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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Decreased Average Albumin-to-Globulin Ratio During Radiotherapy Worsens the Prognosis of Esophageal Squamous Cell Carcinoma:Implications for Nutritional Management显示文摘Objective Malnutrition and cachexia are common in esophageal squamous cell carcinoma(ESCC)patients undergoing radiotherapy.This study evaluated how malnutrition-and cachexia-related indicators,including the albumin-to-globulin ratio(AGR),and their changes during radiotherapy predict the treatment outcomes.Methods We reviewed a total of 172 ESCC patients receiving radiotherapy(as a primary cohort)and performed a Cox regression analysis on potential prognostic factors,including the AGR,as well as the TNM stage and concomitant chemotherapy.A subsequent receiver operating characteristics(ROC)curve and Kaplan Meier survival analysis was performed for ESCC patients stratified by the average AGR cut-off point.Results In addition to the well-documented factors(i.e.TNM stage and concomitant chemotherapy),the average AGR was a significant prognostic factor for ESCC patients receiving radiotherapy.By plotting the ROC curve of the average AGR with regard to the ESCC prognosis,we obtained cut-off points for the overall patients(cut-off point:1.5,AUC:0.636),for patients with stageⅡ/Ⅲdisease(cut-off point:1.5,AUC:0.611),and for patients with stageⅣdisease(cut-off point:1.84,AUC:0.900).The ESCC patients with higher average AGR had a significantly more favorable OS compared with those with a lower average AGR.Notably,ESCC patients who had an increasingΔAGR during radiotherapy had a considerably more favorable OS compared with those with a decreasingΔAGR.All of these findings were reproducible in the validation cohort.Conclusion A lower average AGR is indicative of a poorer prognosis for ESCC patients following radiotherapy.Improving the nutritional status and preventing or ameliorating cachexia might contribute to improving the prognosis of ESCC patients. | Fen Cai Xiu Lian Zhang Xiao Ling Wu Ting Ting Zhuang Lei Huang Yi Fei Tu Yuan Yuan Lu Min Xia Jiang Qing Ying Zhang Yan Lin Chang Chun Ma | 2021 | Journal of Nutritional Oncology2021，6，2： | 8 |
| 3 | Screening of antagonistic Trichoderma strains and their application for controlling stalk rot in maize显示文摘Maize is one of the major crops in China, but maize stalk rot occurs nationwide and has become one of the major challenges in maize production in China. In order to find an environment-friendly and feasible technology to control this disease, a Trichoderma-based biocontrol agent was selected. Forty-eight strains with various inhibition activities to Fusarium graminearum, and Fusarium verticillioides were tested. A group of Trichoderma strains(DLY31, SG3403, DLY1303 and GDFS1009) were found to provide an inhibition rate to pathogen growth in vitro of over 70%. These strains also prevented pathogen infection over 65% and promoted the maize seedling growth for the main root in vivo by over 50%. Due to its advantage in antifungal activity against pathogens and promotion activity to maize, Trichoderma asperellum GDSF1009 was selected as the most promising strain of the biocontrol agent in the Trichoderma spectrum. Pot experiments showed that the Trichoderma agent at 2–3 g/pot could achieve the best control of seedling stalk rot and promotion of maize seedling growth. In the field experiments, 8–10 g/hole was able to achieve over 65% control to stalk rot, and yield increased by 2–11%. In the case of natural morbidity, the control efficiency ranged from 27.23 to 48.84%, and the rate of yield increase reached 11.70%, with a dosage of Trichoderma granules at 75 kg ha^-1. Based on these results, we concluded that the Trichoderma agent is a promising biocontrol approach to stalk rot in maize. | LU Zhi-xiang TU Guang-ping ZHANG Ting LI Ya-qian WANG Xin-hua Zhang Quan-guo SONG Wei CHEN Jie | 2020 | Journal of Integrative Agriculture2020，19，1： | 6 |
| 4 | Comparison of Clinical Efficacy of Three Methods for Cervical Ripening followed by Surgical Evacuation in Early Missed Abortion显示文摘Objective To compare clinical efficacy of three cervical preparations for surgical evacuation in first trimester missed abortion.Methods Two hundred and ten women with early missed abortion were equally randomized into three groups.Three cervical preparations,Dilapan-dilator method(group A,n=70),mifepristone method(group B,n=70),and misoprostol method(group C,n=70),were used 24 h before curettage for terminating missed abortion,respectively.Clinical outcomes and complications for these three methods were compared.Results No differences were found in rates of successful treatment among the three groups(P>0.05).The incidence of fitting number 8 Hegar dilator was slightly high in group A,but it was not different compared with that in group B or group C(P>0.05).Bleeding in previous 24 h in group C was significantly greater than that in group A or group B(P<0.01).The cases of blood loss(>50 ml) during evacuation in group B were more than those in group A(P>0.05).Women in group B had less abdominal pain than those in group A or group C(P<0.01).Side effects in group C were more than those in group A on nausea(P<0.01),vomiting(P<0.05),and diarrhea(P<0.01).Group B had the highest acceptability among the three groups(P<0.05).Conclusion Three methods have the similar clinical efficacies in cervical ripening for surgical treatment of early missed abortion.Based on individual characteristics,different approach would be chosen to avoid some adverse events and improve the clinical application of Dilapan-dilator. | Yu-xia WANG Mi-jiao HUANG Ting HE Rong ZENG Wei-jie ZHU Mei TU | 2012 | Journal of Reproduction and Contraception2012，23，2： | 6 |
| 5 | nvolvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis显示文摘 | Haiyan Chu Ting Wu Wenyu Wu Wenzhen Tu Shuai Jiang Sidi Chen Yanyun Ma Qingmei Liu Xiaodong Zhoua Li Jin Jiucun Wang | 2015 | Protein & Cell2015，6，8： | 5 |
| 6 | Loss of Gn1a/OsCKX2 confers heavy-panicle rice with excellent lodging resistance显示文摘Significant achievements have been made in breeding programs for the heavy-panicle-type(HPT)rice(Oryza sativa) in Southwest China. The HPT varieties now exhibit excellent lodging resistance,allowing them to overcome the greater pressures caused by heavy panicles. However, the genetic mechanism of this lodging resistance remains elusive. Here, we isolated a major quantitative trait locus, Panicle Neck Diameter 1(PND1), andidentified the causal gene as GRAIN NUMBER 1 A/CYTOKININ OXIDASE 2(Gn1 A/Os CKX2). The null gn1 a allele from rice line R498(gn1 aR498) improved lodging resistance through increasing the culm diameter and promoting crown root development.Loss-of-function of Gn1 a/Os CKX2 led to cytokinin accumulation in the crown root tip and accelerated the development of adventitious roots. Gene pyramiding between the null gn1 aR498 allele with two gain-of-function alleles, STRONG CULM 2(SCM2)and SCM3, further improved lodging resistance.Moreover, Gn1 a/Os CKX2 had minimal influence on overall rice quality. Our research thus highlights the distinct genetic components of lodging resistance of HPT varieties and provides a strategy for tailormade crop improvement of both yield and lodging resistance in rice. | Bin Tu Zhang Tao Shiguang Wang Lei Zhou Ling Zheng Chun Zhang Xinzi Li Xiaoyu Zhang Junjie Yin Xiaobo Zhu Hua Yuan Ting Li Weilan Chen Peng Qin Bingtian Ma Yuping Wang Shigui Li | 2022 | Journal of Integrative Plant Biology2022，64，1： | 5 |
| 7 | Evaluation of acute kidney injury as defined by the risk, injury, failure, loss, and end-stage criteria in critically ill patients undergoing abdominal aortic aneurysm repair显示文摘 | YUE Jia-ning LUO Zhe GUO Da-qiao XU Xin CHEN Bin JIANG Jun-hao YANG Jue SHI Zhen-yu ZHU Ting JU Min-jie TU Guo-wei WANG Yu-qi ZHU Du-ming FU Wei-guo | 2013 | Chinese Medical Journal2013，，3： | 4 |
| 8 | Effectiveness and Safety of Moxibustion Robots on Primary Dysmenorrhea:A Randomized Controlled Pilot Trial显示文摘Objective To conduct a pilot trial to explore the effectiveness and safety of moxibustion robots in treating primary dysmenorrhea(PD)and evaluate its feasibility in clinic.Methods A total of 70 participants with PD were allocated to either moxibustion robot(MR)group(35 cases)or manual moxibustion(MM)group(35 cases)using computer-generated randomization.One acupoint Guanyuan(CV 4)was selected to receive moxa heat stimulation.Two groups of participants were given 3 menstrual cycles of MM and MR treatment respectively(once a day,5 days a session)and received another 3 menstrual cycles follow-up.The degree of pain was evaluated by short-form McGill pain questionnaire(SF-MPQ)and the symptoms of dysmenorrhea were evaluated by Cox Menstrual Symptom Scale(CMSS).The safety was measured by the occurrence rate of adverse events(AEs),including burns(blisters,red and swollen),itching,bowel changes,menstrual cycle disorder,menorrhagia and fatigue,etc.Results A total of 62 patients completed the trial,32 in MR group and 30 in MM group.Compared with baseline,scores of SF-MPQ and CMSS significantly decreased in both groups(P<0.05),and no significant difference was observed between the two groups in the 3rd and 6th menstrual cycles(P>0.05).The total occurrence rate of AEs in MR group was 2.1%,which was significantly lower than MM group(7.2%,P<0.05).Conclusions MR has the same effect as MM at SF-MPQ and CMSS in patients with PD.However,MR is safer than MM(Trial registration No.ChiCTR1800018236). | ZHANG Han-rui TU Hai-yan WANG Yu XIA Shi-lin ZHAO Guo-you YANG Ting LI Ying-kun | 2021 | Chinese Journal of Integrative Medicine2021，27，8： | 4 |
| 9 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 10 | Human Vγ9Vδ2-T cells efficiently kill influenzavirus-infected lung alveolar epithelial cells显示文摘 | Hong Li Zheng Xiang Ting Feng Jinrong Li Yinping Liu Yingying Fan Qiao Lu Zhongwei Yin Meixing Yu Chongyang Shen Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 11 | Northward Shift in Landfall Locations of Tropical Cyclones over the Western North Pacific during the Last Four Decades显示文摘This study analyzes landfall locations of tropical cyclones(TCs)over the western North Pacific during 1979–2018.Results demonstrate that the landfall locations of TCs over this region have shifted northward during the last four decades,primarily due to the shift of landfalling TC tracks,with the decreasing/increasing proportion of westward/northward TC tracks.In particular,the northward shift of the landfalling TCs was not related to their formation locations,which have not markedly changed,whereas'no-landed'TCs have significantly shifted northward.TC movement was significantly and positively correlated to the zonal component of the steering flow,while the correlation between TC movement and the meridional component of the steering flow was relatively unobvious.The westward steering flow in the tropical central Pacific that occurred around the formation and early development of the westward TCs was significantly weakened,which was unfavorable for their westward movement,thereby,causing the higher proportions of northward moving tracks.This weakened westward flow was related to the northward shift of the subtropical high ridge,which was caused by significant weakening of the southern part of the subtropical high.The vertical wind shear,sea surface temperature,and convective available potential energy also showed that the northern region of the western North Pacific became more favorable for TC development,whereas the upper divergence,low-layer relative vorticity,and accumulated water vapor content were not obviously related to the northward shift of TCs. | Ting CHEN Shumin CHEN Mingsen ZHOU Chaoyong TU Aoqi ZHANG Yilun CHEN Weibiao LI | 2022 | Advances in Atmospheric Sciences2022，39，2： | 3 |
| 12 | Value of dynamic 31p magnetic resonance spectroscopy technique in in vivo assessment of the skeletal muscle mitochondrial function in type 2 diabetes显示文摘背景磷的磁性的回声光谱学(31p太太)成功地被使用了学习细胞内部的膜混合物和试图为从类型 2 糖尿病的 patients.Methods 在骨胳的肌肉估计精力新陈代谢和 mitochondrial 功能评估动态31p太太的能力的高精力的磷酸盐 metabolism.This 学习动态31p太太与类型 2 糖尿病在 22 个病人上被执行并且当题目是 i 时, 26 健康 volunteers.Spectra | WU Fei-yun TU Hui-juan QIN Bin CHEN Ting XU Hua-feng QI Jing WANG De-hang | 2012 | Chinese Medical Journal2012，，2： | 2 |
| 13 | Energy-limiting factor for coal and gas outburst occurrence in intact coal seam显示文摘This research reviewed the mechanics and gas desorption properties of intact coal,and tested the crushing work ratios of different intact coals,and then,studied the stress conditions for the failure or crushing of intact coal and the gas demand for the pulverization of intact coal particles.When a real-life outburst case is examined,the required minimum stress for intact coal outburst is estimated.The study concludes that the crushing work ratios of three intact coal samples vary from 294.3732 to 945.8048 J/m^(2).For the real-life case,more than 2300 MJ of transport work is needed,and 10062.09,7046.57 and 5895.47 m^(3) of gas is required when the gas pressure is 1,2 and 3 MPa,respectively.The crushing work exceeds the transport work and even reaches 13.96 times of the transport work.How to provide such an enormous crushing work is an energy-limiting factor for the outburst in intact coal.The strain energy is needed for the crushing work,and the required minimum stress is over 54.35 MPa,even reaching 300.44 MPa.These minimum stresses far exceed the in-situ vertical and horizontal stresses that can be provided at the 300–700 m mining depth range. | Qingyi Tu Yuanping Cheng Sheng Xue Ting Ren Xiang Cheng | 2021 | International Journal of Mining Science and Technology2021，31，4： | 2 |
| 14 | 采用动态偏离份额分析法来评价新加坡的出口竞争力显示文摘本文采用动态偏离份额分析法来研究1988—2001年期间新加坡的电子产品和化工产品在美国、欧盟和日本出口市场上的出口业绩。它把新加坡的出口竞争地位和一系列参照经济进行比较,这些经济包括中国、香港、韩国、马来西亚和中国台湾省,它们在上述市场是密切的竞争者。 | 彼得.威尔逊 Ting Su Chern Tu Suh Ping 爱德华.鲁滨逊 齐顺然 | 2007 | 南洋资料译丛2007，，2： | 2 |
| 15 | Gene mapping and candidate gene analysis of aberrant-floral spikelet 1(afs1) in rice(Oryza sativa L.)显示文摘The spikelet is a unique inflorescence structure in grasses. However, the molecular mechanism that regulates its development remains unclear, and we therefore characterize a spikelet mutant of rice(Oryza sativa L.), aberrant-floral spikelet 1(afs1), which was derived from treatment of Xinong 1 B with ethyl methanesulfonate. In the afs1 mutant, the spikelet developed an additional lemma-like organ alongside the other normally developed floral organs, and the paleae were degenerated to differing degrees with or without normally developed inner floral organs. Genetic analysis revealed that the afs1 phenotype was controlled by a single recessive gene. The AFS1 gene was mapped between the insertion/deletion(In Del) marker Indel19 and the simple sequence repeat marker RM16893, with a physical distance of 128.5 kb on chromosome 4. Using sequence analysis, we identified the deletion of a 5-bp fragment and a transversion from G to A within LOC_Os04 g32510/LAX2, which caused early termination of translation in the afs1 mutant. These findings suggest that AFS1 may be a new allele of LAX2, and is involved in the development of floral organs by regulating the expression of genes related to their development. The above results provide a new view on the function of LAX2, which may also regulate the development of spikelets. | ZHANG Ting YOU Jing YU Guo-ling ZHANG Yi CHEN Huan LI Yi-dan YE Li YAO Wan-yue TU Yu-jie LING Ying-hua HE Guang-hua LI Yun-feng | 2020 | Journal of Integrative Agriculture2020，19，4： | 2 |
| 16 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 17 | F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery显示文摘 | Quanyin Hu Guangzhi Gu Zhongyang Liu Mengyin Jiang Ting Kang Deyu Miao Yifan Tu Zhiqing Pang Qingxiang Song Lei Yao Huimin Xia Hongzhan Chen Xinguo Jiang Xiaoling Gao Jun Chen | 2013 | Biomaterials2013，，4： | 1 |
| 18 | Vegetation and Soil Characteristics of Different Desertification Grasslands in Northwest Sichuan显示文摘[Objective]The paper was to study vegetation and soil characteristics of different desertification grasslands in northwest Sichuan. [Method]By taking different desertification grasslands as the research object,the characteristic factors of vegetation community,biomass,soil moisture content,volume weight and porosity were analyzed through scientific investigation,sampling and formula calculation to reveal the changes in vegetation and soil characteristics of different desertification grasslands in Northwest Sichuan. [Result]Community succession presented the pattern of ' hygrophyte-mesophyte-xerophyte' with the aggravation of grassland desertification. The height and coverage of community decreased,species richness was declined by 88%,and composition of dominant species also changed greatly. The diversity index of light-desertification grassland was the highest among tested grasslands. Total biomass was decreased by 90. 4%,and the underground biomass decreased far more than aboveground biomass. In desertification progress,both soil moisture content and water holding capacity decreased,while volume weight showed upward trend and porosity showed downward trend; soil characteristics had large variation in early stage of desertification,so restoration treatment of desertification grassland should be carried out in the early stage of desertification. [Conclusion]The study provided a theoretical basis for researches on causes and management programs of desertification grassland,having an important meaning for ecological restoration of regional grassland and maintenance of ecological security. | Wan Ting Tu Weiguo Xi Huan Li Yudong Tang Xuefang Yang Yichuan | 2014 | Animal Husbandry and Feed Science2014，6，2： | 1 |
| 19 | Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 20 | Spatiotemporal cortical activation underlying self-referencial processing evoked by self-hand显示文摘 | Yanhua Su Antao Chen Huazhan Yin Jiang Qiu Jieyu Lv Dongtao Wei Fang Tian Shen Tu Ting Wang | 2010 | Biological Psychology2010，，2： | 1 |
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