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| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Three benefits of microcatheters for retrograde transvenous obliteration of gastric varices显示文摘AIM:To evaluate the usefulness of the microcatheter techniques in balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices.METHODS:Fifty-six patients with gastric varices underwent BRTOs using microcatheters.A balloon catheter was inserted into gastrorenal or gastrocaval shunts.A microcatheter was navigated close to the varices,and sclerosant was injected into the varices through the microcatheter during balloon occlusion.The next morning,thrombosis of the varices was evaluated by contrast enhanced computed tomography (CE-CT).In patients with incomplete thrombosis of the varices,a second BRTO was performed the following day.Patients were followed up with CE-CT and endoscopy.RESULTS:In all 56 patients,sclerosant was selectively injected through the microcatheter close to the varices.In 9 patients,microcoil embolization of collateral veinswas performed using a microcatheter.In 12 patients with incomplete thrombosis of the varices,additional injection of sclerosant was performed through the microcatheter that remained inserted overnight.Complete thrombosis of the varices was achieved in 51 of 56 patients,and the remaining 5 patients showed incomplete thrombosis of the varices.No recurrence of the varices was found in the successful 51 patients after a median follow up time of 10.5 mo.We experienced one case of liver necrosis,and the other complications were transient.CONCLUSION:The microcatheter techniques are very effective methods for achieving a higher success rate of BRTO procedures. | Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi | 2012 | World Journal of Gastroenterology2012，18，12： | 5 |
| 3 | 堵塞汽球后退为经由脊间的静脉的胃的静脉曲张的 transvenous 涂去显示文摘 Gastric varices are usually associated with a gastrorenal(G-R) shunt.However,the gastric varices described in this case report were not associated with a G-R shunt.The inflow vessel was the posterior gastric vein and the outflow vessels were the narrow inferior phrenic vein and the dilated cardio-phrenic vein.First,percutaneous transhepatic obliteration of the posterior gastric vein was performed,but the gastric varices remained patent.Then,micro-balloon catheterization of the subphrenic vein was carried out via the jugular vein,pericardial vein and cardio-phrenic vein,however,micro-balloon-occluded inferior phrenic venography followed by micro-coil embolization of the cardio-phrenic vein revealed no delineation of gastric varices resulting in no further treatment.Thereafter,as a gastrosubphrenic-intercostal vein shunt developed,a microballoon catheter was advanced to the gastric varices via the intercostal vein and balloon-occluded retrograde transvenous obliteration(BRTO) was performed resulting in the eradication of gastric varices.BRTO for gastric varices via the intercostal vein has not previously been documented. | Hiroki Minamiguchi Nobuyuki Kawai Morio Sato Akira Ikoma Munehisa Sawa Tetsuo Sonomura Shinya Sahara Kouhei Nakata Isao Takasaka Motoki Nakai | 2012 | World Journal of Radiology2012，4，3： | 3 |
| 4 | Emergency balloon-occluded retrograde transvenous obliteration of ruptured gastric varices显示文摘AIM: To evaluate the effectiveness and safety of emergency balloon-occluded retrograde transvenous obliteration(BRTO) for ruptured gastric varices.METHODS: Emergency BRTO was performed in 17 patients with gastric varices and gastrorenal or gastrocaval shunts within 24 h of hematemesis and/or tarry stool.The gastric varices were confirmed by endoscopy,and the gastrorenal or gastrocaval shunts were identified by contrast-enhanced computed tomography(CE-CT).A 6-Fr balloon catheter(Cobra type) was inserted into the gastrorenal shunt via the right internal jugular vein,or into the gastrocaval shunt via the right femoral vein,depending on the varices drainage route.The sclerosant,5% ethanolamine oleate iopamidol,was injected into the gastric varices through the catheter during balloon occlusion.In patients with incom plete thrombosis of the varices after the first BRTO,a second BRTO was performed the following day.Patients were followed up by endoscopy and CE-CT at 1 d,1 wk,and 1,3 and 6 mo after the procedure,and every 6 mo thereafter.RESULTS: Complete thrombosis of the gastric varices was not achieved with the first BRTO in 7/17 patients because of large gastric varices.These patients underwent a second BRTO on the next day,and additional sclerosant was injected through the catheter.Complete thrombosis which led to disappearance of the varices was achieved in 16/17 patients,while the remaining patient had incomplete thrombosis of the varices.None of the patients experienced rebleeding or recurrence of the gastric varices after a median follow-up of 1130 d(range 8-2739 d).No major complications occurred after the procedure.However,esophageal varices worsened in 5/17 patients after a mean follow-up of 8.6 mo.CONCLUSION: Emergency BRTO is an effective and safe treatment for ruptured gastric varices. | Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi | 2013 | World Journal of Gastroenterology2013，19，31： | 2 |
| 5 | Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma显示文摘AIM: A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication.METHODS: Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninfliamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs.RESULTS: Two genes showing 2.5-fold decreased expression with significance set at in UC samples were bomeo box a4 (HOXa4) and mads box transcription enhancer factor 2, polypeptide B (MEF2b). RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma.CONCLUSION: It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 6 | Impact of Thickness of Polymer Electrolyte Membrane and Gas Diffusion Layer on Temperature Distributions in Polymer Electrolyte Fuel Cell Operated at Temperature around 90℃显示文摘Polymer Electrolyte Fuel Cell(PEFC)is desired to be operated at temperature around 90℃ for stationary applications during the period from 2020 to 2025 in Japan.It can be expected thinner polymer electrolyte membrane(PEM)and gas diffusion layer(GDL)would promote the power generation performance of PEFC at this temperature.The aim of this study is to understand the impact of thickness of PEM and GDL on the temperature profile of interface between PEM and catalyst layer at the cathode(i.e.,the reaction surface)in a single PEFC with an initial operation temperature(Tini).An 1D multi-plate heat transfer model based on temperature data of separator measured using thermograph in power generation process was developed to evaluate temperature of the reaction surface(Treact).This study investigated the effect of Tini,flow rate and relative humidity of supply gas on Treact distribution.The study finds that when using thin GDL,the even distribution of Treact – Tini is obtained irrespective of thickness of PEM,Tini and relative humidity conditions.Treact – Tini using Nafion 115 is higher than the other thin PEMs irrespective of Tini and relative humidity conditions.It can be concluded that the even temperature distribution could be achieved by using thin PEM and GDL. | Akira Nishimura Yusuke Sato Satoru Kamiya Tatsuya Okado Kouhei Yamamoto Masafumi Hirota Eric Hu | 2019 | Journal of Energy and Power Engineering2019，13，3： | 2 |
| 7 | Evaluation of the sperm DNA fragmentation index in infertile Japanese men by in-house flow cytometric analysis显示文摘Semen analysis has long been used to evaluate male fertility.Recently,several sperm function tests have been developed.Of those,the sperm DNA fragmentation index(DFI),which describes the status of the sperm DNA,is thought to be a suitable parameter for evaluating male fertility.However,there have been no large-scale studies on the sperm DFI of Japanese men.Therefore,we investigated the feasibility of using an in-house flow cytometry-based sperm DFI analysis based on the sperm DNA fragmentation test of sperm chromatin structure assay(SCSA)to assess male fertility in Japan.This study enrolled 743 infertile and 20 fertile Japanese men.To evaluate reproducibility,inter-and intraobserver precision was analyzed.A receiver operating characteristic curve analysis was used to set a cutoff value for the sperm DFI to identify men who could father children by timed intercourse or intrauterine insemination.The variability of the sperm DFI among fertile volunteers was determined.The relationship between semen parameters and the sperm DFI was assessed by Spearman’s rho test.A precision analysis revealed good reproducibility of the sperm DFI.The cutoff value of sperm DNA fragmentation in infertile men was 24.0%.Semen volume had no relationship with the sperm DFI.Sperm concentration,sperm motility,total motile sperm count,and percentage of normal-shaped sperm were significantly and negatively correlated with the sperm DFI.The median sperm DFI was smaller in fertile volunteers(7.7%)than that in infertile men(19.4%).Sperm DNA fragmentation analysis can be used to assess sperm functions that cannot be evaluated by ordinary semen analysis. | Akiyoshi Osaka Hiroshi Okada Sae Onozuka Takashi Tanaka Toshiyuki Iwahata Yukihito Shimomura Yoshitomo Kobori Kazutaka Saito Kouhei Sugimoto | 2022 | Asian Journal of Andrology2022，24，1： | 2 |
| 8 | Damped Oscillation of Liquid Column in Vertical U-Tube for Newtonian and non-Newtonian Liquids显示文摘在垂直U试管的牛顿的液体的抑制摆动是众所周知的现象和这个液体运动的答案之一因为然而,在圆形的管子中的 laminar 流动政体一般来说被解决,就算由这个答案的 oscillational 运动的时期将近与试验性的结果的被与一致,有由解决的方程的时间的差错的抑制 oscillational 过程的评价不与试验性的结果的一致。因此为牛顿、非牛顿的液体在圆形的 U 试管在 oscillational 运动的速度分布的试验性的结果之上基于, Bingham 塑料流动的速度分发被假定。在直径 D=10mm, 20mm 和 40mm 的垂直 U 试管的免费表面的垂直掉落并且升起的速度的抑制摆动并且也的答案与为牛顿的液体的水和水甘油答案和非牛顿的液体的丙烯酸的共聚物解决方案相比。由新流动模型的这些解决的方程的比较在对试验性的结果的好同意被显示出。上述说的结果详细被描述。 | Akira Ogawa Suguru Tokiwa Masatoshi Mutou Kazutaka Mogi Tonau Sugawara Masahide Watanabe Kouhei Satou Toshikazu Kikawada Keitarou Shishido Naoya Matumoto | 2007 | Journal of Thermal Science2007，16，4： | 2 |
| 9 | A study of the changes in the cause of peptic ulcer bleeding显示文摘AIM: To clarify the frequency of and changes in the cause of peptic ulcer bleeding. METHODS: This study retrospectively evaluated the out- and inpatients who underwent endoscopy between 2002 to 2008. The subjects were patients presenting with peptic ulcer bleeding. The details of these patients were obtained from their endoscopic reports and medical records. RESULTS: The rates of Helicobacter pylori (H. pylori ) infection were significantly low (P = 0.039), while the proportion of nonsteroidal antiinflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively). However, there was no significant difference in the proportion of low-dose aspirin users (P = 0.832).CONCLUSION: It's found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease. It is necessary to take measures to prevent peptic ulcer bleeding among NSAIDs and low dose aspirin users. | Haruka Fujinami Takahiko Kudo Ayumu Hosokawsa Kouhei Ogawa Takako Miyazaki Jun Nishikawa Shinya Kajiura Takayuki Ando Akira Ueda Toshiro Sugiyama | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 10 | Identification of genes specifically methylated in E pstein– B arr virus‐associated gastric carcinomas显示文摘 | Toshiyuki Okada Munetaka Nakamura Jun Nishikawa Kouhei Sakai Yibo Zhang Mari Saito Akihiro Morishige Atsunori Oga Kosuke Sasaki Yutaka Suehiro Yuji Hinoda Isao Sakaida | 2013 | Cancer Sci2013，，10： | 2 |
| 11 | Gene expression profiles predicting the response to IFN-β and a combinationof temozolomide and IFN-β in malignant gliomas显示文摘 | Atsuo Yoshino Shinya Tashiro Akiyoshi Ogino Kazunari Yachi Takashi Ohta Takao Fukushima Takao Watanabe Yoichi Katayama Yutaka Okamoto Emiko Sano Kouhei Tsumoto | 2011 | International Journal of Oncology2011，，3： | 1 |
| 12 | Long-Term Results of Subtotal Esophagectomy with Three-Field Lymphadenectomy for Carcinoma of the Thoracic Esophagus显示文摘 | Masamichi Baba Takashi Aikou Heiji Yoshinaka Shoji Natsugoe Toshitaka Fukumoto Hisaaki Shimazu Kouhei Akazawa | 1994 | Annals of Surgery1994，，3： | 1 |
| 13 | Central and Pe- ripheral Effects of Ghrelin on Energy Balance, Food Intake and Lipid Metabolism in Teleost Fish显示文摘 | Ki Sung Kang Satowa Yahashi Kouhei Matsuda | 2011 | Peptides2011，32，12： | 1 |
| 14 | Achievement of High-Temperature Superconducting Wire with Critical Current Exceeding 200A显示文摘 | Naoki A Masashi K Kouhei Y | 2006 | SEI Technical Review2006，12，63： | 1 |
| 15 | Development of Bi-based Superconducting Wires显示文摘 | Kouhei Y Shin-ichi K Takeshi K | 2004 | SEI Technical Review2004，6，58： | 1 |
| 16 | A growth signal with an artificially induced erythropoietin receptor-gp130 cytoplasmic domain heterodimer 显示文摘 | Masahiro K Hiroshi U Kouhei T | 2001 | Journal of Biochemistry2001，130，： | 1 |
| 17 | Preoperative microcoil embolization of the common hepatic artery for pancreatic body cancer显示文摘AIM:To evaluate safety and feasibility of microcoil embolization of the common hepatic artery under proper or distal balloon inflation in preoperative preparation for en bloc celiac axis resection for pancreatic body cancer.METHODS:Fifteen patients(11 males,4 females;median age,67 years) with pancreatic body cancer involving the nerve plexus surrounding the celiac artery underwent microcoil embolization.To alter the total hepatic blood flow from superior mesenteric artery(SMA),microcoil embolization of the common hepatic artery(CHA) was conducted in 2 cases under balloon inflation at the proximal end of the CHA and in 13 cases under distal microballoon inflation at the distal end of the CHA.RESULTS:Of the first two cases of microcoil embolization with proximal balloon inflation,the first was successful,but there was microcoil migration to the proper hepatic artery in the second.The migrated microcoil was withdrawn to the CHA by an inflated microballoon catheter.Microcoil embolization was successful in the other 13 cases with distal microballoon inflation,with no microcoil migration.Compact microcoil embolization under distal microballoon inflation created sufficient resistance against the vascular wall to prevent migration.Distal balloon inflation achieved the requisite 1 cm patency at the CHA end for vascular clamping.All patients underwent en bloc celiac axis resection without arterial reconstruction or liver ischemia.CONCLUSION:To impede microcoil migration to the proper hepatic artery during CHA microcoil embolization,distal microballoon inflation is preferable to proximal balloon inflation. | Isao Takasaka Nobuyuki Kawai Morio Sato Hirohiko Tanihata Tetsuo Sonomura Hiroki Minamiguchi Motoki Nakai Akira Ikoma Kouhei Nakata Hiroki Sanda | 2012 | World Journal of Gastroenterology2012，18，16： | 1 |
| 18 | Role of DNA methylation in the development of Epstein–Barr virus‐associated gastric carcinoma显示文摘 | Mari Saito Jun Nishikawa Toshiyuki Okada Akihiro Morishige Kouhei Sakai Munetaka Nakamura Shu Kiyotoki Kouichi Hamabe Takeshi Okamoto Atsunori Oga Kohsuke Sasaki Yutaka Suehiro Yuji Hinoda Isao Sakaida | 2012 | J Med Virol2012，，1： | 1 |
| 19 | Metastatic liposarcoma in the jejunum causing intussusception: Report of a case显示文摘 | Yutaka Shibata Kouhei Sato Masashi Kodama Hiroshi Nanjyo | 2008 | Surgery Today2008，，： | 1 |
| 20 | An integrated medical image database and retrieval system using a web application server显示文摘 | Pang Y C Masao H Kouhei A | 2003 | International Journal of Medical Informatics2003，71，1： | 1 |
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