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| 1 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 2 | Preparation of Nano-titanium Dioxide in Propane/Air Diffusion Flame显示文摘 | ZHANG Wei SUN Xue XIE Hongyong | 2004 | 过程工程学报2004，4，z1： | 11 |
| 3 | TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression显示文摘Objective: Targeting protein for Xenopus kinesin-like protein 2(TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been observed in several types of tumors. However, the role of TPX2 in hepatocellular carcinoma(HCC) remains unclear. Our study aimed to investigate the effect of TPX2 on HCC cell invasion.Methods: The immortalized normal human liver cell line L02 and six HCC cell lines including SMMC-7721, BEL-7402, Huh-7, HepG2, Hep3 B and SKHep1 were subjected to qRT-PCR and western blot for TPX2 mRNA and protein, respectively. Furthermore, TPX2 small interfering RNA(siRNA) was used to knock down TPX2 expression in SMMC-7721 and HepG2 cells. Cell proliferation and invasion were determined by MTT and transwell assays. Otherwise, expression of p-AKT, MMP2 and MMP9 were evaluated by western blot in SMMC-7721 cells.Results: The expression of TPX2 in HCC cell lines was markedly higher than that in normal human liver cell line. TPX2 knockdown using a specific TPX2-siRNA reduced the number of invaded cells and inhibited cell proliferation in SMMC-7721 and HepG2 cells. Furthermore, TPX2 knockdown resulted in inactivation of AKT signaling and down-regulation of MMP2 and MMP9 expression in SMMC-7721 cells.Conclusions: Our study identified that TPX2 might contribute to tumor cell invasion through activating AKT signaling and subsequently increasing MMP2 and MMP9 in HCC. | Qingquan Liu Pinghua Yang Kangsheng Tu Hongyong Zhang Xin Zheng Yingmin Yao Qingguang Liu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 11 |
| 4 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 5 | MatDEM-fast matrix computing of the discrete element method显示文摘Discrete element method can effectively simulate the discontinuity,inhomogeneity and large deformation and failure of rock and soil.Based on the innovative matrix computing of the discrete element method,the highperformance discrete element software MatDEM may handle millions of elements in one computer,and enables the discrete element simulation at the engineering scale.It supports heat calculation,multi-field and fluidsolid coupling numerical simulations.Furthermore,the software integrates pre-processing,solver,postprocessing,and powerful secondary development,allowing recompiling new discrete element software.The basic principles of the DEM,the implement and development of the MatDEM software,and its applications are introduced in this paper.The software and sample source code are available online(http://matdem.com). | Chun Liu Hui Liu Hongyong Zhang | 2021 | Earthquake Research Advances2021，1，3： | 4 |
| 6 | Variation of fluxes of water vapor, sensible heat and carbon dioxide above winter wheat and maize canopies显示文摘Surface energy fluxes were measured using Bowen-Ratio Energy Balance technique (BREB) and eddy correlation system at Luancheng of Hebei Province, on the North China Plain from 1999 to 2001. Average diumal variation of surface energy fluxes and CO2 flux for maize showed the inverse 'U 'type. The average peak fluxes did not appear at noon, but after noon. The average peak CO2 flux was about 1.65 mgm-2 s-1. Crop water use efficiency (WUE) increased quickly in the morning, stabilized after 10:00 and decreased quickly after 15:00 with no evident peak value. The ratio of latent heat flux (λE) to net solar radiation (Rn) was always higher than 70% during winter wheat and maize seasons. The seasonal average ratio of sensible heat flux (H) divided by Rn stayed at about 15% above the field surface; the seasonal average ratio of conductive heat flux (G) divided by Rn varied between 5% and 13%, and the average G/Rn from the wheat canopy was evidently higher than that from the maize canopy. The evaporative fraction (EF) is correlated to the Bowen ratio in a reverse function. EF for winter wheat increased quickly during that revival stage, after the stage, it gradually stabilized to 1.0, and fluctuated around 1.0. EF for maize also fluctuated around 1.0 before the later grain filling stage, and decreased after that stage. | ZHANG Yongqiang, SHEN Yanjun, YU Qiang, LIU Changming,A. Kondoh, TANG Changyuan, SUN Hongyong, JIA Jinsheng(1. Inst. of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China 2. Shijiazhang Inst. of Agricultural Modernization, CAS, | 2002 | Journal of Geographical Sciences2002，12，3： | 2 |
| 7 | Consensus of Second- Order Multi - Agent Systems with Exogenous Disturb- ances 显示文摘 | Yang Hongyong Zhang Zhenxing Zhang Siying | 2011 | International Journal of Robust and Nonlinear Control2011，21，9： | 1 |
| 8 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 9 | Dry matter, harvest index,grain yield and water use efficiency as affected by water supply in winter wheat显示文摘 | Xiying Zhang Suying Chen Hongyong Sun | 2008 | Irrigation Science2008，27，： | 1 |
| 10 | Consensus of second - order delayed multi - agent systems with leader - following显示文摘 | Yang Hongyong Zhu Xunlin Zhang Siying | 2010 | European Journal of Control2010，16，2： | 1 |
| 11 | Root size, distribution and soil water depletion as affected by cultivars and environmental factors显示文摘 | Xiying Zhang Suying Chen Hongyong Sun Yanmei Wang Liwei Shao | 2009 | Field Crops Research2009，，1： | 1 |
| 12 | Dry matter, harvest index, grain yield and water use efficiency as affected by water supply in winter wheat显示文摘 | Zhang Xiying Chen Suying Sun Hongyong | 2008 | Irrigation Science2008，27，1： | 1 |
| 13 | Video stabilization and target tracking for airship monitoring system显示文摘 | ZHANG Maolei CHEN Tao YUAN Hongyong | 2010 | Progress in Safety Science and Technology Series2010，3，8： | 1 |
| 14 | Research on fine Spatial Quantitative Model about vulnerability of hazard-affected bodies显示文摘The seriousness of losses caused by disaster dependent on the hazard degree of environment,vulnerability of hazard-affected bodies,and emergency response capacity of the region is studied in this article.The study on hazard-affected bodies is of importance to disaster risk management,regional hazard prevention,reduction,and investment in disaster insurance.With summarizing of various assessment methods of vulnerability of hazard-affected bodies,this paper presents a refined Spatial Quantification Model of regional vulnerability which combines refined spatial geographic data and land-use type data.A quantitative study on regional vulnerability was carried out by defining fine spatial grid as the basic evaluation unit based on GIS. | Zhang Bin Yuan Hongyong Huang Quanyi Wen Renqiang Gu Junqiang | 2010 | International Journal of Digital Earth2010，3，4： | 1 |
| 15 | A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment显示文摘Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies. | Xiao Wang Chunwei Cao Yongshun Li Tang Hai Qitao Jia Ying Zhang Qiantao Zheng Jing Yao Guosong Qin Hongyong Zhang Ruigao Song Yanfang Wang Guanghou Shui Sin Man Lam Zhonghua Liu Hong Wei Anming Meng Qi Zhou Jianguo Zhao | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
| 16 | Hopf bifurcation and harvesting control of a bioeconomic plankton model with delay and diffusion terms显示文摘 | Hongyong Zhao Xuanxuan Huang Xuebing Zhang | 2015 | Physica A: Statistical Mechanics and its Applicat2015，，： | 1 |
| 17 | Consensus of multiagent systems based on disturbance observer显示文摘The objectives of this work are the development and design of disturbance observers (DO’s) for a team of agents that accomplish consensus on agents’ states in the presence of exogenous disturbances. A pinning control strategy is designed for a part of agents of the multiagent systems without disturbances, and this pinning control can bring multiple agents’ states to reaching an expected consensus value. Under the effect of the disturbances, nonlinear disturbance observers are developed for disturbances generated by an exogenous system to estimate the disturbances. Asymptotical consensus of the multiagent systems with disturbances under the composite controller can be achieved. Finally, by applying an example of multiagent systems with switching topologies and exogenous disturbances, the design of the parameters of DO’s are illuminated. | Hongyong YANG 1 , Fucai WANG 2 , Zhenxing ZHANG 3 , Guangdeng ZONG 4 (1.School of Information Science and Engineering, Ludong University, Yantai Shandong 264025, China 2.School of Electronic and Electrical Engineering, Ludong University, Yantai Shandong 264025, China 3.School of Automation, Southeast University, Nanjing Jiangsu 210096, China 4.Institute of Automation, Qufu Normal University, Qufu Shandong 273165, China) | 2010 | 控制理论与应用(英文版)2010，8，2： | 1 |
| 18 | Phylogenetic comparison of classical swine fever virus in China显示文摘 | Changchun Tu Zongji Lu Hongwei Li Xinglong Yu Xiangtao Liu Yuehong Li Hongyong Zhang Zhen Yin | 2001 | Virus Research2001，，1： | 1 |
| 19 | The Properties and kinetics of enzymatic reaction in the process of the enzymatic extraction of fish oil 显示文摘 | QIAN Junqing ZHANG Hongyong LIAO Qiyuan | 2011 | Food Sci Technol2011，48，3： | 1 |
| 20 | Effects of winter wheat row spacing on evapotranspiration,grain yield and water useefficiency显示文摘 | Chen Suying Zhang Xiying Sun Hongyong | 2010 | Agricultural Water Management2010，97，： | 1 |
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