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| 1 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 2 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 3 | Energy measurement system of a large-aperture high power laser experiment platform显示文摘An energy measurement system in a large-aperture high power laser experiment platform is introduced. The entire measurement system includes five calorimeters, which carry out the energy measurement of the fundamental frequency before the frequency conversion unit, remaining fundamental frequency, remaining second-harmonics, third-harmonics,as well as the energy balance measurement after the frequency conversion unit. Combinational indirect calibration and direct calibration are employed to calibrate the sampling coefficients of the calorimeters. The analysis of the data showed that, regarding the energy balance coefficients, combinational calibration approach gives a higher precision, and leads to an energy balance with 1%; and regarding the energy sampling coefficients for the various wavelengths after the frequency conversion, the results from direct and combinational calibration are consistent. The uncertainties for all energy sampling coefficients are within 3%, which guarantees the reliability of the energy measurement for the laser facility. | Yanwen Xia Yue Liang Sen Li Junpu Zhao Zhitao Peng Hongguang Li Hua Liu Zhihong Sun Kuixing Zheng Xiaofeng Wei | 2013 | High Power Laser Science and Engineering2013，1，Z1： | 2 |
| 4 | A Micro Amperometric Immunosensor Based on MEMS显示文摘A micro amperometric immunosensor with the sensitive area of only 1mm^2 was fabricated on silicon using the technique of Micro-Electro-Mechanical Systems (MEMS).A double exposure of SU-8 photoresist process was developed to create both the sensitive pool and reaction pool.Antibody was immobilized via cross-linking with glutaraldehyde on the sensitive area of the electrode surface,which was electropolymerized with polypyrrole previously.The immunosensor was characterized by detection of human immunoglobulin G (HIgG).The immunosensor displayed a good linear response to HIgG concentrations between 5ng/ml and 255ng/ml and demonstrated a fast response time of 3 minutes. | Chao Bian Yuanyuan Xu Hongguang Sun Shaofeng Chen Shanhong Xia | 2006 | 稀有金属材料与工程2006，35，A03： | 2 |
| 5 | A Full CMOS Integration Including ISFET Microsensors and Interface Circuit for Biochemical Applications显示文摘One of today's challenges is the integration of ISFETs in chemical and biochemical Microsystems.This article presents a full integration of ISFET chip containing the ISFET/REFET(reference FET) pair,ISFET/REFET amplifiers,bias current generator,as well as a reference electrode structure,all integrated on the same chip based on CMOS technology.The sensor chip was fabricated in a standard 0.35μm CMOS process(Chartered Semiconductor,Singapore).The extra post processing steps have been developed and added for depositing membranes.Finally,the pH response of the integrated sensor was measured with the interface circuit. | Jinbao Wei Haigang Yang Hongguang Sun Zengjin Lin Shanhong Xia | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 6 | Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13显示文摘 | Junli Liu Hongguang Xia Minsu Kim Lihua Xu Ying Li Lihong Zhang Yu Cai Helin Vakifahmetoglu Norberg Tao Zhang Tsuyoshi Furuya Minzhi Jin Zhimin Zhu Huanchen Wang Jia Yu Yanxia Li Yan Hao Augustine Choi Hengming Ke Dawei Ma Junying Yuan | 2011 | Cell2011，，1： | 1 |
| 7 | Preparation of γ-Al2O3 via Hydrothermal Synthesis Using ρ-Al2O3 as Raw Material for Propane Dehydrogenation显示文摘γ-Al2O3 was prepared by hydrothermal synthesis usingρ-Al2O3 and urea as raw materials.In this work,the eff ects of the molar ratio of CO(NH2)2/Al and reaction temperature were investigated,and a Pt–Sn–K/γ-Al2O3 catalyst was prepared.The ammonium aluminum carbonate hydroxide(AACH),γ-Al2O3,and Pt–Sn–K/γ-Al2O3 were characterized by X-ray diff raction,scanning electron microscopy,transmission electron microscopy,N2 adsorption–desorption,thermogravimetry–differential thermal analysis,and NH3 temperature-programmed desorption techniques.The reactivity of Pt–Sn–K/γ-Al2O3 for propane dehydrogenation was tested in a micro-fixed-bed reactor.The results show thatγ-Al2O3 with a specific surface area of 358.1 m 2/g and pore volume of 0.96 cm 3/g was obtained when the molar ratio of CO(NH2)2/Al was 3:1 and the reaction temperature was 140℃.The alumina obtained by calcination of AACH has a higher specific surface area and larger pore volume than the industrial pseudo-boehmite does.The catalyst prepared from AACH as precursor showed high selectivity and conversion,which can reach 96.1%and 37.6%,respectively,for propane dehydrogenation. | Hongguang Liu Xiaomin Dong Jiping Xia Xiaoyun Li Yanmin Sun Qi Cai | 2020 | Transactions of Tianjin University2020，26，5： | 1 |
| 8 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 9 | Effects of nitrogen fertilizer application on saline-alkali land cotton in China quantified using meta-analysis and regression analysis显示文摘Nitrogen fertilizer application is an important means to promote cotton production in saline-alkali land.A metaanalysis and regression analysis of 49 peer-reviewed studies were conducted using yield data(373 data points),dry matter accumulation(114 data points),and water use efficiency(157 data points)to quantify the effect of nitrogen fertilizer on the yield,dry matter accumulation,and water use efficiency of cotton in saline-alkali land in China for different planting management practices and different growing environments.The results showed that the nitrogen application significantly improved the yield,dry matter accumulation,and water use efficiency by 34.11%,36.27%,and 33.87%,respectively,compared with no nitrogen application.The largest improvements in the yield,dry matter accumulation,and water use efficiency occurred in areas where saline-alkali land had been improved for many years,in Eastern China,South Central China,and Northwest China(areas with annual average precipitation≤200 mm or>800 mm,and annual average evaporation≤800 mm or>2400 mm),in areas with trickle irrigation,and fields with a planting density of 100000 to 250000 plants/hm2.Cotton exhibited the optimal response to nitrogen application at a rate of 300-375 kg/hm2,a basal application ratio of 20%-40%,and top-dressing in the cotton bud,flowering boll,and full boll stages.The effect of nitrogen application increased as the salinity increased.A suitable nitrogen application rate,top-dressing ratio,and top-dressing period are crucial for increasing cotton production in saline-alkali land,although environmental differences and planting measures have to be considered.This study provided information on the correct application of nitrogen fertilizer to maximize its benefits and suggests controlling nitrogen fertilizer inputs in agriculture to protect the soil environment and ensure sustainable agricultural development. | Changkun Yang Hongguang Liu Ping Gong Pengfei Li Xiang Qiao Zhijie Li Hua Jin Qian Zhang Hanji Xia | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 10 | Correction to:Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘CORRECTION TO:PROTEIN CELL HTTPS://DOI.ORG/10.1007/S13238-021-00858-3 In legend of figure 1,this sentence“(C)293THK cells were treated as in a”should be corrected as“(C)293THK cells were treated as in(A)”.In legend of figure 2,“E-64D(10μmol/L)”in description of panel(B)should be removed.In section“Metformin activates chaperone-mediated autophagy”of RESULTS,E-64D in sentence“Metformininduced degradation of HK2 and PKM2 was blocked by lysosomal inhibitors(E-64D,Bafilomycin A1 and Leupeptin+NH4Cl)”should be removed. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2022 | Protein & Cell2022，13，3： | 0 |
| 11 | mTORC1对乙酰转移酶p300的磷酸化调控自噬和脂质合成显示文摘文章简介近年来的研究表明,p300可以乙酰化细胞质中的蛋白,参与调控细胞质中的生物学过程;p300通过乙酰化自噬相关蛋白LC3、Atg5和Atg7等,在细胞内重要的分解代谢过程自噬的起始中发挥关键作用。然而,人们对细胞内p300的活性调控机制却知之甚少。 | Wei Wan Zhiyuan You Yinfeng Xu Li Zhou Zhunlv Guan Chao Peng Catherine C.L.Wong Hua Su Tianhua Zhou Hongguang Xia 刘伟 | 2018 | 科学新闻2018，0，4： | 0 |
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