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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Degradation of metabolites of benzo[a]pyrene by coupling Penicillium chrysogenum with KMnO_4显示文摘benzo 的几主要代谢物[一]分核( BaP )由 Penicilliumchrysogenum 形成了, Benzo [一] pyrene-l , 6-quinone ( BP1,6-quinone ), tran.s-7,8-dihydroxy-7,8-dihydrobenzo [一]分核( BP 7,8-diol ), 3-hydroxybenzo [一]分核( 3-OHBP ),被高效的液体识别因为他们的毒性 tomicroorganisms.However ,要积累并且几乎不是进一步的三代谢物 wereliable 使产生代射变化的层析( HPLC ) .The ,他们的进一步的降级为完全的降级 ofBaP.To | ZANG Shu-yan LI Pei-jun YU Xiao-cai SHI Kun ZHANG Hui CHEN Jing | 2007 | Journal of Environmental Sciences2007，19，2： | 8 |
| 4 | Top-emitting thermally activated delayed fluorescence organic light-emitting devices with weak light-matter coupling显示文摘Resonance interaction between a molecular transition and a confined electromagnetic field can lead to weak or strong light-matter coupling.Considering the substantial exciton–phonon coupling in thermally activated delayed fluorescence(TADF)materials,it is thus interesting to explore whether weak light-matter coupling can be used to redistribute optical density of states and to change the rate of radiative decay.Here,we demonstrate that the emission distribution of TADF emitters can be reshaped and narrowed in a top-emitting organic light-emitting device(OLED)with a weakly coupled microcavity.The Purcell effect of weak microcavity is found to be different for TADF emitters with different molecular orientations.We demonstrate that radiative rates of the TADF emitters with vertical orientation can be substantial increased in weakly coupled organic microcavity.These observations can enhance external quantum efficiencies,reduce efficiency roll-off,and improve color-purities of TADF OLEDs,especially for emitters without highly horizontal orientation. | Chunxiu Zang Shihao Liu Mengxin Xu Ruifang Wang Chen Cao Zelin Zhu Jiaming Zhang Hui Wang Letian Zhang Wenfa Xie Chun-Sing Lee | 2021 | Light(Science & Applications)2021，10，7： | 7 |
| 5 | Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy显示文摘The aim of this study was to understand the characteristics of blood pressure(BP)variability in subjects with diabetic nephropathy(DN),and identify the probable predictors affecting BP variability.Fifty-one chronic kidney disease(CKD)-hypertensive patients without diabetes(NDN group)and sixty type 2 diabetic patients with overt DN(DN group)were enrolled in this study.The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring(ABPM).Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group[(12.23±3.66)vs.(10.74±3.83)mmHg,P<0.05;(11.23±4.82)vs.(9.48±3.69)mmHg,P<0.05].Then the patients of the DN group were divided into two groups according to glycated hemoglobin(HbA1c)level:Group A(HbA1c<7%)and Group B(HbA1c≥7%),and the t-test showed that patients in Group B had larger 24-h diastolic,daytime diastolic,and nighttime systolic/diastolic BP variability compared with Group A.In the DN group,partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic,daytime diastolic,nighttime systolic and diastolic BP variability(P<0.001,P<0.001,P<0.05,and P<0.001,respectively).Taken together,larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency.It may imply that the optimal BP variability level could benefit from a better glycaemic control. | Fang LIU Min WU Yan-huan FENG Hui ZHONG Tian-lei CUI You-qun HUANG Ya-ping LIANG Yong-shu DIAO Li ZANG Ling LI Jing ZANG Hong-yu QIU Song-min HUANG Ping FU | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，11： | 6 |
| 6 | Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma显示文摘Exosome is a crucial manner for cancer cell to cell communication and circulating exosomes sever as promising diagnostic and prognostic markers for various types of diseases.A predominant type of cargo of exosome is small RNAs,especially miRNAs.Here,we profiled plasma exosomal miRNAs of six lung adenocarcinoma patients before and after surgery,as well as six healthy individuals as normal control.Our profiling revealed 38 upregulated and 37 downregulated exosomal miRNAs in the plasma of lung adenocarcinoma patients.Additionally,we found that most upregulated miRNAs were increased in the lung adenocarcinoma samples of TCGA database.We further evaluated the correlation between the upregulated exosomal miRNAs and overall survival with Kaplan-Meier survival analysis using online databases.Our resu ltS suggested that exosomal miR-151a-5p,miR-10b-5p,miR-192-5p,miR-106b-3p,and miR-484 are potential prognostic markers for lung adenocarcinoma.Importantly,we validated candidate miRNAs in lung adenocarcinoma patients before and after surgery as well as in healthy controls and found that miR-484 was significantly increased in the plasma of lung adenocarcinoma patients and strikingly decreased post-surgery.Hence,we provided novel information on lung adenocarcinoma-derived exosomal miRNA and potential non-invasive diagnostic and prognostic markers for lung adenocarcinoma. | Xinying Xue Chen Wang Zhiqiang Xue Jiaxin Wen Jun Han Xidong Ma Xuelei Zang Hui Deng Rui Guo Idorenyin Polycarp Asuquo Chong Qin Haijiao Wang Quansheng Gao Sanhong Liu Jianxin Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 6 |
| 7 | The Science Operations and Data Center (SODC) of the ASO-S mission显示文摘A ground data analysis center is very important to the success of a mission.We introduce the Science Operations and Data Center(SODC)for the ASO-S mission,which consists of a scientific operation subcenter,a data management subcenter,a data analysis subcenter and a user service subcenter.The mission planning process,instrument observation modes and the data volume are presented.We describe the data flow and processing procedures from spacecraft telemetry to high-level science data,and the long-term archival as well.The data policy and distributions are also briefly introduced. | Yu Huang Hui Li Wei-Qun Gan You-Ping Li Jiang-Tao Su Yuan-Yong Deng Li Feng Yang Su Wei Chen Shi-Jun Lei Ying Li Yun-Yi Ge Ying-Na Su Si-Ming Liu Jing-Jing Zang Zun-Lei Xu Xian-Yong Bai Jing-Wei Li | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 3 |
| 8 | Engineered tunneling layer with enhaneed impact ionization for detection improvement in graphene/silicon heterojunction photodetectors显示文摘Here,an engineered tunneling layer enhanced photocurrent multiplication through the impact ionization effect was proposed and experimentally demonstrated on the graphene/silic on heterojunction photodetectors.With con sidering the suitable band structure of the insulation material and their special defect states,an atomic layer deposition(ALD)prepared wide-bandgap insulating(WBI)layer of AIN was introduced into the interface of graphene/silicon heterojunction.The promoted tunneling process from this designed structure dem on strated that can effectively help the impact ionization with photogain not only for the regular minority carriers from silicon,but also for the novel hot carries from graphene.As a result,significantly enhanced photocurrent as well as simultaneously decreased dark current about one order were accomplished in this graphene/insulation/silicon(GIS)heterojunction devices with the optimized AIN thickness of〜15 nm compared to the conventional graphene/silicon(GS)devices.Specifically,at the reverse bias of-10 V,a 3.96-A W_1 responsivity with the photogain of~5.8 for the peak response under 850-nm light illumination,and a 1.03-A W_1 responsivity with~3.5 photogain under the 365 nm ultraviolet(UV)illumination were realized,which are even remarkably higher than those in GIS devices with either AI2O3 or the commonly employed SiO2 insulation layers.This work dem on strates a universal strategy to fabricate broad ba nd,low-cost and high-performance photo-detecting devices towards the graphene-silicon optoelectronic integration. | Jun Yin Lian Liu Yashu Zang Anni Ying Wenjie Hui Shusen Jiang Chunquan Zhang Tzuyi Yang Yu-Lun Chueh Jing Li Junyong Kang | 2021 | Light(Science & Applications)2021，10，6： | 3 |
| 9 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
| 10 | Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma显示文摘Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA. | Xin-ying Xue Yu-xia Liu Chen Wang Xin-jin Gu Zhi-qiang Xue Xue-lei Zang Xi-dong Ma Hui Deng Rong Liu Lei Pan San-hong Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 11 | A novel generic graph model for traffic grooming in heterogeneous WDM mesh networks显示文摘 | Hongyue Zhu Hui Zang Keyao Zhu Biswanath Mukherjee | 2003 | IEEE/ACM Transactions on Networking (TON)2003，，2： | 2 |
| 12 | Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1显示文摘TANK-binding kinase 1(TBK1)is an essential protein kinase for activation of interferon regulatory factor 3(IRF3)and induction of the type I interferons(IFN-I).Although the biochemical regulation of TBK1 activation has been studied,little is known about how enterovirus 71(EV71)employs the deubiquitinases(DUBs)to regulate TBK1 activation for viral immune evasion.Here,we found that EV71 infection upregulated the expression of ubiquitinspecific protease 24(USP24).Further studies revealed that USP24 physically interacted with TBK1,and can reduce K63-linked polyubiquitination of TBK1.Knockdown of USP24 upregulated TBK1 K63-linked polyubiquitination,promoted the phosphorylation and nuclear translocation of IRF3,and in turn improved IFN-I production during EV71 infection.As a consequence,USP24 knockdown dramatically inhibited EV71 infection.This study revealed USP24 as a novel regulator of TBK1 activation,which promotes the understanding of immune evasion mechanisms of EV71 and could provide a potential strategy for treatment of EV71 infection. | Lichao Zang Jin Gu Xinyu Yang Yukang Yuan Hui Guo Wei Zhou Jinhong Ma Yan Chen Yumin Wu Hui Zheng Weifeng Shi | 2023 | Virologica Sinica2023，38，1： | 2 |
| 13 | Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients显示文摘 | Dekai Qiu Qixia Wang Hui Wang Qing Xie Guoqing Zang Hong Jiang Chuantao Tu Jinsheng Guo Shuncai Zhang Jianshe Wang Yi Lu Ying Han Lei Shen Xiaoyu Chen Xiqi Hu Xiaojin Wang Chengwei Chen Qingchun Fu Xiong Ma | 2010 | Journal of Hepatology2010，，： | 2 |
| 14 | Method of GIL partial discharge localization based on natural neighbour interpolation and ECOC‐MLP‐SVM using optical simulation technology显示文摘Partial discharge(PD)is one of the main causes rendering the deterioration of the insulation state in gas‐insulated transmission line(GIL).Accurate and timely localization of the PD source is essential to ensure the safe and stable operation of the GIL.At present,optical PD detection technology shows advantages in terms of high sensitivity and strong anti‐inter-ference performance.Therefore,an optical PD localization method based on optical simulation fingerprint database is proposed.The introduction of simulation conquers the difficulty of obtaining a PD fingerprint database in field experiments.This method con-structs a simulation fingerprint database by performing PD simulation in a GIL simulation model of the same size as the actual GIL.The natural neighbour interpolation algorithm is applied to expand the simulation fingerprint database to cover all locations in the GIL.The two‐level localization method proposed is to match the PD fingerprint to be tested with the expanded fingerprint database,which can reduce the amount of calculation while main-taining the localization accuracy.The experimental results show that the average localiza-tion error of this method is only 9.7 mm,and the localization time is reduced by about 11 times compared with the normal one‐level localization method. | Yiming Zang Yong Qian Hui Wang Antian Xu Gehao Sheng Xiuchen Jiang | 2021 | High Voltage2021，6，3： | 1 |
| 15 | Dynamic traffic grooming in WDM mesh networks using a novel graph model 显示文摘 | Zhu Hong-yue Zang Hui Zhu Ke-yao | 2003 | SPIE Optical Networks Magazine May2003，4，3： | 1 |
| 16 | The rela- tionship between human resource management practices, busi- ness strategy and firm performance:evidence from steel indus- try in Taiwan 显示文摘 | Lee Feng Hui Lee Tzai Zang and Wu Wann Yih | 2010 | The International Journal of Human Re- source Management2010，21，9： | 1 |
| 17 | A review of routing and wavelength assignment approaches for wavelength-routed optical WDM networks显示文摘 | Jue Jasonp Biswanath Mukherjee | 2000 | Optical Networks Magazine2000，1，1： | 1 |
| 18 | A Novel Generic Graph Model for Traffic Grooming in Heterogeneous WDM Mesh Networks显示文摘 | Zhu Hongyue Zang Hui Zhu Keyao | 2003 | IEEE/ACM Transactions on Networking2003，11，2： | 1 |
| 19 | Iterative Learning Control of Antilock Breaking of Electric and Hybrid Vehicles显示文摘 | Mi Chunting Lin Hui Zang Yi | 2005 | IEEE Transactions on Vehicular Technology2005，54，2： | 1 |
| 20 | A novel,generic graph model for traffic grooming in heterogeneous WDM mesh networks显示文摘 | Zhu Hongyue Zang Hui Zhu Keyao | 2003 | IEEE/ACM Trans Networking2003，11，2： | 1 |
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