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| 1 | MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines显示文摘迷走神经神经能通过“一条胆碱能的反煽动性的小径”控制煽动性的反应,它被 α 调停; 7-nicotinic 醋胆素受体(α 7nAChR ) 在巨噬细胞上。然而,连接 α 的细胞内部的机制; 7nAChR 激活和支持 inflammatory cytokine 生产遗体不好理解。在这研究,我们发现 miR-124 是由在暴露 LPS 的房间和老鼠的胆碱能的收缩筋的 upregulated。利用 miR-124 模仿并且 siRNA 击倒,我们证明 miR-124 是为胆碱能的反煽动性的行动的一个批评调停人。而且,我们的数据显示 miR-124 由指向信号变换器和抄写 3 的使活跃之物(STAT3 ) 到减少 IL-6 生产和 TNF-α 调制导致 LPS 的 cytokine 生产;变换酶(不作声) 减少 TNF-α版本。这些结果也显示 miR-124 是为煽动性的疾病的处理的一个潜在的治疗学的目标。 | Yang Sun Qi Li Huan Gui Dong-Ping Xu Yi-LiYang Ding-Feng Su Xia Liu | 2013 | Cell Research2013，23，11： | 35 |
| 2 | Invasion, expansion, and control of Bactrocera dorsalis(Hendel) in China显示文摘The Oriental fruit fly, Bactrocera dorsalis(Hendel), is among the most destructive fruit/vegetable-eating agricultural pests in the world, particularly in Asian countries such as China. Because of its widespread distribution, invasive ability, pest status, and economic losses to fruit and vegetable crops, this insect species is viewed as an organism warranting severe quarantine restrictions by many countries in the world. To understand the characteristics and potential for expansion of this pest, this article assembled current knowledge on the occurrence and comprehensive control of the Oriental fruit fly in China concerning the following key aspects: invasion and expansion process, biological and ecological characteristics, dynamic monitoring, chemical ecology, function of symbionts, mechanism of insecticide resistance, control index, and comprehensive control and countermeasures. Some suggestions for the further control and study of this pest are also proposed. | LIU Huan ZHANG Dong-ju XU Yi-juan WANG Lei CHENG Dai-feng QI Yi-xiang ZENG Ling LU Yong-yue | 2019 | Journal of Integrative Agriculture2019，18，4： | 11 |
| 3 | Three New Anthraquinones from Polygonum cillinerve显示文摘Three new anthraquinones, emodin-8-β-D-(2″-O-coumarate)glucoside 1, emodin-8-β- D-(6′-O-acetyl)glucoside 2 and physicon-8-β-D-(6′-O-acetyl)glucoside 3, were isolated from the roots of Polygonum cillinerve and their structures were established by spectroscopic methods. The biological activity indicated that compound 1 had the scavenging activity on 1,1-diphenyl-2- picrylhydrazyl (DPPH) radicals (the IC50 = 8.5 μmol/L), and compound 1-3 showed no activities against HL-60 and BGC-823 cells by MTT method in vitro. | Huan Yang QI Chao Feng ZHANG Mian ZHANG Jian Qun LIU Zheng Tao WANG | 2005 | Chinese Chemical Letters2005，16，8： | 10 |
| 4 | Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii显示文摘Mogrosides and steroid saponins are tetracyclic triterpenoids found in Siraitia grosvenorii.Squalene synthase(SQS) and cycloartenol synthase(CAS) are key enzymes in triterpenoid and steroid biosynthesis.In this study,full-length cDNAs of SgSQS and SgCAS were cloned by a rapid amplification of cDNA-ends with polymerase chain reaction(RACE-PCR) approach.The SgSQS cDNA has a 1254 bp open reading frame(ORF) encoding 417 amino acids,and the SgCAS cDNA contains a 2298 bp ORF encoding 765 amino acids.Bioinformatic analysis showed that the deduced SgSQS protein has two transmembrane regions in the C-terminal.Both SgSQS and SgCAS have significantly higher levels in fruits than in other tissues,suggesting that steroids and mogrosides are competitors for the same precursors in fruits.Combined in silico prediction and subcellular localization,experiments in tobacco indicated that SgSQS was probably in the cytoplasm or on the cytoskeleton,and SgCAS was likely located in the nucleus or cytosol.These results will provide a foundation for further study of SgSQS and SgCAS gene functions in S.grosvenorii,and may facilitate improvements in mogroside content in fruit by regulating gene expression. | Huan Zhao Qi Tang Changming Mo Longhua Bai Dongping Tu Xiaojun Ma | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 10 |
| 5 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 6 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 7 | Detection of Salmonella and several common Salmonella serotypes in food by loop-mediated isothermal amplification method显示文摘Salmonella Choleraesuis,S.Enteritidis and S.Typhimurium are the main pathogens that contaminate animal products and cause human Salmonella food poisoning.To establish the loop-mediated isothermal amplification(LAMP)method for the rapid detection of Salmonella and 3 common Salmonella serotypes,inner and outer primer sets targeting Salmonella invE gene and 3 serotype-specific genes fliC,lygD and STM4495 were designed.The LAMP reaction conditions were optimized.The specificity of LAMP primers was identified by testing 10 different bacterial strains including S.Choleraesuis,S.Enteritidis and S.Typhimurium.Take S.Choleraesuis as example,the detection limit of LAMP assay was 1.33×10^1 CFU/mL for bacteria culture and 2.0×10^1 CFU/mL for simulated pork sample.The results show that LAMP is a rapid,sensitive and specific method for Salmonella detection and can be used for the rapid detection of Salmonella in food. | Zhongqiang Chen Ke Zhang Huan Yin Qi Li Lan Wang Zhiguo Liu | 2015 | Food Science and Human Wellness2015，4，2： | 8 |
| 8 | BACKGROUND: Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 (HMGB1) is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS: Sixty rats were randomly divided into a normal control group (group A, n=10) anda Vibrio vulnificus sepsis group (group B, n=50). Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus (concentration 6×108 cfu/mL, volume 0.1 mL/100g)) into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance(ANOVA) and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS: Compared to group A (0.652±0.177), HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour (1.161±0.358, P=0.013), 24 hours (1.679±0.235, P=0.000),and 48 hours (1.258±0.274, P=0.004) (P〈0.05), and peaked at 24 hours. Compared to group A(0.594±0.190), HMGB1 protein expression at 6 hours (1.408±0.567, P=0.026) after infection wassignificantly increased (P〈0. 05), and peaked at 24 hours (2.415±1.064, P=0.000) after infection.Compared to group A (0.699±0.054), lung water content was significantly increased at 6 hours(0.759±0.030, P=0.001),12 hours (0.767±0.023, P=0.000), 24 hours (0.771±0.043, P=0.000) and 48hours (0.789±0.137, P=0.000) after infection (P〈0.05). Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION: Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis.显示文摘BACKGROUND: Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 (HMGB1) is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS: Sixty rats were randomly divided into a normal control group (group A, n=10) anda Vibrio vulnificus sepsis group (group B, n=50). Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus (concentration 6×108 cfu/mL, volume 0.1 mL/100g)) into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance(ANOVA) and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS: Compared to group A (0.652±0.177), HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour (1.161±0.358, P=0.013), 24 hours (1.679±0.235, P=0.000),and 48 hours (1.258±0.274, P=0.004) (P〈0.05), and peaked at 24 hours. Compared to group A(0.594±0.190), HMGB1 protein expression at 6 hours (1.408±0.567, P=0.026) after infection wassignificantly increased (P〈0. 05), and peaked at 24 hours (2.415±1.064, P=0.000) after infection.Compared to group A (0.699±0.054), lung water content was significantly increased at 6 hours(0.759±0.030, P=0.001),12 hours (0.767±0.023, P=0.000), 24 hours (0.771±0.043, P=0.000) and 48hours (0.789±0.137, P=0.000) after infection (P〈0.05). Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION: Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. | Qiao-meng Qiu Zhong-wang Li Lu-ming Tang Qi Sun Zhong-qiu Lu Huan Liang Guang-liang Hong Meng-fang Li | 2011 | World Journal of Emergency Medicine2011，2，4： | 7 |
| 9 | A new depsidone from Usnea diffracta显示文摘新 depsidone, diffractione A (1 ) ,以及六已知的酉分的混合物(2 – 7 ) 从 Usnea 被孤立使衍射一。他们的结构被 1D 和 2D NMR 光谱学和 HRESIMS 分析阐明。所有部件从 U 第一次被获得。使衍射一。 | Huan Yang Qi Yuan Peng Jin Yan Ping Shi | 2009 | Chinese Chemical Letters2009，20，2： | 6 |
| 10 | Structural insights into Cas13b-guided CRISPR RNA maturation and recognition显示文摘Dear Editor,CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins)systems are RNA-guided adaptive immune systems in prokaryotes.^1,2 Class 2 CRISPR-Cas systems (including type Ⅱ,Ⅴ,and Ⅵ)involve large single effector proteins in complex with crRNA for interference. | Bo Zhang Weiwei Ye Yangmiao Ye Huan Zhou Abdullah F.U.H.Saeed Jing Chen Jinying Lin Vanja Perculija Qi Chen Chun-Jung Chen Ming-Xian Chang Muhammad lqbal Choudhary Songying Ouyang | 2018 | Cell Research2018，28，12： | 5 |
| 11 | SNHG1 functions as an oncogenic lncRNA and promotes osteosarcoma progression by up-regulating S100A6 viamiR-493-5p显示文摘The mechanism behind the aberrant expression of S100A6 in osteosarcoma is seldom reported so far.This study sought to explore the regulatory axis targeting S100A6 involved in osteosarcoma progression.Clinical samples collected from osteosarcoma patients were used to detect the expressions of SNHG1,miR-493-5p,and S100A6 by western bolt analysis and reverse transcription-quantitative polymerase chain reaction(RT-qPCR).The effects of S100A6 on proliferation and osteogenic differentiation were investigated by the CCK-8 assay,colony formation assay,Ethynyl deoxyuridine staining,matrix mineralization assay,and alkaline phosphatase assay.The potential of lncRNAs/miRNAs targeting S100A6 was identified by the bioinformatics approach,and the results were verified by the dual luciferase assay and RNA immunoprecipitation assay.Both in vitro and in vivo rescue experiments were performed to investigate the regulatory relationship between the identified lncRNAs and S100A6.The results showed that S100A6 is highly expressed in osteosarcoma.S100A6 overexpression not only increases the proliferation but also reduces the osteogenic differentiation of osteosarcoma cells,while S1006A silence exerts the opposite effects.Then,SNHG1 is identified to directly interact with miR-493-5p to attenuate miR-493-5p binding to the 3′-untranslated region of S100A6.Notably,S100A6 silence partially rescues the effect of SNHG1 overexpression on proliferation and osteogenic differentiation of osteosarcoma cells.Furthermore,the suppressive role of SNHG1 silence in the growth of osteosarcoma xenograft tumors is countered by S100A6 overexpression.Collectively,this study reveals that S100A6 plays an important role in osteosarcoma progression,and SNHG1 promotes S100A6 expression by competitively sponging miR-493-5p. | Qi Liu Jiaying Luo Huan Wang Lei Zhang Guoxin Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 5 |
| 12 | Pandemonium Breaks Out:Disruption of Salicylic Acid-Mediated Defense by Plant Pathogens显示文摘Salicylic acid (SA) or 2-hydroxybenoic acid is a phenolic plant hormone that plays an essential role in plant defense against biotrophic and semi-biotrophic pathogens. In Arabidopsis, SA is synthesized from chorismate in the chloroplast through the ICS1 (isochorismate synthase I) pathway during pathogen infectioru The transcription co-activator NPR1 (Non-Expresser of Pathogenesis-Related Gene 1), as the master regulator of SA signaling, interacts with transcription factors to induce the expression of anti-microbial PR (Pathogenesis-Related) genes. To establish successful in fections, plant bacterial, oomycete, fun gal, and viral pathogens have evolved at least three major strategies to disrupt SA-mediated defense? The first strategy is to reduce SA accumulation directly by converting SA into its inactive derivatives. The second strategy is to interrupt SA biosynthesis by targeting the ICS1 pathway. In the third major strategy, plant pathogens deploy different mechanisms to interfere with SA downstream signaling. The wide array of strategies deployed by plant pathogens highlights the crucial role of disruption of SA-mediated plant defense in plant pathogenesis. A deeper understanding of this topic will greatly expand our knowledge of how plant pathogens cause diseases and consequently pave the way for the development of more effective ways to corn trol these diseases. | Guang Qi Jian Chen Ming Chang Huan Chen Katherine Hall John Korin Fengquan Liu Daowen Wang Zheng Qing Fu | 2018 | Molecular Plant2018，11，12： | 5 |
| 13 | Early Changes in Circulatory T Helper Type 1, 2, and 17 Cells of Patients with Out-of-Hospital Cardiac Arrest after Successful Cardiopulmonary Resuscitation显示文摘 | Zhi-Jiang Qi Qiang Zhang Bo Liu Huan Shao Chun-Sheng Li | 2018 | Chinese Medical Journal2018，，17： | 4 |
| 14 | An evaluation of mercury emissions from the chlor-alkali industry in China显示文摘The present status and the history of chlor alkali industry using mercury as cathode in China has been studied. Quantitative mercury emission has been estimated. At present, 17.5%—20% of the consumed mercury is released into water, 49.1%—53.3% of the Hg is discharged to the brine system outside the plants. 10%—14% of the Hg is emitted directly to the atmosphere, 5 3%—6 7% enters waste materials. The chlor alkali industry in China discharged about 17 tons every year. The total amount of mercury released by the chlor alkali industry in China is estimated to be 1400—2700 tons since 50’s. With the result of improved technology and more strict environmental regulations started in late 1970’s, chlorine plants reduced their mercury loss factor from 0 5? ? 4 kg/t NaOH before 1977 to 0.16—0.18 kg/t NaOH in 1997. The number of mercury cells in alkali plants was also reduced. In 1998, China is planning to finish the history of producing chlorine and caustic soda using the mercury cell process in the near future. How to deal with the emitted mercury will remain a main problem. | QI Xiao\|fan 1, LIN Yu\|huan\+1, CHEN Jian\|hua\+1, YE You\|zhong 2 (1. Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China 2. China National Chemical Information Center, Beijing 100029, China) | 2000 | Journal of Environmental Sciences2000，12，S1： | 4 |
| 15 | Synchrotron X-ray diffraction characterization of phase transformations during thermomechanical processing of a Ti38Nb alloy显示文摘The phase transformations during thermomechanical processing can be employed to optimize mechanical properties of β-type Ti alloys.However,such understandings are still lacking for the alloy consisting of dual β+α' phases in solution-treated and quenched state.In this paper,the phase transformations in a Ti38 Nb model alloy subjected to different thermomechanical processing were investigated by using synchrotron X-ray diffraction(SXRD) experiments,and their influence on the Young’s modulus was discussed.The results indicated that highdensity dislocations introduced by cold rolling still existed after annealing at temperatures lower than 573 K,which can decrease the martensitic transformation start temperature to below room temperature.With annealing temperatures increasing,the α'→β,β→ω_(iso),and β→α phase transformations occurred successively.At annealing temperature of 473 K,the specimen consisted of a trace of α'and ω phases as well as dominant β phase which was kept to room temperature by the high density of dislocations,rather than by the chemical stabilization.As a result,an ultralow Young’s modulus of 25.9 GPa was realized.Our investigation not only provides in-depth understandings of the phase transformations during thermomechanical processing of β-type Ti alloys,but also sheds light on designing biomedical Ti alloys with ultralow Young’s modulus. | Qing-Kun Meng Huan Li Chong-Hang Zhao Wen Ma Fu-Xiang Wei Yan-Wei Sui Ji-Qiu Qi | 2021 | Rare Metals2021，40，11： | 4 |
| 16 | Efficacy of comprehensive remote ischemic conditioning in elderly patients with acute ST-segment elevation myocardial infarction underwent primary percutaneous coronary intervention显示文摘BACKGROUND Remote ischemic conditioning(RIC)is used to protect against myocardial injury.However,there is no adequate evidence for comprehensive RIC in elderly patients with ST-segment elevation myocardial infarction(STEMI).This study aimed to test whether comprehensive RIC,started pre-primary percutaneous coronary intervention(PPCI)and repeated daily on 1-30 days post-PPCI,can improve myocardial salvage index(SI),left ventricular ejection fraction(LVEF),Kansas City Cardiomyopathy Questionnaire Clinical Summary Score(KCCQ-CSS)and 6-min walk test distance(6MWD)in elderly patients with acute STEMI during 12 months follow-up.METHODS 328 consenting elderly patients were randomized to receive standard PPCI plus comprehensive RIC(the treatment group)or standard PPCI(the control group).SI at 5-7 days after PPCI,LVEF,left ventricular end-diastolic volume index(LVEDVI),left ventricular end-systolic volume index(LVESVI),KCCQ-CSS,6MWD and adverse events rates were measured and assessed.RESULTS SI was significantly higher in the treatment group[interquartile range(IQR):0.38-0.66,P=0.037].There were no significant differences in major adverse events at 12 months.Although the differences of LVEDVI,LVESVI and LVEF between the treatment group and the control group did not reach statistical significance at 6 months and 12 months,LVEF tended to be higher,LVEDVI tended to be lower in the treatment group.The KCCQ-CSS was significantly higher in the treatment group at 1 month(IQR:46.5-87,P=0.001)and 12 months(IQR:55-93,P=0.008).There was significant difference in 6MWD between the treatment group and the control group(IQR:258-360 vs.IQR:250-345,P=0.002)at 1 month and(IQR:360-445 vs.IQR:345-432,P=0.035)at 12 months.A modest correlation was found between SI and LVEF(r=0.452,P<0.01),KCCQ-CSS(r=0.440,P<0.01)and 6MWD(r=0.384,P<0.01)respectively at 12 months.CONCLUSIONS The comprehensive RIC can improve SI,KCCQ-CSS and 6MWD.It may be an adjunctive therapy to PPCI in elderly patients with STEMI. | Yan-Ling WANG Qi YANG Cheng-Yan HU Yan-Yan CHU Zheng SUN Huan ZHAO Zhi LIU | 2022 | Journal of Geriatric Cardiology2022，19，6： | 4 |
| 17 | Neuroprotective effects of kaempferol against 2VO-induced chronic cerebral ischemia in rats显示文摘OBJECTIVE To investigate the effects of kaempferol(KAE)on chronic cerebral ischemia in rats.METHODS Chronic cerebral ischemia was induced in rats by permanent occlusion of bilateral common carotid arteries(2VO).Then,the rats with chronic cerebral ischemia were randomly divied into three groups:model group,KAE 10 and 30 mg·kg-1group.Another group rats without occlusion of common carotid arteries were used as the sham-operation group.Memory behavior was investigated by Morris water maze test.Prehensile ability was investigated by prehensile traction test.The structure of hippocampus and cortex neurons was observed with Nissel staining.In addition,the SOD activity and MDA content in brain tissue were determined.The DJ-1protein level was determined by Western blotting.RESULTS KAE 10 and 30 mg·kg-1could significantly improve cognitive impairment and prehensile traction ability(P<0.01)induced by chronic cerebral ischemia in rats.The results of the pathological analysis also suggested that KAE could ameliorate the pathological damage induced by chronic cerebral ischemia.In addition,KAE 30 mg·kg-1significantly increased the activity of SOD(P<0.05),but had no effect on the content of MDA in rat brain tissue.Western-blotting confirmed that KAE 10 and30 mg·kg-1could increase the expression of anti-oxidation proteins DJ-1 in hippocampus(P<0.01).CONCLUSION KAE may attenuate the chronic cerebral ischemic injury in rats. | ZHANG Jun CHENG Xiao YANG Huan YANG Yin-lin ZHAO Ting-kun WANG Qi WANG Yue-hua DU Guan-hua | 2016 | 中国药理学与毒理学杂志2016，30，10： | 3 |
| 18 | A Novel Bimetallic Tetrahedron Cobalt Complex Promoting the Addition of Diethylzinc to Benzaldehyde显示文摘Our recent work found a novel bimetallic tetrahedron cobalt complex which can cataly- ze the addition of diethylzinc to benzaldehyde effectively. | Wei Qiang ZHANG, Zhi CHEN, Yu Hua ZHANG, Xin Yi ZHU, Yu Gang CHEN, Huan Wang JING, Yuan Qi YIN* State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 | 2001 | Chinese Chemical Letters2001，12，5： | 3 |
| 19 | An Improved Filter of Progressive TIN Densification for LiD AR Point Cloud Data显示文摘Based on the classic filter of progressive triangulated irregular network(TIN) densification, an improved filter is proposed in this paper. In this method, we divide ground points into grids with certain size and select the lowest points in the grids to reconstruct TIN in the process of iteration. Compared with the classic filter of progressive TIN densification(PTD), the improved method can filter out attached objects, avoid the interference of low objects and obtain relatively smooth bare-earth. In addition, this proposed filter can reduce memory requirements and be more efficient in processing huge data volume. The experimental results show that the filtering accuracy and efficiency of this method is higher than that of the PTD method. | WANG Huan WANG Shugen CHEN Qi JIN Weihua SUN Mingwei | 2015 | Wuhan University Journal of Natural Sciences2015，20，4： | 3 |
| 20 | Complex Precipitation Mechanism of Ti-Nb-V Microalloyed Bainitic Base High Strength Steel显示文摘The addition of high Ti(>0.1%) in microalloyed bainitic high strength steel was designed, and the precipitation morphology of steels with different Ti, Nb, and V contents was studied by utilizing transmission electron microscopy(TEM). Based on the classical nucleation-crystal growth theory and the Johnson-Mehl-Avrami equation, the precipitation thermodynamic and kinetic model of second phase particles in austenite was established in the form of(Nbx,Vy,Tiz)C, and the complex precipitation mechanism of second phase particles was emphatically studied. The experimental results show that the complex precipitation particles could be divided into two categories: the coarser particles with about 100 nm grain size and the independent complex precipitation particles in the form of(Nb,V,Ti)C with 35-50 nm grain size. The latter has a better precipitation strengthening effect, and the calculated PTT curve shows a typical 'C' shape. When the deformed storage energy is 3 820 J·mol^-1, the fastest precipitation temperature of calculated PTT curve is 925℃, and the calculated result is essentially consistent with experimental values. The increase of Ti content increased the nose point temperature and expanded the range of fastest precipitation temperature. | 庞启航 郭菁 LI Weijuan TANG Di ZHAO Zhengzhi QI Huan WANG Jiaji | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，6： | 3 |
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