|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 3 | Structure and Mechanical Properties of Magnesium Alloy Treated by Plasma Electrolysis Oxidation Using Direct Current and High-frequency Bipolar Pulsing Modes显示文摘 | JIN Fanya Chu Paul K. XU Guidong ZHAO Jun SHEN Liru TONG Honghui | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 29 |
| 4 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 5 | Structure and Microwave Absorbing Properties of Fe Particle Containing Alumina Prepared by Micro-arc Oxidation显示文摘 | JIN Fanya TONG Honghui LI Jiong SHEN Liru Chu Paul K. | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 6 |
| 6 | A new species of Megophrys (Amphibia:Anura:Megophryidae) from the northwestern Hunan Province,China显示文摘A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp.nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Megophrystuberogranulatus is closely related to both Megophrys kuatunensis and Megophrys minor. Characters of the new species that differentiatethis species from close relatives are skin granulated with big tubercles on the dorsal sides of both thigh and tibia, thebigger inner metacarpal tubercle, upper eyelid wider than the interorbital space, hind limbs longer, overlapping of the left andright calcaneal parts. The type specimens are deposited in the Animal Museum of Life Sciences College of Hunan Normal University. | Xiaoyang MO Youhui SHEN Honghui LI Xiushan WU | 2010 | Current Zoology2010，56，4： | 6 |
| 7 | Micro-structural and Dielectric Properties of Porous TiO2 Films Synthesized on Titanium Alloys by Micro-arc Discharge Oxidization显示文摘 | JIN Fanya TONG Honghui SHEN Liru WANG Ke Chu Paul K. | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 3 |
| 8 | Composition and Distribution of Planktonic Ciliates in the Southern South China Sea During Late Summer: Comparison Between Surface and 75 m Deep Layer显示文摘Ciliates are very important components in most marine ecosystem.They are trophic link between the microbial food web and grazing food chain.In this study,ciliates were collected from 11 sites in the southern South China Sea(SCS) during August 25 to September 28,2011.Their composition and distribution at the surface and 75 m deep depth of the ocean were studied.A total of 30 species belonging to 22 genera were identified,and 22 species of 15 genera were Tintinnids.Eutintinnus fraknoii and E.stramentus were the most common species.The other dominants were strombidiids ciliates including Strombidium conicum and S.globosaneum,which were followed by the tide form,Mesodinium pulex.Ciliates abundance ranged from 46 ind L^(-1) to 368 ind L^(-1) in the open sites,46–368 ind L^(-1) at surface and 73–198 ind L^(-1) at 75 m deep layer.In the Yongshu reef,ciliates abundance ranged from 167 ind L^(-1) to 365 ind L^(-1) in the water column,similar to that in Sanya coral reef waters.Ciliates composition showed obvious difference between surface and 75 m deep layer at station S2(P < 0.05),while no similar result was observed at other sites.At 75 m deep layer,salinity was negatively related to mixed layer depth(P < 0.05),but positively to chlorophyll a concentration(P < 0.05),indicating that the change of vertical mixing in water column influenced vertical distribution of ciliates in the southern SCS. | LIU Huaxue SHEN Pingping LI Chunhou CHEN Zuozhi QI Zhanhui HUANG Honghui | 2016 | Journal of Ocean University of China2016，15，1： | 3 |
| 9 | Revealing complex optical phenomena through vectorial metrics显示文摘Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical diagnosis.Imaging polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial properties.Despite forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal structure.Certain simpler vectorial metrics are derived from subsets of the MM elements.These metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these metrics.We harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous tissue.This provides new insight for the broader usage of such asymmetric inferred vectorial information. | Chao He Jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan Jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq Jingyu Wang Jacopo Antonello Yang Dong Ji Qi Jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma Martin J.Booth | 2022 | Advanced Photonics2022，4，2： | 2 |
| 10 | Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance显示文摘 | Shuai Chen Mingjun Zhang Honghui Ma Hexige Saiyin Suqin Shen Jiajie Xi Bo Wan Long Yu | 2008 | Cancer Chemotherapy and Pharmacology2008，，： | 1 |
| 11 | Mutual information unsupervised feature selection for underwater acoustic targets显示文摘 | SHEN Sheng YANG Honghui YUAN Shuai | 2013 | Technical Acoustics2013，32，6： | 1 |
| 12 | Binding to m6A RNA promotes YTHDF2-mediated phase separation显示文摘Dear Editor,As one of the most abundant modifications on mRNA in mammal,A^6-methyladenosine(m6A)has been demonstrated to play important roles in various biological processes including nuclear RNA export,mRNA splicing,miRNA processing,mRNA degradation and translation(Shi et al.,2019).Importantly,different m6A reader proteins have been shown to play central roles in these processes. | Jiahua Wang Liyong Wang Jianbo Diao Yujiang Geno Shi Yang Shi Honghui Ma Hongjie Shen | 2020 | Protein & Cell2020，11，4： | 1 |
| 13 | Rare inherited missense variants of POGZ associate with autism risk and disrupt neuronal development显示文摘Excess de novo likely gene-disruptive and missense variants within dozens of genes have been identified in autism spectrum disorder(ASD)and other neurodevelopmental disorders.However,many rare inherited missense variants of these high-risk genes have not been thoroughly evaluated.In this study,we analyzed the rare missense variant burden of POGZ in a large cohort of ASD patients from the Autism Clinical and Genetic Resources in China(ACGC)and further dissected the functional effect of diseaseassociated missense variants on neuronal development.Our results showed a significant burden of rare missense variants in ASD patients compared to the control population(P=4.6×10-5,OR=3.96),and missense variants in ASD patients showed more severe predicted functional outcomes than those in controls.Furthermore,by leveraging published large-scale sequencing data of neurodevelopmental disorders(NDDs)and sporadic case reports,we identified 8 de novo missense variants of POGZ in NDD patients.Functional analysis revealed that two inherited,but not de novo,missense variants influenced the cellular localization of POGZ and failed to rescue the defects in neurite and dendritic spine development caused by Pogz knockdown in cultured mouse primary cortical neurons.Significantly,L1CAM,an autism candidate risk gene,is differentially expressed in POGZ deficient cell lines.Reduced expression of L1cam was able to partially rescue the neurite length defects caused by Pogz knockdown.Our study showed the important roles of rare inherited missense variants of POGZ in ASD risk and neuronal development and identified the potential downstream targets of POGZ,which are important for further molecular mechanism studies. | Wenjing Zhao Jieqiong Tan Tengfei Zhu Jianjun Ou Ying Li Lu Shen Huidan Wu Lin Han Yanling Liu Xiangbin Jia Ting Bai Honghui Li Xiaoyan Ke Jingping Zhao Xiaobing Zou Zhengmao Hu Hui Guo Kun Xia | 2019 | Journal of Genetics and Genomics2019，46，5： | 0 |
| 14 | Investigation on the radioactivity levels of seawater,sediments,and biota in Daya Bay,China显示文摘Objective:To investigate the radioactivity levels of seawater,sediments,and biota in the Daya Bay sea area,China,in order to establish the radioactivity baseline values,and provide basic data for the assessment of potential radiological risks that might result from the application of nuclear technology or human activities.Methods:Samples of seawater,sediments,and biota were collected from the Daya Bay sea area and analyzed.Their radioactivity baseline data were then compared with information from other regions in China and around the world reported in related literature.Results:For the seawater samples,the activity concentrations of natural radionuclide ^(40)K were 9.9-10.4 Bq/L,while ^(238)U,226Ra,^(210)Pb,^(137)Cs,and ^(110)Ag^(m) were below the minimum detectable activity(MDA).Regarding the sediment samples,the activity concentrations of ^(238)U,^(228)Ra,^(226)Ra,^(210)Pb,^(40)K,and ^(137)Cs were 38.1-40.4,49.1-53.7,32.6-38.6,59-95,590-650,and 0.48-0.88 Bq/(kg dry weight),respectively,while ^(110)Agm was below the MDA.For the marine shrimps in the biota samples,the activity concentrations of ^(228)Ra,^(226)Ra,^(40)K,and ^(137)Cs were 1.14-2.75,0.17-0.43,63-76,and 0.038-0.045 Bq/(kg wet weight),respectively,while ^(238)U,^(210)Pb,and ^(110)Agm were all below the MDA.Furthermore,for the marine fishes in the biota samples,the activity concentrations of ^(228)Ra,^(226)Ra,^(210)Pb,^(40)K,and ^(137)Cs were 2.1-19.7,0.32-3.78,<2.2-2.8,59-70,and<0.007-0.026 Bq/(kg wet weight),respectively,while ^(238)U and ^(110)Ag^(m) were all below the MDA.^(228)Ra was found to be concentrated in Osteomugil ophuyseni with 19.7 Bq/(kg wet weight).Conclusions:The radioactivity levels of seawater and marine sediments in the Daya Bay sea area are within the range of the normal background values.Osteomugil ophuyseni exhibited higher concentrations of ^(228)Ra than other species in this study,while the other species in the biota show no significant difference in the radioactivity levels from data in relevant literature. | Fan Cui Honghui Huang Yi Shen Zhan Tan Pengxiang Qu Ming Dai Hongwei Yu Weixu Huang Zixiang Wu Huifeng Chen Weizhen Guo Yuxin Jia Yanbing Liu | 2023 | Radiation Medicine and Protection2023，4，3： | 0 |
| 15 | Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau显示文摘The uplift of the Tibetan Plateau significantly altered the geomorphology and climate of the Euroasia by creating large mountains and rivers.Fishes are more likely to be affected relative to other organisms,as they are largely restricted to river systems.Faced with the rapidly flowing water in the Tibetan Plateau,a group of catfish has evolved greatly enlarged pectoral fins with more numbers of fin-rays to form an adhesive apparatus.However,the genetic basis of these adaptations in Tibetan catfishes remains elusive.In this study,we performed comparative genomic analyses based on the chromosome-level genome of Glyptosternum maculatum in family Sisoridae and detected some proteins with conspicuously high evolutionary rates in particular in genes involved in skeleton development,energy metabolism,and hypoxia response.We found that the hoxd12a gene evolved faster and a loss-of-function assay of hoxd12a supports a potential role for this gene in shaping the enlarged fins of these Tibetan catfishes.Other genes with amino acid replacements and signatures of positive selection included proteins involved in low temperature(TRMU)and hypoxia(VHL)responses.Functional assays reveal that the G.maculatum TRMU allele generates more mitochondrial ATP than the ancestral allele found in low-altitude fishes.Functional assays of VHL alleles suggest that the G.maculatum allele has lower transactivation activity than the low-altitude forms.These findings provide a window into the genomic underpinnings of physiological adaptations that permit G.maculatum to survive in the harsh environment of the Tibetan Himalayas that mirror those that are convergently found in other vertebrates such as humans. | Liandong Yang Ning Sun Honghui Zeng Ying Wang Wenjun Chen Zufa Ding Yang Liu Jing Wang Minghui Meng Yanjun Shen Jingliang Kang Xiuhui Ma Wenqi Lv Juan Chen Axel Meyer Baocheng Guo Shunping He | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 16 | Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor显示文摘Genome editing through adeno-associated viral(AAV) vectors is a promising gene therapy strategy for various diseases,especially genetic disorders. However, homologous recombination(HR) efficiency is extremely low in adult animal models. We assumed that increasing AAV transduction efficiency could increase genome editing activity, especially HR efficiency, for in vivo gene therapy. Firstly, a mouse phenylketonuria(PKU) model carrying a pathogenic R408W mutation in phenylalanine hydroxylase(Pah) was generated. Through co-delivery of the general AAV receptor(AAVR), we found that AAVR could dramatically increase AAV transduction efficiency in vitro and in vivo. Furthermore, co-delivery of SaCas9/sgRNA/donor templates with AAVR via AAV8 vectors increased indel rate over 2-fold and HR rate over 15-fold for the correction of the single mutation in Pah;mice. Moreover, AAVR co-injection successfully increased the site-specific insertion rate of a 1.4 kb Pah cDNA by 11-fold, bringing the HR rate up to 7.3% without detectable global off-target effects. Insertion of Pah cDNA significantly decreased the Phe level and ameliorated PKU symptoms. This study demonstrates a novel strategy to dramatically increase AAV transduction which substantially enhanced in vivo genome editing efficiency in adult animal models, showing clinical potential for both conventional and genome editing-based gene therapy. | Shuming Yin Lie Ma Tingting Shao Mei Zhang Yuting Guan Liren Wang Yaqiang Hu Xi Chen Honghui Han Nan Shen Wenjuan Qiu Hongquan Geng Yongguo Yu Shichang Li Weishi Yu Mingyao Liu Dali Li | 2022 | Science China(Life Sciences)2022，65，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员