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| 1 | Resistance to rice blast (Pyricularia oryzae) caused by the expression of trichosanthin gene in transgenic rice plants transferred through agrobacterium method显示文摘The gene of trichosanthin has been transferred into rice plants through agrobacterium method. The single copy insertion and the expression of foreign gene have been proved in regenerated plants. In antifungal assay the degrees of rice blast (Pyricularia oryzae) infection of the transgenic plants expressing trichosanthin and expressing GUS gene as control have been evaluated. The differences such as the time of disease symptom observed, the number of infected plants and damaged leaves, the growth of infected plants of the two transgenic plants after being inoculated by rice blast (Pyricularia oryzae) are significant. The transgenic plants with trichosanthin gene grew faster than the plants with GUS gene, even when humidity environment was removed. The results show that the transgenic plants that expressed trichosanthin are able to delay the infection of rice blast compared with the plants as control. In addition, no damage caused by the expression of trichosanthin gene in transgenic plants has been | Xiaotian Ming Lijiang Wang Chengcai An Huayi Yuan Zhangliang Chen | 2000 | Chinese Science Bulletin2000，45，19： | 12 |
| 2 | MLKL forms cation channels显示文摘 | Bingqing Xia Sui Fang Xueqin Chen Hong Hu Peiyuan Chen Huayi Wang Zhaobing Gao | 2016 | Cell Research2016，26，5： | 10 |
| 3 | Size and Characteristic of Housing Bubbles in China's Major cities:1999-2010显示文摘在关于定义和在中国的住房水泡的测量的出版文学有某争论。扩大黑等的分析框架。(2006 ) ,现在的论文从 1999 的第二季度测量中国的 35 个主要城市的住房水泡到 2010 的第二季度。结果显示中国的 35 个主要城市里的住房水泡在样品间隔是相对小的,但是自从 2005,在东方宗主国的水泡例如北京,上海,深圳, Hangzhou 和 Ningbo,相对大。大多数城市里的住房水泡的变化趋势高度在房地产政策与变化相应。这篇论文分解 35 个城市的住房水泡,并且发现荒谬的水泡而非价格推测产生的合理内在的水泡的一个大比例。基于实验分析,这份报纸为阻止住房水泡的产生和扩大建议政策建议。 | Huayi Yu | 2011 | China & World Economy2011，19，6： | 7 |
| 4 | Effect of Banxiaxiexin Tang on treatment of functional dyspepsia: a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To evaluate the efficacy of Banxiaxiexin Tang compared with Western Medicine in the treatment of functional dyspepsia(FD) through Meta-analysis.METHODS: Literature was searched in the following databases: MEDLINE, Excerpta Medica Database, Chinese Medical Current Contents, China Science and Technology Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. Randomized controlled trials evaluating the efficacy of Banxiaxiexin Tang for the treatment of FD were selected according to certain standards including clear general situation of patients, specific diagnostic criteria, definite clinical outcomes, etc. Articles were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analysis was conducted with RevMan 5.0.23 software.RESULTS: Ten articles with a total of 972 patients were included. The comparison of efficacy between Banxiaxiexin Tang and Western Medicine showed a combined effect size [OR=2.75, 95% CI(1.86-4.07)]andcombinedeffectofvalueofZ=5.07(P<0.000 01),suggesting a significant difference between the groups.CONCLUSION: Banxiaxiexin Tang was more effective thanWestern Medicine in treating FD. | Yongkang Gan Huayi Liu Liu Yang Kuo Yang | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 7 |
| 5 | A comprehensive update:gastrointestinal microflora,gastric cancer and gastric premalignant condition,and intervention by traditional Chinese medicine显示文摘With the recent upsurge of studies in the field of microbiology,we have learned more about the complexity of the gastrointestinal microecosystem.More than 30 genera and 1000 species of gastrointestinal microflora have been found.The structure of the normal microflora is relatively stable,and is in an interdependent and restricted dynamic equilibrium with the body.In recent years,studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer(GC)and precancerous lesions.So,restoring the balance of gastrointestinal microflora is of great significance.Moreover,intervention in gastric premalignant condition(GPC),also known as precancerous lesion of gastric cancer(PLGC),has been the focus of current clinical studies.The holistic view of traditional Chinese medicine(TCM)is consistent with the microecology concept,and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract,restoring the homeostasis of gastrointestinal microflora to prevent canceration.However,large gaps in knowledge remain to be addressed.This review aims to provide new ideas and a reference for clinical practice. | Yuting LU Huayi LIU Kuo YANG Yijia MAO Lingkai MENG Liu YANG Guangze OUYANG Wenjie LIU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 6 |
| 6 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 7 | Study on Quantitative Relationship between Surface Wettability and Frictional Coefficient of Liquid Flowing in a Turbulent Horizontal Pipe显示文摘This paper had investigated the effects of surface wettability on the frictional resistance of turbulent horizontal flow for tap water in five pipes made of various materials and four kinds of liquids in a polytetrafluoroethylene(PTFE) pipe,with the same inner diameter of 14 mm. Pressure drops were measured under different flow rates through an experimental flow loop. The contact angles and adhesion work of liquids in contact with pipe surfaces were determined using a contact angle meter. Based on the dimension and regression analyses, two kinds of modified relationships between the frictional coefficient and the surface wettability were established according to the measured results corresponding to tap water in five pipes and four liquids in PTFE pipe. The experimental results show that the surface wettability has some influence on frictional coefficient of the studied liquids flowing in macroscale pipes, and the frictional coefficient decreases with the increase of the contact angle at the same Reynolds number. Meanwhile the effect of wettability on the hydrophobic surface is greater than that on the hydrophilic one. The frictional coefficients predicted by the modified formulas have verified to be in good agreement with the experimental values, the relative errors of which are within ±6% and ±3% for the tap water flowing in five different pipes and four kinds of liquids flowing in PTFE pipe, respectively. | Jing Jiaqiang Qi Hongyuan Jiang Huayi Liang Aiguo Shi Jianying Wang Yulong Sun Nana Zhang Yixiang | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，3： | 4 |
| 8 | Regulating electrolytic Fe_(0.5)CoNiCuZn_(x) high entropy alloy electrodes for oxygen evolution reactions in alkaline solution显示文摘The properties of high entropy alloys(HEAs)depend on their phase structures and compositions.However,it is difficult to control the composition of the HEAs that contain highly volatile metals by the conventional arc melting method.In this paper,homogeneous powdery face centered cubic(FCC)phase Fe_(0.5)CoNiCuZn_(x) HEAs were prepared by the electrolysis of metal oxides in molten Na_(2)CO_(3)-K_(2)CO_(3) using a stable Ni11Fe10Cu inert oxygen-evolution anode.The use of oxide precursors and relatively low synthetic temperature are beneficial to efficiently preparing HEAs that contain highly volatile elements such as Zn.Moreover,the microstructures and compositions of the electrolytic HEAs can be easily tailored by adjusting the components of oxide precursors,then further regulating its properties.Thus,the electrocatalytic activity of Fe_(0.5)Co NiCuZn_(x) HEAs towards oxygen evolution reactions(OER)was investigated in 1 M KOH.The results show that Zn promotes the OER activity of Fe_(0.5)CoNiCuZn_(x) HEAs,i.e.,the HEA(Zn_(0.8))shows the best OER activity exhibiting a low overpotential of 340 m V at 10 m A/cm^(2) and excellent stability of 24 h.Hence,molten salt electrolysis not only provides a green approach to prepare Fe_(0.5)CoNiCuZn_(x) HEAs but also offers an effective way to regulate the structure of the alloys and thereby optimizes the electrocatalytic activities for water electrolysis. | Jian Huang Peilin Wang Peng Li Huayi Yin Dihua Wang | 2021 | Journal of Materials Science & Technology2021，，34： | 4 |
| 9 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 10 | Deep-blue organic light-emitting diodes based on a doublet d-f transition cerium(Ⅲ) complex with 100% exciton utilization efficiency显示文摘Compared to red and green organic light-emitting diodes(OLEDs),blue OLEDs are still the bottleneck due to the lack of efficient emitters with simultaneous high exciton utilization efficiency(EUE)and short excited-state lifetime.Different from the fluorescence,phosphorescence,thermally activated delayed fluorescence(TADF),and organic radical materials traditionally used in OLEDs,we demonstrate herein a new type of emitter,cerium(Ⅲ)complex Ce-1 with spin-allowed and parity-allowed d-f transition of the centre Ce^(3+) ion.The compound exhibits a high EUE up to 100% in OLEDs and a short excited-state lifetime of 42 ns,which is considerably faster than that achieved in efficient phosphorescence and TADF emitters.The optimized OLEDs show an average maximum external quantum efficiency(EQE)of 12.4% and Commission Internationale de L’Eclairage(CIE)coordinates of(0.146,0.078). | Liding Wang Zifeng Zhao Ge Zhan Huayi Fang Hannan Yang Tianyu Huang Yuewei Zhang Nan Jiang Lian Duan Zhiwei Liu Zuqiang Bian Zhenghong Lu Chunhui Huang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 11 | A polypropylene melt-blown strategy for the facile and efficient membrane separation of oil-water mixtures显示文摘Porous materials with selective wettability and permeability have significant importance in oil-water separation,but complex fabrication processes are typically required to obtain the desired structures with suitable surface chemistry.In this work,an industrial melt-blown strategy that utilized commercially available polypropylene(PP)was used for the large-scale fabrication of superhydrophobic/superoleophilic membranes with staggered fabric structures.These membranes could readily separate different oils including pump oil and crude oil from various aqueous solutions such as strongly acidic,alkaline,and saline media.In addition,the separation efficiencies of these membranes exceeded 99%,and they could remain functional even after exposure to corrosive media.We anticipate that this work will further the design of membranes and enhance their applicability in oil-water separation,and provide researchers and engineers with a more effective tool for performing challenging separations and mitigating pollution. | Zhenqiang Zhang Danfeng Yu Xiubin Xu Huayi Li Taoyan Mao Cheng Zheng Jianjia Huang Hui Yang Zihan Niu Xu Wu | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 3 |
| 12 | Geometric optimization model for the solar cavity receiver with helical pipe at different solar radiation显示文摘In consideration of geometric parameters, several researches have already optimized the thermal efficiency of the cylindrical cavity receiver. However, most of the optimal results have been achieved at a fixed solar radiation. At different direct normal irradiance (DNI), any single optimal result may not be suitable enough for different regions over the world. This study constructed a 3-D numerical model of cylindrical cavity receiver with DNI variation. In the model of a cylindrical cavity receiver containing a helical pipe, the heat losses of the cavity and heat transfer of working medium were also taken into account. The simulation results show that for a particular DNI in the range of 400 W/m2 to 800 W/m2, there exists a best design for achieving a highest thermal efficiency of the cavity receiver. Besides, for a receiver in constant geometric parameters, the total heat losses increases dramatically with the DNI increasing in that range, as well as the temperature of the working medium. The thermal efficiency presented a different variation tendency with the heat losses, which is 2.45% as a minimum decline. In summary, this paper proposed an optimization method in the form of a bunch of fitting curves which could be applied to receiver design in different DNI regions, with comparatively appropriate thermal performances. | Chongzhe ZOU Huayi FENG Yanping ZHANG Quentin FALCOZ Cheng ZHANG Wei GAO | 2019 | Frontiers in Energy2019，13，2： | 3 |
| 13 | The Subnational Penn Effect: Evidence from China显示文摘在我们估计的这份报纸,相对消费者价格为 36 个主要中国城市 2008 铺平,用故意地设计修正存在文学的三个主要缺点的一个创新方法,它是( 1 ) marketized 的在表示下面在样品数据满足,( 2 )偏导消费重量,并且( 3 )在样品分类和消费重量之间的失配。我们的评价结果显示出由唐( 2012 )定义的 subnational 佩恩效果,即,在人口尺寸,相对价格水平,人均的名字、真实的收入,和人的资本之中的强壮的城市间的关联储备,从而证明城市间的价格分散的理论模特儿由唐( 2012 )求婚了在中国是适用的。我们的结论,方法论,和评价结果为包括的中国经济的各种各样的方面有重要含意地区性,城市并且房地产经济。 | Huayi Yu Xiang Tang Rui Wu | 2012 | Frontiers of Economics in China-Selected Publications from Chinese Universities2012，7，4： | 3 |
| 14 | Microfluidic-enabled ambient-temperature synthesis of ultrasmall bimetallic nanoparticles显示文摘The production of bimetallic nanoparticles with ultrasmall sizes is the constant pursuit in chemistry and materials science because of their promising applications in catalysis,electronics and sensing.Here we report ambient-temperature preparation of bimetallic NPs with tunable size and composition using microfluidic-controlled co-reduction of two metal precursors on silicon surface.Instead of free diffusion of metal ions in bulk system,microfluidic flow could well control the local ions concentration,thus leading to homogenous and controllable reduction rate among different nucleation sites.By controlling precursor concentration,flow rate and reaction time,we rationally design a series of bimetallic NPs including Ag-Cu,Ag-Pd,Cu-Pt,Cu-Pd and Pt-Pd NPs with ultrasmall sizes(~3.0 nm),tight size distributions(relative standard deviation(RSD)<21%),clean surface,and homogenous elemental compositions among particles(standard deviation(SD)of weight ratios<3.5%).This approach provides a facile,green and scalable method toward the synthesis of diverse bimetallic NPs with excellent activity. | Huayi Shi Bin Song Runzhi Chen Qiang Zhang Guyue Hu Jing Li Jinhua Wang Xinyu Meng Houyu Wang Yao He | 2022 | Nano Research2022，15，1： | 2 |
| 15 | Blossom of CRISPR technologies and applications in disease treatment显示文摘Since 2013,the CRISPR-based bacterial antiviral defense systems have revolutionized the genome editing field.In addition to genome editing,CRISPR has been developed as a variety of tools for gene expression regulations,live cell chromatin imaging,base editing,epigenome editing,and nucleic acid detection.Moreover,in the context of further boosting the usability and feasibility of CRISPR systems,novel CRISPR systems and engineered CRISPR protein mutants have been explored and studied actively.With the flourish of CRISPR technologies,they have been applied in disease treatment recently,as in gene therapy,cell therapy,immunotherapy,and antimicrobial therapy.Here we present the developments of CRISPR technologies and describe the applications of these CRISPR-based technologies in disease treatment. | Huayi Liu Lian Wang Yunzi Luo | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 2 |
| 16 | Spatial-Temporal Changes of Housing Bubbles in China's Major Cities: 1999 to 2012显示文摘存在文学被某些缺乏在在中国测量住房水泡描绘。由扩大黑等的分析框架。(2006 ) 组织到一个空间面板增值商,这份报纸在瓷器测量住房水泡从 1999Q2 的 35 个主要城市到 2012Q3 和分析这些城市里的住房水泡的空间时间的变化。结果显示那 1 )大多数城市里的住房水泡的变化高度总体上与变化相应这个乡村的房地产政策并且 2 )象北京,上海,深圳, Hangzhou ,和 Ningbo 那样的东方发达城市里的住房水泡,尽管平均住房水泡不在 35 个主要城市上是很严肃的,在最近的年里相对大。通过内核密度函数和空间自相关分析的本地指示物,这份报纸发现住房水泡在几个东方发达城市里被集中。基于实验分析,这份报纸在禁止住房水泡的扩大和散开上建议政策建议。 | Huayi Yu | 2015 | Frontiers of Economics in China-Selected Publications from Chinese Universities2015，10，1： | 2 |
| 17 | Conversion of Carbonyl Compounds to Olefins via Enolate Intermediate显示文摘Summary of main observation and conclusion A general and efficient protocol to synthesize substituted olefins from carbonyl compounds via nickel catalyzed C-O activation of enolates was developed.Besides ketones,aldehydes were also suitable substrates for the presented catalytic system to produce di-or tri-substituted olefins.It is worth noting that this approach exhibited good tolerance to highly reactive tertiary alcohols,which could not survive in other reported routes for converting carbonyl compounds to olefins.This method also showed good regio-and stereo-selectivity for olefin products.Preliminary mechanistic studies indicated that the reaction was accomplished through nickel catalyzed C-O activation of enolates,thus offering helpful contribution to current enol chemistry. | Zhi-Chao Cao Pei-Lin Xu Qin-Yu Luo Xiao-Lei Li Da-Gang Yu Huayi Fang Zhang-Jie Shi | 2019 | Chinese Journal of Chemistry2019，37，8： | 2 |
| 18 | Design and Implementation of Verification Code Identification Based on Anisotropic Heat Kernel显示文摘Many websites use verification codes to prevent users from using the machine automatically to register,login,malicious vote or irrigate but it brought great burden to the enterprises involved in internet marketing as entering the verification code manually.Improving the verification code security system needs the identification method as the corresponding testing system.We propose an anisotropic heat kernel equation group which can generate a heat source scale space during the kernel evolution based on infinite heat source axiom,design a multi-step anisotropic verification code identification algorithm which includes core procedure of building anisotropic heat kernel,settingwave energy information parameters,combing outverification codccharacters and corresponding peripheral procedure of gray scaling,binarizing,denoising,normalizing,segmenting and identifying,give out the detail criterion and parameter set.Actual test show the anisotropic heat kernel identification algorithm can be used on many kinds of verification code including text characters,mathematical,Chinese,voice,3D,programming,video,advertising,it has a higher rate of 25%and 50%than neural network and context matching algorithm separately for Yahoo site,49%and 60%for Captcha site,20%and 52%for Baidu site,60%and 65%for 3DTakers site,40%,and 51%.for MDP site. | LIU Lizhao LIU Jian DAI Yaomei XU Huarong YIN Huayi ZHU Shunzhi | 2016 | China Communications2016，13，1： | 2 |
| 19 | The capacitive performances of carbon obtained from the electrolysis of CO_(2) in molten carbonates: Effects of electrolysis voltage and temperature显示文摘The electrochemical reduction of CO2 to capacitive carbon in molten Li2 CO3–Na2 CO3–K2 CO3 is an effective strategy for capturing and utilizing CO2. This paper reports the effects of the cell voltages and operating temperatures(450–650 °C) of the molten salt electrolysis on the capacitive performance of electrolytic carbon. The electrolytic carbon delivers excellent specific capacitance when the cell voltage is 4.5 V and the temperature of molten salt is 450 °C. The carbon obtained at 450 °C and under 4.5 V delivers a specific capacitance of 550 F g^(-1) at 0.2 A g^(-1) in 1 M aqueous H2 SO4, and the capacity retention rate is73% after 10000 cycles. The specific capacitance of the electrolytic carbon increases as the electrolysis temperature decreases, and the optimal cell voltage is 4.5 V. | Diyong Tang Yanpeng Dou Huayi Yin Xuhui Mao Wei Xiao Dihua Wang | 2020 | Journal of Energy Chemistry2020，29，12： | 2 |
| 20 | Prototype of multi-filament electron curtain accelerator显示文摘 | LI Guohua TANG Huaping LIU Jinsheng ZHANG Huayi LIU Yaohong ZHANG Dongsheng HE Yu LI Jian GUAN Weiqiang | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
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