pregnant patients developed marked lymphopenia and higher inflammation evident by higher C-reactive protein and IL-6.To elucidate the pathways that might contribute to immunopathology or protective immunity against COVID-19 during pregnancy,we applied single-cell mRNA sequencing to profile peripheral blood mononuclear cells from four pregnant and six non-pregnant female patients after recovery along with four pregnant and three non-pregnant healthy donors.We found normal clonal expansion of T cells in the pregnant patients,heightened activation and chemotaxis in NK,NKT,and MAIT cells,and differential interferon responses in the monocyte compartment.Our data present a unique feature in both innate and adaptive immune responses in pregnant patients recovered from COVID-19. | Ge Chen Yiming Zhang Yaoyao Zhang Jihui Ai Bin Yang Mengge Cui Qiuyue Liao Hanxiao Chen Hualin Bai Dashing Shang Jing Chen ChaoYang Sun Haiyi Liu Fengyuan Liu Bin Mao Guoqiang Sun Lu Chen Jing-wen Lin Kezhen Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 9 | Integrated evaluation of HPLC fingerprints for the quality control of Ginseng Yang Rong Wan by multi-wavelength fusion fingerprint method显示文摘The aim of this study was to develop comprehensive evaluation methods for the quality control of Ginseng Yang Rong Wan(RSYRW).Multi-wavelength fusion fingerprints were successfully developed by high-performance liquid chromatography,which avoided the one-sidedness of single fingerprinting.Characteristic fingerprints of thirty batches of samples were generated at five wavelengths and evaluated by quantified ratio fingerprint method(QRFM).The results showed that thirty batches of samples were classified into seven grades.The methods established in this paper were found suitable for the analysis of Ginseng Yang Rong Wan. | Hanxiao Chi Guoxiang Sun | 2019 | Asian Journal of Traditional Medicines2019，14，4： | 0 |
| 10 | 针对功率MEMS器件而设计的高电感密度3D MEMS片内螺线管电感器显示文摘在本文中,我们报告了3D电磁电感的设计和测量,该电感嵌入在Si基板中并且可以集成铁芯。通过兼容CMOS的MEMS制造工艺,我们制造出具有良好结构完整性和可重复性的各种电感器设计。电感器的平均电感和品质因数峰峰值变化低于10%,这表明制造工艺是可重复的。在没有铁芯的电感器中,5匝电感器达到最高品质因数(21MHz时为37.6),20Ω电感器中达到了最高的电感和电感密度(分别为86.6nH和21.7nH/mm^2)。在铁芯电感器中,15匝电感器的电感为1063nH,电感密度为354.3nH/mm^2,比不带铁芯的相同设计高近18倍,据我们所知,这是MEMS微电感的最高电感密度。这种类型的电感器是RF MEMS和电磁功率MEMS器件中的重要组件,可以提高其性能和效率。 | Tiantong Xu Jiamian Sun Hanxiao Wu Haiwang Li Hanqing Li Zhi Tao | 2020 | 磁性元件与电源2020，，6： | 0 |
| 11 | Erratum to:Turnpike Properties for Stochastic Linear-Quadratic Optimal Control Problems显示文摘Erratum to:https://doi.0rg/10.1007/s11401-022-0374-x 1.The third line of page 999,the first author's name Jiangrui SUN should be changed to JingruiSUN.2.The seventh lineofpage 6 of file totalcontents-43B6.pdf,JiangruiSUN should be changed to Jingrui SUN. | Jingrui SUN Hanxiao WANG Jiongmin YONG | 2023 | Chinese Annals of Mathematics,Series B2023，44，1： | 0 |
| 12 | Evaluating the quality consistency of compound Liangmianzhen buccal tablets during accessories replacement by HPLC/UV related with its active profiling and UV dissolution profiles显示文摘Compound Liangmianzhen buccal tablet is a drug that exhibits notable effect on cough and diphtheria.Since the accessory has been changed,along with the difficulties in traditional Chinese drug-evaluation,it is imperative to set up a reliable method to evaluate the drug and ensure the quality consistency.First,the content of the Compound Liangmianzhen buccal tablets reflected by fingerprints were evaluated by the comprehensive linearly quantified fingerprint method and systematic quantified fingerprint method,in which thirteen fingerprint peaks was selected and gallic acid was chosen as the reference peak.The results of the two methods showed all batches in grades 1–3 of above good level with the qualitative similarities of Sl and Sm above 0.90,and the quantitative ones of Pl%and Pm%from 80%–120%,indicating all samples far qualified.Second,the measurement of antioxidant effect based on DPPH free radical clearance test has demonstrated the consistency between the old prescription group and the new ones and further dug up the major antioxidant compositions.Third,dissolution profiles at 190 to 400 nm that evaluate the curative effect consistency were evaluated by f2 and the correlation of the dissolution curve.In conclusion,the combination of 3 kinds of analysis methods can comprehensively assess the quality of the traditional Chinese drug and be served as a routine procedure to evaluate the herbal medicine consistency. | Yue Yu Hanxiao Chi Guoxiang Sun Fangliang Yang Wanyang Sun Jiayue Hu Yanhua Zhang | 2020 | Asian Journal of Traditional Medicines2020，15，1： | 0 |
| 13 | Group 2 innate lymphoid cells can engulf and destroy bacteria显示文摘Group 2 innate lymphoid cells(ILC2s)are now known to play prominent roles in many inflammatory responses involving the production of Th2-type cytokines,which contribute to parasitic infections,tissue repair,and metabolic homeostasis[1].More recently,it has emerged that ILC2s may act as antigen-presenting cells,although corresponding evidence of phagocytic activity of these cells is currently scarce[2,3].Herein,we investigated whether ILC2s can phagocytose bacteria,through in vitro experiments. | Yiran Yang Yan Li Yingjie Xu Hanxiao Zhang Yuhan Diao Shihao Chen Ye Cui Chris J.Corrigan Wei Wang Sun Ying | 2021 | Cellular & Molecular Immunology2021，18，11： | 0 |
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