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| 1 | Floralozone protects endothelial function in atherosclerosis by ameliorating NHE1显示文摘Endothelial dysfunction is the pathological basis of atherosclerosis.Incomplete understanding of endothelial dysfunction etiology has impeded drug development for this devastating disease despite the currently available therapies.Floralozone,an aroma flavor,specifically exists in rabbit ear grass.Recently,floralozone has been demonstrated to inhibit atherosclerosis,but the underlying mechanisms are undefined.The present study was undertaken to explore whether floralozone pharmacologically targets endothelial dysfunction and therefore exerts therapeutic effects on atherosclerosis.The Na+/H+exchanger 1(NHE1),a channel protein,plays a vital role in atherosclerosis.Whether NHE1 is involved in the therapeutic effects of floralozone on endothelial dysfunction has yet to be further answered.By performing oil red staining and hematoxylin–eosin staining,vascular functional study,and oxidative stress monitoring,we found that floralozone not only reduced the size of carotid atherosclerotic plaque but also prevented endothelial dysfunction in atherosclerotic rats.NHE1 expression was upregulated in the inner membrane of carotid arteries and H2O2-induced primary rat aortic endothelial cells.Inspiringly,floralozone prevented the upregulation of NHE1 in vivo and in vitro.Notably,the administration of NHE1 activator LiCl significantly weakened the protective effect of floralozone on endothelial dysfunction in vivo and in vitro.Our study demonstrated that floralozone exerted its protective effect on endothelial dysfunction in atherosclerosis by ameliorating NHE1.NHE1 maybe a drug target for the treatment of atherosclerosis,and floralozone may be an effective drug to meet the urgent needs of atherosclerosis patients by dampening NHE1. | Ning Huang Yue Qiu Yanhua Liu Tianheng Liu Xianjun Xue Ping Song Jian Xu Yutian Fu Ruili Sun Yaling Yin Peng Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 2 | 5 - 14 Application of Position Sensitive Detector on Gas-filled Separator显示文摘 | Zhang Zhiyuan Huang Minghui Huang Tianheng Ma Long Jia Guobin Gan Zaiguo Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 3 | Study on Superheavy Nuclide 271Ds显示文摘 | Zhang Zhiyuan Gan Zaiguo Ma Long Huang Minghui Huang Tianheng Wu Xiaolei Jia Guobin Li Guangshun Yu Lin Ren Zhongzhou Zhou Shangui Zhang Yuhu Zhou Xiaohong Xu Hushan Zhang Huanqiao Xiao Guoqing Zhan Wenlong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 4 | Nucleus-Nucleus Interaction Potential Energy of Di-nuclear System显示文摘The nucleus-nucleus interaction potential is very important for studying the formation and the evolution of the DNS. The potential energy of the DNS can be written as: U(A1,A2,R) | Jia Fei, Xu Hushan, Huang Tianheng, Xu Huagen, Chen Ruofu and Li Junqing | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 5 | 2-18 Research Progress in the Exotic Nuclei Group显示文摘In order to study short-lived isotopes with submilisecond half-life and very low recoil energy, some technicalimprovements were made: (1) A VME data acquisition system was introduced to replace the old CAMMAC system.This allows to study isotopes with half-life down to 10 s. (2) Electrical isolation and filtering were introduced,the front end electronic noises have been reduced from 8 MeV down to 2 MeV and the 16 kHz noise producedby the engine of the rotating target system has been removed. (3) A cooling system for the energy degrader wasinstalled and the degrader can be cooled to 0?C. | Liu Zhong Huang Tianheng Ding Bing Sun Mingdao Ma Junbing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 6 | 2-19 Introduction to the SEASTAR Data Analysis显示文摘The first SEASTAR (Shell Evolution and Search for Two-plus energies At RIBF) campaign was carried out inMay 2014. We are analyzing the data for 58??63V and 63??66Mn.The experiment was performed at the Radioactive Isotope Beam Factory in RIKEN. A high-intensity 238U beamwas accelerated to bombard beryllium target to produce secondary beams. The B??ΔE??B method was applied toselect and purify secondary beams. An ionization chamber located at the focal point F7 (F11) measured the energyloss ΔE, yielding the fragments' element number Z in BigRIPS (ZDS)[1]. | Ding Bing Liu Zhong Huang Tianheng Sun Mingdao Xu Zhengyu Lee Jenny Pieter Doornenbal Obertelli Alexandre the SEASTAR collaboration | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 7 | 2-20 Attempt to Synthesize a New Neutron-de cient Isotope 224Np显示文摘Nuclei in the light actinide region with Z 92,N 134 are predicted to be candidates for shape coexistence[1],some nuclei in this region are also predicted to have stable octupole deformation[2]. Actinide nuclei with N=134have been produced up to plutonium (228Pu), and the lightest plutonium isotope and neptunium isotope discoveredso far are 228Pu and 225Np respectively. A campaign has been started to investigate the nuclei in this region. Thereaction 20Ne + 209Bi was used to produce 224Np (N=131) in fusion-evaporation reaction as the first step. | Huang Tianheng Liu Zhong Ding Bing Sun Mingdao | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 8 | 2-21 Attempt to Study the a-decay of 216U by 40Ca+natHf Reaction显示文摘An attempt has been made recently to synthesize very neutron-decient 216U isotope in 40Ca+natHf reaction atthe gas-lled recoil separator SHANS[1]. A beam of 40Ca12+ at an energy of Elab=194.6 MeV was delivered by thesector focusing cyclotron of the Heavy Ion Research Facility in Lanzhou (HIRFL). The average beam intensity wasabout 100 pnA. Self-support targets of natural hafnium foils with thickness of 420 g/cm2 was mounted in a edframe. Evaporation residues recoiled from the target were separated from the primary beam by the separator andthen implanted into the Si-box detector (consist of three position sensitive silicon detectors and eight non-positionsensitive silicon detectors)[2]. In order to distinguish the -decay events from the implantation events, two multi-wire proportional counters (MWPCs) were mounted upstream from the Si-box detector. Behind the Si-box detectora fourfold segmented Clover detector was installed for -ray studies. | Yang Huabin Zhang Zhiyuan Ma Long Yu Lin Jiang Jian Gan Zaiguo Wang Jianguo Tian Yulin Huang Tianheng Wang Yongsheng Sun Mingdao | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 9 | Metallic Aluminum Suboxides with Ultrahigh Electrical Conductivity at High Pressure显示文摘Aluminum,as the most abundant metallic elemental content in the Earth's crust,usually exists in the form of alumina(Al_(2)O_(3)).However,the oxidation state of aluminum and the crystal structures of aluminum oxides in the pressure range of planetary interiors are not well established. | Tianheng Huang Cong Liu Junjie Wang Shuning Pan Yu Han Chris J.Pickard Ravit Helled Hui-Tian Wang Dingyu Xing Jian Sun | 2023 | Research2023，，2： | 0 |
| 10 | Testing Velocity Separator with Alpha Source显示文摘A velocity separator has been installed at the entrance of the Radioactive Ion Beam Line in Lanzhou (RIBLL) aiming to the experiment of fusion-evaporation reactions. It consists of 2 quadruple triplets and a perpendicular electric and magnetic field acting as a Wien filter. The total length of of the separator is 5. 1 m, and the designed maximum electric and magnetic fields are 15 kV/cm and 5 kG, respectively. | Huang Tianheng,Zheng Chuan, Zhang Xueheng Yuan Xiaohua, Sun Zhiyu and Xu Hushan | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 11 | 奇异核组研究进展显示文摘Digital decay spectroscopy of actinide isotopes at the gas lled separator SHANS Deacy spectroscopy of nuclei with Z>90 were performed using the 187Re+40Ar reaction with isotopically enriched 187Re targets.The 40Ar beam was accelerated to 188 MeV by the Sector-Focusing Cyclotron(SFC)of the Heavy Ion Research Facility in Lanzhou(HIRFL).The beam intensity on target,monitored via Faraday Cups upstream and downstream of the target chamber,was around 320 pnA on average during the entire experiment of 110 h. | Liu Zhong Huang Tianheng Ding Bing Zhang Wenqiang Sun Mingdao Liu Xiaoyu Lu Hongyang Hou Dongsheng Zhou Bingqian | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 12 | 5-3 A New Method of Energy Calibration of Position Sensitive Silicon Detector显示文摘In -decay spectroscopy, there are two steps in the energy calibration of a position sensitive silicon detector(PSSD), the linear calibration and the correction of it. Here we present a new method to correct the linearcalibration. The procedure of this new method is much simpler than that of the traditional one[1]. Moreover, byusing this new method, the energy resolution is improved. | Sun Mingdao Huang Tianheng Liu Zhong Ding Bing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | Charge Equilibration Time of U Ions in Carbon Foil显示文摘During the collision of swift heavy ions with the solids, various processes, such as electron capture, ionization,excitation, vacancy production and the consequent phenomena like energy loss, are closely related with the projectile charge state evolution in the target. To measure the projectile charge state distribution after passing through a foil is an important method to study the microscopic processes of atomic collision in solids. | Fang Yan, Xiao Guoqing, Xu Hushan, Sun Zhiyu,Hu Zhengguo, Zhao Yongtao, Xu Huagen Zhang Xueying, Jia Fei, Yuan Xiaohua, Chen Ruofu, Huang Tianheng Wang Yuyu, Zhang Hongbin, Xu Zhiguo and Zheng Chuan | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 14 | 奇异核组研究进展显示文摘Digital decay spectroscopy of actinide isotopes at the gas lled separator SHANS Deacy spectroscopy of nuclei with Z>90 were performed using the ^(187)Re+^(40)Ar reaction with isotopically enriched 187Re targets.The 40Ar beam was accelerated to 188 MeV by the Sector-Focusing Cyclotron(SFC)of the Heavy Ion Research Facility in Lanzhou(HIRFL).The beam intensity on target,monitored via Faraday Cups upstream and downstream of the target chamber,was around 320 pnA in average during the entire experiment of 110 h. | Liu Zhong Huang Tianheng Ding Bing Zhang Wenqiang Sun Mingdao Liu Xiaoyu Lu Hongyang Hou Dongsheng | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 15 | 2 - 2 New Detector Array on Gas-filled Separator, SHANS显示文摘 | Zhang Zhiyuan Huang Minghui Huang Tianheng Ma Long Yu Lin Yang Huabin Gan Zaiguo | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 16 | 重离子冷却储存环CSRm上的类铍^(40)Ar^(14)+离子的双电子复合和三电子复合显示文摘Electron-ion recombination of Be-like ^(40)Ar^(14)+has been measured by employing the electron-ion merged-beams method at the cooler storage ring CSRm.The measured absolute recombination rate coefficients for collision energies from 0 to 60 eV are presented in Fig.1,covering all dielectronic recombination(DR)resonances associated with 2s^(2)→2s2p core transitions.In addition,strong trielectronic recombination(TR)resonances associated with 2s^(2)→2p^(2) core transitions were observed.Both DR and TR processes lead to series of peaks in the measured recombination spectrum,which have been identified by the Rydberg formula.Theoretical calculations of recombination rate coefficients were performed using the state-of-the-art multi-configuration Breit-Pauli(MCBP)atomic structure code AUTOSTRUCTURE to compare with the experimental results.The plasma rate coefficients for DR+TR of Ar14+were deduced from the measured electron-ion recombination rate coefficients in the temperature range from 10^(3) to 10^(7) K,and compared with calculated data from the literature. | Huang Zhongkui Wen Weiqiang Wang Hanbing Xu Xin Zhu Linfan Wang shuxing Dou Lijun Zhu Xiaolong Yao ke Xu Tianheng Mao Lijun Li Jie Yang Jiancheng Yuan Youjinand Ma Xinwen | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 17 | 2-2 Lifetime Measurement of the Low-lying Excited States 7/21^+in^87Zr显示文摘Lifetime measurements of low-lying excited states in^87Zr have been performed viaβ-γcoincidences.The 127 MeV^32S beam was delivered from the Sector-Focusing Cyclotron(SFC)of the Heavy Ion Research Facility in Lanzhou(HIRFL).The parent nuclei^87Nb were produced by the reaction 58Ni(32S,2p1n),at a beam energy 127 MeV through a 8 um Al degrader.A 200ug/cm^2 layer of 58Ni evaporated onto a 200ug/cm^2 thick carbon foil was employed as the target.After evaporation residues were separated from the projectile beams by the gas-filled recoil separator SHANS[1],the nuclei of interest 87Zr can be obtained with a higher purity and then were implanted into a 300um silicon detector. | Qiang Yunhua Liu Minliang Zhou Xiaohong Wang Jianguo Guo Song Wang Kailong Lv Bingfeng Zheng Yong Gan Zaiguo Ma Long Yang Huabin Ding Bing Huang Tianheng Sun Mingdao | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 18 | 2-18 Research Progress in the Exotic Nuclei Group显示文摘Digital decay spectroscopy of actinide isotopes at the gas filled separator SHANS All over the chart of nuclides,the region to the“north-east”of 208Pb,with Z≥84 and N=128~130,hosts the shortest-livedαradioactivities,with half-lives in the range of nanoseconds to microseconds.Synthesis and detection of neutron-deficient isotopes above thorium in this region are challenging due to their low production cross sections and short half-lives. | Liu Zhong Huang Tianheng Ding Bing Zhang Wenqiang Sun Mingdao Liu Xiaoyu Lu Hongyang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 19 | 2-19 First Identification of theγh11/2 band in 117Ba显示文摘Taking advantage of the largeγ-detector array Gammasphere and the recoil mass separator FMA,highspin states in 117Ba were investigated through the recoil-β-delayed proton decay tagging technique via the heavy-ion induced fusion-evaporation reaction 64Zn(58Ni,2p3n)117Ba,at a beam energy of 305 MeV.Promptγrays belonging to 117Ba have been identified furthermore,a rotational band has been identified for the first time and presented as band A in Fig.1. | Ding Bing Liu Zhong Huang Tianheng Sun Mingdao Zhang Wenqiang Liu Xiaoyu Lu Hongyang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 20 | 2-20α-decay Studies of 220Pa Using Digital Pulse Processing Technique显示文摘Theα-decay of neutron-deficient heavy nuclei far from stability is an indispensable spectroscopic tool to study their low-energy structure.220Pa,a trans-lead isotope near the shell closure N=126,its decay properties are still not well established,though it was studied in twoα-decay experiments 30 years ago[1,2].Recently,we applied successfully the modern digital pulse processing(DPP)technique[3,4]to the decay spectroscopy in the Z≥91 and N=128~131 region[5]and the decay chain of 220Pa was established at the first time. | Huang Tianheng Sun Mingdao Liu Zhong Zhang Wenqiang Liu Xiaoyu Ding Bing Lu Hongyang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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