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| 1 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial显示文摘 | Florian Lordick Yoon-Koo Kang Hyun-Cheol Chung Pamela Salman Sang Cheul Oh Gy?rgy Bodoky Galina Kurteva Constantin Volovat Vladimir M Moiseyenko Vera Gorbunova Joon Oh Park Akira Sawaki Ilhan Celik Heiko G?tte Helena Melezínková Markus Moehler | 2013 | Lancet Oncology2013，，6： | 14 |
| 2 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 3 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 4 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 5 | Thermolytic molecular precursor route to active and selective vanadia-zirconia catalysts for the oxidative dehydrogenation of propane显示文摘 | Jonathan L Male Heiko G Niessen Alexis T Bell | 2000 | J Catal2000，194，2： | 1 |
| 6 | Analysis of tumou necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancertitis European Journal of Gastroenterology ? 显示文摘 | Greenstein G Teich Niels Witt Heiko | 2003 | Hepatc2003，15，： | 1 |
| 7 | TPR study on the preparation of impregnated Co/SiO2 catalysts显示文摘 | ERIC V S SEWELL G S MAKHOTHE R A MAKHOTHE CRAIG M HEIKO M MARTIJIN D L CYRIL T O | 1996 | J Catal1996，162，2： | 1 |
| 8 | Expanded product,plus kinetic and mechanistic studies ofpolyoxoanion-based cyclohexane oxidation catalysis:the detection of ~70 products at higher conversion leading to a simple product based test for the presence of olefine autoxidation显示文摘 | Heiko Weiner Alessandro Trovarei Richard G Fink | 2003 | J Mol Catal A:Chem2003，191，2： | 1 |
| 9 | Telechelic and star-shaped poly(L-lactide) s by means of bismuth ( Ⅲ ) acetate as initiator 显示文摘 | Kricheldorf H R Heiko H T Schwarz G | 2004 | Biomacromolecules2004，5，2： | 1 |
| 10 | Particle-size distribution of PAH in the air of a remote Norway spruce forest in northern Bavaria显示文摘 | Heiko S Georg G Klaus P | 2001 | Water Air and Soil Pollution2001，128，： | 1 |
| 11 | Periodontal disease as a risk factor for ischemic stroke 显示文摘 | Armin G Heiko B Christoph Z | 2004 | Stroke2004，35，3： | 1 |
| 12 | Innovation of product-related services显示文摘 | Heiko G Regine K Elgar F Thomas F | | 0，，04： | 1 |
| 13 | miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions显示文摘 | Helge Siemens Rene Jackstadt Sabine Hünten Markus Kaller Antje Menssen Ursula G?tz Heiko Hermeking | 2011 | Cell Cycle2011，，24： | 1 |
| 14 | Approximate entropy as an electrocencephalographie measure of anesthetic drug effect during desflurane anesthesia显示文摘 | Jorgen B Heiko G Ropcke T | 2000 | Anesthesiology2000，92，： | 1 |
| 15 | Expanded product, plus kinetic and mechanistic, studies of polyoxoanionbased cyclohexene oxidation catalysis: the detection of - 70 products at higher conversion leading to a simple, product - based test for the presence of olefin autoxidation 显示文摘 | Heiko Weiner Alessandro Trovarelli Richard G Finki | 2003 | Journal of Molecular Catalysis A:Chemical2003，，191： | 1 |
| 16 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 1 |
| 17 | High level and low level plagiogranites from the Nicoya ophiolite complex, Cosa Rica, Cebtral America显示文摘 | Heiko G H Wildberg Karlsruhe | 1987 | Geologische Rundschau1987，761，： | 1 |
| 18 | Innovation of Product - related Services 显示文摘 | Heiko G Regine K Elgar F Thomas | 2008 | Managing Service Quality2008，18，4： | 1 |
| 19 | IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis显示文摘 | Rokavec Matjaz ?ner Meryem G?lfem Li Huihui Jackstadt Rene Jiang Longchang Lodygin Dmitri Kaller Markus Horst David Ziegler Paul K Schwitalla Sarah Slotta-Huspenina Julia Bader Franz G Greten Florian R Hermeking Heiko | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 20 | Foresight supportsystems to facilitate regional innovations: A conceptu-alization case for a German logistics cluster 显示文摘 | Keller J MarkmannC Heiko A G | 2015 | Technological Forecasting Social Change2015，97，： | 1 |
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