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| 1 | Early evaluation of growth traits of Larix kaempferi clones显示文摘Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection.To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L.kaempferi clones were measured over many different growth years.The results indicated that, except for age × clone interaction for diameter at breast height(P = 0.741), there were significant differences among all variation sources(P < 0.01).The coefficient of phenotypic variation ranged from 14.89 to 35.65%for height and from 19.17 to 23.86% for diameter at breast height in different growth years.The repeatability of height and of diameter at breast height among clones was high,ranging from 0.6181 to 0.8531(height) and from 0.8443 to0.8497(diameter at breast height), in different growth years.There were significant positive correlations between all pairs of growth traits except between height in the 2 nd growth year and height in the 30 th growth year; and between height in the 2 nd growth year × diameter at breast height in the 30 th growth year.With a comprehensive evaluation method and a selection ratio of 10%, L65,L1, L62, L9, L15, and L78 were selected as excellent clones in the 30 th growth year.Their average values of height and diameter at breast height were 9.81 and 16.57%higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively.This study provides a theoretical foundation for the genetic improvement of L.kaempferi. | Yanyan Pan Shuchun Li Chenglu Wang Wenjun Ma Guiyou Xu Lili Shao Kailong Li Xiyang Zhao Tingbo Jiang | 2018 | Journal of Forestry Research2018，29，4： | 10 |
| 2 | Anticubilin Antisense RNA Ameliorates Adriamycin-Induced Tubulointerstitial Injury in Experimental Rats显示文摘 | Jun Liu Kailong Li Yani He Jianguo Zhang Huiming Wang Jurong Yang Jun Zhan Haijun Liang | 2011 | The American Journal of the Medical Sciences2011，，6： | 1 |
| 3 | Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin overload显示文摘 | Jurong Yang Yani He Haiying Shen Hanlu Ding Kailong Li Huiming Wang | 2008 | Frontiers of Medicine in China2008，，1： | 1 |
| 4 | Stochastic speed prediction for connected vehicles using improved bayesian networks with back propagation显示文摘Advanced vehicular control technologies rely on accurate speed prediction to make ecological and safe decisions. This paper proposes a novel stochastic speed prediction method for connected vehicles by incorporating a Bayesian network(BN) and a Back Propagation(BP) neural network. A BN model is first designed for predicting the stochastic vehicular speed in a priori. To improve the accuracy of the BN-based speed prediction, a BP-based predicted speed error compensation module is constructed by formulating a mapping between the predicted speed and its corresponding prediction error. In the end, a filtering algorithm is developed to smoothen the compensated stochastic vehicular speed. To validate the workings of the proposed approaches in experiments, two typical scenarios are considered: one predecessor vehicle in a double-vehicle scenario and two predecessor vehicles in a multi-vehicle scenario. Simulation results under the considered scenarios demonstrate that the proposed BN-BP fusion method outperforms the BN-based method with respect to the root mean square error, standardized residuals, and R-squared, and the online prediction time of proposed fusion prediction can satisfy a real-time application requirement. The main highlighted contributions of this article are threefold:(1) We put forward an improved BN method, which is combined with a BP neural network, to construct a stochastic vehicular speed prediction method under connected driving;(2) different from existing methods, a unique interconnected framework that consists of a stochastic vehicular speed prediction module, a compensation module, and a speed smoothing module is proposed;(3) extensive simulation studies based on a set of evaluation metrics are illustrated to reveal the advantages and merits of the proposed approaches. | WANG LiHua CUI YaHui ZHANG FengQi COSKUN Serdar LIU KaiLong LI GuangLei | 2022 | Science China(Technological Sciences)2022，65，7： | 1 |
| 5 | Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition显示文摘Inositol-requiring enzyme 1α(IRE1α)is the most conserved endoplasmic reticulum(ER)stress sensor with two catalytic domains,kinase and RNase,in its cytosolic portion.IRE1αinhibitors have been used to improve existing clinical treatments against various cancers.In this study we identified toxoflavin(TXF)as a new-type potent small molecule IRE1αinhibitor.We used luciferase reporter systems to screen compounds that inhibited the IRE1α-XBP1s signaling pathway.As a result,TXF was found to be the most potent IRE1αRNase inhibitor with an IC50 value of 0.226μM.Its inhibitory potencies on IRE1αkinase and RNase were confirmed in a series of cellular and in vitro biochemical assays.Kinetic analysis showed that TXF caused time-and reducing reagent-dependent irreversible inhibition on IRE1α,implying that ROS might participate in the inhibition process.ROS scavengers decreased the inhibition of IRE1αby TXF,confirming that ROS mediated the inhibition process.Mass spectrometry analysis revealed that the thiol groups of four conserved cysteine residues(CYS-605,CYS-630,CYS-715 and CYS-951)in IRE1αwere oxidized to sulfonic groups by ROS.In molecular docking experiments we affirmed the binding of TXF with IRE1α,and predicted its binding site,suggesting that the structure of TXF itself participates in the inhibition of IRE1α.Interestingly,CYS-951 was just near the docked site.In addition,the RNase IC50 and ROS production in vitro induced by TXF and its derivatives were negative correlated(r=−0.872).In conclusion,this study discovers a new type of IRE1αinhibitor that targets a predicted new alternative site located in the junction between RNase domain and kinase domain,and oxidizes conserved cysteine residues of IRE1αactive sites to inhibit IRE1α.TXF could be used as a small molecule tool to study IRE1α’s role in ER stress. | Kailong Jiang Chang-mei Liu Li-tong Nie Hai-ni Jjang Lei Xu Kun-zhi Zhang Li-xia Fan An-hui Gao Lu-ling Lin Xiang-yu Wang Ming-jia Tan Qi-qing Zhang Yu-bo Zhou Jia Li | 2023 | Acta Pharmacologica Sinica2023，44，1： | 0 |
| 6 | 2-2 Complete and Incomplete Fusion of 9Be + 169Tm, 187Re at Near-barrier Energies显示文摘Fusion cross sections with weakly bound nuclei have been a subject of great interest in the last few years[1;2]. Inthis field, the basic question is whether complete fusion (CF) is enhanced or suppressed due to diffused density andhigh probability of breakup. The answer to this question depends on the energy regime (above or below Coulombbarrier) and on different target mass regions. Therefore, one important approach to investigate this subject is tostudy the systematic behavior of the CF suppression as a function of the target mass or charge.For fusion induced by 9Be, there are some reported works on the CF on different targets, ranging from 89Y to209Bi[2], but the suppression factor of the CF at near barrier energies does not follow a systematic behavior. Forlighter targets, like 27Al and 64Zn [3;4] and for 238U[5], only total fusion (TF) cross sections were measured. Inorder to contribute to the investigation of the fusion of 9Be, we performed experiments to measure complete andincomplete fusion (ICF) of 9Be on the 187Re and 169Tm targets at energies close to the Coulomb barrier. | Fang Yongde Zhang Ningtao Li Guangshun Liu Minliang Wang Jianguo Guo Song Qiang Yunhua Zhou Xiaohong Zhang Yuhu Lei Xiangguo Zheng Yong Gao Bingshui He Xiaofeng Wang Kailong Ding Bing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 7 | 2-3 High-spin Level Structure of the Neutron-rich Nucleus 91Y显示文摘The high-spin states of near-spherical nuclei can be constructed by coupling the angular momentums of openshell nucleons. The maximum-spin state of valence space is made by aligning the angular momentums of all valenceFig. 1 The revised level scheme of 91Y deduced from thepresent work.nucleons. Beyond that, the higher-spin states can begenerated by breaking the shell closures. Many studieshave been made about such excitation process of nucleiaround the quasi-doubly magic nucleus[1??4]. | Wang Kailong Zhou Xiaohong Liu Minliang He Xiaofeng Wang Jianguo Guo Song Qiang Yunhua Zheng Yong Fang Yongde Li Guangshun | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 8 | Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin overload显示文摘Sustained proteinuria is an independent risk factor leading to kidney fibrosis and end-stage renal fail-ure.Over-reabsorption of filtered proteins,notably albu-min,has been proved to trigger interstitial inflammation and fibrosis in proteinuric renal disease.Cubilin,an endo-cytic receptor expressed on the renal tubular brush bor-der,is responsible for albumin reabsorption in physiologic condition.However,little is known about whether it is required for activation of tubular cells induced by albu-min overload.In this work,we investigated the change of cubilin expression and its potential role in albumin-induced up-regulation of chemokines synthesis in vivo and in vitro.Twenty-six patients with nephrotic syndrome were enrolled in this study.Proximal tubule uptake of albumin,expression of apical membrane cubilin and infiltrating cells in kidney interstitium were determined by immunocytochemistry.In vitro,the transcription of cubilin in HK2 cells after exposure to albumin was ana-lyzed by real-time PCR.Endocytosis of albumin in HK2 cells was examined by fluorescent microscope.The influ-ence of inhibition of cubilin on albumin-induced expres-sions of monocyte chemoattractant protein 1(MCP-1)and regulated upon activation normal T-cell expressed and secreted(RANTES)was investigated by Western blot.The intensity of luminal cubilin and tubular accu-mulation of albumin were significantly increased in nephrotic kidneys.The expression of MCP-1 and RANTES was up-regulated,and there were spatial rela-tionships in localization between these chemokines and cubilin as well as intracellular albumin in kidney tissues.Infiltration of CD-3 and ED-1-positive cells was predom-inant in tubulointerstitial areas displaying signs of increases of cubilin expression and albumin accumula-tion.In vitro,the transcription of cubilin mRNA in HK2 cells was enhanced after 24 h exposure to albumin in a dose-dependent manner.Inhibition of endocytosis of albumin by antisense cubilin nucleotide markedly reduced expression of MCP-1 and RANTES.Cubilin was required for handling a greater amount of protein in nephrotic status and albumin-induced production of MCP-1 and RANTES by renal tubular cells,which further initiated tubulointerstitial inflammation in proteinuric disease. | Jurong YANG Yani HE Haiying SHEN Hanlu DING Kailong LI Huiming WANG | 2008 | Frontiers of Medicine2008，2，1： | 0 |
| 9 | Qu-2,a robust poplar suspension cell line for molecular biology显示文摘Populus spp.have long been used as model woody plant species for molecular biology research.However,tissues of poplar are often recalcitrant to experimental procedures for molecular studies.We generated a hormone autotrophic poplar suspension cell line from a hybrid of Populus alba×P.berolinensis‘Yinzhong’,named Qu-2.Qu-2 cells are suitable as a model biological system for studying woody plants.Qu-2 cells have many advantages over suspension cell lines derived so far from any other woody plants.Qu-2 cells are very easy to cultivate and can grow on several common plant culture media without the addition of any plant hormone.They show exceptionally high growth rates,reaching an approximately 150-fold increase in biomass after one week of culturing.Another important unique characteristic of Qu-2 cells is that they can be cryopreserved and readily reactivated.Qu-2 cells are suitable for molecular manipulations such as protoplast production,transient transformation,and RNA-seq analysis.Therefore,Qu-2 cells have the great potential to be an excellent model cell line in tree molecular biological research,ranging from physiology to gene function.The Qu-2 cells will be made available to the plant community for research. | Caixia Liu Kailong Li Meng Wang Erqin Fan Chuanping Yang Junhui Wang Pengyue Fu Xiaolan Ge Heike W.Sederoff Ronald RSederoff Vincent LChiang Sui Wang Guanzheng Qu | 2021 | Journal of Forestry Research2021，32，2： | 0 |
| 10 | 2-2 Lifetime Measurement of the Low-lying Excited States 7/21^+in^87Zr显示文摘Lifetime measurements of low-lying excited states in^87Zr have been performed viaβ-γcoincidences.The 127 MeV^32S beam was delivered from the Sector-Focusing Cyclotron(SFC)of the Heavy Ion Research Facility in Lanzhou(HIRFL).The parent nuclei^87Nb were produced by the reaction 58Ni(32S,2p1n),at a beam energy 127 MeV through a 8 um Al degrader.A 200ug/cm^2 layer of 58Ni evaporated onto a 200ug/cm^2 thick carbon foil was employed as the target.After evaporation residues were separated from the projectile beams by the gas-filled recoil separator SHANS[1],the nuclei of interest 87Zr can be obtained with a higher purity and then were implanted into a 300um silicon detector. | Qiang Yunhua Liu Minliang Zhou Xiaohong Wang Jianguo Guo Song Wang Kailong Lv Bingfeng Zheng Yong Gan Zaiguo Ma Long Yang Huabin Ding Bing Huang Tianheng Sun Mingdao | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 11 | 2-3 Lifetime Measurement of the First 7/2^+State in 143Eu Based on Gas-flled Spectroscopy显示文摘The application of Lanthanum Bromide(LaBr3)detectors provides a unique opportunity to measure lifetime of excited states in picosecond-nanosecond region.Reducing the background is of critical importance to get precise results.For some excited states feeding from isomers with lifetime longer than 1μs,it can be achieved by the Spectrometer for Heavy Atom and Nuclear Structure(SHANS)[1].143Eu nuclei were populated via the 123Sb(24Mg,4n)fusion-evaporation reaction.Most of the evaporation residues at ground state or long-lived isomers were transferred to detection terminal after a flight of about 1.4μs in SHANS.In the case of 143Eu,three transitions have been observed(Fig.1). | Guo Song Wang Kailong Liu Minliang Zheng Yong Zhou Xiaohong Wang Jianguo Qiang Yunhua Zhang Yuhu Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Ding Bing Jiang Jian Fang Yongde Li Guangshun Zheng Kuankuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 12 | 2-22 Fine Structure in theαDecay of 223U显示文摘Isotope 223U synthesized and identified[1;2].αenergy of 8 780(40)keV and a half-life of 55(10)μs.Theαenergy was calculated by subtracting knownαenergy of 219Th from measured decay sum energy of 223U and its daughter 219Th.Based on the advanced digital pulse processing technique,a new measurement forα-particle energy and half-life of 223U was performed at the gas-filled recoil separator,Spectrometer for Heavy Atoms and Nuclear Structure(SHANS).The isotope 223U was produced in the fusion-evaporation reaction 187Re(40Ar,p3n)223U. | Sun Mingdao Liu Zhong Huang Tianheng Zhang Wenqiang Wang Jianguo Liu Xiaoyu Ding Bing Gan Zaiguo Ma Long Yang Huabing Zhang Zhiyuan Yu Lin Jiang Jian Wang Kailong Wang Yongsheng Liu Minliang Li Zhihuan Li Jing Wang Xiang Lu Hongyang Lin Chenjian Sun Lijie Ma Nanru Yuan Cenxi Zuo Wei Xu Hushan Zhou Xiaohong Xiao Guoqing | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 13 | 2-2 Lifetime Measurements of the Low-lying Excited States in 87 Zr and 87 Nb显示文摘Lifetime measurements of low-lying excited states in 87Zr and 87Nb have been performed via and coincidences. The 124 MeV 32S beam was delivered from the Sector-Focusing Cyclotron (SFC) of the Heavy Ion R-esearch Facility in Lanzhou (HIRFL). The parent nuclei 87Nb and 87Mo were produced by the respective reactions 58Ni (32S, 3p) and 58Ni (32S, 2p1n), at a beam energy 100 MeV through the 8 m Al degrader. | Qiang Yunhua Liu Minliang Zhou Xiaohong Wang Jianguo Wang Kailong Lv Bingfeng Zheng Yong Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Jiang Jian Sun Mingdao | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 14 | 2-3 Lifetime Measurement of the First Excited State in 37S显示文摘We have found that the excited energy from the ground state with 1f7=2 configuration to the first excited state with 2p3=2 configuration in 37S is obviously lower compared with that in nearby N=21 isotones 35Si, 39Ar and 41Ca (see Fig. 1, The insert indicates the relevant single-particle orbits of proton and neutron). This interesting phenomenon may result from the collapse of N=28 closure, which gives the sufficient valence space for collective deformation which can been revealed from the B(E2) value. Therefore, to obtain the B(E2), we perform the experiments for measuring the lifetime of the first excited state in 37S. | Wang Kailong Liu Minliang Wang Jianguo Qiang Yunhua Gao Bingshui Zheng Yong Lv Bingfeng Zhang Zhiyuan Zhang Wenqiang Zhou Xiaohong Wang Jiansong Yang Yanyun Bai Zhen Ma Peng Jin Shilun Ma Junbing Duan Fangfang Zhang Xing Jiao Lei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | 2-14 Production of New Nuclides 216U and 215U显示文摘The study on the decay properties of new isotopes located far from the beta stability line is current the focus of nuclear physics. For isotopes in the region Z >82 and N <126, -emission prevails as radioactive decay mode and -spectroscopy is the most important tool to obtain information on the nuclear structure. In the heavy nuclei region with N=124 and 126 isotones, an intruder state (h9=2.f7=2)8+ based on the attractive interaction of f7=2 protons and f5=2 neutrons has been significantly observed, which increases the binding energy of this configuration with increasing proton number. | Yang Huabin Gan Zaiguo Zhang Zhiyuan Ma Long Yu Lin Jiang Jian Wang Jianguo Tian Yulin Wang Yongsheng Ding Bing Sun Mingdao Huang Tianheng Wang Kailong | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | Online Identification of Lithium-ion Battery Model Parameters with Initial Value Uncertainty and Measurement Noise显示文摘Online parameter identification is essential for the accuracy of the battery equivalent circuit model(ECM).The traditional recursive least squares(RLS)method is easily biased with the noise disturbances from sensors,which degrades the modeling accuracy in practice.Meanwhile,the recursive total least squares(RTLS)method can deal with the noise interferences,but the parameter slowly converges to the reference with initial value uncertainty.To alleviate the above issues,this paper proposes a co-estimation framework utilizing the advantages of RLS and RTLS for a higher parameter identification performance of the battery ECM.RLS converges quickly by updating the parameters along the gradient of the cost function.RTLS is applied to attenuate the noise effect once the parameters have converged.Both simulation and experimental results prove that the proposed method has good accuracy,a fast convergence rate,and also robustness against noise corruption. | Xinghao Du Jinhao Meng Kailong Liu Yingmin Zhang Shunli Wang Jichang Peng Tianqi Liu | 2023 | Chinese Journal of Mechanical Engineering2023，36，1： | 0 |
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