|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C显示文摘AIM:To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C (CHC). METHODS: Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group (stage 0). Twenty- five patients with sustained virological response (SVR) to interferon (IFN) therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness (LS) was performed by elastography. RESULTS: Medians (50% levels) of LS were 4.1 (3.5-4.9), 6.3 (4.8-8.5), 8.8 (6.8-12.0), 14.6 (10.5-18.6), and 22.2 (15.4-28.0), respectively, in the fibrosis stages 0-4 (P < 0.001). LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 (3.5-5.6), 5.2 (4.4-6.8), 6.8 (6.1-7.6), and 6.1 (3.6-7.9), respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide. CONCLUSION: LS correlated well with the histologicalstage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography. | Tadashi Takeda Takahiro Yasuda Yuji Nakayama Mika Nakaya Megumi Kimura Mariko Yamashita Ayumi Sawada Koji Abo Setsuko Takeda Hiroki Sakaguchi Susumu Shiomi Hitoshi Asai Shuichi Seki | 2006 | World Journal of Gastroenterology2006，12，48： | 16 |
| 2 | Complete response to preoperative chemoradiotherapy in highly advanced gastric adenocarcinoma显示文摘This report presents a case of highly advanced gastric cancer that achieved a histologically complete response (CR) to preoperative chemoradiotherapy with S-1 plus low-dose Cisplatin. A 60-year-old male patient underwent FDG positron emission tomography (PET) during a routine health examination. The patient was found to have swollen paraaortic lymph nodes. Shortly thereafter, he was diagnosed with gastric carcinoma with a type 2 tumor in the antrum with paraaortic lymph node metastases based on FDG-PET, endoscopic examination and abdominal computed tomography. After the completion of chemoradiation therapy (CRT), the tumor and the paraaortic lymph node metastases disappeared. The patient underwent surgery 5 wk after the completion of CRT, including a subtotal gastrectomy with Rouxen-Y reconstruction, D3 lymph node dissection and a left adrenalectomy. No cancer cells were detected in the resected specimen either in the primary lesion or lymph nodes, thus confirming a pathologically CR to CRT (CR grade 3). The patient has been stable and well without any evidence of recurrence for 48 mo after surgery. Such a preoperative CRT regimen might therefore be very effective for treatment of some advanced gastric cancers. | Hironori Shigeoka Haruhiko Imamoto Yasumasa Nishimura Taro Shimono Hiroshi Furukawa Hiroshi Imamura Takushi Yasuda Hitoshi Shiozaki | 2010 | World Journal of Gastrointestinal Oncology2010，2，6： | 6 |
| 3 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 4 | Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes显示文摘 | Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda Hitoshi Imaizumi Yuko Nawa Xiaojie Meng Binita Shrestha Teruto Hashiguchi Ikuro Maruyama | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，10： | 1 |
| 5 | Neoadjuvant Chemotherapy followed by Salvage Surgery: Effect on Survival of Patients with Primary Noncurative Gastric Cancer显示文摘 | Masahiko Yano Hitoshi Shiozaki Masatoshi Inoue Shigeyuki Tamura Yuichiro Doki Takushi Yasuda Yoshiyuki Fujiwara Toshimasa Tsujinaka Morito Monden | 2002 | World Journal of Surgery2002，，9： | 1 |
| 6 | Age-related changes of mitochondrial structure and function in Caenorhabditis elegans 显示文摘 | Kayo Yasuda Takamasa Ishii Hitoshi Suda | 2006 | Mech Ageing Dev2006，127，： | 1 |
| 7 | Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamouscell carcinoma显示文摘 | Hiroaki Kato Tokuzo Arao Kazuko Matsumoto Yoshihiko Fujita Hideharu Kimura Hidetoshi Hayashi Kouhei Nishiki Mitsuru Iwama Osamu Shiraishi Atsushi Yasuda Masayuki Shinkai Motohiro Imano Haruhiko Imamoto Takushi Yasuda Kiyotaka Okuno Hitoshi Shiozaki Kazuto | 2013 | International Journal of Oncology2013，，4： | 1 |
| 8 | Real-time rapid reverse transcriptase-polymerase chain reaction for intraoperative diagnosis of lymph node micrometastasis: Clinical application for cervical lymph node dissection in esophageal cancers显示文摘 | Setsuko Yoshioka Yoshiyuki Fujiwara Yurika Sugita Yoshihiro Okada Masahiko Yano Shigeyuki Tamura Takushi Yasuda Shuji Takiguchi Hitoshi Shiozaki Morito Monden | 2002 | Surgery2002，，： | 1 |
| 9 | Role of triggering receptor expressed on myeloid cells-1 in experimental severe acute pancreatitis显示文摘 | Keiko Kamei Takeo Yasuda Takashi Ueda Fu Qiang Yoshifumi Takeyama Hitoshi Shiozaki | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，3： | 1 |
| 10 | The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer显示文摘 | Koichi Suzuki Sumiko Ohnami Chikako Tanabe Hiroki Sasaki Jun Yasuda Hitoshi Katai Kimio Yoshimura Masaaki Terada Manuel Perucho Teruhiko Yoshida | 2003 | Gastroenterology2003，，5： | 1 |
| 11 | Phase I clinical trial of vaccination with LY6K-derived peptide in patients with advanced gastric cancer显示文摘 | Hajime Ishikawa Motohiro Imano Osamu Shiraishi Atsushi Yasuda Ying-Feng Peng Masayuki Shinkai Takushi Yasuda Haruhiko Imamoto Hitoshi Shiozaki | 2014 | Gastric Cancer2014，，： | 1 |
| 12 | Diabetic neuropathy and nerve regeneration显示文摘 | Hitoshi Yasuda Masahiko Terada | 2003 | Progress in Neurobiology2003，60，4： | 1 |
| 13 | Dipeptidyl peptidase‐4 inhibitors are effective in J apanese type 2 diabetic patients with sustained endogenous insulin‐secreting capacity, a higher body mass index and insulin resistance显示文摘 | Junji Kozawa Tetsuhiro Kitamura Hitoshi Nishizawa Tetsuyuki Yasuda Norikazu Maeda Michio Otsuki Kohei Okita Hiromi Iwahashi Hideaki Kaneto Tohru Funahashi Akihisa Imagawa Iichiro Shimomura | 2012 | J Diabetes Invest2012，，2： | 1 |
| 14 | A new amide from the leaves and twigs of Litsea auriculata显示文摘 | Hitoshi Tanaka Saya Yatsuhashi Tadashi Yasuda Masaru Sato Eiji Sakai Chen Xiao Hiroko Murata Jin Murata | 2009 | Journal of Natural Medicines2009，，3： | 1 |
| 15 | Surgical outcomes in the newly introduced phase of intracorporeal anastomosis following laparoscopic distal gastrectomy is safe and feasible compared with established procedures of extracorporeal anastomosis显示文摘 | Shingo Kanaji Hitoshi Harada Shunji Nakayama Takashi Yasuda Taro Oshikiri Kentaro Kawasaki Masashi Yamamoto Tatsuya Imanishi Tetsu Nakamura Satoshi Suzuki Kenichi Tanaka Yasuhiro Fujino Masahiro Tominaga Yoshihiro Kakeji | 2014 | Surgical Endoscopy2014，，4： | 1 |
| 16 | Rotavirus-Associated Encephalopathy With a Reversible Splenial Lesion显示文摘 | Seiji Fukuda Kazuko Kishi Kenji Yasuda Hitoshi Sejima Seiji Yamaguchi | 2009 | Pediatric Neurology2009，，2： | 1 |
| 17 | Revised Equations for Estimated GFR From Serum Creatinine in Japan显示文摘 | Seiichi Matsuo Enyu Imai Masaru Horio Yoshinari Yasuda Kimio Tomita Kosaku Nitta Kunihiro Yamagata Yasuhiko Tomino Hitoshi Yokoyama Akira Hishida | 2009 | American Journal of Kidney Diseases2009，，6： | 1 |
| 18 | Neoadjuvant Chemotherapy followed by Salvage Surgery: Effect on Survival of Patients with Primary Noncurative Gastric Cancer显示文摘 | Masahiko Yano Hitoshi Shiozaki Masatoshi Inoue Shigeyuki Tamura Yuichiro Doki Takushi Yasuda Yoshiyuki Fujiwara Toshimasa Tsujinaka Morito Monden | 2002 | World Journal of Surgery2002，，9： | 1 |
| 19 | Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu显示文摘The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,2018.During its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in history.The Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth line.This orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the asteroid.This paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping operation.First,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is introduced.Following the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first report.Consequently,this paper states that the HP.keeping operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period. | Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru Takahashi Hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki Satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda Takanobu Shimada Masanobu Ozaki Masanao Abe Satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki Kato Seiji Yasuda Kota Matsushima Tetsuya Masuda Makoto Yoshikawa Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 0 |
| 20 | 使用ATP酶敏感钾离子通道开放剂—尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘(接4月下)4实验结果4.1每组患者的特征对两组患者的临床和生理学特征进行了总结,并在附表1呈现。观察他们的背景,包括年龄,性别,是否存在风险因素,以及造影定量评估的冠状动脉狭窄的严重程度,结果显示无显著性差异。冠状动脉成形术在所有44例患者中是成功的。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose MakotoIwamaa Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，22，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员