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| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 3 | Pore-scale visualization on a depressurization-induced CO2 exsolution显示文摘The pore-scale behavior of the exsolved CO_2 phase during the depressurization process in CO_2 geological storage was investigated.The reservoir pressure decreases when the injection stops or when a leaking event or fluid extraction occurs.The exsolution characteristics of CO_2 affect the migration and fate of CO_2 in the storage site significantly.Here,a micromodel experimental system that can accommodate a large pressure variation provides a physical model with homogeneous porous media to dynamically visualize the nucleation and growth of exsolved CO_2 bubbles.The pressure decreased from 9.85 to 3.95 MPa at different temperatures and depressurization rates,and the behavior of CO_2 bubbles was recorded.At the pore-scale,the nuclei became observable when the CO_2 phase density was significantly reduced,and the pressure corresponding to this observation was slightly lower than that of the severe expansion pressure region.The lower temperature and faster depressurization rate produced more CO_2 nuclei.The exsolved CO_2 bubble preferentially grew into the pore body instead of the throat.The progress of smaller CO_2 bubbles merging into a larger CO_2 bubble was first captured,which validated the existence of the Ostwald ripening mechanism.The dispersed CO_2 phase after exsolution shows similarity with the residually trapped CO_2.This observation is consistent with the low mobility and high residual trapping ratio of exsolved CO_2 measured in the core-scale measurement,which is considered to be a self-sealing mechanism during depressurization process in CO_2 geological storage. | Ruina Xu Rong Li Feng Huang Peixue Jiang | 2017 | Science Bulletin2017，62，11： | 10 |
| 4 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 5 | Three-dimensional porous graphene sponges assembled with the combination of surfactant and freeze-drying显示文摘与表面活化剂和 freeze-drying 的联合,我们开发了二种 graphene 多孔的结构。在一方面,把肥皂水泡的泡沫用作模板,有富有的层次毛孔的三维的多孔的 graphene 海绵被综合了。材料的毛孔包含长度规模的三个层次,包括毫米,测微计和纳米。结构能被改变结冰媒介调节,调整激动人心的率或增加功能的添加剂。由 graphene 氧化物 / 表面活化剂暂停的直接 freeze-drying,在另一方面,有方向性地排列的毛孔的一个多孔的框架被准备。表面活化剂给 graphene 氧化物表的更好的分散,导致一个高特定的表面区域。两个获得的材料展出优秀吸收能力和好压缩性能,提供大量可能的应用程序,例如吸收剂,存储媒介,和搬运人。 | Rujing Zhang Yachang Cao Peixu Li Xiaobei Zang Pengzhan Sun Kunlin wang Minlin Zhong Jinquan Wei Dehai Wu Feiyu Kang Hongwei Zhu | 2014 | Nano Research2014，7，10： | 10 |
| 6 | Temporal and spatial variations of stem CO_(2) efflux of three species in subtropical China显示文摘Aims Although stem CO_(2) efflux is critical to ecosystem carbon and energy balance and its feedback to future climate change,little information is available on stem CO_(2) efflux and its responses to temperature,especially in subtropical China.This study aims to(i)evaluate the temporal and spatial variations of stem CO_(2) efflux of three species,including oak(Quercus acutissima Carr.),masson pine(Pinus massoniana Lamb.)and loblolly pine(Pinus taeda Linn.)in subtropical China and(ii)analyze the temperature sensitivity of stem CO_(2) efflux in the three species based on 2-year field measurements.Methods We measured stem CO_(2) efflux and stem temperature(at 3 cm depth)of the three species using the horizontally oriented soil chamber technique from September 2008 to August 2010.We also conducted a 24-h measurement to examine the diurnal variation of stem CO_(2) efflux in three consecutive days in April 2009.Important findings The temporal dynamics of stem CO_(2) efflux followed the change of the stem temperature in a 3-cm depth with a bell-shaped curve in the three species.Stem temperature explained 77–85%of the seasonal variations of stem CO_(2) efflux over the entire study period in the three species.The temperature sensitivity(Q_(10))of stem CO_(2) efflux was obviously different among the three species with higher Q10 value found in oak(2.24)and lower values in the coniferous species(1.76 and 1.63).Our results also showed that the Q10 values of stem CO_(2) efflux in all the three species were lower in the growing season than that in the non-growing season,indicating that the growth and maintenance respiration had different temperature responses.Moreover,we found that the temperature-normalized stem CO_(2) efflux(R_(10))changed greatly between the growing and non-growing seasons in oak and masson pine,but not in loblolly pine.Additionally,we also found that in the non-growing season,the principal factor responsible for the spatial variation of stem CO_(2) efflux among the 15 sampling trees was sapwood volume,whereas in the growing season,stem CO_(2) efflux was closely related to annual dry-matter production in the three subtropical species. | Qingpeng Yang Ming Xu Yonggang Chi Yunpu Zheng Ruichang Shen Peixue Li Huitang Dai | 2012 | Journal of Plant Ecology2012，5，2： | 7 |
| 7 | Recent progress in synthesis of lanthanide-based persistent luminescence nanoparticles显示文摘Persistent luminescence nanoparticles(PLNPs)are a kind of phosphors that can remain luminescent for seconds to several days after the stoppage of excitation.Lanthanides show the special capability to largely broaden the emission range and enhance the luminescence intensity of PLNPs due to their dense energy structure and unique electronic configurations.In the past decades,various methods have been developed for the synthesis of lanthanide-based PLNPs with excellent pe rsistent luminescence propertie s,and the lanthanide-based PLNPs are widely studied in areas including biome dicine,energy,and information storage.In this review,we summarized the research progress in the synthe sis of lanthanidebased PLNPs and outline d several typical synthesis methods.We discussed the fundamental concepts of preparation methods as well as the advantages and drawbacks of the typical synthetic approache s.Moreove r,the current challenges and the potential solutions for the development of lanthanide-based PLNP s are also discussed in an attempt to provide strate gies to further improve the optical properties of lanthanide-based PLNPs.We hope this review can contribute to the design of lanthanide-based PLNPs with desired properties and further promote their applications in biomedicine,energy,and information science. | Yurong Wei Chengxu Gong Min Zhao Lei Zhang Shaodan Yang Peixu Li Zhao Ding Quan Yuan Yanbing Yang | 2022 | Journal of Rare Earths2022，40，9： | 2 |
| 8 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 9 | A layered Virtual Organization architecture for grid显示文摘 | Yongqiang Zou Li Zha Xiaoning Wang Haojie Zhou Peixu Li | 2010 | The Journal of Supercomputing2010，，3： | 1 |
| 10 | Encapsulated carbon nanotube-oxide-silicon solar cells with stable 10 % efficiency 显示文摘 | JIA Yi LI Peixu GUI Xuchun | 2011 | ApplPhysLett2011，98，13： | 1 |
| 11 | Experi- mental investigation of convection heat transfer of COz at supercritical pressures in a vertical circular tube显示文摘 | LI Zhihui JIANG Peixue ZHAO Chenru | 2010 | Ex- perimental Thermal and Fluid Science2010，34，8： | 1 |
| 12 | Echinoside A from Pearsonothuria graeffei Exert the Cytotoxicity to MDA-MB-231 Cells via Mitochondrial Membrane and Modulation of PI3K/Akt/mTOR Pathway显示文摘A kind of triterpene glycosides echinoside A(EA)was extracted from sea cucumber Pearsonothuria graeffei,and its yield was about 0.78%.The purity of EA was 99.0%,and its molecular weight was 1206 Da.EA was a linear tetrasaccharide attached to a pentacyclic triterpene aglycon.It inhibited the growth of MDA-MB-231 cells in vitro.The antitumor effect was related to elevate ROS level,decrease mitochondrial membrane potential,enhance caspase-3 expression,induce cells apoptosis and arrest cell cycle at G2/M phase.EA also dose-dependently suppressed the expressions of phophorylation proteins p-PI3K,p-Akt,and p-mTOR as analyzed by western blotting.These results suggested that EA caused MDA-MB-231 cells apoptosis via intrinsic mitochondrial and PI3K/Akt/mTOR pathway.EA can be a potential anti-breast cancer agent to enhance the clinical efficacy. | LI Hongyan CUI Huanhuan CONG Peixu XU Jie XIE Wancui WANG Yuming XUE Changhu | 2023 | Journal of Ocean University of China2023，22，1： | 0 |
| 13 | Author Corrections: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘Correction to:Cell Research https://doi.org/10.1038/cr.2014.10,published online 24 January 2014 In the original version of this article,1 there is an error in Fig.2G.Specifically,in the Ctrl group of Fig.2G,the A549 microscope image was mistakenly used with the CRL-5872 microscope image.The correct image has been provided.The authors regret this error. | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2021 | Cell Research2021，31，10： | 0 |
| 14 | CuI-Si Heterojunction Solar Cells with Carbon Nanotube Films as Flexible Top-Contact Electrodes显示文摘我们作为一个透明电极与碳 nanotubes (CNT ) 报导 CuI-Si 异质接面太阳能电池的制造。一个灵活 CNT 网络被转移到多晶的 CuI 层的顶上,做有与内在的 CuI 的好接触的保角的涂层。太阳能电池在 6% ~ 10.5% 的范围显示出力量变换效率,当在设备在空中被存储为 8 天以后,效率降级是不到 10% 时。与象铟听氧化物(ITO ) 那样的常规僵硬电极相比玻璃, CNT 电影的灵活性与活跃的层保证更好的接触并且为出版社接触电极移开需要。降级的房间能由 CNT 电极做的酸恢复他们的原来的表演。我们的结果建议 CNT 电影与不平的表面是为不平的材料和结构的合适的电的接触。 | Peixu Li ShanshanWang Yi Jia Zhen Li Chunyan Ji Luhui Zhang Hongbian Li Enzheng Shi Zuqiang Bian Chunhui Huang Jinquan Wei Kunlin Wang Hongwei Zhu Dehai Wu Anyuan Cao | 2011 | Nano Research2011，4，10： | 0 |
| 15 | Staurosporine targets the Hippo pathway to inhibit cell growth显示文摘 | Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding Yun Zhao Fa-Xing Yu Xiangbing Qi Lei Zhang | 2018 | Journal of Molecular Cell Biology2018，10，3： | 0 |
| 16 | Growth suppressor lingerer regulates bantam microRNA to restrict organ size显示文摘The evolutionarily conserved Hippo signaling pathway plays an important role in organ size control by regulating cell proliferation and apoptosis.Here,we identify Lingerer(Lig)as a growth suppressor using RNAi modifying screen in Drosophila melanogaster.Loss of lig increases organ size and upregulates bantam(ban)and the expression of the Hippo pathway target genes,while overexpression of lig results in diminished ban expression and organ size reduction.We demonstrate that Lig C-terminal exhibits dominant-negative function on growth and ban expression,and thus plays an important role in organ size control and ban regulation.In addition,we provide evidence that both Yki and Mad are essential for Lig-induced ban expression.We also show that Lig regulates the expression of the Hippo pathway target genes partially via Yorkie.Moreover,we find that Lig physically interacts with and requires Salvador to restrict cell growth.Taken together,we demonstrate that Lig functions as a critical growth suppressor to control organ size via ban and Hippo signaling. | Liang Dong Jinhui Li Hongling Huang Meng-Xin Yin Jinjin Xu Peixue Li Yi Lu Wenqing Wu Hang Yang Yun Zhao Lei Zhang | 2015 | Journal of Molecular Cell Biology2015，7，5： | 0 |
| 17 | Research Progress of Sunscreen Agents and Encapsulate Technology显示文摘The harm of ultraviolet radiation to human skin and the mechanism of traditional sunscreen agents and natural sunscreen agents were reviewed.Sunscreen agents were usually encapsulated with delivery systems due to the instability and skin permeability.The research progress of several common sunscreen delivery systems was introduced,the future research direction of sunscreen agents was also prospected. | Zheng Xiaoyang Meng Xiangjing Li Min Liu Bo Zhang Xiangkui Duan Chong gang Zhang Daizhou Ling Peixue Wang Dongliang | 2023 | China Detergent & Cosmetics2023，8，2： | 0 |
| 18 | Jurassic integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas显示文摘The Qinghai-Tibetan Plateau experienced a unique geological evolution during the Jurassic,driven by the termination of the Palaeotethys and the reduction of the Neotethys.The Indian Plate separated from the northern margin of Gondwana and drifted northward from the Southern Hemisphere.Given that the timing of strata serves as the basis for reconstructing geological history,the present work aimed to develop a new multiple stratigraphic and chronologic framework for the Jurassic strata of the Qinghai-Tibetan Plateau region via a synthesis of the material on lithostratigraphy,palaeontology,iso-radiometric dating,magnetostratigraphy,and other techniques with an emphasis on recent progress and findings.The new framework included the Jurassic System from the four major subdivisions of the plateau:the Baryan Har,Qiangtang,Lhasa-Gandise,and Southern Xizang(Himalaya).Ultimately,a more complete,refined biostratigraphic sequence was proposed,comprising the most common fossils in the plateau and those that are stratigraphically significant for the Jurassic stratigraphy,including ammonites,bivalves,brachiopods,foraminifera,radiolarians,and dinoflagellate cysts for the marine strata,and pollen and spores,and charophytes for the terrestrial sediments.This biostratigraphic framework was correlated with the Jurassic international standard zonation of the Geological Time Scale 2020 via standard or representative species or genera of ammonites.Based on this framework,we constructed a lateral correlation of the Jurassic strata between different basins of the plateau.The palaeontologic correlation in the present work shows that the Lhasa-Gandise Block had a closer relationship with the Qiangtang Block than with the Southern Xizang Himalaya during the Jurassic Period.Meanwhile,the Lhasa-Gandise Block and Qiangtang Block shared similar marine fauna features of the north marginal East Tethys.This contrasts the opinion suggesting that the Yarlung Zangbo Tethys was a small back-arc basin.A combination of stratigraphical,palaeontological,and sedimentological analyses implies that the Bangong Co-Nujiang Tethys may have begun rifting in the Late Triassic,evolving to the birth at the late Early Jurassic with the formation of ocean crust.However,this resulted in failure after it grew into the climax at the end of the Middle Jurassic when the Qiangtang Block began subducting under the Lhasa-Gandise Block.In the Early Cretaceous,the two blocks finally merged. | Jianguo LI Xin RAO Lin MU Xiaohui CUI Xin LI Hui LUO Peixue LIU | 2024 | Science China Earth Sciences2024，67，4： | 0 |
| 19 | Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi显示文摘Fragile X syndrome(Fra X), the most common form of inherited mental retardation, is caused by the absence of the evolutionally conserved fragile X mental retardation protein(FMRP). While neuronal functions of FMRP have been intensively studied for the last two decades, its role in non-neuronal cells remains poorly understood. Piwi, a key component of the Piwi-interacting RNA(pi RNA) pathway,plays an essential role in germline development. In the present study, we report that similar to piwi, dfmr1, the Drosophila homolog of human FMR1, is required for transposon suppression in the germlines. Genetic analyses showed that dfmr1 and piwi act synergistically in heterochromatic silencing, and in inhibiting the differentiation of primordial germline cells and transposon expression. Northern analyses showed that roo pi RNA expression levels are reduced in dfmr1 mutant ovaries, suggesting a role of dfmr1 in pi RNA biogenesis.Biochemical analysis demonstrated a physical interaction between d FMRP and Piwi via their N-termini. Taken together, we propose that d FMRP cooperates with Piwi in maintaining genome integrity by regulating heterochromatic silencing in somatic cells and suppressing transposon activity via the pi RNA pathway in germlines. | Fangfang Jiang Falong Lu Peixue Li Wei Liu Lu Zhao Qifu Wang Xiaofeng Cao Lei Zhang Yong Q.Zhang | 2016 | Journal of Genetics and Genomics2016，43，1： | 0 |
| 20 | Research, development and application of compound-vertical-retort technology for magnesium production显示文摘This paper comprehensively introduces a new magnesium production technology the compound-vertical-retort technology, involving in the related fundamental researches, core equipment development, working flow, and technical characteristics. Scale-up test and an annual1200-ton-magnesium demonstration-level test was conducted to confirm the rationality, reliability, and advancement of the equipment, system and process design. It is indicated that the new technology solved a series of problems of traditional silicothermic process including adhesion and glaze, short life of retort, low efficiency, high impurity of crystallized magnesium, large heat losses, and poor working environment,making a great technological breakthrough in this field. Representatively, the new well-designed ceramic-lined steel retort serves 2~3 times in life than the normal retorts. The magnesium yield per retort is improved 4~5 times, with purity of >99.8%. The energy consumption in reduction stage is reduced by more than 20%. The mechanical production is fully realized and operating environment is significantly improved. | Rongbin Li Shaojun Zhang Peixu Yang Jinhui Liu Fengqin Liu | 2023 | Journal of Magnesium and Alloys2023，11，12： | 0 |
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