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| 1 | On developing data-driven turbulence model for DG solution of RANS显示文摘High-order Discontinuous Galerkin(DG) methods have been receiving more and more attentions in the area of Computational Fluid Dynamics(CFD) because of their high-accuracy property. However, it is still a challenge to obtain converged solution rapidly when solving the Reynolds Averaged Navier–Stokes(RANS) equations since the turbulence models significantly increase the nonlinearity of discretization system. The overall goal of this research is to develop an Artificial Neural Networks(ANNs) model with low complexity acting as an algebraic turbulence model to estimate the turbulence eddy viscosity for RANS. The ANN turbulence model is off-line trained using the training data generated by the widely used Spalart–Allmaras(SA) turbulence model before the Optimal Brain Surgeon(OBS) is employed to determine the relevancy of input features.Using the selected relevant features, a fully connected ANN model is constructed. The performance of the developed ANN model is numerically tested in the framework of DG for RANS, where the‘‘DG+ANN' method provides robust and steady convergence compared to the ‘‘DG+SA' method. The results demonstrate the promising potential to develop a general turbulence model based on artificial intelligence in the future given the training data covering a large rang of flow conditions. | Liang SUN Wei AN Xuejun LIU Hongqiang LYU | 2019 | Chinese Journal of Aeronautics2019，32，8： | 7 |
| 2 | Hotspots and trends of biological water treatment based on bibliometric review and patents analysis显示文摘In order to reveal the hotspots and trends of biological water treatment from the perspectives of scientific and technological innovation, both of the bibliometric review and patents analysis were performed in this study. The Web of Science Core Collection database and Derwent Innovation Index database recorded 30023 SCI papers and 50326 patents, respectively were analyzed via information visualization technology. The results showed that China ranked the first in both papers and patents, while the United States and Japan had advantages in papers and patents, respectively. It was concluded through literature metrology analysis that microbial population characteristics, biodegradation mechanism,toxicity analysis, nitrogen and phosphorus removal and biological treatment of micropolluted wastewater were the research hotspots of SCI papers. Activated sludge process and anaerobic-aerobic combined process were the two mainstream technologies on the basis of patent technology classification analysis. Technology evolution path of biological water treatment was also elucidated in three stages based on the citation network analysis. Furthermore, the future directions including research on the law of interaction and regulation of biological phases and pollutants and the technology innovations towards the targeted biotransformation or selective biodegradation of pollutants and resource reuse of wastewater were prospected. | Lili Jin Xiangzhou Sun Hongqiang Ren Hui Huang | 2023 | Journal of Environmental Sciences2023，，3： | 4 |
| 3 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 4 | An h-adaptive Discontinuous Galerkin Method for Laminar Compressible Navier-Stokes Equations on Curved Mesh显示文摘An h-adaptive method is developed for high-order discontinuous Galerkin methods(DGM)to solve the laminar compressible Navier-Stokes(N-S)equations on unstructured mesh.The vorticity is regarded as the indicator of adaptivity.The elements where the vorticity is larger than a pre-defined upper limit are refined,and those where the vorticity is smaller than a pre-defined lower limit are coarsened if they have been refined.A high-order geometric approximation of curved boundaries is adopted to ensure the accuracy.Numerical results indicate that highly accurate numerical results can be obtained with the adaptive method at relatively low expense. | Sun Qiang L yu Hongqiang Wu Yizhao | 2016 | Transactions of Nanjing University of Aeronautics and Astronautics2016，33，5： | 2 |
| 5 | The Association Between Epoxide Hydrolase Genetic Variant and Effectiveness of Nicotine Replacement Therapy in a Han Chinese Population显示文摘Dear Editor,Nicotine is a psychoactive alkaloid that is thought to play a key role in addiction to commercial tobacco products[1]and cotinine is its primary metabolite[2].Pharmacological treatment,such as nicotine replacement therapy(NRT),is a valid solution to this problem.Tobacco smoke contains many carcinogens such as nitrosamines[i.e.,nicotinederived nitrosamine ketone(NNK)and N-nitrosonornicotine(NNN)],and | Fan Wang Yanlong Liu Song Guo Dafang Chen Hongqiang Sun | 2016 | Neuroscience Bulletin2016，32，6： | 2 |
| 6 | High‑Performance Flexible Microneedle Array as a Low‑Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography显示文摘Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording.The normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes. | Junshi Li Yundong Ma Dong Huang Zhongyan Wang Zhitong Zhang Yingjie Ren Mengyue Hong Yufeng Chen Tingyu Li Xiaoyi Shi Lu Cao Jiayan Zhang Bingli Jiao Junhua Liu Hongqiang Sun Zhihong Li | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 7 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 8 | A single-cell transcriptome atlas of the aging human and macaque retina显示文摘The human retina is a complex neural tissue that detects light and sends visual information to the brain.However,the molecular and cellular processes that underlie aging primate retina remain unclear.Here,we provide a comprehensive transcriptomic atlas based on 119520 single cells of the foveal and peripheral retina of humans and macaques covering different ages.The molecular features of retinal cells differed between the two species,suggesting distinct regional and species specializations of the human and macaque retinae.In addition,human retinal aging occurred in a region-and cell-type-specific manner.Aging of human retina exhibited a foveal to peripheral gradient.MYO9A-rods and a horizontal cell subtype were greatly reduced in aging retina,indicating their vulnerability to aging.Moreover,we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease,which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases.Such datasets are valuable to understanding of the molecular characteristics of primate retina,as well as molecular regulation of aging progression and related diseases. | Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue | 2021 | National Science Review2021，8，4： | 1 |
| 9 | Logging-while-drilling formation dip interpretation based on long short-term memory显示文摘Azimuth gamma logging while drilling(LWD)is one of the important technologies of geosteering but the information of real-time data transmission is limited and the interpretation is difficult.This study proposes a method of applying artificial intelligence in the LWD data interpretation to enhance the accuracy and efficiency of real-time data processing.By examining formation response characteristics of azimuth gamma ray(GR)curve,the preliminary formation change position is detected based on wavelet transform modulus maxima(WTMM)method,then the dynamic threshold is determined,and a set of contour points describing the formation boundary is obtained.The classification recognition model based on the long short-term memory(LSTM)is designed to judge the true or false of stratum information described by the contour point set to enhance the accuracy of formation identification.Finally,relative dip angle is calculated by nonlinear least square method.Interpretation of azimuth gamma data and application of real-time data processing while drilling show that the method proposed can effectively and accurately determine the formation changes,improve the accuracy of formation dip interpretation,and meet the needs of real-time LWD geosteering. | SUN Qifeng LI Na DUAN Youxiang LI Hongqiang TANG Haiquan | 2021 | Petroleum Exploration and Development2021，48，4： | 1 |
| 10 | A dynamic real-time method for monitoring epithelial barrier function in vitro显示文摘 | Mingjiao Sun Huiying Fu Hongqiang Cheng | 2012 | Anal Biochem2012，，425： | 1 |
| 11 | Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic显示文摘In early 2020,the COVID-19 outbreak complicated the diagnosis,treatm ent and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours,such as online gaming disorders,in the general public.Substance use disorder is a chronic recurrent brain disease characterised by strong cravings,high recurrence rates,and a high proportion of comorbidity of mental and physical disorders.1 Therefore,regular long-term therapeutic interventions are critical to preventing dm g relapses while maintaining withdrawal. | Jiang Du Ni Fan Min Zhao Wei Hao Tieqiao Liu Lin Lu Jie Shi Haifeng Jiang Na Zhong Xiaochang Lan Shichao Xu Hongxian Chen Xiaojun Xiang Xuyi Wang Hongqiang Sun Bing Li Yu-Ping Ning Jing Li Wanjun Guo Yajuan Niu Lixia Sheng Yi Li Xuebin Liu Xuhui Zhou Mincai Qian Wenhua Zhou Ruiling Zhang Hongxing Hu Yan Xia Zhonghua Su Ruimin Zhang Mei Yang Fen Liu Wei Yuan | 2020 | General Psychiatry2020，33，4： | 1 |
| 12 | A Straightforward hp-Adaptivity Strategy for Shock-Capturing with High-Order Discontinuous Galerkin Methods显示文摘In this paper,high-order Discontinuous Galerkin(DG)method is used to solve the two-dimensional Euler equations.A shock-capturing method based on the artificial viscosity technique is employed to handle physical discontinuities.Numerical tests show that the shocks can be captured within one element even on very coarse grids.The thickness of the shocks is dominated by the local mesh size and the local order of the basis functions.In order to obtain better shock resolution,a straightforward hp-adaptivity strategy is introduced,which is based on the high-order contribution calculated using hierarchical basis.Numerical results indicate that the hp-adaptivity method is easy to implement and better shock resolution can be obtained with smaller local mesh size and higher local order. | Hongqiang Lu Qiang Sun | 2014 | Advances in Applied Mathematics and Mechanics2014，6，1： | 1 |
| 13 | A High-OrderDiscontinuous GalerkinMethod for the Two-Dimensional Time-Domain Maxwell’s Equations on Curved Mesh显示文摘In this paper,a DG(Discontinuous Galerkin)method which has been widely employed in CFD(Computational Fluid Dynamics)is used to solve the twodimensional time-domain Maxwell’s equations for complex geometries on unstructured mesh.The element interfaces on solid boundary are treated in both curved way and straight way.Numerical tests are performed for both benchmark problems and complex cases with varying orders on a series of grids,where the high-order convergence in accuracy can be observed.Both the curved and the straight solid boundary implementation can give accurate RCS(Radar Cross-Section)results with sufficiently small mesh size,but the curved solid boundary implementation can significantly improve the accuracy when using relatively large mesh size.More importantly,this CFD-based high-order DG method for the Maxwell’s equations is very suitable for complex geometries. | Hongqiang Lu Yida Xu Yukun Gao Wanglong Qin Qiang Sun | 2016 | Advances in Applied Mathematics and Mechanics2016，8，1： | 1 |
| 14 | Status and Correlates of Hypersomnia in Hospitalized Patients with Unipolar Depression—Beijingf Henanf and Shandong,China,August 2019-March 2021显示文摘Summary What is already known about this topic?Hypersomnia is an atypical characteristic of unipolar depression(UD),indicating a high risk of bipolar depression.Identifying the symptom should be prioritized in patients with UD.However,the status and correlated factors of hypersomnia greatly varied across investigations.What is added by this report? | Yun Chen Lyufeng Zhang Sifan Hu Hongle Zhang Qiqing Sun Mengyue Hong Yuying Qian Lin Lu Hongqiang Sun | 2021 | China CDC weekly2021，3，42： | 0 |
| 15 | Supramolecular nanoparticles constructed by orthogonal assembly of pillar[5]arene-cyclodextrin dimacrocycle for chemo-photodynamic combination therapy显示文摘Chemotherapy combined with photodynamic therapy has emerged as a promising strategy for cancer treatment.However,simultaneously delivering chemotherapeutic drugs and photosensitizers and precisely adjusting the ratio of the two components as needed remains a challengeable task.Herein,novel supramolecular nanoparticles(donated as BODIPY-CPT-NPs)for chemo-photodynamic combination cancer therapy are constructed from a glutathione-responsive camptothecin-based prodrug,BODIPY photosensitizer,and dimacrocyclic host molecule through orthogonal host-guest recognitions and co-assembly.With this strategy,the ratio of prodrugs and photosensitizers in nanoparticles can be easily and precisely controlled as needed.Benefiting from the strong host-guest interactions and stable self-assembly,the nanoparticles exhibit excellent stability and photobleaching resistance.Furthermore,camptothecin can be released from nanoparticles for chemotherapy in the presence of reduction agent and single oxygen can be efficiently generated for PDT with light irradiation.The combined effects of the BODIPY-CPT-NPs have been verified in CT26 and HeLa cancer cells. | Yongfei Yin Penghao Sun Hongqiang Dong Yi Chen Shigui Chen Lu Wang | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 16 | Stable operation of polymer electrolyte-solid-state batteries via lonepair electron fillers显示文摘Due to the increasing demand and wide applications of lithium-ion batteries,higher requirements have been placed on the energy density and safety.Polymer solid-state electrolytes have gained significant popularity due to their excellent interface compatibility and safety.However,their applications have been greatly restricted by the high crystallinity at room temperature,which hinders the transport of lithium ions.Herein,we utilize inorganic tubular fillers with abundant lone-pair atoms to reduce the crystallinity of the polyethylene oxide(PEO)solid-state electrolyte membrane and improve its ionic conductivity at room temperature,enabling stable operation of the battery.The tubular lone-pair-rich inorganic fillers play a key role in providing avenues for both internal and external charge transportation.The surface lone-pair electrons facilitate the dissociation and transport of lithium ions,while the internally tubular electron-rich layer attracts ions into the cavities,further enhancing the ion transport.After 100 cycles at room temperature,the lithium battery loaded with this solid-state electrolyte membrane delivers a specific capacity of 141.6 mAh·g−1,which is 51.3%higher compared to the membrane without the fillers. | Hongbin Liu Qing Sun Jun Cheng Hongqiang Zhang Xiao Xu Yuanyuan Li Zhen Zeng Yue Zhao Deping Li Jingyu Lu Lijie Ci | 2023 | Nano Research2023，16，11： | 0 |
| 17 | The hidden risk of microplastic-associated pathogens in aquatic environments显示文摘Increasing studies of plastisphere have raised public concern about microplastics(MPs)as vectors for pathogens,especially in aquatic environments.However,the extent to which pathogens affect human health through MPs remains unclear,as controversies persist regarding the distinct pathogen colonization on MPs as well as the transmission routes and infection probability of MP-associated pathogens from water to humans.In this review,we critically discuss whether and how pathogens approach humans via MPs,shedding light on the potential health risks involved.Drawing on cutting-edge multidisciplinary research,we show that some MPs may facilitate the growth and long-range transmission of specific pathogens in aquatic environments,ultimately increasing the risk of infection in humans.We identify MP-and pathogen-rich settings,such as wastewater treatment plants,aquaculture farms,and swimming pools,as possible sites for human exposure to MP-associated pathogens.This review emphasizes the need for further research and targeted interventions to better understand and mitigate the potential health risks associated with MP-mediated pathogen transmission. | Huan Zhong Mengjie Wu Christian Sonne Su Shiung Lam Raymond W.M.Kwong Yuelu Jiang Xiaoli Zhao Xuemei Sun Xuxiang Zhang Chengjun Li Yuanyuan Li Guangbo Qu Feng Jiang Huahong Shi Rong Ji Hongqiang Ren | 2023 | Eco-Environment & Health2023，2，3： | 0 |
| 18 | Change of Disease Spectrum Characteristics of Psychiatric Inpatients Before and After Lockdown Lifted During the COVID-19 Pandemic—Wuhan City,Hubei Province,China,2021显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic poses a significant threat to mental health globally and may change the proportion of hospitalized patients.What is added by this report?This report analyzed and compared the disease characteristics of psychiatric inpatients one year before and after Wuhan lifted lockdown during COVID-19.About 50%of the inpatients were diagnosed with bipolar disorder;females and adolescents had a higher prevalence of mental disorders.What are the implications for public health practice?More attention should be paid to the mental health of children,adolescents,and females. | Jingfang Liu Xuan Gong Xiaofen Li Zhiying Wan Hongqiang Sun Lijun Kang Zhongchun Liu | 2022 | China CDC weekly2022，4，18： | 0 |
| 19 | 细胞核内病毒RNA受体SAFA连接天然免疫和染色质重塑显示文摘文章简介天然免疫免疫从上世纪发现模式识别受体在现在一直学界研究的热点,而细胞核内的天然免疫识别和调节机制还不为人所知。本研究揭示了SAFA作为一个新型的细胞核内病毒双链RNA(dsRNA)监测器,连接染色质重塑和抗病毒天然免疫反应。该研究显示多种病毒感染宿主细胞后,在细胞核中产生dsRNA,被SAFA监测结合,引起SAFA发生寡聚化。 | Lili Cao Shengde Liu Yunfei Li Guang Yang Yujie Luo Siji Li Hongqiang Du Yingchi Zhao Dandan Wang Jingxuan Chen Zeming Zhang Mo Li Songying Ouyang Xiang Gao Yujie Sun Zekun Wang Long Yang Rongtuan Lin Penghua Wang 游富平 | 2020 | 科学新闻2020，，2： | 0 |
| 20 | Clinical efficacy of low-dose emetine for patients with COVID-19:a real-world study显示文摘Objective:Emetine,an isoquinoline alkaloid that is enriched at high concentrations in the lung,has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The aim of this study was to better understand the effectiveness of low-dose emetine for patients with coronavirus disease 2019(COVID-19).Methods:In this real-world study,63 patients with mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals in Anhui Province,China from February to March 2020.Thirty-nine patients from Wuhan Fangcang Shelter Hospital were assigned to a pragmatic randomized controlled clinical trial,and 24 patients from the 5 COVID-19-designated hospitals in Anhui Province underwent a real-world study.The medication course of emetine was less than 10 days.The main symptoms and adverse reactions of all patients were observed and recorded.The primary outcome measure was the time required for a negative SARS-CoV-2 RNA result or the negative result rate on day 10.Secondary outcomes included axillary temperature,transcutaneous oxygen saturation,and respiratory frequency recovery.The study was approved by the Ethics Committee of The First Affiliated Hospital of Anhui Medical University on February 20,2019(approval No.PJ2020-03-19)and was registered with the Chinese Clinical Trial Registry on February 20,2019(registration number:ChiCTR2000030022).Results:The oxygen saturation values were higher in the treatment group than in the control group on the first day after enrollment for patients treated at Fangcang Shelter Hospital.The axillary body temperature,respiratory rate,and oxygen saturation among patients in Fangcang Shelter Hospital were related to the time effect but not to the intervention measures.The respiratory rate and oxygen saturation of patients in the Anhui designated hospitals were related to the intervention measures but not to the time effect.The axillary body temperature of patients in Anhui designated hospitals was related to the time effect but not to the intervention measures.Conclusion:Our preliminary study shows that low-dose emetine combined with basic conventional antiviral drugs improves clinical symptoms in patients with mild and common COVID-19 without apparent adverse effects,suggesting that moderately increased doses of emetine may have good potential for treatment and prevention of COVID-19. | Song Fan Qi Zhen Cheng Chen Wenjun Wang Qibing Wu Huihui Ma Chengyuan Zhang Li Zhang Baojing Lu Huiyao Ge Liang Yong Bao Li Yafen Yu Weiwei Chen Yiwen Mao Guangbo Qu Li Su Aoli Wang Zhen Ding Haiwen Li Jin Zhang Yonglian Wang Yufeng Gao Xihai Xu Zhongming Zhu Jun Chen Long Zhang Hongqiang Liang Song Wu Meng Huang Quan Xia Ping Li Yehuan Sun Chaozhao Liang Wei Wei Qingsong Liu Liangdan Sun | 2021 | Journal of Bio-X Research2021，4，2： | 0 |
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