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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(https://ngdc.cncb.ac.cn/gsa/),GSA for Human(GSA-Human,https://ngdc.cncb.ac.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,https://ngdc.cncb.ac.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://bigd.big.ac.cn/gsa or http://gsa.big.ac.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 3 | Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1α upregulation显示文摘Hyperlipidemia 在 ischemic 心疾病的发展被认为是一个独立风险因素,并且它能增加心肌的危险性到 ischemia/reperfusion (I/R ) 损害。Ischemic postconditioning (Postcon ) 被表明了稀释 I/R 处于正常条件导致的心肌的损害。但是 hyperlipidemic 动物上的 ischemic Postcon 的效果是未知的。组织缺氧可诱导的 factor-1 (HIF-1 ) 被表明了由 preconditioning 在 cardioprotection 起一个中央作用,它除了 Postcon 是保护的策略之一。这研究的目的是决定 Postcon 是否能在 hyperlipidemic 动物减少心肌的损害并且估计 HIF-1 是否涉及 Postcon 机制。在用高胖的饮食或正常饮食喂了 8 个星期以后,男 Wistar 老鼠经历了左前面的下降冠的吸藏因为 30 min 由灌注的 180 min 列在后面与或没有 Postcon。I/R 侮辱导致的有害索引包括了梗塞尺寸,血浆肌酸 kinase 活动和 caspase-3 活动。结果证明 hyperlipidemia 显著地提高了 I/R 导致的心肌的损害,当 Postcon 显著地减少了时在 normolipidemic 和 hyperlipidemic 老鼠的心肌的损害。而且, hyperlipidemia 和 I/R 支持了 HIF-1 表示。最重要地,我们第一次证明了 Postcon 进一步不仅在 normolipidemic 而且处于 hyperlipidemic 条件在 HIF-1 蛋白质水平导致了重要增加。因此, Postcon 减少 I/R 在正常和 hyperlipidemic 导致的心肌的损害动物,和 HIF-1 upregulation 可以在调停 Postcon 的 cardioprotective 机制包含。 | Huanxin Zhao Yehong Wang Ye Wu Xiaoyu Li Guangzhao Yang Xiurui Ma Rongmi Zhao Huirong Liu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 9 |
| 4 | Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats显示文摘Hyperlipidemia 是在 ischemic 心疾病的发展的一个独立风险因素,它能增加心肌的危险性到 ischemia/reperfusion (I/R ) 损害。Ischemic postconditioning (PostC ) 现在作为新奇策略被表明了处于正常条件对心肌的 I/R 损害利用自然的保护。然而, hyperlipidemic 动物上的 PostC 的效果留下逃犯。PostC 减少心肌的 I/R 损害,这在我们的以前的学习被显示出,并且组织缺氧可诱导的 factor-1 (HIF-1 ) 可以在正常老鼠上在 PostC 的 cardioprotective 机制起一个重要作用。这里,我们测试了 hyperlipidemic 老鼠上的 PostC 的 cardioprotection 与起来调整的 HIF-1 表示被联系的假设。男 Wistar 老鼠用一本高脂肪的食谱被喂 8 个星期,然后随机把组划分了成五:假冒, I/R, dimethyloxalylglycine (DMOG )+ I/R, PostC,和 DMOG + PostC 组织。I/R 损害导致的有害索引包括了梗塞尺寸,血浆肌酸 kinase (CK ) 活动和 caspase-3 活动。,结果与 I/R 组相比证明 PostC 能减少梗塞尺寸,它与血浆 CK 的重要底层一致活动和 caspase-3 活动,和那它在 hyperlipidemic 老鼠增加了 HIF-1 的表示。当 DMOG 在 PostC 前被给起来调整 HIF-1 蛋白质水平时, I/R 损害的度被稀释。在结论,这些数据建议 HIF-1 的起来规定可以是对在 hyperlipidemic 老鼠的 I/R 损害的 PostC 的 cardioprotective 机制之一。 | Xiaoyu Li Huanxin Zhao Ye Wu Suli Zhang Xiaoqin Zhao Yan Zhang Jin Wang Jie Wang Huirong Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 9 |
| 5 | Numerical Study of Unsteady Flows with Cavitation in a High-Speed MicroCentrifugal Pump显示文摘The unsteady flows caused by the interaction between the impeller and the volute in a high-speed micro centrifugal pump are numerically studied. The internal flows of both with and without cavitations are analyzed using the CFX. The characteristics of unsteady pressure on the blade surfaces and the symmetric plane of the volute are presented and compared. The results show that the amplitudes of pressure fluctuations of critical cavitation on the blade pressure surface(PS) are bigger as compared with those at the non-cavitation condition, but on the suction surface(SS), the situation is on the contrary. When cavitation occurs, reduction of load in the impeller is a result. In the present study, such reduction of load is observed mainly on the first half of the blades. Pressure fluctuations at five monitoring points, denoted by WK1 to WK5 in the volute, are also analyzed. No matter at the critical cavitation or at the non-cavitation conditions, the monitored pressure fluctuations are at the same frequencies, which equal to the blade passing frequency(BPF) and its multiples. However, the amplitudes of the fluctuations at critical cavitation condition are considerably stronger, as compared with those for without cavitation. | LI Yeqiang YUAN Shiwei LAI Huanxin | 2017 | Journal of Thermal Science2017，26，1： | 9 |
| 6 | Variations in paleoproductivity and the environmental implications over the past six decades in the Changjiang Estuary显示文摘Total organic carbon and organic carbon stable isotope, biogenic silica, chlorin were measured from a high resolution sediment core to indicate the variation in paleoproductivity and the environmental implications over the past decades (1942 to 1997) in the Changjiang Estuary. Based on these biomarkers, the shift in the phytoplankton community structure in the past decades was discussed in response to the long-term variations in nutrient concentrations and nutrient ratios. The results showed that the δ 13 C values varied from –26.15‰ to –19.5‰, suggesting the combined organic carbon sources of riverine and marine organisms. Based on the biogenic proxies, paleoproductivity changes were categorized into three stages: low production before 1950; an increase in production with the dominance of diatoms during 1950 to 1980, consistent with increasing of nutrient concentrations; a decrease in production after 1980 when the diatom production decreased while the production of non-silicious phytoplankton increased due to high nutrient inputs, and high N/P and P/Si ratios in the Changjiang Estuary. The sedimentation records also indicated that the riverine organic carbon increased since 1980. | JIN Haiyan CHEN Jianfang WENG Huanxin LI Hongliang ZHANG Weiyan XU Jie BAI Youcheng WANG Kui | 2010 | Acta Oceanologica Sinica2010，29，3： | 8 |
| 7 | Towards full-spectrum photocatalysis: Achieving a Z-scheme between Ag2S and TiO2 by engineering energy band alignment with interfacial Ag显示文摘Z 计划是一条有希望的途径完成用途广泛的光催化。有有 1.0 eV 的乐队差距的另一个半导体的 TiO 2 的集成将对紫外的收获和在可见附近理想为光催化的红外线的光;然而,大多数 narrow-bandgap 半导体让与组成一个障碍到为 photocatalytic 氢生产形成 Z 计划的 TiO 2, 跨骑乐队结构排列。在这通讯,我们表明 Ag 2 是的 S 在哪儿的一个模型系统精力乐队分享一个接口,一个金属罐头克服的 narrow-bandgap 半导体换高速档这限制。制作设计,我们开发了一条唯一的途径综合 Ag 2 SAgTiO 2 混血儿结构。戏剧性地展出的获得的第三的混合结构在完整光谱的轻照明下面在 photocatalytic 氢生产提高了性能。这些活动比 Ag 2 SAgTiO 2 结构在下面 < 400 nm 并且 > 他们在任何轻照明下面的对应物的象那些一样的 400 nm 照耀调节。 | Yanrui Li Leilei Li Yunqi Gong Song Bai Huanxin Ju Chengming Wang Qian Xu Junfa Zhu Jun Jiang Yujie Xiong | 2015 | Nano Research2015，8，11： | 5 |
| 8 | 3D hierarchical microspheres constructed by ultrathin MoS2-C nanosheets as high-performance anode material for sodium-ion batteries显示文摘MoS2/C composites are considered to have great application potential in sodium-ion batteries(SIBs).It is a challenging and meaningful subject that developing high-performance anode materials via combining MoS2 and carbon effectively to give free rein to their advantages in sodium ion storage.In this work,a novel MoS2-C material was designed by using cellulose nanocrystals(CNCs)as low-cost and green carbon source.3 D hierarchical microspheres(200-250 nm)constructed by ultrathin MoS2-C nanosheets were synthesized by synchronizing the pre-carbonization of CNCs with the formation of MoS2 in hydrothermal reaction and subsequent pyrolysis process.It is found that the ultrathin MoS2-C nanosheets were composed of CNCs-derived short-range ordered carbon and few-layered MoS2.Benefiting from the unique structure and robust combination of MoS2 and CNCs-derived carbon,the ultrathin MoS2-C nanosheets composite was proved to have excellent cycling stability and superior rate performance in sodium-ion half-cell test and have high first reversible specific capacity of 397.9 m Ah/g in full-cell test.This work provides a significant and effective pathway to prepare MoS2-C materials with excellent electrochemical performance for the application in large-scale energy storage systems. | Wenlong Zhang Haihui Zhou Zhongyuan Huang Songlin Li Chuqing Wang Huanxin Li Zhanheng Yan Teng Hou Yafei Kuang | 2020 | Journal of Energy Chemistry2020，29，10： | 3 |
| 9 | Remineralization of initial enamel caries in vitro using a novel peptide based on amelogenin显示文摘 | Danxue LI Xueping LV Huanxin TU Xuedong ZHOU Haiyang YU Linglin ZHANG | 2015 | Frontiers of Materials Science2015，9，3： | 3 |
| 10 | Iodine biofortification of vegetable plants-An innovative method for iodine supplementation显示文摘To elevate the iodine level in edible plants has been shown to be an excellent approach to correct iodine deficiency.We have proposed an innovative approach to produce iodine supplementation by growing vegetables on soils with algal-based iodized organic fertilizer.Ten species of vegetables were tested.The biological absorption and migration of the iodine within the vegetable plants were revealed using microscopy with silver iodide precipitation technique.The results show that the absorption of iodine by the vegetable increases with increasing amount of the algal-based iodized organic fertilizer in general.And the uptake of iodine by leaf vegetable is significantly greater than that by fruit vegetable.Distribution of iodine in various plant organs shows a trend of decreasing iodine concentration from root,leaf,stalk,to fruit.A similar of decreasing concentration can also be found in various cells(cytoplasm>cytoderm>organelles).The exploration of the iodine uptake and biogeochemistry migration mechanisms provides an important scientific foundation for establishing a new method of producing a natural iodine supplementation by iodine biofortification of vegetables. | WENG HuanXin HONG ChunLai XIA TianHong BAO LiTing LIU HuiPing LI DeWang | 2013 | Chinese Science Bulletin2013，58，18： | 3 |
| 11 | The Contribution of Opal-Associated Phosphorus to Bioavailable Phosphorus in Surface and Core Sediments in the East China Sea显示文摘To improve the burial flux calculations of bioavailable phosphorus(P) and study opal-associated P(Opal-P) in the East China Sea(ECS), surface and core sediments were collected in the Changjiang Estuary(CE) and the south of the Cheju Island. In this study, sedimentary P was operationally divided into seven different forms using modified sedimentary extraction(SEDEX) technique: LSor-P(exchangeable or loosely sorbed P), Fe-P(easily reducible or reactive ferric Fe-bound P), CFA-P(authigenic carbonate fluorapatite and biogenic apatite and CaCO_3-bound P), Detr-P(detrital apatite), Org-P(organic P), Opal-P and Ref-P(refractory P). The data revealed that the concentrations of the seven different P forms rank as Detr-P > CFA-P > Org-P > Ref-P > Opal-P > Fe-P > LSor-P in surface sediments and CFA-P > Detr-P > Org-P > Ref-P > Fe-P > Opal-P > LSor-P in core sediments. The distributions of the total phosphorus(TP), TIP, CFA-P, Detr-P are similar and decrease from the CE to the south of the Cheju Island. Meanwhile, Org-P and Opal-P exhibit different distribution trends; this may be affected by the grain size and TOM. The concentrations of potentially bioavailable P are 9.6-13.0 μmol g^(-1) and 10.0-13.6 μmol g^(-1), representing 61%-70% and 41%-64% of the TP in surface and core sediments, respectively. The concentrations of Opal-P are 0.6-2.3 μmol g^(-1) and 0.6-1.4 μmol g^(-1) in surface and core sediments, accounting for 5.3%-19.8% and 4.2%-10.6% of bioavailable P, respectively. The total burial fluxes of Opal-P and bioavailable P are 1.4×10~9 mol yr^(-1) and 1.1×10~10 mol yr^(-1) in the ECS, respectively. Opal-P represents about 12.7% of potentially bioavailable P, which should be recognized when studying P cycling in marine ecosystems. | LI Huanxin HE Huijun YANG Shifeng LIU Yanli CHE Hong LI Mujian ZHANG Jing | 2018 | Journal of Ocean University of China2018，17，3： | 2 |
| 12 | Limited ecological risk of insect-resistance transgene flow from cultivated rice to its wild ancestor based on life-cycle fitness assessment显示文摘Ecological impact caused by transgene flow from genetically engineered(GE) crops to their wild relatives is largely determined by the fitness effect brought by a transgene. To estimate such impact is critical for the ecological risk assessment prior to the commercialization of GE crops. We produced F1 and F2hybrid descendants from crosses of two insect-resistant GE rice lines(Bt, Bt/Cp TI)and their non-GE rice parent with a wild rice(Oryza rufipogon) population to estimate the transgenic fitness. Insect damages and life-cycle fitness of GE and non-GE crop–wild hybrid descendants as well as their wild parent were examined in a common-garden experiment. No significant differences in insect damages were observed between the wild rice parent and GE hybrid descendants under highinsect pressure. The wild parent showed significantly greater relative survival-regeneration ratios than its GE and non-GE hybrid descendants under both high- and low-insect pressure. However, more seeds were produced in GE hybrid descendants than their non-GE counterparts under high-insect pressure. Given that the introduction of Bt and Bt/Cp TI transgenes did not provide greater insect resistance to crop–wild hybrid descendants than their wild parent, we predict that transgene flow from GE insect-resistant rice to wild rice populations may not cause considerable ecological risks. | Lei Li Xiao Yang Lei Wang Huanxin Yan Jun Su Feng Wang Bao-Rong Lu | 2016 | Science Bulletin2016，61，18： | 1 |
| 13 | Effect of maturity and petroleum expulsion on pyrrolic nitrogen compound yields and distributions in Duvernay formation petroleum source rocks in central Alberta, Canada显示文摘 | Li Maowen Yao Huanxin Stasiuk L D | 1997 | Organic Geochemistry1997，26，： | 1 |
| 14 | Towards Practical Application of Li-S Battery with High Sulfur Loading and Lean Electrolyte:Will Carbon-Based Hosts Win This Race?显示文摘As the need for high-energy–density batteries continues to grow, lithium-sulfur(Li–S) batteries have become a highly promising next-generation energy solution due to their low cost and exceptional energy density compared to commercially available Li-ion batteries. Research into carbon-based sulfur hosts for Li–S batteries has been ongoing for over two decades, leading to a significant number of publications and patents.However, the commercialization of Li–S batteries has yet to be realized. This can be attributed, in part, to the instability of the Li metal anode. However, even when considering just the cathode side, there is still no consensus on whether carbon-based hosts will prove to be the best sulfur hosts for the industrialization of Li–S batteries. Recently, there has been controversy surrounding the use of carbon-based materials as the ideal sulfur hosts for practical applications of Li–S batteries under high sulfur loading and lean electrolyte conditions. To address this question, it is important to review the results of research into carbon-based hosts, assess their strengths and weaknesses, and provide a clear perspective. This review systematically evaluates the merits and mechanisms of various strategies for developing carbon-based host materials for high sulfur loading and lean electrolyte conditions. The review covers structural design and functional optimization strategies in detail, providing a comprehensive understanding of the development of sulfur hosts. The review also describes the use of efficient machine learning methods for investigating Li–S batteries. Finally, the outlook section lists and discusses current trends, challenges, and uncertainties surrounding carbon-based hosts, and concludes by presenting our standpoint and perspective on the subject. | Yi Gong Jing Li Kai Yang Shaoyin Li Ming Xu Guangpeng Zhang Yan Shi Qiong Cai Huanxin Li Yunlong Zhao | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 15 | Determinants of host susceptibility in aggressive periodontitis 显示文摘 | Meng Huanxin Xu Li Li Qiyan | 2007 | Periodontology 20002007，43，1： | 1 |
| 16 | Proton belt variations traced back to Fengyun-1C satellite observations显示文摘We used historical data to trace trapped protons observed by the Fengyun-1C(FY-1C)satellite at low Earth orbits(~800 km)and chose data at 5–10 MeV,10–40 MeV,40–100 MeV,and^100–300 MeV from 25 March to 18 April 2000 to analyze the proton variations.Only one isolated strong storm was associated with a solar proton event during this period,and there was no influence from previous proton variations.Complex dynamic phenomena of proton trapping and loss were affected by this disturbance differently depending on the energy and L location.The flux of 5–10 MeV protons increased and created new trapping with a maximum at L^2.0,and the peak flux was significantly higher than that at the center of the South Atlantic Anomaly.However,at higher L,the flux showed obvious loss,with retreat of the outer boundary from L^2.7 to L^2.5.The increase in the 10–40 MeV proton flux was similar to that of the 5–10 MeV flux;however,the peak flux intensity was lower than that at the center of the South Atlantic Anomaly.The loss of the 10–40 MeV proton flux was closer to the Earth side,and the outer boundary was reduced from L^2.3 to L^2.25.For the higher energy protons of 40–100 MeV and 100–300 MeV,no new trapping was found.Loss of the 40–100 MeV protons was observed,and the outer boundary shifted from L^2.0 to L^1.9.Loss was not obvious for the 100–400 MeV protons,which were distributed within L<1.8.New proton trapping was more likely to be created at lower energy in the region of solar proton injection by the strong magnetic storm,whereas loss occurred in a wide energy range and reduced the outer boundary on the Earth side.Similar dynamic changes were observed by the NOAA-15 satellite in the same period,but the FY-1C satellite observed more complex changes in lower energy protons.These results revealed that the dynamic behavior of protons with different L-shells was due to differences in the pitch angle.Possible mechanisms related to new trapping and loss are also discussed.These mechanisms are very important for understanding the behavior of the proton belt in the coming solar cycle. | ChunQin Wang Zheng Chang XiaoXin Zhang GuoHong Shen ShenYi Zhang YueQiang Sun JiaWei Li Tao Jing HuanXin Zhang Ying Sun BinQuan Zhang | 2020 | Earth and Planetary Physics2020，4，6： | 1 |
| 17 | Determinants of host susceptibility in aggressive periodontitis显示文摘 | Meng Huanxin Xu Li Li Qiyan | 2007 | Periodontol 20002007，43，1： | 1 |
| 18 | Supercritical fluid extraction for the separation of organochlorine pesticides residue in Angelica siuensis显示文摘 | ZHAO Chunjie HAO Guiming LI Huanxin | 2002 | Biomed Chromatogr2002，16，7： | 1 |
| 19 | Determinants of host susceptibility in aggressive periodontitis 显示文摘 | Meng Huanxin Xu Li Li Qiyan | 2007 | Periodontol 20002007，43，： | 1 |
| 20 | Surface etching induced ultrathin sandwich structure realizing enhanced photocatalytic activity显示文摘Photocatalytic conversion efficiency is limited by serious charge carrier recombination. Efficient carrier separation is usually achieved by elegantly-designed multi-component structures connected by directional electric field. Herein, we developed a twodimensional(2 D) sandwich structure, as a new photocatalytic system, to realize high-efficiency carrier separation. This strategy integrated multifunction into a single structure for the first time, which successfully introduces a stable built-in electric field,realizing high-effective carrier separation. Besides, the carrier concentration is dramatically increased due to dimensional confinement. Benefiting from above synergic advantages, 2 D sandwich photocatalyst achieves the highest nitrogen fixation rate(435 μmol g^(-1) h^(-1)) in inorganic solid photocatalysts under visible light irradiation. We anticipate that 2 D sandwich photocatalyst holds promises for the application and expansion of 2 D materials in photocatalysis research. | Bo Yang Wentuan Bi Yangyang Wan Xiaogang Li Mingcan Huang Ruilin Yuan Huanxin Ju Wangsheng Chu Xiaojun Wu Linghui He Changzheng Wu Yi Xie | 2018 | Science China Chemistry2018，61，12： | 1 |
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