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| 1 | 亚洲高血压合并左心室肥厚诊治专家共识显示文摘流行病学调查发现,高血压合并左心室肥厚(left ventricular hypertrophy,LVH)的比例很高,由于诊断标准的差异,不同研究LVH的检出率差别也很大。高血压合并LVH显著增加心血管事件的风险,但临床实践中仍关注不足,诊疗欠规范。亚洲高血压合并左心室肥厚诊治专家共识在LVH的诊断流程、治疗策略和患者随访等方面详细地进行了文献回顾和方案推荐,对于规范高血压防治有重要意义。 | 孙宁玲 Jaw-Wen Chen 王继光 谢良地 陈鲁原 牟建军 孙跃民 Chern-En Chiang Cheuk-Man Yu Huay Cheem Tan Razali Omar 霍勇 无 | 2016 | 中华高血压杂志2016，24，7： | 122 |
| 2 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 3 | MATHEMATICAL MODEL FOR THE FLOW WITH SUBMERGED AND EMERGED RIGID VEGETATION显示文摘The article summarizes previous studies on the flow in open channels with rigid vegetation, and constructs a mathematical model for submerged and emerged rigid vegetation. The model involves the forces balance in the control volume in one-dimensional steady uniform flow. For submerged vegetation, the whole flow is divided into four regions: external region, upper vegetated region, transition region and viscous region. According to the Karman similarity theory, the article improves the mixing length expression, and then gives an analytical solution to predict the vertical distribution of stream-wise velocity in the external region. For emerged vegetation, the flow is divided into two region: outer region and viscous region. In the two circumstances, the thicknesses of each region are determined respectively. The comparison between the calculated results and our experimental data and other researchers' data proves that the proposed model is effective. | HUAI Wen-xin CHEN Zheng-bing HAN Jie ZHANG Li-xiang ZENG Yu-hong | 2009 | Journal of Hydrodynamics2009，21，5： | 26 |
| 4 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 5 | Cr^(Ⅵ) adsorption on four typical soil colloids: equilibrium and kinetics显示文摘It is observed that the adsorption of chromium are greater on kaolinite minerals, red soil (R) and laterite (L) colloids than that on montmorillonite, indicotic black (IB) and yellow brown (YB) soil colloids. The adsorption process of Cr Ⅵ on these media can be further described by Langmuir or Freundlich equation quite well. The adsorption reaction of Cr Ⅵ is fast, and the adsorption equilibrium can be reached within the first two hours in moderate temperature. The adsorption quantity of Cr Ⅵ to kaolinite mineral increased with the increasing pH in the range of 2.0 to 7.0, then decreased at higher pH. But it showed some consistence among the four soil colloids. The lower the pH, the stronger the adsorption. The possible mechanisms are further discussed here. Meanwhile the influence of temperature on Cr Ⅵ adsorption on different soil colloid and clay minerals are also investigated. | ZHOU Dong\|mei, CHEN Huai\|man * (LMCP, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China) | 2000 | Journal of Environmental Sciences2000，12，3： | 15 |
| 6 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22显示文摘AIM:To investigate whether therapeutic treatment with melatonin could protect rats against acute pancreatitis and its associated lung injury.METHODS:Seventy-two male Sprague-Dawley rats were randomly divided into three groups:the sham operation(SO),severe acute pancreatitis(SAP),and melatonin treatment(MT) groups.Acute pancreatitis was induced by infusion of 1 mL/kg of sodium taurocholate(4% solution) into the biliopancreatic duct.Melatonin(50 mg/kg) was administered 30 min before pancreatitis was induced,and the severity of pancreatic and pulmonary injuries was evaluated 1,4 and 8 h after induction.Serum samples were collected to measure amylase activities,and lung tissues were removed to measure levels of mRNAs encoding interleukin 22(IL-22) and T helper cell 22(Th22),as well as levels of IL-22.RESULTS:At each time point,levels of mRNAs encoding IL-22 and Th22 were significantly higher(P < 0.001) in the MT group than in the SAP group(0.526 ± 0.143 vs 0.156 ± 0.027,respectively,here and throughout,after 1 h;0.489 ± 0.150 vs 0.113 ± 0.014 after 4 h;0.524 ± 0.168 vs 0.069 ± 0.013 after 8 h,0.378 ± 0.134 vs 0.122 ± 0.015 after 1 h;0.205 ± 0.041 vs 0.076 ± 0.019 after 4 h;0.302 ± 0.108 vs 0.045 ± 0.013 after 8 h,respectively) and significantly lower(P < 0.001) in the SAP group than in the SO group(0.156 ± 0.027 vs 1.000 ± 0.010 after 1 h;0.113 ± 0.014 vs 1.041 ± 0.235 after 4 h;0.069 ± 0.013 vs 1.110 ± 0.213 after 8 h,0.122 ± 0.015 vs 1.000 ± 0.188 after 1 h;0.076 ± 0.019 vs 0.899 ± 0.125 after 4 h;0.045 ± 0.013 vs 0.991 ± 0.222 after 8 h,respectively).The mean pathological scores for pancreatic tissues in the MT group were significantly higher(P < 0.01) than those for samples in the SO group(1.088 ± 0.187 vs 0.488 ± 0.183 after 1 h;2.450 ± 0.212 vs 0.469 ± 0.242 after 4 h;4.994 ± 0.184 vs 0.513 ± 0.210 after 8 h),but were significantly lower(P < 0.01) than those for samples in the SAP group at each time point(1.088 ± 0.187 vs 1.969 ± 0.290 after 1 h;2.450 ± 0.212 vs 3.344 ± 0.386 after 4 h;4.994 ± 0.184 vs 6.981 ± 0.301 after 8 h).The severity of SAP increased significantly(P < 0.01) over time in the SAP group(1.088 ± 0.187 vs 2.450 ± 0.212 between 1 h and 4 h after inducing pancreatitis;and 2.450 ± 0.212 vs 4.994 ± 0.184 between 4 and 8 h after inducing pancreatitis).CONCLUSION:Melatonin protects rats against acute pancreatitis-associated lung injury,probably through the upregulation of IL-22 and Th22,which increases the innate immunity of tissue cells and enhances their regeneration. | Jia-Ping Huai Xue-Cheng Sun Meng-Jun Chen Yin Jin Xiao-Hua Ye Jian-Sheng Wu Zhi-Ming Huang | 2012 | World Journal of Gastroenterology2012，18，36： | 12 |
| 7 | FLOW STRUCTURE IN PARTIALLY VEGETATED RECTANGULAR CHANNELS显示文摘This article discusses the transverse distributions of the depth averaged velocity and the Reynolds stress in a steady uniform flow in partially vegetated rectangular channels.The momentum equation is expressed in dimensionless form and solved to obtain the depth averaged velocity.The analytical solution of the velocity in dimensionless form shows that the depth-averaged velocity is determined by gravity and its distribution is mainly determined by the frictions due to water or vegetations.The analytical solution of the Reynolds stress is also obtained.A relationship between the second flow and the inertia is established and it is assumed that the former is proportional to the square of the depth averaged velocity.The Acoustic Doppler Velocimeter(Micro ADV) was used to measure the steady uniform flow with emergent artificial rigid vegetation.Comparisons between the measured data and the computed results show that our method does well in predicting the transverse distributions of the stream-wise velocity and the Reynolds stress in rectangular channels with partially vegetations. | CHEN Gang HUAI Wen-xin HAN Jie ZHAO Ming-deng | 2010 | Journal of Hydrodynamics2010，22，4： | 11 |
| 8 | Using balance of seasonal herbage supply and demand to inform sustainable grassland management on the Qinghai–Tibetan Plateau显示文摘To mitigate the impacts of grassland degradation on the Qinghai–Tibetan Plateau(QTP), in recent decades China has been implementing large-scale conservation programs and has invested about 42 billion CNY(7 billion USD). However, these programs are faced with major challenges involving trade-offs between ecological function, livestock production and income of pastoralists.Scientific assessments, as well as technical and policy issues, have not fully captured the complex ecological,social and economic dynamics of the challenges facing grassland management on the QTP. Pastoral livestock production on the QTP is characterized by imbalance in both quality and quantity between livestock seasonal nutrient requirements and herbage production, which forces pastoralists to keep larger numbers of livestock for longer periods, leading to overgrazing. To solve these problems, an integrated crop-livestock system is promoted to improve the efficiency of livestock production and conserve natural grassland as well for a sustainable system for the QTP. | Xinquan ZHAO Liang ZHAO Qi LI Huai CHEN Huakun ZHOU Shixiao XU Quanmin DONG Gaolin WU Yixin HE | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 11 |
| 9 | Speciation and fractionation of heavy metals in soil experimentally contaminated with Pb, Cd, Cu and Zn together and effects on soil negative surface charge显示文摘Speciation and fractionation of heavy metals in soil subsamples experimentally loaded with Pb, Cd, Cu and Zn in orthogonal design was investigated by sequential extraction, and operationally defined as water soluble and exchangeable(SE), weakly specific adsorbed(WSA), Fe and Mn oxides bound(OX) and organic bound(ORG). The results showed that fractions of heavy metals in the soil subsamples depended on their speciation. About 90% of Cd and 75% of Zn existed in soil subsamples in the SE fraction. Lead and Cu existed in soil subsamples as SE, WSA and OX fractions simultaneously, although SE was still the major fraction. Organic bound heavy metals were not clearly apparent in all the soil subsamples. The concentration of some heavy metal fractions in soil subsamples showed the good correlation with ionic impulsion of soil, especially for the SE fraction. Continuous saturation of soil subsamples with 0.20 mol/L NH 4Cl, which is the first step for determination of the negative surface charge of soil by the ion retention method, resulted in desorption of certain heavy metals from the soil. It was found that the percentage desorption of heavy metals from soil subsamples depended greatly on pH, the composition and original heavy metal content of the soil subsamples. However, most of the heavy metals in the soil subsamples were still be retained after multiple saturation. Compared with the parent soil, the negative surface charge of soil subsamples loaded with heavy metals did not show difference significantly from that of the parent one by statistical analysis. Heavy metals existed in the soil subsamples mainly as exchangeable and precipitated simultaneously. | ZHOU Dong mei, HAO Xiu zhen, TU Cong, CHEN Huai man, SI You bin (Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China. ) | 2002 | Journal of Environmental Sciences2002，14，4： | 10 |
| 10 | Early Pleistocene hominid teeth recovered in Mohui cave in Bubing Basin, Guangxi, South China显示文摘Two hominid teeth recovered in Mohui cave are morphologically distinguished from Australopithecus in Af-rica, but close to Homo erectus in China. These teeth are therefore provisionally assigned to Homo erectus. The associ-ated mammalian fauna include Gigantopithecus blacki, Nes-toritherium sp., Sus xiaozhu, Sus peii and Ailuropoda microta, which are typical early Pleistocene taxa in South China. The general characteristics of the Mohui faunal assemblage are similar to the Longgupo site, which is dated to 2 Ma, imply-ing a contemporaneity for the two sites. To date, compared with the discoveries in Africa, far fewer early Pleistocene hominid fossils have been recovered in Asia, and there are intensive controversies concerning their stratigraphic prove-nience and typological and temporal positions. The hominid fossils from Mohui cave, with their reliable biostratigraphic positions and distinct typological features, provide important evidence regarding the issue of early human origins and evo-lution. | WANG Wei Richard Potts HOU Yamei CHEN Yunfa WU Huaying YUAN Baoyin HUANG Weiwen | 2005 | Chinese Science Bulletin2005，50，23： | 8 |
| 11 | Identification of an Early–Middle Jurassic oxidized magmatic belt,south Gangdese,Tibet,and geological implications显示文摘The south Gangdese region is the site of subduction of the Neo-Tethys and subsequent continental collision. Compared with widespread Cretaceous and Cenozoic magmatism, Early–Middle Jurassic magmatic rocks and related deposits are rarely reported. Our work identified a >200 km long felsic rock belt associated with Cu mineralization in the south Gangdese region. We report here zircon U–Pb ages, zircon Ce^(4+)/Ce^(3+)values, and mineral assemblages of two Cu mineralized intrusions within the belt. A hornblende granite and a diorite porphyry were emplaced at 177.3 Ma and 166.3 Ma, respectively.Geological occurrence and magmatic hematite–magnetite–chalcopyrite intergrowths suggest that Cu mineralization formed coeval with Jurassic intrusions. Mineralized intrusions have high zircon Ce^(4+)/Ce^(3+)and EuN/Eu?N ratios, and hematite–magnetite intergrowths, suggesting their parent magmas were highly oxidized. Hornblende is common and primary fluid inclusions are found in titanite and apatite,indicating their parent magmas were water-saturated and exsolved volatile phases at early stage of magmatic evolution. Those magma characters contribute to the formation of porphyry Cu deposits. Given that majority subduction-related porphyry Cu systems have been eroded following uplift and denudation, the well-preserved Early–Middle Jurassic Cu mineralized igneous rocks in south Gangdese are favorable prospecting targets for subduction-related porphyry Cu deposits. | Yinqiao Zou Xilian Chen Wenting Huang Jian Zhang Huaying Liang Jifeng xu Ling Chen | 2017 | Science Bulletin2017，62，12： | 7 |
| 12 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 13 | Bushen Qiangjin capsule(补肾强筋胶囊) inhibits the Wnt/β-catenin pathway to ameliorate papain-induced knee osteoarthritis in rats显示文摘OBJECTIVE:To evaluate the molecular mechanism underlying the beneficial effect of Bushen Qiangjin capsule(补肾强筋胶囊,BSQJ),a Traditional Chinese Medicine,on knee osteoarthritis(KOA).METHODS:In the present study,32 female Sprague-Dawley rats were randomly divided into four groups:control,KOA,high-dose BSQJ(H-BSQJ),and low-dose BSQJ(L-BSQJ).After successfully establishing the KOA model by intra-articular injection of papain,H-BSQJ and L-BSQJ groups were intragastrically administered 0.243 and 0.122 g/kg BSQJ,respectively,daily for 6 weeks.At the end of the experiment,knee articular cartilage tissues of rats were collected for evaluation by hematoxylin and eosin staining,Safranin O-Fast Green staining,and terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay.Serum interleukin-1βand tumor necrosis factor-αlevels of rats were detected with an enzyme-linked immunosorbent assay method.Gene expression of Wnt-4,β-catenin,Frizzled-2,glycogen synthase kinase-3β(GSK-3β),cysteinyl aspartate-specific proteinases 3 and 9(caspases 3 and 9),collagen typeⅡalpha 1(Col2 a1),and matrix metalloproteinases 1 and 13(MMP-1 and MMP-3)of rat knee articular cartilage was quantified by reverse transcription-quantitative polymerase chain reaction analysis.Wnt-4,β-catenin,Frizzled-2,GSK-3β,cleaved caspase-3,and cleaved caspase-9 protein expression in rat knee articular cartilage was determined by western blot analysis.RESULTS:BSQJ obviously reduced pathological damage and matrix degradation of articular cartilage in KOA rats.Compared with the KOA group,H-BSQJ rats exhibited downregulated m RNA and protein expression of Wnt-4,β-catenin,Frizzled-2,and caspase-3,as well as upregulated m RNA and protein expression of GSK-3β.In addition,H-BSQJ significantly increased m RNA expression of Col2 a1 and decreased m RNA expression of MMP-1 and MMP-13.CONCLUSION:BSQJ exerted a beneficial effect on KOA by a mechanism involving downregulation of the Wnt/β-catenin pathway,which inhibited both cartilage extracellular matrix degradation and chondrocyte apoptosis to ameliorate KOA in rats. | YAO Nan CHEN Guocai LU Yanyan XU Xuemeng ZHAO Chuanxi HUANG Xuejun LIU Wengang PENG Sha WU Huai | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 5 |
| 14 | Interaction of Cd and citric acid, EDTA in red soil显示文摘Adsorption and desorption process of cadmium in red soil (Ferrisols) as well as the influence by media’s pH were investigated in detail with and without citric acid and EDTA. Experimental results clearly showed that Cd adsorption in red soil was affected significantly by the coexisted organic chemicals. In the presence of citric acid and EDTA, Cd adsorption in red soil increased with pH in acid media but decreased in high pH one. Further studies placed stress on the adsorbed Cd in red soil which was found to be existed mainly as exchangeable one at pH<5 5, and desorption rate by 0 10 mol/L NaNO 3 gave a peak shaped curve due to the difference of specifically and nonspecifically adsorbed Cd with pH’s change. | ZHOU Dong mei WANG Shen-qiang CHEN Huai man | 2001 | Journal of Environmental Sciences2001，13，2： | 5 |
| 15 | Correlation of fibrinogen-like protein 2 with progression of acute pancreatitis in rats显示文摘AIM: To examine fibrinogen-like protein 2 (fgl2) expression during taurocholate-induced acute pancreatitis progression in rats and its correlation with pancreatic injury severity. METHODS: Forty-eight male Sprague-Dawley rats were randomly divided into the severe acute pancreatitis (SAP) group (n = 24) and the sham operation (SO) group (n = 24). Sodium taurocholate (4% at doses of 1 mL/kg body weight) was retrogradely injected into the biliopancreatic ducts of the rats to induce SAP. Pancreatic tissues were prepared immediately after sacrifice. At the time of sacrifice, blood was obtained for determination of serum amylase activity and isolation of peripheral blood mononuclear cells (PBMCs). Pancreatic tissue specimens were obtained for routine light microscopy including hematoxylin and eosin staining, and the severity of pancreatic injury was evaluated 1, 4 and 8 h after induction. Expression of fgl2 mRNA was measured in the pancreas and PBMCs using reverse transcription polymerase chain reaction. Expression of fgl2 protein was evaluated in pancreatic tissues using Western blotting and immunohistochemical staining. Masson staining was also performed to observe microthrombosis. RESULTS: At each time point, levels of fgl2 mRNAs in pancreatic tissues and PBMCs were higher (P < 0.05) in the SAP group than in the SO group. For pancreatic tissue in SAP vs SO, the levels were: after 1 h, 3.911 ± 1.277 vs 1.000 ± 0.673; after 4 h, 9.850 ± 3.095 vs 1.136 ± 0.609; and after 8 h, 12.870 ± 3.046 vs 1.177 ± 0.458. For PBMCs in SAP vs SO, the levels were: after 1 h, 2.678 ± 1.509 vs 1.000 ± 0.965; after 4 h, 6.922 ± 1.984 vs 1.051 ± 0.781; and after 8 h, 13.533 ± 6.575 vs 1.306 ± 1.179. Levels of fgl2 protein expression as determined by Western blotting and immunohistochemical staining were markedly up-regulated (P < 0.001) in the SAP group compared with those in the SO group. For Western blotting in SAP vs SO, the results were: after 1 h, 2.183 ± 0.115 vs 1.110 ± 0.158; after 4 h, 2.697 ± 0.090 vs 0.947 ± 0.361; and after 8 h, 3.258 ± 0.094 vs 1.208 ± 0.082. For immunohistochemical staining in SAP vs SO, the results were: after 1 h, 1.793 ± 0.463 vs 0.808 ± 0.252; after 4 h, 4.535 ± 0.550 vs 0.871 ± 0.318; and after 8 h, 6.071 ± 0.941 vs 1.020 ± 0.406. Moreover, we observed a positive correlation in the pancreas (r = 0.852, P < 0.001) and PBMCs (r = 0.735, P < 0.001) between fgl2 expression and the severity of pancreatic injury. Masson staining showed that microthrombosis (%) in rats with SAP was increased (P < 0.001) compared with that in the SO group and it was closely correlated with fgl2 expression in the pancreas (r = 0.842, P < 0.001). For Masson staining in SAP vs SO, the results were: after 1 h, 26.880 ± 9.031 vs 8.630 ± 3.739; after 4 h, 53.750 ± 19.039 vs 8.500 ± 4.472; and after 8 h, 80.250 ± 12.915 vs 10.630 ± 7.003.CONCLUSION: Microthrombosis due to fgl2 overexpression contributes to pancreatic impairment in rats with SAP, and fgl2 level may serve as a biomarker during early stages of disease. | Xiao-Hua Ye Tan-Zhou Chen Jia-Ping Huai Guang-Rong Lu Xiao-Ju Zhuge Ren-Pin Chen Wu-Jie Chen Chen Wang Zhi-Ming Huang | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 16 | The global dynamics of a discrete nonlinear hierarchical population system显示文摘This paper is concerned with the global dynamics of a hierarchical population model,in which the fertility of an individual depends on the total number of higher-ranking members.We investigate the stability of equilibria,nonexistence of periodic orbits and the persistence of the population by means of eigenvalues,Lyapunov function,and several results in discrete dynamical systems.Our work demonstrates that the reproductive number governs the evolution of the population.Besides the theoretical results,some numerical experiments are also presented. | Ze-Rong He Huai Chen Shu-Ping Wang | 2019 | International Journal of Biomathematics2019，12，2： | 4 |
| 17 | Towards a paradigm for open and free sharing of scientific data on global change science in China显示文摘Despite great progress in data sharing that has been made in China in recent decades,cultural,policy,and technological challenges have prevented Chinese researchers from maximizing the availability of their data to the global change science community.To achieve full and open exchange and sharing of scientific data,Chinese research funding agencies need to recognize that preserva-tion of,and access to,digital data are central to their mission,and must support these tasks accord-ingly.The Chinese government also needs to develop better mechanisms,incentives,and rewards,while scientists need to change their behavior and culture to recognize the need to maximize the usefulness of their data to society as well as to other researchers.The Chinese research communi-ty and individual researchers should think globally and act personally to promote a paradigm of open,free,and timely data sharing,and to increase the effectiveness of knowledge development. | Changhui Peng Xinzhang Song Hong Jiang Qiuan Zhu Huai Chen Jing MChen Peng Gong Chang Jie Wenhua Xiang Guirui Yu Xiaolu Zhou | 2016 | Ecosystem Health and Sustainability2016，2，5： | 4 |
| 18 | Collusion-Proof Result Inference in Crowdsourcing显示文摘在传统的 crowdsourcing,工人们被期望提供独立答案给任务以便保证答案的差异。然而,最近的研究证明人群不是许多独立工人,但是相反工人们与对方一起交流并且协作。与小努力追求更多的报酬,一些工人可以共谋勾结提供重复答案,它将损坏聚集的结果的质量。尽管如此,就在 crowdsourcing 的结果推理上的串通的否定影响而言有很少努力。在这份报纸,我们特殊在公共平台为一般 crowdsourcing 任务担心防串通的结果推理问题。到那个目的,我们设计一个度量标准,工人表演变化率,由在移开重复答案前后计算吝啬的工人表演的差别识别共谋勾结的答案。然后,我们把串通察觉结果合并到存在结果推理方法甚至与串通行为的出现保证聚集的结果的质量。与真实世界、合成的数据集,我们进行了我们的途径的评估的一个广泛的集合。试验性的结果与最先进的方法比较表明我们的途径的优势。 | Peng-Peng Chen Hai-Long Sun Yi-Li Fang Jin-Peng Huai | 2018 | Journal of Computer Science & Technology2018，33，2： | 3 |
| 19 | Phenotypic identification of peanut germplasm for resistance to southern stem rot显示文摘Southern stem rot,caused by Sclerotium rolfsii Sacc.,is a destructive soil fungal disease of peanut in China and other countries.To evaluate resistant germplasm,a total of 256 peanut accessions were investigated on their resistance to southern stem rot in 3 environments by artificial inoculation.Variance analysis indicated that disease index was significantly influenced by environment,genotype and genotypeenvironment interactions.Peanut accessions of var.vulgaris type exhibited higher resistance to southern stem rot.Disease index was significantly negatively correlated with linoleic acid content,while positively correlated with oleic acid content.Six resistant accessions were identified,including Hua 28,Shandongzai,ICG 6326,Quanhua 7,Quanhua 9 and Guihua 836,with their disease indexes under 40 and mortality were less than 30%in the three environments.The identified resistant accessions showed the great potential to be applied in resistant peanut breeding,and would be good genetic resources for enhancing the resistance to southern stem rot. | Pengmin Fan Wanduo Song Yanping Kang Liyun Wan Yong Lei Dongxin Huai Yuning Chen Xin Wang Huifang Jiang Liying Yan Boshou Liao | 2020 | Oil Crop Science2020，5，4： | 3 |
| 20 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
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