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| 1 | Effect of Banxiaxiexin Tang on treatment of functional dyspepsia: a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To evaluate the efficacy of Banxiaxiexin Tang compared with Western Medicine in the treatment of functional dyspepsia(FD) through Meta-analysis.METHODS: Literature was searched in the following databases: MEDLINE, Excerpta Medica Database, Chinese Medical Current Contents, China Science and Technology Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. Randomized controlled trials evaluating the efficacy of Banxiaxiexin Tang for the treatment of FD were selected according to certain standards including clear general situation of patients, specific diagnostic criteria, definite clinical outcomes, etc. Articles were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analysis was conducted with RevMan 5.0.23 software.RESULTS: Ten articles with a total of 972 patients were included. The comparison of efficacy between Banxiaxiexin Tang and Western Medicine showed a combined effect size [OR=2.75, 95% CI(1.86-4.07)]andcombinedeffectofvalueofZ=5.07(P<0.000 01),suggesting a significant difference between the groups.CONCLUSION: Banxiaxiexin Tang was more effective thanWestern Medicine in treating FD. | Yongkang Gan Huayi Liu Liu Yang Kuo Yang | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 7 |
| 2 | A comprehensive update:gastrointestinal microflora,gastric cancer and gastric premalignant condition,and intervention by traditional Chinese medicine显示文摘With the recent upsurge of studies in the field of microbiology,we have learned more about the complexity of the gastrointestinal microecosystem.More than 30 genera and 1000 species of gastrointestinal microflora have been found.The structure of the normal microflora is relatively stable,and is in an interdependent and restricted dynamic equilibrium with the body.In recent years,studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer(GC)and precancerous lesions.So,restoring the balance of gastrointestinal microflora is of great significance.Moreover,intervention in gastric premalignant condition(GPC),also known as precancerous lesion of gastric cancer(PLGC),has been the focus of current clinical studies.The holistic view of traditional Chinese medicine(TCM)is consistent with the microecology concept,and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract,restoring the homeostasis of gastrointestinal microflora to prevent canceration.However,large gaps in knowledge remain to be addressed.This review aims to provide new ideas and a reference for clinical practice. | Yuting LU Huayi LIU Kuo YANG Yijia MAO Lingkai MENG Liu YANG Guangze OUYANG Wenjie LIU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 6 |
| 3 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 4 | Deep-blue organic light-emitting diodes based on a doublet d-f transition cerium(Ⅲ) complex with 100% exciton utilization efficiency显示文摘Compared to red and green organic light-emitting diodes(OLEDs),blue OLEDs are still the bottleneck due to the lack of efficient emitters with simultaneous high exciton utilization efficiency(EUE)and short excited-state lifetime.Different from the fluorescence,phosphorescence,thermally activated delayed fluorescence(TADF),and organic radical materials traditionally used in OLEDs,we demonstrate herein a new type of emitter,cerium(Ⅲ)complex Ce-1 with spin-allowed and parity-allowed d-f transition of the centre Ce^(3+) ion.The compound exhibits a high EUE up to 100% in OLEDs and a short excited-state lifetime of 42 ns,which is considerably faster than that achieved in efficient phosphorescence and TADF emitters.The optimized OLEDs show an average maximum external quantum efficiency(EQE)of 12.4% and Commission Internationale de L’Eclairage(CIE)coordinates of(0.146,0.078). | Liding Wang Zifeng Zhao Ge Zhan Huayi Fang Hannan Yang Tianyu Huang Yuewei Zhang Nan Jiang Lian Duan Zhiwei Liu Zuqiang Bian Zhenghong Lu Chunhui Huang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Blossom of CRISPR technologies and applications in disease treatment显示文摘Since 2013,the CRISPR-based bacterial antiviral defense systems have revolutionized the genome editing field.In addition to genome editing,CRISPR has been developed as a variety of tools for gene expression regulations,live cell chromatin imaging,base editing,epigenome editing,and nucleic acid detection.Moreover,in the context of further boosting the usability and feasibility of CRISPR systems,novel CRISPR systems and engineered CRISPR protein mutants have been explored and studied actively.With the flourish of CRISPR technologies,they have been applied in disease treatment recently,as in gene therapy,cell therapy,immunotherapy,and antimicrobial therapy.Here we present the developments of CRISPR technologies and describe the applications of these CRISPR-based technologies in disease treatment. | Huayi Liu Lian Wang Yunzi Luo | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 2 |
| 6 | Design and Implementation of Verification Code Identification Based on Anisotropic Heat Kernel显示文摘Many websites use verification codes to prevent users from using the machine automatically to register,login,malicious vote or irrigate but it brought great burden to the enterprises involved in internet marketing as entering the verification code manually.Improving the verification code security system needs the identification method as the corresponding testing system.We propose an anisotropic heat kernel equation group which can generate a heat source scale space during the kernel evolution based on infinite heat source axiom,design a multi-step anisotropic verification code identification algorithm which includes core procedure of building anisotropic heat kernel,settingwave energy information parameters,combing outverification codccharacters and corresponding peripheral procedure of gray scaling,binarizing,denoising,normalizing,segmenting and identifying,give out the detail criterion and parameter set.Actual test show the anisotropic heat kernel identification algorithm can be used on many kinds of verification code including text characters,mathematical,Chinese,voice,3D,programming,video,advertising,it has a higher rate of 25%and 50%than neural network and context matching algorithm separately for Yahoo site,49%and 60%for Captcha site,20%and 52%for Baidu site,60%and 65%for 3DTakers site,40%,and 51%.for MDP site. | LIU Lizhao LIU Jian DAI Yaomei XU Huarong YIN Huayi ZHU Shunzhi | 2016 | China Communications2016，13，1： | 2 |
| 7 | Prototype of multi-filament electron curtain accelerator显示文摘 | LI Guohua TANG Huaping LIU Jinsheng ZHANG Huayi LIU Yaohong ZHANG Dongsheng HE Yu LI Jian GUAN Weiqiang | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 8 | A stable oxygen evolution splitting electrocatalysts high entropy alloy FeCoNiMnMo in simulated seawater显示文摘Stabilizing anode for oxygen evolution(OER)in chlorine-containing electrolytes is a significant challenge.Adding corrosion inhibitors in electrolytes can alleviate this problem,but the type and dosage of cor-rosion inhibitors need a lot of exploration,and side reactions may occur to reduce current efficiency.Herein,we prepared a FeCoNiMnMo High entropy alloy(HEA)electrode for OER in simulated seawa-ter without corrosion inhibitors.It exhibits great electrocatalytic activity(overpotential(η)=237 mV at 10 mA cm^(-2))and excellent stability(200 h at 100 mA cm^(-2)).Experiments and Density Functional The-ory(DFT)calculation show that the protective layer containing K_(2)MoO_(4)is the crucial factor for chlorine resistance of FeCoNiMnMo electrode.The tightly adsorbed state of Cl-and K_(2)MoO_(4)ensures that other oxides are not corroded.And the externally added K_(2)MoO_(4)cannot protect the electrode.In addition,the high-entropy effect of HEA reduces the dissolution of the alloy.This work provides an efficient way to prepare a noble-free HEA catalyst that can stabilize oxygen evolution in corrosive electrolytes. | Peng Li Yuanpeng Yao Wengen Ouyang Ze Liu Huayi Yin Dihua Wang | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 9 | RECOVERY A POSTERIORI ERROR ESTIMATES FOR GENERAL CONVEX ELLIPTIC OPTIMAL CONTROL PROBLEMS SUBJECT TO POINTWISE CONTROL CONSTRAINTS显示文摘一个 posteriori 错误为一般凸的最佳的控制问题有限元素近似估计的 Superconvergence 和恢复在这份报纸被调查。我们获得有限元素答案的 superconvergence 性质,并且由使用 superconvergence 结果,我们得到一个 posteriori 错误估计在一些整齐条件下面是 asymptotically 准确的恢复。一些数字例子被提供验证理论结果。[从作者抽象] | Yanping Chen Yao Fu Huanwen Liu Yongquan Dai Huayi Wei | 2009 | Journal of Computational Mathematics2009，27，4： | 2 |
| 10 | Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase显示文摘 | Liming Sun Huayi Wang Zhigao Wang Sudan He She Chen Daohong Liao Lai Wang Jiacong Yan Weilong Liu Xiaoguang Lei Xiaodong Wang | 2012 | Cell2012，，1： | 2 |
| 11 | Therapeutic potential of traditional Chinese medicine for vascular endothelial growth factor显示文摘Vascular endothelial growth factor(VEGF)is the main regulator of physiological angiogenesis during embryonic development,bone growth,and reproductive function,and it also participates in a series of pathological changes.Traditional Chinese medicine(TCM),with a history of more than 2000 years,has been widely used in clinical practice,while the exploration of its mechanisms has only begun.This review summarizes the research of recent years on the influence of TCM on VEGF.It is found that many Chinese medicines and recipes have a regulatory effect on VEGF,indicating that Chinese medicine has broad prospects as a complementary and alternative therapy,providing new treatment ideas for clinical applications and the theoretical basis for research on the mechanisms of TCM. | Yijia MAO Lingkai MENG Huayi LIU Yuting LU Kuo YANG Guangze OUYANG Yanran BAN Shuang CHEN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，5： | 1 |
| 12 | Effect of electron irradiation on nitrofurans and their metabolites 显示文摘 | Zhitao Liu Huayi Zhanga Yaohong Liu | 2007 | Radiation Physics and Chemistry2007，76，： | 1 |
| 13 | Degradation of 3-amino-2-oxazolidinone (AOZ) in aqueous solutions by electron beam irradiation 显示文摘 | Liu Zhitao Song Lihui Yang Chengdui Zhang Huayi | 2006 | Nuclear Instruments and Methods in Physics Research B2006，243，： | 1 |
| 14 | Immersed finite element method and its applications to biological systems显示文摘 | Wing Kam Liu Yaling Liu David Farrell Lucy Zhang X. Sheldon Wang Yoshio Fukui Neelesh Patankar Yongjie Zhang Chandrajit Bajaj Junghoon Lee Juhee Hong Xinyu Chen Huayi Hsu | 2005 | Computer Methods in Applied Mechanics and Engineering2005，，13： | 1 |
| 15 | Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase显示文摘 | Liming Sun Huayi Wang Zhigao Wang Sudan He She Chen Daohong Liao Lai Wang Jiacong Yan Weilong Liu Xiaoguang Lei Xiaodong Wang | 2012 | Cell2012，，1： | 1 |
| 16 | Multi-Embed Nonlinear Scale-Space for Image Trust Root Generation显示文摘An image trust root is a special type of soft trust root for trusted computing. However,image trust root generation is difficult,as it needs a corresponding stable logic feature generation model and algorithm for dynamical and sustained authentication. This paper proposes a basic function of constructing new scale-spaces with deep detecting ability and high stability for image features aimed at image root generation. According to the heat distribution and spreading principle of various kinds of infinitesimal heat sources in the space medium,a multi-embed nonlinear diffusion equation that corresponds to the multi-embed nonlinear scale-space is proposed,a HARRIS-HESSIAN scale-space evaluation operator that aims at the structure acceleration characteristics of a local region and can make use of image pixels' relative spreading movement principle was constructed,then a single-parameter global symmetric proportion(SPGSP) operator was also constructed. An authentication test with 3000 to 5000 cloud entities shows the new scale-space can work well and is stable,when the whole cloud has 5%-50% behavior with un-trusted entities. Consequently,it can be used as the corresponding stable logic feature generation model and algorithm for all kinds of images,and logic relationships among image features for trust roots. | Lizhao Liu Wentu Gao Jian Liu Huayi Yin Huarong Xu Shunzhi Zhu | 2016 | China Communications2016，13，11： | 1 |
| 17 | Effect of electron ilTadiation on nitrofurans and their metabolites 显示文摘 | Liu Zhitao Zhang Huayi Liu S aohong | 2007 | Radiat Phys Chem2007，76，： | 1 |
| 18 | ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth显示文摘 | Hart Lori S Cunningham John T Datta Tatini Dey Souvik Tameire Feven Lehman Stacey L Qiu Bo Zhang Haiyan Cerniglia George Bi Meixia Li Yan Gao Yan Liu Huayi Li Changhong Maity Amit Thomas-Tikhonenko Andrei Peri Alexander E Koong Albert Fu | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 19 | Text GCN-SW-KNN:a novel collaborative training multi-label classification method for WMS application themes by considering geographic semantics显示文摘Without explicit description of map application themes,it is difficult for users to discover desired map resources from massive online Web Map Services(WMS).However,metadata-based map application theme extraction is a challenging multi-label text classification task due to limited training samples,mixed vocabularies,variable length and content arbitrariness of text fields.In this paper,we propose a novel multi-label text classification method,Text GCN-SW-KNN,based on geographic semantics and collaborative training to improve classifica-tion accuracy.The semi-supervised collaborative training adopts two base models,i.e.a modified Text Graph Convolutional Network(Text GCN)by utilizing Semantic Web,named Text GCN-SW,and widely-used Multi-Label K-Nearest Neighbor(ML-KNN).Text GCN-SW is improved from Text GCN by adjusting the adjacency matrix of the heterogeneous word document graph with the shortest semantic distances between themes and words in metadata text.The distances are calculated with the Semantic Web of Earth and Environmental Terminology(SWEET)and WordNet dictionaries.Experiments on both the WMS and layer metadata show that the proposed methods can achieve higher F1-score and accuracy than state-of-the-art baselines,and demonstrate better stability in repeating experiments and robustness to less training data.Text GCN-SW-KNN can be extended to other multi-label text classification scenario for better supporting metadata enhancement and geospatial resource discovery in Earth Science domain. | Zhengyang Wei Zhipeng Gui Min Zhang Zelong Yang Yuao Mei Huayi Wu Hongbo Liu Jing Yu | 2021 | Big Earth Data2021，5，1： | 1 |
| 20 | Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development显示文摘Dear Editor,Necroptosis,a form of caspase-independent cell death,is tightly regulated to maintain tissue homeostasis.The execution of necroptosis depends on receptor interacting protein kinase 3(RIP3)-activated mixed lineage kinase domain-like protein(MLKL).MLKL is phosphorylated by RIP3,which releases MLKL autoinhibi-tion and drives its self-oligomerization.1-3 Oligomerized MLKL translocates to cellular membranes,where it disrupts membrane integrity causing necroptotic cell death. | Xinxin Zhu Na Yang Yu Yang Feiyang Yuan Dandan Yu Yu Zhang Zhaoqian Shu Ning Nan Hong Hu Xiaoyan Liu She Chen Liming Sun Huayi Wang | 2022 | Cell Research2022，32，4： | 1 |
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