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| 1 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 2 | H. pylori Escape Host Immunoreaction Through Inhibiting ILK Expression by VacA显示文摘Helicobacter pylori (H。pylori ) 尽管有精力旺盛的有免疫力的回答,固执地开拓殖民地于胃的 mucosa。Vacuolating 细胞毒素由 H 藏匿了。pylori 结果是有势力 immunomodulatory 毒素,而是包含的信号 transduction 小径没在巨噬细胞被学习。我们在这研究观察了那 vacA 缺乏的 H。pylori 导致了连接 integrin 的 kinase (同类) 和 endothelial 的显著地更高的表示氮的氧 synthase (eNOS ) ,并且显著地在 monocyte/macrophage-like U937 房间的反应的氧种类(ROS ) 的更多的生产,同样与 isogenic vacA+H 相比。pylori。在 U937 房间 overexpressing 同类的 eNOS mRNA 的表示显著地与空向量与那些 transfected 相比被增加。因此, vacA 缺乏的 H。pylori 出现到 upregulate 同类表示,调制 eNOS 并且作为结果的表示,刺激 ROS 的生产。,帮助 H 是 VacA 由禁止同类表示阻止如此的进程。pylori 逃跑主人免疫反应。这机制解释,至少部分地, H 的坚持的感染。在胃的 pylori。 | Jianping Yuan Ping Li Jing Tao Xiaodong Shi Baoyu Hu Huabiao Chen Xiaokui Guo | 2009 | Cellular & Molecular Immunology2009，6，3： | 12 |
| 3 | Bifurcation analysis on full annular rub of a nonlinear rotor system显示文摘In this paper, analytical and numerical studies are carried out on the full annular rub motions of a nonlinear Jeffcott rotor. Transition sets of the synchronous full annular rub are given with the help of averaging method and constraint bifurcation theory to discuss the effects of system parameters on jump phenomena. Routh-Hurwitz criteria are employed to analyze the stability of synchronous full annular rub solution and determine the boundaries of static and Hopf bifurcations. Finally, the response and onset condition of reverse dry whip are investigated numerically, and at the same time, the influences of rotor parameters and rotation speed on the characteristics of the rotor response are investigated. | ZHANG HuaBiao CHEN YuShu | 2011 | Science China(Technological Sciences)2011，54，8： | 9 |
| 4 | A modified HLA-A^(*)0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses显示文摘We previously identified human phosphatidylethanolamine-binding protein 4(hPEBP4)as an antiapoptotic protein with increased expression levels in breast,ovarian and prostate cancer cells,but low expression levels in normal tissues,which makes hPEBP4 an attractive target for immunotherapy.Here,we developed hPEBP4-derived immunogenic peptides for inducing antigen-specific cytotoxic T lymphocytes(CTLs)targeting breast cancer.A panel of hPEBP4-derived peptides predicted by peptide-MHC-binding algorithms was evaluated to characterize their HLAA2.1 affinity and immunogenicity.We identified a novel immunogenic peptide,P40–48(TLFCQGLEV),that was capable of eliciting specific CTL responses in HLA-A2.1/K^(b) transgenic mice,as well as in peripheral blood lymphocytes from breast cancer patients.Furthermore,amino-acid substitutions in the P40–48 sequence improved its immunogenicity against hPEBP4,a self-antigen,thus circumventing tolerance.We designed peptide analogs by preferred auxiliary HLA-A^(*)0201 anchor residue replacement,which induced CTLs that were crossreactive to the native peptide.Several analogs were able to stably bind to HLA-A^(*)0201 and elicit specific CTL responses better than the native sequence.Importantly,adoptive transfer of CTLs induced by vaccination with two analogs more effectively inhibited tumor growth than the native peptide.These data indicate that peptide analogs with high immunogenicity represent promising candidates for peptide-mediated therapeutic cancer vaccines. | Weihong Sun Junyi Shi Jian Wu Junchu Zhang Huabiao Chen Yuanyuan Li Shuxun Liu Yanfeng Wu Zhigang Tian Xuetao Cao Nan Li | 2018 | Cellular & Molecular Immunology2018，15，8： | 4 |
| 5 | Numerical investigation of granular flow similarity in rotating drums显示文摘The theory of flow similarity has not been well established for granular flows,in contrast to the case for conventional fluids,owing to a lack of reliable and general constitutive laws for their continuum description.A rigorous investigation of the similarity of velocity fields in different granular systems would be valuable to theoretical studies.However,experimental measurements face technological and physical problems.Numerical simulations that employ the discrete element method(DEM) may be an alternative to experiments by providing similar results,where quantitative analysis could be implemented with virtually no limitation.In this study,the similarity of velocity fields is investigated for the rolling regime of rotating drums by conducting simulations based on the DEM and using graphics processing units.For a constant Froude number,it is found that the particle-to-drum size ratio plays a dominant role in the determination of the velocity field,while the velocity field is much more sensitive to some material properties than to others.The implications of these findings are discussed in terms of establishing theoretical similarity laws for granular flows. | Huabiao Qi Ji Xu Guangzheng Zhou Feiguo Chen Wei Ge Jinghai Li | 2015 | Particuology2015，13，5： | 4 |
| 6 | In vitro inhibition of HIV-1 replication in autologous CD4*T cells indicates viral containment by multifactorial mechanisms显示文摘HIV-1-specific cytotoxic T lymphocytes(CTLs) and neutralizing antibodies(NAbs) are present during chronic infection, but the relative contributions of these effector mechanisms to viral containment remain unclear. Here, using an in vitro model involving autologous CD4+ T cells,primary HIV-1 isolates, HIV-1-specific CTLs, and neutralizing monoclonal antibodies, we show that b12, a potent and broadly neutralizing monoclonal antibody to HIV-1, was able to block viral infection when preincubated with virus prior to infection, but was much less effective than CTLs at limiting virus replication when added to infected cell cultures. However, the same neutralizing antibody was able to contain viruses by antibody-dependent cell-mediated virus inhibition in vitro,which was mediated by natural killer cells(NKs) and dependent on an Fc-Fc receptor interaction.Meanwhile, bulk CTLs from HIV-1 controllers were more effective in suppression of virus replication than those from progressors. These findings indicate that control of HIV-1 replication in activated CD4^+ T cells is ineffectively mediated by neutralizing antibodies alone, but that both CTLs and antibody-dependent NK-mediated immune mechanisms contribute to viral containment. Our study systemically compared three major players in controlling HIV-1 infection, CTLs, NAbs, and NKs, in an autologous system and highlighted the multifactorial mechanisms for viral containment and vaccine success. | Ting Tu Jianbo Zhan Danlei Mou Wei Li Bin Su Tong Zhang Tao Li Ning Li Hao Wu Cong Jin Huabiao Chen | 2017 | Virologica Sinica2017，32，6： | 0 |
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