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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The naturalhistory of primary dysmen orrhea:a longitudinal study显示文摘 | Weismann A M Hartz A J Hansen M D | 2004 | Br J Obstet Gynaecol2004，111，4： | 1 |
| 3 | Novel glimepiride derivatives with potential as double-edged swords against type II diabetes显示文摘 | Müller G Schulz A Hartz D | 2010 | Arch Physiol Biochem2010，116，1： | 1 |
| 4 | Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier显示文摘 | Bauer B Hartz A M Miller D S | | 0，，03： | 1 |
| 5 | Managing fruit solu- ble solids with late-seasan deficitirrigation in drip-irrigated processing tomato production 显示文摘 | Johnstone P R Hartz T K LeStrange M | 2005 | Hortscience2005，40，6： | 1 |
| 6 | Coordinated nuclear receptor regulation of the efflux transporter,Mrp2,and the phaseII metabolizing enzyme,GSTpi,at the blood-brain barrier显示文摘 | Bauer B Hartz A M Lucking J R | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 7 | Rapid regulation of p-glycoprotein at the blood-brain barrier by endothelin-1显示文摘 | HARTZ A M BAUER B FRICKER G | 2004 | Mol Pharmacol2004，10，： | 1 |
| 8 | Mortality study of 18 000 patients treated with omeprazole显示文摘 | Bateman DN Colin-Jones D Hartz S Langman M Logan RF Mant J | 2003 | Gut2003，52，： | 1 |
| 9 | Accurate value-at-risk forecasting based on the normal-GARCH model显示文摘 | Hartz C Mittnik S Paolella M | 2006 | Computational Statistics & Data Analysis2006，51，4： | 1 |
| 10 | Pharmacologic induction of posterior vitreous detachment in the rabbit显示文摘 | Verstraeten TC Chapman C Hartze M | 1993 | Arch Ophthalmol1993，111，6： | 1 |
| 11 | Secondary organic aerosol from biogenic volatile organic compound mixtures显示文摘 | HATFIELD M L HUFF HARTZ K E | 2011 | Atmospheric Environment2011，45，22： | 1 |
| 12 | Amyloid-p contributes to blood-brain barrier leakagein transgenic human amyloid precursor protein mice and inhumans with cerebral amyloid angiopathy显示文摘 | Anika M S Hartz Bjorn Bauer Emma L B Soldner | 2012 | Stroke2012，43，2： | 1 |
| 13 | Accurate value-at-risk forecasting based on the normal-GARCH model显示文摘 | Hartz C Mittnik S Paolella M | 2006 | Computational Statistics & Data Analysis2006，51，4： | 1 |
| 14 | Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier显示文摘 | Bauer B Hartz A M S Fricker G Miller D S | 2004 | Mol Pharmacol2004，66，： | 1 |
| 15 | Secondary organic aerosol frombiogenic volatile organic compound mixtures 显示文摘 | Hatfield M L Huff Hartz K E | 2011 | AtmosphericEnvironment2011，45，13： | 1 |
| 16 | Accurate Value-at-risk Forecasting Based on the Normal-GARCH Model显示文摘 | HARTZ C MITTNIK S Paolella M | | 0，，04： | 1 |
| 17 | Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants 显示文摘 | Weissman A M Levy B T Hartz A J | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 18 | Regulation of ABC transporters at the blood-brain barrier:new targets for CNS therapy显示文摘 | Hartz A M Bauer B | 2010 | Mol Interv2010，10，5： | 1 |
| 19 | Managing fruit soluble solids with late-season deficit irrigation in drip-irrigated processing tomato production显示文摘 | Johnstone P R Hartz T K LeStrange M | 2005 | Hortscience2005，40，6： | 1 |
| 20 | Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants显示文摘 | WEISSMAN A M LEVY B T HARTZ A J | 2004 | The American Journal of Psychiatry2004，161，6： | 1 |
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