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| 1 | Indosinian Orogenesis in the Lhasa Terrane, Tibet: New Muscovite ^(40)Ar-^(39)Ar Geochronology and Evolutionary Process显示文摘Muscovite 40 Ar-39 Ar dating of muscovite-quartz schist, eclogite and retrograde eclogite indicates an Indosinian orogenesis occurred at 220-240 Ma in the Lhasa terrane, which is caused by the closure of Paleo-Tethyan ocean basin and the following collision of the northern Lhasa terrane and southern Gondwana land. This Indosinian orogenesis is further confirmed by the regional sedimentary characteristics, magmatic activity and ophiolite mélange. This evidence suggests that the Indosinian orogenic belt in the Lhasa terrane is widely distributed from the Coqen county in the west, and then extends eastward through the Ningzhong and Sumdo area, finally turning around the eastern Himalayan syntaxis into the Bomi county. Based on the evolutionary process, the geological development of Lhasa terrane from early Paleozoic to early Mesozoic can be divided into seven stages. All of the seven stages make up a whole Wilson circle and reveal a perfect evolutionary process of the Paleo-Tethys ocean between the northern Lhasa terrane and southern Gondwana land. The Indosinian orogenisis is a significant event for the evolution of the Lhasa terrane as well as the Tibetan Plateau. | LI Huaqi XU Zhiqin YANG Jingsui TANG Zhemin | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 10 |
| 2 | Combination therapy for advanced hepatocellular carcinoma:do we see the light at the end of the tunnel?显示文摘Importance:Combination therapies of anti-PD-1 and anti-angiogenesis regimens are emerging rapidly and exhibit more promising anti-tumor efficacy for advanced hepatocellular carcinoma(HCC),and consistently it is the hotspot in clinical studies.Objective:To elaborate several issues which are warranted further consideration as more regimens are being investigated in combination therapies.Evidence Review:We searched PubMed,MEDLINE,Cochrane Library and Google Scholar by 2021 February for publications on combination therapies for HCC.Findings:Several clinical issues are worth reconsidering,such as the evaluation on appropriate primary endpoints in phase III clinical trials as for different practical problems,the translation of surrogate endpoint objective response rate(ORR)benefits into overall survival(OS)benefits,and whether conversion surgery contributes to initial expectations of long-term survival or not.New concepts in novel immunotherapy and targeted therapy in combination with loco-regional therapies may improve overall survival for HCC.Conclusions and Relevance for Reviews:Comprehensive understanding of the mechanism of immunotherapy and targeted therapy contributes to better prognosis of advanced HCC and more explorative combination therapies are needed. | Ti Zhang Philippe Merle Huaqi Wang Haitao Zhao Masatoshi Kudo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 7 |
| 3 | A new method for evaluating the drought tolerance of upland rice cultivars显示文摘Worldwide, approximately 27 million ha of rice are grown in upland rather than paddy fields, and is subject to drought stress. To counter this stress, it is desirable to breed new rice cultivars with improved drought tolerance. For breeding purposes, especially for breeding upland rice, it is desirable to develop a simple and accurate method to evaluate rice drought tolerance. We describe a new method that can be used to evaluate efficiently the drought tolerance degree(DTD) of upland rice cultivars, and call it the DTD method.DTD is defined as the mean of the ratios of green leaf length to total leaf length of the top three leaves in every rice seedling after drought treatment, and thus takes values from zero to one. To test whether the DTD method works effectively to evaluate drought tolerance of upland rice cultivars, we determined the DTD values of 13 upland rice cultivars showing varying degrees of drought tolerance in drought-tolerance trials. The idrl-1 mutant, which displayed the strongest drought tolerance of the 13 cultivars as identified by drought-tolerance trials under severe drought stress, had the highest DTD value and297-28, displaying the weakest drought tolerance, had the lowest DTD value. Further analyses of water potential, survival rate, panicles per plant, spikelets per panicle, seed setting rate, yield per plant, and contents of proline, chlorophyll, and malondialdehyde(MDA) indicated that DTD values are in general correlated with the values of these traits,making this new method useful for assessing the drought tolerance of upland rice cultivars.These results show that the DTD method is a simple, direct and relatively accurate evaluation method for drought-tolerance breeding of upland rice. | Xiaofeng Zu Yanke Lu Qianqian Wang Peifeng Chu Wei Miao Huaqi Wang Honggui La | 2017 | The Crop Journal2017，5，6： | 5 |
| 4 | Human Health Risk Assessment Model of Organic Pollution in Groundwater:Shijiazhuang Industrial Zone显示文摘在这研究,一个基于风险的管理模型被开发并且适用于一个工业地区。模特儿由美国环境保护机构和汉被在在半衰期煮并且删除相关参数以后增加不稳定的有机化合物(VOC ) 的剩余比率一直在改进求婚了。用这个改进模型,一个综合过程被用来在学习区域估计人的健康风险水平。与水质量分析相比,结果强调在风险层次和水保护上为决策使用一条综合途径的重要性。这研究的结果表明了那:(1 ) 与在中国(GB 38382002 ) 和美国的国家的主要喝酒水规定的这些可允许的水平标准相比,居民的日常生活没被地下水在这个区域影响了(除了 HB34 和 HB36 的相对的坏水质量) ;(2 ) 所有地下水样品的典型检测器官的沾染物是氯仿,碳四氯化物, trichloroethylene 和 tetrachloroethene,并且污染来源主要是由初步的调查的工业来源;(3 ) 至于地下水,所有样品的 non-carcinogenic 风险价值不超过 1.0 的可允许的水平, carcinogenic 风险价值比对 1.00E-04 的 1.00E-06 的可允许的水平相对低;(4 ) 喝 trichloroethylene 和 tetrachloroethylene 的水小径主要贡献在学习区域增加居民的健康风险;(5 ) 以 non-carcinogenic,风险和 carcinogenic 冒险,为喝水小径的健康风险顺序和真皮的接触小径:喝的水小径 > 真皮的接触小径。 | YANG Mei FEI Yuhong JU Yiwen LI Huaqi | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 4 |
| 5 | Geochemistry and Petrogenesis of Late Cretaceous–Paleocene Granites from the Tengchong Block, Western Yunnan: Implications for Angle-switching of Subducting Slab显示文摘The Cenozoic geological hallmark of Western Yunnan is the characteristic voluminous Late Cretaceous-Eocene granites;however, their geological background and petrogenesis have not been well constrained and elucidated. In this study, we present new zircon U-Pb dating, along with geochemical and Sr-Nd-Hf isotopic data for granites from the Tengchong–Lianghe granitoid belt(as abbreviated to Tengliang belt) and West Yingjiang batholiths from the Tengchong block. The mineralogical and geochemical features of the Tengliang granites and the West Yingjiang batholiths are ascribed to aluminous S-type granites and weak peraluminous I-type, respectively. Zircon U-Pb analyses yielded consistent ages ranging from 67.5 Ma, 68.4 Ma and 66.2 Ma from the Tengliang granitoid belt and 50.4 Ma to 60.8 Ma for three samples from the west Yingjiang batholiths. The Tengliang granites were emplaced during the Late Cretaceous(68-66 Ma) and demonstrate negative ε_(Hf)(t) values(-24 to-4) and initial ~(87)Sr/~(86)Sr ratios of 0.7101–0.7139 and significant negative ε_(Nd)(t) values from-8.91 to-13.2, indicating a Proterozoic sedimentary source or enriched components. The hornblende-bearing I-type granites from West Yingjiang are characterized by lower initial ~(87)Sr/~(86)Sr ratios of 0.7076–0.7106, compared to Tengliang granite and negative whole-rock ε_(Nd)(t) values from-4.0 to-11.9. The early Eocene west Yingjiang gneissic granites show wide ranges of ε_(Hf)(t) values from +7.4 to-8.5 and T_(2DM) of 1.30–0.65 Ga, indicating partial melting of ancient crust with contributions of depleted mantle materials. In combination with the regional background and previous studies, we propose that such a spatio-temporal distribution of the Tengchong granitoid belt might be related to the rollback or angleswitching of the Neo-Tethyan subducting slab. This study sheds new light on the evolutionary history of the Tengchong block. | CHEN Xijie MENG Yuanku CAI Zhihui LI Huaqi LIU Xiaojia | 2022 | Acta Geologica Sinica(English Edition)2022，96，5： | 3 |
| 6 | Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration显示文摘在果蝇成年 midgut 的肠的干细胞(ISC ) 为维持织物动态平衡是必要的,并且他们的增长和区别加快以便为填满遇见需求响应损害的失去的房间。包括 JAK-STAT, EGFR 和河马(Hpo ) 小径的几个发信号小径在导致损坏的 ISC 增长被含有,但是集成这些小径的机制留下了逃犯。这里,我们证明 oncoprotein Myc (dMyc ) 的果蝇相当或相同的事物这些下游地工作表明小径调停他们 ISC 增长上的效果。在先锋房间的 dMyc 表示响应织物损坏被刺激,并且 dMyc 为加速的 ISC 增长和 midgut 新生是必要的。我们证明葡聚糖硫酸盐钠喂引起的那织物损坏经由 Hpo 小径刺激 dMyc 表示,而喂的 bleomycin 通过 JAK-STAT 和 EGFR 小径激活 dMyc。我们提供 dMyc 表示是的证据 transcriptionally 由多重发信号的小径的 upregulated,它响应织物为最佳的 ISC 增长被要求损坏。我们也获得了证据那织物损坏罐头 upregulate dMyc 表情 post-transcriptionally。最后,我们证明 dMyc 表示的基础水平在正常织物动态平衡期间为 ISC 维护,增长和系区别被要求。 | Fangfang Ren Qing Shi Yongbin Chen Alice Jiang Y Tony Ip Huaqi Jiang Jin Jiang | 2013 | Cell Research2013，23，9： | 2 |
| 7 | Involvement of calcium-sensing receptor in inhibition of lipolysis through intracel- lular cAMP and calcium pathways in human adipocytes 显示文摘 | He Yonghan Zhang Huaqi Teng Jianghua | 2011 | Biochem Biophys Res Commun2011，404，1： | 1 |
| 8 | Performance of temperate aerobic rice under different water regimes in North China 显示文摘 | Yang Xiaoguang Bouman B A M Wang Huaqi | 2005 | Agric Water Manag2005，74，： | 1 |
| 9 | Performance of aerobic rice varieties under irrigated conditions in North China 显示文摘 | Bouman B A M Yang Xiaoguang Wang Huaqi | 2006 | Field Crops Res2006，97，： | 1 |
| 10 | Acute Thoracic Aortic Dissection (Stanford Type B) Complicated with Acute Renal Failure显示文摘 | Li Li ShunJiu Zhuang ShaoHong Qi JiaSheng Cui JunWen Zhou Huaqi Zhu Wan Zhang Ming Li Weiguo Fu M. Matson S. Yamashiro | 2013 | Case Reports in Vascular Medicine2013，，： | 1 |
| 11 | Performance of aerobic rice varieties under irrigated conditions in North China显示文摘 | B.A.M. Bouman Xiaoguang Yang Huaqi Wang Zhimin Wang Junfang Zhao Bin Chen | 2005 | Field Crops Research2005，，1： | 1 |
| 12 | Evaluation indexes for completed oil and gas exploration projects and quantified evaluation显示文摘 | Huang Xunan Li Huaqi Wang Xizhu | 2010 | International Petroleum Economics2010，18，1： | 1 |
| 13 | Performance of temperate aerobic rice different water regimes in North China 显示文摘 | Yang Xiaoguang Bouman B A M Wang Huaqi | 2005 | Agric Water Manag2005，74，： | 1 |
| 14 | Performance of aerobic rice varieties under irrigated conditions in North China显示文摘 | Bouman B A M Yang Xiaoguang Wang Huaqi | 2006 | Field Crops Res2006，97，： | 1 |
| 15 | Performance of temperate aerobic rice different water regimes in North China显示文摘 | Yang Xiaoguang Bouman B A M Wang Huaqi | 2005 | Journal of Agricultural water management2005，74，： | 1 |
| 16 | Performance of aerobic rice varieties under irrigated conditions in North China显示文摘 | Bouman B A M Yang Xiaoguang Wang Huaqi | 2006 | Journal of Field Crops Research2006，97，： | 1 |
| 17 | Performance of temperate aerobic rice different water regimes in North China 显示文摘 | Yang Xiaoguang Bouman B A M Wang Huaqi | 2005 | Journal of Agricultural Water Management2005，74，2： | 1 |
| 18 | Performance of aerobic rice varieties under irrigated conditions in North China显示文摘 | Bouman B A M Yang Xiaoguang Wang Huaqi | 2006 | Field Crops Research2006，97，： | 1 |
| 19 | Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1αpathway显示文摘Background Mitochondrial dysfunction induced by excessive mitochondrial reactive oxygen species(ROS)damages embryonic development and leads to growth arrest.Objective The purpose of this study is to elucidate whether maternal zinc(Zn)exert protective effect on oxidative stress targeting mitochondrial function using an avian model.Result In ovo injected tert-butyl hydroperoxide(BHP)increases(P<0.05)hepatic mitochondrial ROS,malondialdehyde(MDA)and 8-hydroxy-2-deoxyguanosine(8-OHdG),and decreases(P<0.05)mitochondrial membrane potential(MMP),mitochondrial DNA(mtDNA)copy number and adenosine triphosphate(ATP)content,contributing to mitochondrial dysfunction.In vivo and in vitro studies revealed that Zn addition enhances(P<0.05)ATP synthesis and metallothionein 4(MT4)content and expression as well as alleviates(P<0.05)the BHP-induced mitochondrial ROS generation,oxidative damage and dysfunction,exerting a protective effect on mitochondrial function by enhancing antioxidant capacity and upregulating the mRNA and protein expressions of Nrf2 and PGC-1α.Conclusions The present study provides a new way to protect offspring against oxidative damage by maternal Zn supplementation through the process of targeting mitochondria involving the activation of Nrf2/PGC-1αsignaling. | Liang Huang Wei Gao Xuri He Tong Yuan Huaqi Zhang Xiufen Zhang Wenxuan Zheng Qilin Wu Ju Liu Wence Wang Lin Yang Yongwen Zhu | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 0 |
| 20 | New Start-up Method for a Closed-Cycle Compression System with Gas Bearings and Its Characteristics显示文摘Gas bearings,which have the advantages of low frictional resistance and power loss,high rotational speed and high temperature operation,and long life,are more suitable than are traditional liquid lubricated bearings because of their high precision,high rotational speed,and special condition support.However,the problem of starting a closed-cycle compression system with gas bearings still needs to be solved for practical application.Thus,a new start-up method for a closed-cycle compression system with aerostatic gas bearings is proposed in this paper.Further,this paper presents a numerical simulation and experimental investigation of the method’s feasibility and characteristics during the start-up process when the gas tank’s initial pressure is fixed.The results show that the gas tank volume is approximately directly proportional to the start-up time allowable,and a gas tank volume sufficiently small,which not only ensures the feasibility of start-up,but also affects other components only slightly,can be obtained.A perfect combination of radial and axial loads also can be achieved to make the start-up time allowable as long as possible.R134a is a better choice for the working medium than is air,as the start-up time allowable is longer,which leads to a smaller gas tank.This research proposes a new start-up method for a closed-cycle compression system with aerostatic gas bearings which has sufficient load capacity to support system during the start-up method. | Huaqi Lian Hong Wu Yulong Li Chengjun Rong | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 0 |
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