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| 1 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 2 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 3 | Basic Topology and Key Devices of the Five-Terminal DC Grid显示文摘Due to their high controllability and flexibility,DC power grids have broad application prospects in the fields of networking of renewable energy and the power supply for oceanic archipelagos and future cities.This paper describes the system topology,control strategy,DC breaker configuration,and research,development and testing of converter valves and DC breaker equipment of the Zhoushan multi-terminal DC transmission system.Zhejiang Zhoushan has unique geographical and developmental features to demonstrate the irreplaceable technical advantages of a DC power grid for providing reliable power supply.The experience gained from the Zhoushan DC power grid project can offer valuable insights into the development and utilization of this technology worldwide. | Guangfu Tang Zhiyuan He Hui Pang Xiaoming Huang Xiao-Ping Zhang | 2015 | CSEE Journal of Power and Energy Systems2015，1，2： | 30 |
| 4 | The value of vegetation ecosystem services:a case of Qinling-Daba Mountains显示文摘According to differences in vegetation types and their coverage, combining the latest research, using theory and method on the value of vegetation ecosystem services, this paper not only calculated goods produced by different types of vegetation but also estimated the value of various vegetation ecosystem services and set up database, GIS and eco-account of vegetation ecosystem. The result was as follows: the value of vegetation’s primary productivity, soil and fertility conservation, water conservation, CO 2 fixation and O 2 release was 199.6 billion yuan/a, 22.64 billion yuan/a, 22.66 billion yuan/a, 352.24 billion yuan/a and 374.19 billion yuan/a, respectively. The total value of ecosystem services was 968.33 billion yuan/a. The temperate deciduous broad-leaved forest had the highest contribution rate, accounting for 16.42%. The result of value can reflect regional reality more exactly. | REN Zhiyuan,ZHANG Yanfang,LI Jing(College of Tourism and Environment, Shaanxi Normal University, Xi’an 710062, China) | 2003 | Journal of Geographical Sciences2003，13，2： | 20 |
| 5 | A Hybrid Forecasting Framework Based on Support Vector Regression with a Modified Genetic Algorithm and a Random Forest for Traffic Flow Prediction显示文摘The ability to perform short-term traffic flow forecasting is a crucial component of intelligent transportation systems. However, accurate and reliable traffic flow forecasting is still a significant issue due to the complexity and variability of real traffic systems. To improve the accuracy of short-term traffic flow forecasting, this paper presents a novel hybrid prediction framework based on Support Vector Regression(SVR) that uses a Random Forest(RF) to select the most informative feature subset and an enhanced Genetic Algorithm(GA) with chaotic characteristics to identify the optimal forecasting model parameters. The framework is evaluated with real-world traffic data collected from eight sensors located near the I-605 interstate highway in California. Results show that the proposed RFCGASVR model achieves better performance than other methods. | Lizong Zhang Nawaf R Alharbe Guangchun Luo Zhiyuan Yao Ying Li | 2018 | Tsinghua Science and Technology2018，23，4： | 19 |
| 6 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 7 | Diversity and high nitrogenase activity of endophytic diazotrophs isolated from Oryza rufipogon Griff.显示文摘Diversity and nitrogenase activity of endophytic diazotrophs colonized in the wild rice Oryza rufipogon Griff grown in Boluo, Huilai County in Guangdong Province and Lingshui County in Hainan Province were studied. Thirty-seven isolates obtained from Oryza rufipogon were identified as putative endophytic nitrogen-fixing bacteria by ARA (acetylene reduction assay) test and further confirmed by PCR amplification of nifH gene fragments. All obtained strains have ARA activity and the same sized nifH gene fragments. Above the similarity level of 80%, the obtained isolates were assigned as Group Ⅰ to Ⅷ by the clustering of IS-PCR fingerprints. The SDS-PAGE whole-cell protein patterns were similar to those of IS-PCR fingerprints. Components and contents of fatty acid methyl esters (FAMEs) were used to differentiate the representative strains (Ls13, Ls8, BL1, BL12, HL6, Ls4) from Group Ⅰ to Group Ⅵ. The six representative strains showed significant difference in contents and components of cellular fatty acid methyl ester. 16S rDNA sequencing analysis showed that strains of Group Ⅰ to Ⅶ were located in Enterobacteraceae (γ-proteobacteria). Strains of Group Ⅰ and Group II were closely related to Klebsiella sp.; Strain Ls8 of Group Ⅱ was a little far away from the genus of Pantoea (homology level 96% with Pantoea agglomerans), which may represent a new species or genus in Enterobacteraceae; Strains of Groups IV and V belonged to different Enterobacter sp.; Strain Ls4 and Ls 9 representing Group Ⅵ were close to Citrobacter amalonaticus with 98% sequence similarity; Strain Ls15 of Group Ⅶ showed 98% sequence identity with Pantoea sp.; Strains of Group Ⅷ were assigned to the genus Ideonella (β-proteobacteria). Based on the above results, endophytic diazotrophs isolated from O. rufipogon showed great diversity and some diazotrophs showed high nitrogenase activity with 42.52 μmol/mL·h C2H4. Inoculation to rice tests indicated that the isolated endophytic diazotrophs significantly promoted the rice growth. | TAN ZhiYuan PENG GuiXiang XU PeiZhi AI ShaoYing TANG ShuanHu ZHANG GuoXia ZENG FengYun | 2009 | Chinese Science Bulletin2009，54，16： | 14 |
| 8 | Hypoxia induces PGC-la expression and mitochondrial biogenesis in the myocardium of TOF patients显示文摘 | Qiang Wang Lin Zhang Zhixiang Fang Fang Zhao Zhiyuan Lv Zuguang Gu Junfeng Zhang Jin Wang Ke Zen Yang Xiang Dongjin Wang Chen-Yu Zhang | 2010 | Cell Research2010，20，6： | 13 |
| 9 | Influence of coupled boundary layer suction and bowed blade on flow field and performance of a diffusion cascade显示文摘Based on the investigation of mid-span local boundary layer suction and positive bowed cascade, a coupled local tailored boundary layer suction and positive bowed blade method is developed to improve the performance of a highly loaded diffusion cascade with less suction slot. The effectiveness of the coupled method under different inlet boundary layers is also investigated.Results show that mid-span local boundary layer suction can effectively remove trailing edge separation, but deteriorate the flow fields near the endwall. The positive bowed cascade is beneficial for reducing open corner separation, but is detrimental to mid-span flow fields. The coupled method can further improve the performance and flow field of the cascade. The mid-span trailing edge separation and open corner separation are eliminated. Compared with linear cascade with suction, the coupled method reduces overall loss of the cascade by 31.4% at most. The mid-span loss of the cascade decreases as the suction coefficient increases, but increases as bow angle increases. The endwall loss increases as the suction coefficient increases. By contrast, the endwall loss decreases significantly as the bow angle increases. The endwall loss of coupled controlled cascade is higher than that of bowed cascade with the same bow angle because of the spanwise inverse ‘‘C' shaped static pressure distribution. Under different inlet boundary layer conditions, the coupled method can also improve the cascade effectively. | Cao Zhiyuan Liu Bo Zhang Ting Yang Xiqiong Chen Pingping | 2017 | Chinese Journal of Aeronautics2017，30，1： | 12 |
| 10 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 11 | Heterotic Group Classification of 63 Inbred Lines and Hybrid Purity Identification by Using SSR Markers in Winter Cabbage(Brassica Oleracea L. var. capitata)显示文摘Winter cabbage is an important crop cultivated through winter in the region near the Yangtze River, enabling the supply of fresh cabbage there at that time of year. However, a problem has emerged regarding the newly developed parents of winter cabbage, which is completely different from spring and autumn cabbage, namely, how to combine these parents to breed an elite hybrid. To classify the heterotic groups and improve the efficiency of parent selection in winter cabbage breeding, 20 polymorphic SSR markers were selected to screen 63 winter cabbage inbred lines. Seventeen pairs among the 20 SSR markers amplified polymorphic bands. These primers amplified two to six bands,with an average of 2.8 bands per primer, and a total of 47 polymorphic bands were generated in the 63 inbred lines. These lines included flatheaded morphotype and round-headed morphotype, thus they were separately classified into heterotic groups based on the SSR markers. The flat-headed morphotype contained 21 inbred lines and was classified into three heterotic groups, named Hanchun 4, Jiali, and Dongsheng, in accordance with the representative germplasm contained in each group. The round-headed morphotype contained 42 inbred lines and was classified into five heterotic groups, named Parte, Bejo1039, YK-143, SCA002, and Golden B90. Meanwhile, parent analysis of 20 developed elite combinations showed that their parents were all distributed in different heterotic groups, indicating that the group classification was reasonable,which can provide a basis for further parent selection in winter cabbage breeding. Furthermore, polymorphic SSR primers were successfully used to identify the hybrid purity of three elite varieties. | LI Xing YU Hailong LI Zhiyuan LIU Xiaoping FANG Zhiyuan LIU Yumei YANG Limei ZHUANG Mu LV Honghao ZHANG Yangyong | 2018 | Horticultural Plant Journal2018，4，4： | 11 |
| 12 | Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies显示文摘Brassica rapa comprises several important cultivated vegetables and oil crops.Current reference genome assemblies of Brassica rapa are quite fragmented and not highly contiguous,thereby limiting extensive genetic and genomic analyses.Here,we report an improved assembly of the B.rapa genome(v3.0)using single-molecule sequencing,optical mapping,and chromosome conformation capture technologies(Hi-C).Relative to the previous reference genomes,our assembly features a contig N50 size of 1.45 Mb,representing a~30-fold improvement.We also identified a new event that occurred in the B.rapa genome~1.2 million years ago,when a long terminal repeat retrotransposon(LTR-RT)expanded.Further analysis refined the relationship of genome blocks and accurately located the centromeres in the B.rapa genome.The B.rapa genome v3.0 will serve as an important community resource for future genetic and genomic studies in B.rapa.This resource will facilitate breeding efforts in B.rapa,as well as comparative genomic analysis with other Brassica species. | Lei Zhang Xu Cai Jian Wu Min Liu Stefan Grob Feng Cheng Jianli Liang Chengcheng Cai Zhiyuan Liu Bo Liu Fan Wang Song Li Fuyan Liu Xuming Li Lin Cheng Wencai Yang Mai-he Li Ueli Grossniklaus Hongkun Zheng Xiaowu Wang | 2018 | Horticulture Research2018，5，1： | 10 |
| 13 | Effects of urea plus nitrate pretreated rice straw and corn oil supplementation on fiber digestibility,nitrogen balance,rumen fermentation,microbiota and methane emissions in goats显示文摘Background: Urea pretreatment is an efficient strategy to improve fiber digestibility of low quality roughages for ruminants. Nitrate and oil are usually used to inhibit enteric methane(CH4) emissions from ruminants. The objective of this study was to examine the combined effects of urea plus nitrate pretreated rice straw and corn oil supplementation to the diet on nutrient digestibility, nitrogen(N) balance, CH4 emissions, ruminal fermentation characteristics and microbiota in goats. Nine female goats were used in a triple 3 × 3 Latin Square design(27 d periods). The treatments were: control(untreated rice straw, no added corn oil), rice straw pretreated with urea and nitrate(34 and 4.7 g/kg of rice straw on a dry matter [DM] basis, respectively, UN), and UN diet supplemented with corn oil(15 g/kg soybean and15 g/kg corn were replaced by 30 g/kg corn oil, DM basis, UNCO).Results: Compared with control, UN increased neutral detergent fiber(NDF) digestibility(P < 0.001) and copies of protozoa(P < 0.001) and R. albus(P < 0.05) in the rumen, but decreased N retention(-21.2%, P < 0.001), dissolved hydrogen concentration(-22.8%, P < 0.001), molar proportion of butyrate(-18.2%, P < 0.05),(acetate + butyrate) to propionate ratio(P < 0.05) and enteric CH4 emissions(-10.2%, P < 0.05). In comparison with UN, UNCO increased N retention(+34.9%, P < 0.001) and decreased copies of protozoa(P < 0.001) and methanogens(P < 0.001). Compared with control, UNCO increased NDF digestibility(+8.3%, P < 0.001), reduced ruminal dissolved CH4 concentration(-24.4%, P < 0.001) and enteric CH4 emissions(-12.6%, P < 0.05).Conclusions: A combination of rice straw pretreated with urea plus nitrate and corn oil supplementation of the diet improved fiber digestibility and lowered enteric CH4 emissions without negative effects on N retention. These strategies improved the utilization of rice straw by goats. | Xiumin Zhang Rodolfo F.Medrano Min Wang Karen A.Beauchemin Zhiyuan Ma Rong Wang Jiangnan Wen Lukuyu A.Bernard Zhiliang Tan | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 10 |
| 14 | Personalized Real-Time Movie Recommendation System:Practical Prototype and Evaluation显示文摘With the eruption of big data,practical recommendation schemes are now very important in various fields,including e-commerce,social networks,and a number of web-based services.Nowadays,there exist many personalized movie recommendation schemes utilizing publicly available movie datasets(e.g.,MovieLens and Netflix),and returning improved performance metrics(e.g.,Root-Mean-Square Error(RMSE)).However,two fundamental issues faced by movie recommendation systems are still neglected:first,scalability,and second,practical usage feedback and verification based on real implementation.In particular,Collaborative Filtering(CF)is one of the major prevailing techniques for implementing recommendation systems.However,traditional CF schemes suffer from a time complexity problem,which makes them bad candidates for real-world recommendation systems.In this paper,we address these two issues.Firstly,a simple but high-efficient recommendation algorithm is proposed,which exploits users1 profile attributes to partition them into several clusters.For each cluster,a virtual opinion leader is conceived to represent the whole cluster,such that the dimension of the original useritem matrix can be significantly reduced,then a Weighted Slope One-VU method is designed and applied to the virtual opinion leader-item matrix to obtain the recommendation results.Compared to traditional clusteringbased CF recommendation schemes,our method can significantly reduce the time complexity,while achieving comparable recommendation performance.Furthermore,we have constructed a real personalized web-based movie recommendation system,MovieWatch,opened it to the public,collected user feedback on recommendations,and evaluated the feasibility and accuracy of our system based on this real-world data. | Jiang Zhang Yufeng Wang Zhiyuan Yuan Qun Jin | 2020 | Tsinghua Science and Technology2020，25，2： | 10 |
| 15 | Study of utilizing differential gear train to achieve hybrid mechanism of mechanical press显示文摘The problems of hybrid input of mechanical press are studied in this paper, with differential gear train as transmission mechanism. It is proposed that “adjust-able-speed amplitude” or “differential-speed ratio” is the important parameters for the hybrid input mechanism. It not only defines the amplitude of the adjustable speed, but also determines the ratio of the power of the servomotor to the power of the conventional motor. The calculating equations of the ratio of transmission in all axes, the power of two motors, and the working load distribution are deduced. The two kinds of driving schemes are put forward that the servomotor and the conven-tional motor simultaneously drive and the servomotor and the conventional motor separately drive. The calculating results demonstrate that the latter scheme can use much lower power of the servomotor, so this scheme makes manufacture and use cost much lower. The latter scheme proposes a feasible way to apply the hybrid mechanism of mechanical press in practice engineering. | HE YuPeng ZHAO ShengDun ZOU Jun ZHANG ZhiYuan | 2007 | Science China(Technological Sciences)2007，50，1： | 9 |
| 16 | Exploring the driving factors and their mitigation potential in global energy-related CO2 emission显示文摘In order to quantify the contribution of the mitigation strategies,an extended Kaya identity has been proposed in this paper for decomposing the various factors that influence the CO2 emission.To this end,we provided a detailed decomposition of the carbon intensity and energy intensity,which enables the quantification of clean energy development and electrification.The logarithmic mean divisia index(LMDI)has been applied to the historical data to quantify the contributions of the various factors affecting the CO2 emissions.Further,the global energy interconnection(GEI)scenario has been introduced for providing a systematic solution to meet the 2℃goal of the Paris Agreement.By combining LMDI with the scenario analysis,the mitigation potential of the various factors for CO2 emission has been analyzed.Results from the historical data indicate that economic development and population growth contribute the most to the increase in CO2 emissions,whereas improvement in the power generation efficiency predominantly helps in emission reduction.A numerical analysis,performed for obtaining the projected future carbon emissions,suggests that clean energy development and electrification are the top two factors that can decrease CO2 emissions,thus showing their great potential for mitigation in the future.Moreover,the carbon capture and storage technology serves as an important supplementary mitigation method. | Zhiyuan Ma Shining Zhang Fangxin Hou Xin Tan Fengying Zhang Fang Yang Fei Guo | 2020 | Global Energy Interconnection2020，3，5： | 9 |
| 17 | Intermetallic Compounds in the Banded Structure and Their Effect on Mechanical Properties of Al/Mg Dissimilar Friction Stir Welding Joints显示文摘Dissimilar friction stir welding(FSW) between aluminum and magnesium alloy was performed, using various tool rotational speed(TRS) at a ?xed travel speed, with tool offset to aluminum to investigate the formation of intermetallic compounds(IMCs) in the banded structure(BS) zone and their effect on mechanical properties. Large quantities of IMCs, in the form of alternating bands of particles or lamellae, were found in the BS zone, where drastic material intermixing occurred during FSW. The BS microstructural characters in terms of the morphology of the bands and the quantity and distribution of IMC particles varied with TRS. All welds exhibited brittle fracture mode with their fracture paths propagating mainly in/along the IMCs in the BS. It is shown that these BS microstructural characters have signi?cant effect on the mechanical properties of the joints. Suggestions on tailoring the BS microstructure were proposed for improving the strength of the BS zone and the ?nal mechanical properties of the Al/Mg FSW joints. | Hui Shi Ke Chen Zhiyuan Liang Fengbo Dong Taiwu Yu Xianping Dong Lanting Zhang Aidang Shan | 2017 | Journal of Materials Science & Technology2017，33，4： | 8 |
| 18 | Concentration level and distribution of polycyclic aromatic hydrocarbons in soil and grass around Mt. Qomolangma, China显示文摘High mountains may serve as a condenser for persistent organic pollutants. In the present study, soil and grass samples from Mt. Qomolangma region, China were collected from 4600 to 5620 m a.s.l and were analyzed for polycyclic aromatic hydrocarbons (PAHs) to determine if they are concentrated at colder, more elevated sites and to evaluate their possible resources and fractionation. The total PAHs concentration in soil samples was < 600 ng g?1, the critical value to differentiate PAHs levels in remote and urban regions. This implied the PAHs levels at Mt. Qomolangma are relatively low and what one might expect in such a remote region of the world. These low values may represent a soil background for mid-latitude Northern Hemisphere soils away from the direct influence of an anthropogenic source. As for the distribution pattern, the low molecular weight PAHs were prone to accumulate at higher altitude, while the high molecular weight PAHs inversely related or unrelated with elevation. Based on high concentration of phenanthrene at elevated sample site and the ratios of individual PAHs, we deduced that home-heating combustion and vehicle emission may result in the constitution trait of PAHs in this mountain region. Monsoon traveling over India, Pakistan and other countries with dense population may carry contaminant to Mt. Qomolangma region. | WANG XiaoPing YAO TanDong CONG ZhiYuan YAN XinLiang KANG ShiChang ZHANG Yong | 2007 | Chinese Science Bulletin2007，52，10： | 8 |
| 19 | Characteristics of air pollution by polychlorinated dibenzo-p-dioxins and dibenzofurans in the typical industrial areas of Tangshan City,China显示文摘The ambient air in vicinity of different industrial sources for PCDD/PCDFs was sampled by TSP/PM 10 active samplers and passive PUF disk samplers in Tangshan City,a metropolis containing clusters of various industrial plants.The ΣTEQ concentrations of ΣPCDD/ΣPCDFs ranged from 44.2 to 394.1 fg I-TEQ/m 3 with an average of 169.9 fg I-TEQ/m 3.2,3,4,7,8-PeCDF was the dominant contributor to TEQ,contributing 41% (12% to 55%),while 1,2,3,4,6,7,8-HpCDF,OCDD and OCDF were the major congeners for the total concentrations.The ratios of PCDF/PCDD reached 2.54 on average,suggesting that de novo synthesis in thermal processes played an important role to the airborne pollution of PCDD/PCDFs.The similarities congener profiles indicated that TSP and PM 10 active sampling methods are comparable for the determination of the PCDD/PCDFs in ambient air,and the ratios of concentrations determined by the two methods suggested that the PCDD/PCDFs tended to stay in fine particles.It was found that 2,3,7,8-TCDF and OCDD were the dominating congeners in the passive PUF disks samples.Through principal components analysis,the coke industry was suggested to be a relatively high potential emission source for PCDD/PCDFs in the ambient air of Tangshan,which was possibly formed by de novo synthesis mechanism.In this study,the atmospheric impacts to the environment from different industrial sources could be ranked as follows (from high to low):coking,iron sintering,steel making,power generation and chlorinate alkali chemical production industries. | Zhiyuan Ren Bing Zhang Pu Lu Cheng Li Lirong Gao Minghui Zheng | 2011 | Journal of Environmental Sciences2011，23，2： | 8 |
| 20 | Exosome-mediated metabolic reprogramming:the emerging role in tumor microenvironment remodeling and its influence on cancer progression显示文摘Metabolic reprogramming is reported to be one of the hallmarks of cancer,which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.Recently,extracellular vesicles(EVs)known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment(TME).Meanwhile,the TME is a highly heterogeneous ecosystem incorporating cancer cells,fibroblasts,adipocytes,endothelial cells,mesenchymal stem cells,and extracellular matrix.Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells,which facilitate cancer progression,angiogenesis,metastasis,drug resistance,and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells.In this review,we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.In addition,we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis,and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy.Furthermore,a better understanding of the link between exosomes and metabolic reprogramming,and their impact on cancer progression,would provide novel insights for cancer prevention and treatment in the future. | Enli Yang Xuan Wang Zhiyuan Gong Miao Yu Haiwei Wu Dongsheng Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
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