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| 1 | Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension显示文摘BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal hemodynamics.In this report we describe an alarming case of group B streptococcus(GBS)infection after splenectomy in a patient with LC.METHODS:A 72-year-old woman with a history of LC was admitted to our emergency department because of respiratory failure.The patient had received left lateral segmentectomy of the liver and splenectomy three months before admission.Pulmonary examination revealed significant wheezing during inspiration and expiration,but no crackles and stridor.Chest radiography and CT showed no infiltrates.A presumptive diagnosis of bronchial asthma caused by upper respiratory infection was made.Four days after admission,GBS infection was confirmed by blood culture and penicillin G was administered.Antibiotics were given intravenously for a total of 12 days.RESULTS:The patient was discharged on the 12th day after admission.CONCLUSIONS:Although efficacy of splenectomy in patients with LC has been reported,immune status should be evaluated for a longer period.Patients who have undergone splenectomy are highly susceptible to bacteria;moreover,LC itself is an independent risk factor for mortality in patients with sepsis.Since prophylaxis against GBS has not been established,immediate action should be taken.Emergency physicians should be aware of invasive GBS infection in the context of the critical risk factors related to splenectomy and LC,particularly the expected increase of splenectomy performed in LC patients. | Tomoya Okazaki Toru Hifumi Arisa Manabe Hikari Matsumura Satoshi Egawa Hideyuki Hamaya Nastuyo Shinohara Koshiro Takano Hajime Shishido Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda | 2016 | World Journal of Emergency Medicine2016，7，1： | 6 |
| 2 | Fog simulation using a mesoscale model in and around the Yodo River Basin,Japan显示文摘In this study,fog simulations were conducted using the Fifth-Generation NCAR/Penn State Mesoscale Model (MM5) in and around the Yodo River Basin,Japan.The purpose is to investigate the MM5 performance of fog simulation for long-term periods.The simulations were performed for January,February,March,and July,2005 with a coarse 3-kin and a nested fine 1-km grid domains. Results of the simulations were compared with data from ten meteorological observatories,fog sampling site in Mt.Rokko,and visibility measu... | HIKARI Shimadera KUNDAN Lal Shrestha AKIRA Kondo AKIKAZU Kaga YOSHIO Inoue | 2008 | Journal of Environmental Sciences2008，20，7： | 4 |
| 3 | Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-β42 peptide显示文摘OBJECTIVE: To examine the effects of Yokukansan(YKS) extract on two endogenous modulators of anxiety, brain-derived neurotrophic factor(BDNF)and serotonin (5-HT)_(2A) receptors pharmacologically, in the ischemic rat model of dementia.METHODS: The cerebral ischemia(CI) was induced by bilateral occlusion of the vertebral and common carotid arteries(4-vessel occlusion ischemia). The CI was combined with the amyloid-β42 peptide(A42) injected intracerebroventricularly, and referreβdto as CI+Aβ. Anxiety-like behaviors were assessed by elevated plus maze(enclosed arm), light/dark transition test(dark chamber), and open-field test.Wet-dog shakes were induced by the 5-HT_(2A) receptor agonist 2, 5-dimethoxy-4-iodoamphetamine(DOI). The concentration of BDNF in serum was determined by enzyme-linked immuno sorbent assay.RESULTS: CI + Aβ increased anxiety, as demonstrated by the increase of time spent in the enclosed arms and dark chambers, and locomotion in the outer zone of the open field(thigmotaxis). CI + Adecreased the serum concentration of BDNF. YKS reβ-duced the anxiety-like behaviors, suppressed the DOI-induced wet-dog shakes and increased serum BDNF concentrations.CONCLUSION: Our findings suggest that YKS extract improves CI + Aβ-induced anxiety by antagonizing 5-HT_(2A) receptors and increasing BDNF. | Ai Nogami-Hara Kaori Kubota Kotaro Takasaki Takuya Watanabe Nobuaki Egahira Hikari Iba Risako Fujikawa Shutaro Katsurabayashi Funda Bolukbasi Hatip Izzettin Hatip-Al-Khatib Katsunori Iwasaki | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 3 |
| 4 | Comprehensive proteomics analysis of autophagy-deficient mouse liver显示文摘 | Naomi Matsumoto Junji Ezaki Masaaki Komatsu Katsuyuki Takahashi Reiko Mineki Hikari Taka Mika Kikkawa Tsutomu Fujimura Mitsue Takeda-Ezaki Takashi Ueno Keiji Tanaka Eiki Kominami | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 1 |
| 5 | A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor显示文摘 | Grazia Chiellini James W. Apriletti Hikari Al Yoshihara John D. Baxter Ralff C.J. Ribeiro Thomas S. Scanlan | 1998 | Chemistry & Biology1998，，6： | 1 |
| 6 | Vertical Intra-industry trade and FDI in East Asia 显示文摘 | Kyoji Fukao Hikari Ishido and Keiko Ito | 2003 | Journal of the Japanese and International Economies2003，17，： | 1 |
| 7 | Development of suitability maps for ground-coupled heat pump systems using groundwater and heat transport models显示文摘 | Hikari Fujii Tadasuke Inatomi Ryuichi Itoi | 2007 | Geothermics2007，34，5： | 1 |
| 8 | Electrochemical properties of FeOCI derivatives prepared by the reaction of FeOCl intercalated with 2, 2-bithiophene and H2O显示文摘 | Hikari S Shunich H Fujimoto K K | 2002 | Solid State Ionics2002，79，： | 1 |
| 9 | Preparation of a FeOCl derivative with pyrrole and its performance as a cathode material in a secondary lithium battery system显示文摘 | Hikari S Shunich H | 1995 | J Power Sources1995，56，： | 1 |
| 10 | Defeating EpCAM + liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma显示文摘 | Kouki Nio Taro Yamashita Hikari Okada Mitsumasa Kondo Takehiro Hayashi Yasumasa Hara Yoshimoto Nomura Sha Sha Zeng Mariko Yoshida Tomoyuki Hayashi Hajime Sunagozaka Naoki Oishi Masao Honda Shuichi Kaneko | 2015 | Journal of Hepatology2015，，5： | 1 |
| 11 | Vertical Intra-industry Trade and Foreign Direct Investment in East Asia显示文摘 | Kyoji Fukao Hikari Ishido and Keiko Ito | 2003 | Journal of the Japanese and International Economics2003，，1： | 1 |
| 12 | Synthesis, cation distribution, and electrochemical properties of Fe-substituted Li2 MnO3 as a novel 4 V positive electrode material 显示文摘 | Mitsuharu Tabuchi Akiko Nakashima Hikari Shigemura | 2002 | Journal of the Electrochemical Society2002，149，5： | 1 |
| 13 | Roles of Phosphatidylinositol 3-Kinase-Akt and NADPH Oxidase in Adenosine 5′-Triphosphate–Sensitive K+ Channel Function Impaired by High Glucose in the Human Artery显示文摘 | Hiroyuki Kinoshita Naoyuki Matsuda Hikari Kaba Noboru Hatakeyama Toshiharu Azma Katsutoshi Nakahata Yasuhiro Kuroda Kazuaki Tange Hiroshi Iranami Yoshio Hatano | 2008 | Hypertension2008，，3： | 1 |
| 14 | Permeability prediction by hydraulic flow units - theory and applications显示文摘 | Maghsood Abbaszaden Hikari Fujii Fujio gujimoto | 1996 | SPE 301581996，，： | 1 |
| 15 | Vertical intra-industry trade and foreign direct investment in East Asia显示文摘 | Kyoji Fukao Hikari Ishido Keiko Ito | 2003 | The Japa- nese and International Economies2003，17，4： | 1 |
| 16 | Preparation of NiS2 using spark-plasma-sintering process and its electrochemical properties显示文摘 | Tomomari T Hikari S Hiroyuki K | 2008 | J Electrochem Soc2008，1，： | 1 |
| 17 | Vertical intra-industry trade and foreign direct investment in EastAsia显示文摘 | Fukao Kyoji Hikari Ishido and Keiko Ito | 2003 | Journal of the Japanese and International Economies2003，，17： | 1 |
| 18 | Permeability Prediction by Hydraulic Flow Units Theory and Applications显示文摘 | Maghsood Abbaszadeh Hikari Fujii Fujio Fujimoto | 1996 | SPE Formation Evaluation1996，，： | 1 |
| 19 | Vertical intm- industry trade and foreign direct invest- ment in Ease Asia 显示文摘 | Kyoji Fukao Hikari Ishido Keiko lto | 2003 | The Japanese and Inter- national Economies2003，，17： | 1 |
| 20 | Effect of aluminum compound addition on graphitization of wood charcoal by direct electric pulse heating method显示文摘 | Koei Nishimiya Toshimitsu Hata Hikari Kikuchi Yuji Imamura | 2004 | Journal of Wood Science2004，，2： | 1 |
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