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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Cancer immunotherapy显示文摘Unprecedented progress has seen made in the last decade in the fi eld of cancer immunotherapy.The recent approval of nivolumab(Opdivo),the fi rst anti-programmed cell death-1(PD-1)antibody,for metastatic melanoma in Japan,marked a milestone in the rapidly advancing fi eld of cancer immunotherapy.Nivolumab together | Li Yan Helen X.Chen | 2014 | Chinese Journal of Cancer2014，33，9： | 10 |
| 3 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 4 | 深圳水围柠盟人才公寓显示文摘在深圳,城中村一直都是一个热门的话题,多种观点相互碰撞。在过去的一二十年里,城中村的改造就意味着大规模的拆迁,彻底推倒重建,拆迁改善了生活环境,创造了财富,但导致了城市空间匀质化,同时,造成了一些社会问题,更割断了城市的历史。目前深圳市新出台的政策是通过综合整治,让城中村全面进入柔性改造的通道,鼓励在原来的用地上开展城中村的综合整治。然而新政策出台不久之后,却又发生了原住民反对综合整治,要求城市更新的情况。说明政策的转变对城中村的居民和开发企业都产生了很大的影响,“综合整治”和“拆除重建”的投入产出模型完全不同,两种模式的转变,意味着居民的诉求和企业的战略都应当做出相应的调整,在新形势下共同努力,继续探索。为此,我们选登了通过综合整治获得比较成功的水围村项目,该项目保留了城市的肌理、文脉和集体记忆,同时,也提升了消防、市政配套,及改善了生活设施。并增加空中连廊、电梯,创造出了一个符合现代标准的宜居空间立体的社区。该项目改造后,由政府返租补贴,并以低于市场的价格出租,以确保改造后的房源租金在可负担的范围内。水围村项目为城中村的改造提供了一种可能,并引发了社会各界对城中村改造的再思考,这也反映出有关城中村的争论还在继续,城中村的改造还需要不断的探索…… | Chris Lai Jasmine M.Y.Tsoi Kwan Yee Wong Cindy Yan David Wen Demi Han Zachary Bao Jack Ou Nita Lin Red Liu Ann Hu Morning Dong Ananda de Vos Helene Pohl Arnound Stavenuiter Bert Oostdijk 王晓勇 | 2019 | 世界建筑导报2019，34，1： | 2 |
| 5 | Scoring of sperm chromosomal abnormalities by manual and automated approaches:qualitative and quantitative comparisons显示文摘精子 disomy 的层次相关到不孕的层次,现在是众所周知的(象另外的因素一样) 。永久维持 aneuploidy 到经历 intracytoplasmic 精子注射(ICSI ) 的不肥沃的男性的后代的风险在帮助复制成为了一个暑热地辩论的问题;然而,在那里仍然是障碍到为精子提供在一个临床的背景屏蔽的 disomy 的实际实现。主要障碍是花到分析的操作员时间一统计上有意义(足够) 房间的数字。“自动化点数”的介绍软件鈥揾a rdware 联合介绍一个潜在的解决方案给这个问题。在这初步的确认研究,我们分析了 10 个病人,手工地并且用一个商业地可得到的点阻止。结果显示出在两条途径之间的统计上重要的关联因为当为双精子得分时,精子 disomy,而是没有关联得分被发现。对后者的最可能的解释作为一个单个双房间是二个仔细联系的精子头的明显的 overscoring。这些结果,和将续起的类似的进一步的研究,通知费用鈥揵e nefit 的帮助分析那单个诊所需要执行以便决定是否采用从要求 ICSI 治疗的人为对精子的评价作为一个平淡的工具屏蔽的精子 aneuploidy。 | Helen G. Tempest Siu Yan Cheng David J. Gillott Alan H. Handyside Alan R. Thomhill Darren K. Griffin | 2010 | Asian Journal of Andrology2010，12，2： | 2 |
| 6 | Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate显示文摘 | Dunyaporn Trachootham Yan Zhou Hui Zhang Yusuke Demizu Zhao Chen Helene Pelicano Paul J. Chiao Geetha Achanta Ralph B. Arlinghaus Jinsong Liu Peng Huang | 2006 | Cancer Cell2006，，3： | 1 |
| 7 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 8 | Ion-sensitive properties of organic electrochemical transistors显示文摘 | Lin Peng Yan Feng Helen L W Chan | 2010 | ACS Applied Materials & Interfaces2010，2，6： | 1 |
| 9 | Regulation of retinal capillary cells by basic fibroblast growth factor, vascular endothelial growth factor, and hypoxia显示文摘 | QI Yan Yi Li Anita Hendrickson E. Helene Sage | 2001 | In Vitro Cellular & Developmental Biology - Animal2001，，1： | 1 |
| 10 | Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting显示文摘The US Chinese Anti-Cancer Association(USCACA)teamed up with Chinese Society of Clinical Oncology(CSCO)to host a joint session at the17th CSCO Annual Meeting on September 20th,2014in Xiamen,China.With a focus on breakthrough cancer medicines,the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and China.The goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China.A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China. | Feng Roger Luo Jian Ding Helen X. Chen Hao Liu Man-Cheong Fung Maria Koehler Jean Pierre Armand Lei Jiang Xiao Xu Ge Zhang Li Xu Pascal Qian Li Yan | 2014 | Chinese Journal of Cancer2014，33，12： | 1 |
| 11 | Microwave-assisted catalyst-free hydrolysis of fibrous cellulose for deriving sugars and biochemicals显示文摘Microwave(MW)assisted catalyst-free hydrolysis of fibrous cellulose(FC,cellulolysis)at 200℃promoted a cellulose conversion o f ca.37.2%and quantitative production o f valuable C5/C6 sugars(e.g.,glucose)and the according platform biochemicals(e.g.,5-hydroxymethylfurfliral),corresponding to an overall selectivity o f 96.5%.Conversely,conventional hydrothermal cellulolysis under similar conditions was not effective,even after 24 h,carbonising the FC.Based on the systematic study of MW-assisted cellulolysis,the specific interaction between water molecules and macroscopic FC under the MW irradiation was proposed,accounting for the interpretation o f the experimental observation.The kinetic energy o f water molecules under the MW irradiation facilitated the C-C(in the non-hindered surface-CH2OH groups)and C-O-C bond breaking(inside the cellulose cavities)in FC,producing primary cellulolysis products of xylose,glucose and cellobiose. | Songshan Jiang Helen Daly Huan Xiang Ying Yan Huiping Zhang Christopher Hardacre Xiaolei Fan | 2019 | Frontiers of Chemical Science and Engineering2019，13，4： | 1 |
| 12 | Equilibrium morphology of gas–liquid Janus droplets: A numerical analysis of buoyancy effect显示文摘In this article, a theoretical model for predicting the equilibrium morphology of gas–liquid Janus droplets was built. Based on this model, the effects of bubble radius and volume ratio on morphology change was systematically studied. The increase of bubble radius causes the two parts(bubble and oil drop) in Janus droplets tend to merge while the impact of volume ratio is complicated. When volume ratio increases, these two parts firstly tend to merge, then gradually separate. The accuracy of this model was verified by experimental results. | Shaobin Zhang Helen Yan Yuhao Geng Ke Wang Jianhong Xu | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 13 | 显示文摘 | Yan F Bao B Helen L W Chan | 2002 | Thin Solid Films2002，406，： | 1 |
| 14 | The improvement of glucose bioelectrocatalytic properties of platinum electrodes modified with electrospun TiO 2 nanofibers显示文摘 | Hao Tang Feng Yan Qidong Tai Helen L.W. Chan | 2009 | Biosensors and Bioelectronics2009，，7： | 1 |
| 15 | 显示文摘 | Yan F Bao P Helen L W Chan | 2002 | Thin Solid Films2002，406，： | 1 |
| 16 | Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via perioheral adaptors显示文摘 | HELEN HN YAN C | 2005 | PNAS2005，102，11： | 1 |
| 17 | Melanocortin MC 1 receptor in human genetics and model systems显示文摘 | Kimberley A. Beaumont Shu S. Wong Stephen A. Ainger Yan Yan Liu Mira P. Patel Glenn L. Millhauser Jennifer J. Smith Paul F. Alewood J. Helen Leonard Richard A. Sturm | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 18 | A multicenter, randomized, controlled study to investigate EX tending the time for T hrombolysis in E mergency N eurological D eficits with I ntra‐ A rterial therapy ( EXTEND‐IA )显示文摘 | Bruce C. V. Campbell Peter J. Mitchell Bernard Yan Mark W. Parsons S?ren Christensen Leonid Churilov Richard J. Dowling Helen Dewey Mark Brooks Ferdinand Miteff Christopher Levi Martin Krause Timothy J. Harrington Kenneth C. Faulder Brendan S. Steinfort T | 2014 | Int J Stroke2014，，1： | 1 |
| 19 | Hybrid solar cells based on poly(3-hexylthiophene) and electrospun TiO_2 nanofibers modified with CdS nanoparticles显示文摘Organic–inorganic hybrid solar cells based on poly(3-hexylthiophene) and electrospun TiO2 nano bers were fabricated by solution process.The ef ciency of the device was improved by modifying CdS nanoparticles on the surface of TiO2 by electrochemical method.The CdS layer can lead to the increase of both open circuit voltage and short circuit current of the device,which are attributed to enhanced exciton dissociation and light absorption and suppressed carrier recombination by CdS at the heterojunction.However,too thick CdS layer led to increased series resistance and decreased ef ciency of the device.Therefore,the optimum condition of the CdS deposition was obtained,which increased the power conversion ef ciency of the device for about 50%.Our results indicate that the surface modi cation on the inorganic semiconductor layer is an effect way to improve the performance of the hybrid solar cells. | Shingchung Lo Zhike Liu Jinhua Li Helen Laiwa Chan Feng Yan | 2013 | Progress in Natural Science:Materials International2013，23，5： | 0 |
| 20 | 不怕出错,才会出色显示文摘哈佛大学积极心理学家艾伦?兰格曾做过一项研究,他将参与者随机分成三组,让他们做演讲:A组被告知“出错是不好的”,B组被告知“出错是难免的”,而C组被告知“请在演讲中出一个错误,而且还可以出更多意外错误”。结果,C组在演讲中感到最舒服,最不焦虑,并且得到了观众的最高评分。 | Helen Yan | 2019 | 学习之友2019，0，3： | 0 |
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