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| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | MicroRNA-4661 inhibits antiviral innate immune response by targeting interferon-alpha显示文摘 | Yingke Li Xiaohua Fan Xingying He Haijing Sun Zui Zou Hongbin Yuan Haitao Xu Chengcai Wang Xueyin Shi | 2012 | Cellular & Molecular Immunology2012，9，6： | 8 |
| 3 | CFD investigation and PIV validation of flow field in a compact return diffuser under strong part-load conditions显示文摘The internal flow fields in a compact return diffuser under strong part-load conditions are investigated both numerically and experimentally.For numerical simulation,three-dimensional unsteady Reynolds-Averaged Navier–Stokes equations are solved on high-quality structured grids in conjunction with the shear stress transport k–turbulence model by employing the computational fluid dynamics(CFD)software ANSYS-Fluent 14.5.For flow field measurements,a special test rig is designed and the two-dimensional particle image velocimetry(PIV)measurements are conducted in the diffuser midplane to capture the complex flow field and for validation of the CFD results.The analysis of the results has been focused on the flow structure in the diffuser,especially under part-load conditions.The detailed comparison between CFD and PIV results is performed.Vortical flow and recirculation flow patterns in the diffuser are captured and analyzed.Large flow separation and backflow appear under the part-load flow conditions.This paper provides a good data set for developing as well as evaluating the accuracy of various CFD models for capturing the complex flow field in a compact return diffuser used with multistage pumps. | ZHOU Ling SHI WeiDong CAO WeiDong YANG HongBin | 2015 | Science China(Technological Sciences)2015，58，3： | 8 |
| 4 | Thermodynamic prediction of thermal diffusivity and thermal conductivity in Mg–Zn–La/Ce system显示文摘Basic thermal properties and mechanical properties are critical parameters for the structural magnesium alloys.Solute atoms and second phases can improve mechanical properties,but are deteriorating the heat dissipation performance.Through experimental determination of alloys,it is found that REMg12 phases have fewer negative impacts on thermal diffusivities thanτ;phases.With the same intermetallic compound,the solute atom Zn have more negative influences on thermal diffusivities of Mg-Zn-La/Ce alloys than the content of second phases.In order to quantitatively evaluate thermal conductivities and further design Mg alloys with both high strength and high thermal conductivity,a calculated method is provided to describe the thermal diffusivity of alloys as a function of alloy composition and phase constitution.A set of parameters for expression of thermal diffusivity of Mg-Zn-La/Ce alloys were obtained through assessing the experimental data.The thermal conductivities of Mg-Zn-La/Ce system were predicted and agreed well with experimental values with calculation error of 1.6%and standard error of±3.0 W/(m K).The calculation method considering thermal diffusivity resistivity improves the calculation accuracy and would be physically significant. | Tianci Xie Hui Shi Hongbin Wang Qun Luo Qian Li Kuo-Chih Chou | 2022 | Journal of Materials Science & Technology2022，，2： | 5 |
| 5 | Dendritic BiVO4 decorated with MnOx co-catalyst as an efficient hierarchical catalyst for photocatalytic ozonation显示文摘An appropriate co-catalyst can significantly promote the photocatalytic efficacy, but this has been seldom studied in the visible-light photocatalysis combined with ozone, namely photocatalytic ozonation. In this work, a dendritic bismuth vanadium tetraoxide (BiVO4) material composited with highly dispersed MnOv nanoparticles was synthesized, and its catalytic activity is 86.6% higher than bare BiVO4 in a visible light and ozone combined process. Catalytic ozonation experiments, ultraviolet- visible (UV-Vis) diffuse reflectance spectra and photoluminescence spectra jointly indicate that MnOA plays a triple role in this process. MnOv strengthens the light adsorption and promotes the charge separation on the composite material, and it also shows good activity in catalytic ozonation. The key reactive species in this process is OH, and various pathways for its generation in this process is proposed. This work provides a new direction of catalyst preparation and pushes forward the application of photocatalytic ozonation in water treatment. | Jin Yang Xuelian Liu Hongbin Cao Yanchun Shi Yongbing Xie Jiadong Xiao | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 5 |
| 6 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 7 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 8 | The IAA-and ABA-responsive transcription factor CgMYB58 upregulates lignin biosynthesis and triggers juice sac granulation in pummelo显示文摘In citrus,lignin overaccumulation in the juice sac results in granulation and an unpleasant fruit texture and taste.By integrating metabolic phenotyping and transcriptomic analyses,we found 702 differentially expressed genes(DEGs),including 24 transcription factors(TFs),to be significantly correlated with lignin content.CgMYB58 was further identified as a critical R2R3 MYB TF involved in lignin overaccumulation owing to its high transcript levels in Huanong Red-fleshed pummelo(HR,Citrus grandis)fruits.Transient expression of CgMYB58 led to an increase in the lignin content in the pummelo fruit mesocarp,whereas its stable overexpression significantly promoted lignin accumulation and upregulated 19 lignin biosynthetic genes.Among these genes,CgPAL1,CgPAL2,Cg4CL1,and CgC3H were directly modulated by CgMYB58 through interaction with their promoter regions.Moreover,we showed that juice sac granulation in pummelo fruits could be affected by indole-3-acetic acid(IAA)and abscisic acid(ABA)treatments.In HR pummelo,ABA significantly accelerated this granulation,whereas IAA effectively inhibited this process.Taken together,these results provide novel insight into the lignin accumulation mechanism in citrus fruits.We also revealed the theoretical basis via exogenous IAA application,which repressed the expression of CgMYB58 and its target genes,thus alleviating juice sac granulation in orchards. | Meiyan Shi Xiao Liu Haipeng Zhang Zhenyu He Hongbin Yang Jiajing Chen Jia Feng Wenhui Yang Youwu Jiang Jia-Long Yao Cecilia Hong Deng Juan Xu | 2020 | Horticulture Research2020，7，1： | 4 |
| 9 | Comparative studies on fouling of homogeneous anion exchange membranes by different structured organics in electrodialysis显示文摘Five negatively charged organic compounds with different structures, sodium methane sulfonate(MS), sodium benzene sulfonate(BS), sodium 6-hydroxynaphthalene-2-sulfonate(NSS), sodium dodecyl sulfate(SDS), and sodium dodecyl benzene sulfonate(SDBS), were used to examine the fouling of an anion exchange membrane(AEM) in electrodialysis(ED),to explore the effect of molecular characteristics on the fouling behavior on the AEM and changes in the surface and electrochemical properties of the AEM. Results indicated that the fouling degree of the AEM by the different organics followed the order:SDBS > SDS > NSS > BS > MS. SDBS and SDS formed a dense fouling layer on the surface of the AEM, which was the main factor in the much more severe membrane fouling, and completely restricted the transmembrane ion migration. The other three organics caused fouling of the AEM by adsorption on the surface and/or accumulation in the interlayer of the AEM, and exhibited almost no influence on the transmembrane ion migration. It was also concluded that the organics with benzene rings caused more severe fouling of the AEM due to the stronger affinity interaction and steric effect between the organics and the AEM compared with organics with aliphatic chains. | Zhijuan Zhao Shaoyuan Shi Hongbin Cao Yujiao Li Bart Van der Bruggen | 2019 | Journal of Environmental Sciences2019，31，3： | 4 |
| 10 | Very Short-term Spatial and Temporal Wind Power Forecasting: A Deep Learning Approach显示文摘In power systems that experience high penetration of wind power generation,very short-term wind power forecast is an important prerequisite for look-ahead power dispatch.Conventional univariate wind power forecasting methods at presentonly utilize individual wind farm historical data.However,studies have shown that forecasting accuracy canbe improved by exploring both spatial and temporal correlations among adjacent wind farms.Current research on spatial-temporal wind power forecasting is based on relatively shallow time series models that,to date,have demonstrated unsatisfactory performance.In this paper,a convolution operation is used to capture the spatial and temporal correlations among multiple wind farms.A novel convolution-based spatial-temporal wind power predictor(CSTWPP)is developed.Due to CSTWPP’s high nonlinearity and deep architecture,wind power variation features and regularities included in the historical data can be more effectively extracted.Furthermore,the online training of CSTWPP enables incremental learning,which makes CSTWPP non-stationary and in conformity with real scenarios.Graphics processing units(GPU)is used to speed up the training process,validating the developed CSTWPP for real-time application.Case studies on 28 adjacent wind farms are conducted to show that the proposed model can achieve superior performance on 5-30 minutes ahead wind power forecasts. | Tianyu Hu Wenchuan Wu Qinglai Guo Hongbin Sun Libao Shi Xinwei Shen | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 3 |
| 11 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 12 | Intensive Radiosonde Measurements of Summertime Convection over the Inner Mongolia Grassland in 2014:Difference between Shallow Cumulus and Other Conditions显示文摘Using radiosonde measurements from 26 July to 30 July 2014 at Baiqi over the Inner Mongolia grassland of China, the vertical structure of shallow cumulus(SCu) clouds and associated environmental conditions were investigated. The cloud base height and the cloud top height of SCu was 3.4 km and 5 km, respectively. The temperature of the SCu layer was less than 0℃. The horizontal advection of specific humidity was smaller than the vertical transport in the atmosphere below 5 km.Above 5 km, the thermodynamic structure of the atmosphere remained stable. At the interface of the cloud layer and free air atmosphere, there was obvious wind shear and a temperature inversion(~2.9℃). Comparisons of environmental parameters associated with cumulus congestus, rain and clear days, showed that the formation of SCu was characterized by a higher Bowen ratio(high sensible heat flux and low latent heat flux), which indicated intensive turbulence in the boundary layer. The formation of SCu was associated with the boundary layer height exceeding the lifting condensation level. The maintenance of SCu was likely associated with the lower convective available potential energy, weak wind shear, and weak subsidence of the synoptic system, which did not favor the dramatic vertical development of SCu and thereby the transformation of SCu to cumulus congestus. | Hongrong SHI Hongbin CHEN Xiang'ao XIA Xuehua FAN Jinqiang ZHANG Jun LI Chao LING | 2017 | Advances in Atmospheric Sciences2017，34，6： | 2 |
| 13 | Measuring boundary-layer height under clear and cloudy conditions using three instruments显示文摘 | Chenggang Wang Hongrong Shi Lianji Jin Hongbin Chen Huayang Wen | 2016 | Particuology2016，14，5： | 2 |
| 14 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 15 | Steam Oxidation Resistance of Silicon Carbide Castables at Elevated Temperatures显示文摘Silicon carbide castables of different SiC contents(86%and 71%,by mass)were prepared using white fused corundum,silicon carbide particles and fines,activated alumina powder,silica fume and pure calcium aluminate cement as main starting materials,heat treating at 1000℃ for 3 h,and oxidizing in steam atmosphere at 1000℃ for different durations(100,200,300,400 and 500 h).The mass and volume before and after oxidation,the bulk density,the apparent porosity and the cold compressive strength were tested.The phase composition and the microstructure before and after oxidation were analyzed by XRD and SEM.The results indicate that:(1)within 300 h of oxidation duration,silicon carbide shows an increasing oxidation rate;however,the oxidation rate is low during 300-500 h of oxidation duration;2)the oxidation rate of the specimen with 71%SiC is slightly higher than the one with 86%SiC;3)with the increasing oxidation degree of silicon carbide,the apparent porosity of the specimens tends to increase,followed by the declining bulk density and cold compressive strength. | SHI Huiying WANG Jiaping WU Jiguang HUANG Zhigang QIN Hongbin | 2021 | China's Refractories2021，30，3： | 2 |
| 16 | Isolation and Identification of Photobacterium damselae subsp.damselae(PDD) from Tongue Sole显示文摘In May 2016,an epizootic occured among cultured tongue soles caused mass deaths in a fish farm in Qinhuangdao,China.In order to find out the etiological agent,a bacterial strain was isolated from ascites and other tissues of sick tongue sole aseptically collected.The isolate was identified as Photobacterium damselae subsp.damsela(PDD) by isolation culture,Gram staining,physiological identification,morohological observation,biochemical identification and 16S rDNA sequence analysis.The results showed that the isolate shared 99.6% homology with the reference strain in GenBank.The animal regression test displayed that the isolate had very strong pathogenicity to tongue sole.The LD_(50) was 3.1 × 10~4 CFU/mL,and it showed pathogenicity to mammals.The antimicrobial susceptibility test showed the isolate was highly sensitive to nrofloxacin,Norfloxacin,Ciprofloxacin,Mequindox;moderately sensitive to Cefradine,Doxycycline;and insensitive to Gentamicin,Ceftriaxone,Tilmicosin,etc.. | Yang Nan Zhang Zhiqiang Wu Tonglei Zhu Jianxin Fu Yanfang Han Hongsheng Wang Hongbin Shi Qiumei Gao Guisheng | 2018 | Animal Husbandry and Feed Science2018，10，2： | 2 |
| 17 | A Novel Red Phosphor Mg2 GeO4 Doped with Eu^3+ for PDP Applications 显示文摘 | Yang Hongmei Shi Jianxin Liang Hongbin | 2006 | MaterSciEngB2006，127，23： | 1 |
| 18 | Therapeutic Effect and Mechanism of New Maixian Powder on DSS-induced UC Rats显示文摘[Objectives] To study the therapeutic effect and mechanism of New Maixian Powder on ulcerative colitis( UC) rats through observing its regulatory effect on the protein kinase R-like endoplasmic reticulum kinase( PERK)/eukaryotic translation initiation factor-2α( e IF-2α)/nuclear transcription factor-kappa B( NF-κB) signaling pathway. [Methods]First,60 SD rats were randomly divided into normal group,model group,mesalazine group,and New Maixian Powder low,medium and high dose groups,10 rats each group. Then,dextran sulfate sodium( DSS) was used to induce UC rats. The mesalazine group was given 0. 42 g/( kg·d) of mesalazine sustained-release granule suspension,New Maixian Powder low,medium and high dose groups were given 1. 5,3,and 6 g/( kg·d) of New Maixian Powder suspension,respectively,and other groups were given an equal volume of physiological saline,continuous intragastric administration for 14 d. Next,the disease activity index( DAI) of UC rats was evaluated; the expression of NF-κB in serum was measured by enzyme-linked immunosorbent assay( ELISA); the expression of PERK and e IF-2α protein and m RNA in colon tissue was detected by Western blot and real-time quantitative polymerase chain reaction( RT q-PCR). [Results] Compared with the normal group,the DAI score and serum NF-κB level in the model group were significantly higher( P < 0. 05),and PERK and e IF-2α protein and m RNA levels in the colon tissue were increased( P < 0. 05); compared with the model group,the DAI score decreased and serum NF-κB level declined in the New Maixian Powder group,and the expression of PERK and e IF-2α protein and m RNA in New Maixian Powder medium dose and high dose groups declined( P < 0. 05). [Conclusions]New Maixian Powder has good therapeutic effect on UC rats,and its mechanism may be connected with the inhibition of the activation of PERK/e IF-2α/NF-κB signaling pathway. | Minjun FU Rongzhen SHI Jianjun SHEN Meixia YANG Hongbin ZHENG | 2018 | Medicinal Plant2018，9，3： | 1 |
| 19 | Damage to urban buildings in zones of intensities Ⅷ and Ⅶ during the Wenchuan earthquake and discussion on some typical damages显示文摘The outline and typical characteristics of damages to building in Jiangyou city and Anxian county(intensity VⅢ), Mianyang city and Deyang city(intensity VII) are introduced in the paper.The damage ratios, based on the sample statistics of multi-story brick buildings together with multi-story brick buildings with RC frame at first story(BBF), are presented.Then some typical damages, such as horizontal cricks of brick masonry buildings, X-shaped cricks on the walls under windows, the damages to columns, beams and infill walls of frame buildings and the damage to half circle-shaped masonry walls, are discussed. | Jingjiang Sun Yuhong Tang Chao Zheng Hongbin Shi Lin Lin Zhongxian Sun | 2009 | Earthquake Science2009，22，2： | 1 |
| 20 | Comparative studies on solder joint reliability of CTBGA assemblies with various adhesives using the array -based package shear test 显示文摘 | Hongbin Shi Toshitsugu Ueda | 2011 | Microelectronics Reliability2011，51，： | 1 |
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