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| 1 | Thermal fatigue behavior of K465 superalloy显示文摘The thermal fatigue behavior of K465 superalloy was investigated at the peak temperature of 1050°C. By scan-ning electron microscopy (SEM) and optical microscopy, the main crack length was observed and measured. The initiation sites of the tested alloys are different in as-cast (named as K465) and solution heat treatment (named as SK465) conditions. In K465 alloy, most thermal fatigue cracks nucleate at (Nb,W,Ti)C carbides. In SK465 alloy, thermal fatigue cracks initiate in interdendritic regions, MC-type carbides and some interfaces. Thermal fatigue cracks propagate in transdendritic mode, and M6C-type carbides could retard thermal fatigue crack growth for SK465 superalloy. | YANG Jinxia ZHENG Qi SUN Xiaofeng GUAN Hengrong HU Zhuangqi | 2006 | Rare Metals2006，25，3： | 15 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 4 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 5 | Modes of Grain Selection in Spiral Selector during Directional Solidification of Nickel-base Superalloys显示文摘The modes of grain selection in spiral selector were investigated by both a ProCAST simulation and experimental confirmation.The results show that the efficiency of grain selection in starter block is associated with the geometry shape.At the early stage of grain selection,the optimization of grain orientation is dominated by competitive grain growth,but the optimization of grain orientation in starter block is gradually dominated by geometry shape at the later stage of grain selection.Besides,the spiral part could also optimize the orientation of the selected single crystal when the initial angle is large enough,and the single crystal selection in spiral parts with different pitch lengths and initial angles is dominated by different modes.The simulation results agree well with experimental ones. | Xiangbin Meng Qi Lu Jinguo Li Tao Jin Xiaofeng Sun Jun Zhang ZhongqiangChen Yanhui Wang Zhuangqi Hu | 2012 | Journal of Materials Science & Technology2012，28，3： | 8 |
| 6 | Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3显示文摘 | Yang Zhong Xiaofeng Xue Zhiqiang Liu Yongshuo Ma Kewu Zeng Lida Han Jingjing Qi Dae-Kyun Ro Soren Bak Sanwen Huang Yuan Zhou Yi Shang | 2017 | Molecular Plant2017，10，7： | 7 |
| 7 | Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke显示文摘Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion(MCAO)at the acute stage using18 F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO.Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together,the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research. | Shengxiang Liang Xiaofeng Jiang Qingqing Zhang Shaofeng Duan Tianhao Zhang Qi Huang Xi Sun Hua Liu Jie Dong Weilin Liu Jing Tao Shujun Zhao Binbin Nie Lidian Chens Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 5 |
| 8 | A systematic theoretical study on FeOx-supported single-atom catalysts: M1/FeOx for CO oxidation显示文摘 | Jinxia Liang Qi Yu Xiaofeng Yang Tao Zhang Jun Li | 2018 | Nano Research2018，11，3： | 5 |
| 9 | A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants显示文摘Herbgenomics is an emerging field of traditional Chinese medicine(TCM)research and development.By combining TCM research with genomics,herbgenomics can help to establish the scientific validity of TCM and bring it into wider usage within the field of medicine.Salvia Linn.(S.Linn.)is a large genus of Labiatae that includes important medicinal plants.In this herbgenomics study,the complete chloroplast(cp)genomes of two Salvia spp.—namely,S.przewalskii and S.bulleyana,which are used as a surrogate for S.miltiorrhiza—were sequenced and compared with those of two other reported Salvia spp.—namely,S.miltiorrhiza and S.japonica.The genome organization,gene number,type,and repeat sequences were compared.The annotation results showed that both Salvia plants contain 114 unique genes,including 80 protein-coding,30 transfer RNA(tRNA),and four ribosomal RNA(rRNA)genes.Repeat sequence analysis revealed 21 forward and 22 palindromic sequences in both Salvia cp genomes,and 17 and 21 tandem repeats in S.przewalskii and S.bulleyana,respectively.A synteny comparison of the Salvia spp.cp genomes showed a high degree of sequence similarity in the coding regions and a relatively high divergence of the intergenic spacers.Pairwise alignment and single-nucleotide polymorphism(SNP)analyses found some candidate fragments to identify Salvia spp.,such as the intergenic region of the trnV–ndhC,trnQ–rps16,atpI–atpH,psbA–ycf3,ycf1,rpoC2,ndhF,matK,rpoB,rpoA,and accD genes.All of the results—including the repeat sequences and SNP sites,the inverted repeat(IR)region border,and the phylogenetic analysis—showed that S.przewalskii and S.bulleyana are extremely similar from a genetic standpoint.The cp genome sequences of the two Salvia spp.reported here will pave the way for breeding,species identification,phylogenetic evolution,and cp genetic engineering studies of Salvia medicinal plants. | Conglian Liang Lei Wang Juan Lei Baozhong Duan Weisi Ma Shuiming Xiao Haijun Qi Zhen Wang Yaoqi Liu Xiaofeng Shen Shuai Guo Haoyu Hu Jiang Xu Shilin Chen | 2019 | Engineering2019，5，5： | 5 |
| 10 | Progress of phase-field investigations of γrafting in nickel-base single-crystal superalloys显示文摘With the development of nucleation theory,the calculation of phase diagrams(CALPHAD)method and microscopic elasto-plasticity mechanics,it is possible to apply the phase-field method to simulate the γrafting behavior of nickel-base single-crystal superalloys under the conditions of heat treatment,fatigue and creep testing.Based on the experimental progress in γrafting behavior and in combination with the microstructural simulation of the precipitation and rafting of c0phase,this paper reviews the phase-field investigation of γrafting in nickel–base single-crystal superalloys. | Yan Zhao Hongyu Zhang Hua Wei Qi Zheng Tao Jin Xiaofeng Sun | 2014 | Chinese Science Bulletin2014，59，15： | 3 |
| 11 | Design for aircraft engine multi-objective controllers with switching characteristics显示文摘The aircraft engine multi-loop control system is described and the switching control theory is introduced to solve the regulating and protecting control problems in this paper. The aircraft engine multi-loop control system is firstly described and the control problems are formulated. Secondly, the theory of the smooth switching control is devoted and a new extended scheme for the smooth switching of a switched control system is introduced. Then, for the key technologies of aero-engines switching control, a design algorithm is presented which can determine which candidate controller should be put in feedback with the plant to achieve a desired performance and the procedure to design the aircraft engine multi-loop control system is detailed. The switching performance objectives and the switching scheme are given and a family of PID controllers and compensators is designed. The simulation shows that using the switching control design method can not only improve the dynamic performance of the aircraft engine control system and reduce the switching times, but also guarantee the stability in some peculiar occasions. | Liu Xiaofeng Shi Jing Qi Yiwen Yuan Ye | 2014 | Chinese Journal of Aeronautics2014，27，5： | 3 |
| 12 | An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke显示文摘Positron emission tomography(PET) imaging of functional metabolism has been widely used to investigate functional recovery and to evaluate therapeutic efficacy after stroke. The voxel intensity of a PET image is the most important indicator of cellular activity, but is affected by other factors such as the basal metabolic ratio of each subject. In order to locate dysfunctional regions accurately,intensity normalization by a scale factor is a prerequisite in the data analysis, for which the global mean value is most widely used. However, this is unsuitable for stroke studies.Alternatively, a specified scale factor calculated from a reference region is also used, comprising neither hyper-nor hypo-metabolic voxels. But there is no such recognized reference region for stroke studies. Therefore, we proposed a totally data-driven automatic method for unbiased scale factor generation. This factor was generated iteratively until the residual deviation of two adjacent scale factors was reduced by < 5%. Moreover, both simulated and real stroke data were used for evaluation, and these suggested that our proposed unbiased scale factor has better sensitivity and accuracy for stroke studies. | Binbin Nie Shengxiang Liang Xiaofeng Jiang Shaofeng Duan Qi Huang Tianhao Zhang Panlong Li Hua Liu Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 2 |
| 13 | Efficient Synthesis of Functionalized Benzimidazoles and Perimidines: Ytterbium Chloride Catalyzed CmC Bond Cleavage显示文摘 | Cai, Lijian Ji, Xiaofeng Yao, Zhigang Xu, Fan Shen, Qi | 2011 | Chinese Journal of Chemistry2011，29，9： | 2 |
| 14 | Fabrication of 150-nm Al_(0.48)In_(0.52)As/Ga_(0.47)In_(0.53)As mHEMTs on GaAs substrates显示文摘High performance 150-nm gate-length metamorphic Al0.48In0.52As/Ga0.47In0.53 As high electron mobility transistors(mHEMTs) with very good device performance have been successfully fabricated.A T-shaped gate is fabricated by using a combined technique of optical and e-beam photolithography,which is beneficial to decreasing parasitic capacitance and parasitic resistance of the gate.The ohmic contact resistance R c is as low as 0.03 mm when using a novel ohmic contact metal system(Ni/Ge/Ti/Au).The devices exhibit excellent DC and RF performance.A peak extrinsic transconductance of 775 mS/mm and a maximum drain current density of 720 mA/mm are achieved.The unity current gain cut-off frequency(fT) and the maximum oscillation frequency(f max) are 188.4 and 250 GHz,respectively. | WU XiaoFeng LIU HongXia LI HaiOu LI Qi HU ShiGang XI ZaiFang ZHAO Jin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 2 |
| 15 | A preliminary study on the volcanic intrusive complex type beryllium metallogenic belt from the southeast coast of China显示文摘Beryllium(Be)is one of the unsubstitutable key metals in strategic emerging industries and national defense industries,mainly originating from volcanogenic Be deposits.Thus,volcanogenic Be deposits have become important research objects of key metal deposits,with a focus on their occurrence,metallogenic mechanism,and resource distribution.In the southeast coast of China,the Late Mesozoic volcanic intrusive complex has a good Be metallogenic background,and strong Be mineralization occurs in some areas.Field geological investigation and analyses of samples from Southeast Zhejiang as well as Northeast and Southeast Fujian indicate that Be mineralization in the southeast coast of China is closely related to the hydrothermal processes in the volcanic intrusive complex.In Southeast Zhejiang,Be ore in the Qingtian area mainly occurs in granite porphyry,with the Be content reaching 939 ppm,while strong Be mineralization from Zhangji rhyolite porphyry in the Pingyang area contains up to 11400 ppm Be.In Xiapu County,Northeastern Fujian,the Dawan Be deposit is characterized by constituents of helvite and beryl.In Pinghe County,Southeastern Fujian,the Fulishi Be ore is a quartz vein beryl-type ore.These results suggest that the volcanic intrusive complex area in the southeast coast of China has a wide range of Be mineralization and better Be metallogenic potential,and it is expected to become an important Be metallogenic belt in China.Thus,we should thoroughly investigate the Be resources of granite porphyry,rhyolite porphyry,quartz porphyry,and quartz vein in this volcanic rock area,which can provide a theoretical basis for the exploration and guiding prospecting of volcanic intrusive complex Be deposits. | Can RAO Rucheng WANG Fuyuan WU Xudong CHE Xiaofeng LI Qi WANG Zhiqi ZHANG Runqiu WU | 2022 | Science China Earth Sciences2022，65，8： | 2 |
| 16 | Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants显示文摘RNA 第二等的结构在基因规定起一个关键作用。瑞斯(Oryza sativa ) 是在世界上的最重要的食物庄稼之一。然而,在米饭的 RNA 结构几乎没被学习。这里,我们成功地产生了在 ? 在米饭的 vivo Structure-seq 图书馆。我们发现 mRNAs 的结构的灵活性可能与生物功能的动力学联系。更高的 N 6-methyladenosine (m 6 一) 修正趋于在 3 UTR 有更少的 RNA 结构,而 GC 内容显著地不影响在 ? 维持象翻译那样的有效生物过程的 vivo mRNA 结构。在米饭和 Arabidopsis 之间的 RNA structurome 的比较分析揭示了内容不导致的那更高的 GC 更强壮的结构和更少 RNA 结构的灵活性。而且,我们发现了在顺序和在米饭和 Arabidopsis 之间的 orthologs 的结构保存之间的弱关联。顺序并且在的保存和分叉 ? vivo RNA 结构对应于多样、特定的生物过程。我们的结果显示那 RNA 第二等的结构可能把选择的分开的层提供给在 monocot 和 dicot 之间的顺序。因此,我们的学习暗示那 RNA 结构在各种各样的生物进程不同地演变在被子植物进化期间在开发和 adaptational 灵活性维持坚韧性。 | Hongjing Deng Jitender Cheema Hang Zhang Hugh Woolfenden Matthew Norris Zhenshan Liu Qi Liu Xiaofei Yang Minglei Yang Xian Deng Xiaofeng Cao Yiliang Ding | 2018 | Molecular Plant2018，11，4： | 2 |
| 17 | Encapsulation of lyophilized platelet-rich fibrin in alginate-hyaluronic acid hydrogel as a novel vascularized substitution for myocardial infarction显示文摘Cardiovascular diseases such as myocardial infarction(MI)are among the major causes of death worldwide.Although intramyocardial injection of hydrogels can effectively enhance the ventricular wall,this approach is limited because of its restriction to the poor vascularization in the infarcted myocardium.Here,we reported a new type of hydrogel composed of alginate(ALG)and hyaluronic acid(HA)with lyophilized platelet-rich fibrin(Ly-PRF)for releasing abundant growth factors to realize their respective functions.The results of in vitro studies demonstrated favorable mechanical property and release ability of ALG-HA with Ly-PRF.When injected into the infarcted myocardium,this composite hydrogel preserved heart function and the Ly-PRF within the hydrogel promoted angiogenesis and increased vascular density in both infarcted and border zone,which rescued the ischemic myocardium.These beneficial effects were also accompanied by macrophage polarization and regulation of myocardial fibrosis.Moreover,the autologous origin of Ly-PRF with ALG-HA hydrogel offers myriad advantages including safety profile,easiness to obtain and cost-effectiveness.Overall,this study demonstrated the versatile therapeutic effects of a novel composite hydrogel ALG-HA with Ly-PRF,which optimizes a promising vascularized substitution strategy for improving cardiac function after MI. | Bei Qian Qi Yang Mingliang Wang Shixing Huang Chenyu Jiang Hongpeng Shi Qiang Long Mi Zhou Qiang Zhao Xiaofeng Ye | 2022 | Bioactive Materials2022，7，1： | 2 |
| 18 | Comparisons between Movement Speed of Main Types of Dunes:A Case Study of Desert Areas in Hexi Region of Gansu Province显示文摘In desert areas in Hexi region,11 barchan dunes,6 chains of barchan dunes,6 pyramid dunes,6 parabolic dunes and 6 accumulated sand-belts were chosen to study their movement speed based on images obtained by Google Earth in various periods.The results show that among the dunes,the movement of the barchan dunes was the fastest,followed by the chains of barchan dunes,and only the tops of the pyramid dunes swayed,while the parabolic dunes and accumulated sand-belts hardly moved forward.The higher the barchan dunes(or the chains of barchan dunes) were,the slower the movement was.On the contrary,the higher the pyramid dunes were,the faster the swing was.There was a positive correlation between the movement speed of the barchan dunes and the average wind speed of sandstorms. | CHANG Zhaofeng ZHU Shujuan SHI Xuegang ZHANG Jinhu LI Ya WANG Qi ZHANG Dekui DUAN Xiaofeng | 2016 | Journal of Landscape Research2016，8，6： | 2 |
| 19 | Trends of Mortality in End-Stage Liver Disease—China,2008–2020显示文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics. | Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou | 2023 | China CDC weekly2023，5，30： | 1 |
| 20 | Regulation of morphology and mechanical properties of polypropylene/poly(ethylene-co-propylene) in-reactor alloys by multi-stage sequential polymerization显示文摘 | Dong Qi Wang Xiaofeng Fu Zhisheng | | 0，，20： | 1 |
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